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61. 发明专利

JP2009079026A Skin-lightening preparation for external use 审中-公开
标题翻译：皮肤外用制剂外用
公开(公告)号：JP2009079026A
公开(公告)日：2009-04-16
申请号：JP2007298990
申请日：2007-11-19
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SUZUKI MICHIKO , YAMAMOTO SHUHEI , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： A61K8/88 , A61K8/44 , A61K8/60 , A61K8/64 , A61K8/67 , A61K8/73 , A61K8/81 , A61K8/86 , A61K8/97 , A61K8/98 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a skin-lightening preparation for external use, which is free from sticky touch and creaky touch, has excellent usability, and also keeps a certain level of viscosity, even when highly containing a skin-lightening component, is stable over a long period, and does not cause water separation or the like. SOLUTION: The skin-lightening preparation for external use is characterized by comprising (a) one or more compounds selected from poly-γ-L-glutamic acid, the salts of the poly-γ-L-glutamic acid, a poly-γ-L-glutamic acid cross-linked product, and the salts of the poly-γ-L-glutamic acid cross-linked product, and (b) a skin-lightening agent component. The skin-lightening agent component is preferably one or more compounds selected from L-ascorbic acid and its derivatives, arbutin and its derivatives, glutathione, tranexamic acid and its derivatives, a placenta extract, and plant extracts, especially magnesium L-ascorbate phosphate. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供没有粘性触感和吱吱嘎吱的触摸的外用皮肤发光制剂，具有优异的可用性，并且还保持一定水平的粘度，即使高度含有皮肤发光长时间稳定，不会发生水分离等。解决方案：外用皮肤增亮剂的特征在于包含（a）一种或多种选自聚-γ-L-谷氨酸，聚-γ-L-谷氨酸的盐，聚 -γ-L-谷氨酸交联产物和聚-γ-L-谷氨酸交联产物的盐，和（b）皮肤增亮剂组分。亮肤剂成分优选为选自L-抗坏血酸及其衍生物，熊果苷及其衍生物，谷胱甘肽，氨甲环酸及其衍生物，胎盘提取物，植物提取物，特别是L-抗坏血酸钾镁的一种或多种化合物。版权所有（C）2009，JPO＆INPIT

62. 发明专利

JP2009050273A Stabilized sarcosine oxidase 审中-公开
标题翻译：稳定的焦磷酸氧化酶
公开(公告)号：JP2009050273A
公开(公告)日：2009-03-12
申请号：JP2008262877
申请日：2008-10-09
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12Q1/26
摘要： PROBLEM TO BE SOLVED: To provide sarcosine oxidase which has improved stability as liquid, and is obtained by modifying a protein having sarcosine oxidase activity by a protein engineering method, to provide a method for producing the same, and to provide a use thereof. SOLUTION: In the modified sarcosine oxidase, the 204-methionine of an amino acid sequence comprising a specific sequence is substituted with alanine. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供作为液体具有改善的稳定性的肌氨酸氧化酶，并且通过蛋白质工程方法修饰具有肌氨酸氧化酶活性的蛋白质获得，以提供其制备方法，并提供使用其中。解决方案：在修饰的肌氨酸氧化酶中，包含特定序列的氨基酸序列的204-甲硫氨酸被丙氨酸取代。版权所有（C）2009，JPO＆INPIT

63. 发明专利

JP2009034090A Mannosyl erythritol lipid and method for producing the same 有权
标题翻译：花青素脂质体及其制备方法
公开(公告)号：JP2009034090A
公开(公告)日：2009-02-19
申请号：JP2008003615
申请日：2008-01-10
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： KITAGAWA MASARU , SOGABE ATSUSHI , FUKUOKA TOKUMA , MORITA TOMOTAKE , IMURA TOMOHIRO , KITAMOTO MASARU
IPC分类号： C12P19/44 , C07H15/04 , C12R1/645
摘要： PROBLEM TO BE SOLVED: To provide a mannosyl erythritol lipid (MEL) having a 1-O-β-D-mannopyranosyl-meso-erythritol structure which is an optical isomer of a conventional MEL having a 4-O-β-D-mannopyranosyl-meso-erythritol structure and to provide a method for producing the MEL.
SOLUTION: A microorganism belonging to the genus Pseudozyma and having ability producing a mannopyronosyl erythritol lipid is cultured to produce the mannosyl erythritol lipid having the 1-O-β-D-mannopyranosyl-meso-erythritol structure.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有1-O-β-D-吡喃甘露糖基 - 内消旋 - 赤藓糖醇结构的甘露糖基赤藓糖醇脂质（MEL），其为具有4-O-β- D-甘露吡喃糖基 - 内消旋 - 赤藓糖醇结构，并提供一种生产MEL的方法。培养具有1-O-β-D-吡喃甘露糖基 - 内消旋赤藓糖醇结构的甘露糖基赤藓糖醇脂质的具有产生甘露聚糖苷类赤藓糖醇脂质的能力的微生物属于假酶属的微生物。版权所有（C）2009，JPO＆INPIT

64. 发明专利

JP2008156330A Activating agent and anti-aging agent 审中-公开
标题翻译：活化剂和抗老化剂
公开(公告)号：JP2008156330A
公开(公告)日：2008-07-10
申请号：JP2007082264
申请日：2007-03-27
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KASUKABE YOSHIHISA , SUZUKI MICHIKO , SOGABE ATSUSHI
IPC分类号： A61K31/132 , A23L1/30 , A61K8/41 , A61P43/00 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To solve a problem wherein although various kinds of activating agents and anti-aging agents of animal or vegetable origins have been found, an effect sufficient and stable enough to an industrially applicable level has not actually been achieved yet; and to provide an activating agent or an anti-aging agent which is excellent in cell activating or anti-aging effect and sufficiently durable for a long time use. SOLUTION: The activating agent or the anti-aging agent for cells contains a polyamine as an effective component. A method for using the same in cosmetics, quasi drugs (skin external agents, bath agents, hair growth promoters, etc.), food or drink, and drugs and medicines as effective components is also provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题为了解决已经发现动物或蔬菜来源的各种活化剂和抗老化剂的问题，其实际上已经没有实现足够和足够稳定到工业上适用水平的效果 ; 并提供细胞活化或抗老化作用优异的活化剂或抗老化剂，长期使用时具有足够的耐久性。解决方案：活化剂或细胞的抗老化剂含有多胺作为有效成分。还提供了在化妆品，准药物（皮肤外用剂，浴剂，毛发生长促进剂等），食品或饮料以及作为有效成分的药物和药物中使用它们的方法。版权所有（C）2008，JPO＆INPIT

65. 发明专利

JP2007291027A Method for preparing polyamine composition from plant 有权
标题翻译：从植物制备聚氨酯组合物的方法
公开(公告)号：JP2007291027A
公开(公告)日：2007-11-08
申请号：JP2006122044
申请日：2006-04-26
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KASUKABE YOSHIHISA , SOGABE ATSUSHI
IPC分类号： C07C209/86 , A61K8/41 , A61K8/97 , C07C209/84 , C07C211/09 , C07C211/13 , C07C211/14
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing a polyamine or a polyamine composition in high yield from a plant material having high safety, because the polyamine or the polyamine composition is utilized for health, cosmetics, foods and medicines, but, sufficient method for preparing the polyamine or the polyamine composition are not established. SOLUTION: The method for preparing the polyamine composition comprises (1) a step for treating a plant and/or a plant extract under acidic conditions and (2) a step for separating a liquid fraction. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：为了提供从高安全性的植物材料制备多胺或多胺组合物的方法，因为多胺或多胺组合物用于健康，化妆品，食品和药物，但是没有建立足够的制备多胺或多胺组合物的方法。解决方案：制备多胺组合物的方法包括（1）在酸性条件下处理植物和/或植物提取物的步骤和（2）分离液体馏分的步骤。版权所有（C）2008，JPO＆INPIT

66. 发明专利

JP2007112749A Carrier for delivering nucleic acid molecule for non-proliferative cell 审中-公开
标题翻译：用于非增殖细胞递送核酸分子的载体
公开(公告)号：JP2007112749A
公开(公告)日：2007-05-10
申请号：JP2005305959
申请日：2005-10-20
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： NAKANISHI MAMORU , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： A61K47/48 , A61K9/127 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/28 , A61K48/00 , A61P25/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a carrier for delivering a nucleic acid molecule having low cytotoxicity even for a non-proliferative cell such as a neurocyte and excellent gene expression efficiency and to provide a method and a kit for gene transfer using the carrier for delivering the nucleic acid molecule.
SOLUTION: The carrier for delivering the nucleic acid molecule comprises a phospholipid, a cationic lipid and a mannoside lipidic glycolipid compound. The method for gene transfer comprises using the carrier for delivering the nucleic acid molecule. The kit comprises the carrier for delivering the nucleic acid molecule.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了提供用于递送具有低细胞毒性的核酸分子的载体，即使对于非增殖性细胞如神经细胞也具有优异的基因表达效率，并且提供用于基因转移的方法和试剂盒，用于递送核酸分子的载体。解决方案：用于递送核酸分子的载体包含磷脂，阳离子脂质和甘露糖苷脂质糖脂化合物。用于基因转移的方法包括使用载体递送核酸分子。试剂盒包含用于递送核酸分子的载体。版权所有（C）2007，JPO＆INPIT

67. 发明专利

JP2007031316A Anti-ultraviolet stimulating agent using anti-mutagenicity 审中-公开
标题翻译：使用抗致突变性的抗紫外线刺激剂
公开(公告)号：JP2007031316A
公开(公告)日：2007-02-08
申请号：JP2005214394
申请日：2005-07-25
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SUZUKI MICHIKO , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： A61K36/18 , A23L1/30 , A61K8/00 , A61K8/96 , A61K31/26 , A61K36/00 , A61P17/00 , A61P17/16 , A61P35/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an anti-ultraviolet stimulating agent comprising an active component having gene damage restoring activity caused by an external factor such as the ultraviolet ray, and to provide a cosmetic, skin care preparation, functional food and toiletries utilizing the anti-ultraviolet stimulating agent. SOLUTION: The invention relates to the anti-ultraviolet stimulating agent comprising the antimutagenic substance, for example, the substance originating from horseradish, and the invention relates to the skin care preparation, functional food and toiletries comprising the anti-ultraviolet stimulating agent as the active component. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种抗紫外线刺激剂，其包含由外部因素如紫外线引起的具有基因损伤恢复活性的活性成分，并提供化妆品，护肤品，功能性食品和化妆品利用抗紫外线刺激剂。解决方案：本发明涉及包含抗诱变物质的抗紫外线刺激剂，例如来自辣根的物质，本发明涉及包含抗紫外线刺激剂的护肤制剂，功能性食品和洗发剂作为活性成分。版权所有（C）2007，JPO＆INPIT

68. 发明专利

JP2005281146A Gene transfer carrier consisting of liposome 有权
标题翻译：基因转移载体包含脂质体
公开(公告)号：JP2005281146A
公开(公告)日：2005-10-13
申请号：JP2004093524
申请日：2004-03-26
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： YONETANI YOSHIE , HATTORI YOSHIYUKI , IGARASHI SAKI , KITAMOTO MASARU , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： C12N15/09 , A61K9/127 , A61K47/24 , A61K47/26 , A61K47/28 , A61K48/00
摘要： PROBLEM TO BE SOLVED: To provide a gene transfer technology capable of transferring genes efficiently.
SOLUTION: A gene transfer carrier is provided which is composed of liposome containing mannosylerythritol lipid and phospholipid and having a particle size of 100 nm or smaller.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够有效转移基因的基因转移技术。解决方案：提供由含有甘露糖醇酯脂质和磷脂并且粒径为100nm以下的脂质体构成的基因转移载体。版权所有（C）2006，JPO＆NCIPI

69. 发明专利

JP2005192538A New creatinine amidinohydrolase, method for producing the same and use of the same 审中-公开
标题翻译：新颖的氨基磺酰脲，其生产方法及其用途
公开(公告)号：JP2005192538A
公开(公告)日：2005-07-21
申请号：JP2004004863
申请日：2004-01-09
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SOGABE ATSUSHI , HATTORI TAKASHI , NISHIYA YOSHIAKI , KAWAMURA YOSHIHISA
IPC分类号： C12N15/09 , C12N9/78 , C12Q1/34
摘要： PROBLEM TO BE SOLVED: To provide a creatinine amidinohydrolase having a small Km value, preferably approximately ≤15.0 as a general clinical testing enzyme.
SOLUTION: This new creatinine amidinohydrolase having the following physicochemical properties is obtained by using a gene encoding the creatinine amidinohydrolase and derived from bacteria belonging to the genus Alcaligenes, introducing a mutation in the gene and by using a protein engineering method. As the creatine or creatinine determination reagent, the enzyme is used. The physicochemical properties are as follows: The activity is: Creatine + H
2 O → Sarcosine + Urea. Optimal temperature is approximately 40-50°C. Optimal pH is approximately 8-9. Thermal stability is approximately ≤50°C (at pH 7.5 for 30 min). Km value for the creatine is 3.0-10.0 mM in the case of performing an activity measurement by using sarcosineoxidase and peroxidase as coordinate enzymes. Molecular weight is approximately 43,000 (SDS-PAGE). Isoelectric point is approximately 4.5.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供具有小Km值的肌酸酐脒基水解酶，优选约≤15.0作为一般临床测试酶。解决方案：通过使用编码肌酸酐脒基水解酶并衍生自产碱杆菌属的细菌的基因，在基因中引入突变并通过使用蛋白质工程方法，获得具有以下物理化学性质的新的肌酸酐脒基水解酶。作为肌酸或肌酸酐测定试剂，使用该酶。物理化学性质如下：活性为：肌酸+ H 2 O→肌氨酸+尿素。最佳温度约为40-50°C。最佳pH值约为8-9。热稳定性约≤50℃（pH7.5，30分钟）。在使用肌氨酸氧化酶和过氧化物酶作为配位酶进行活性测定的情况下，肌酸的Km值为3.0-10.0mM。分子量约为43,000（SDS-PAGE）。等电点约为4.5。版权所有（C）2005，JPO＆NCIPI

70. 发明专利

JP2005073631A Method for modifying substrate specificity of enzyme and modified enzyme having modified substrate specificity 审中-公开
标题翻译：改性酶基因特异性修饰方法及修饰基因特异性修饰酶
公开(公告)号：JP2005073631A
公开(公告)日：2005-03-24
申请号：JP2003309897
申请日：2003-09-02
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： MATSUMURA TADAYASU , KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI , MATSUSHITA KAZUNOBU , TOYAMA HIROHIDE
IPC分类号： G01N33/66 , C12N9/04 , C12N15/09 , C12Q1/32
摘要： PROBLEM TO BE SOLVED: To provide a method for modifying the properties of an enzyme by modifying the enzyme with a mediator and provide a method for modifying enzymatic properties by modifying a pyrroloquinoline quinone-dependent glucose dehydrogenase with a mediator.
SOLUTION: The invention for the modification at a protein level is based on the assumption that the enzymatic properties can be improved by modifying amino acids constituting the enzyme protein with other compounds. As a result of various experiments, the invention has been achieved by the finding that the substrate specificity is improved by modifying the amino group of an enzyme with ferrocene carboxyaldehyde.
COPYRIGHT: (C)2005,JPO&NCIPI

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