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51. 发明专利

JP2012103265A Fluid control and processing system 审中-公开
标题翻译：流体控制和处理系统
公开(公告)号：JP2012103265A
公开(公告)日：2012-05-31
申请号：JP2011289711
申请日：2011-12-28
申请人： Cepheid , セフィードCepheid
发明人： DORITY DOUGLAS B
IPC分类号： G01N35/08 , B01L3/00 , C12M1/34 , G01N1/00 , G01N35/10
CPC分类号： G01N35/1097 , B01L3/502 , B01L2200/16 , B01L2300/0681 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N35/08
摘要： PROBLEM TO BE SOLVED: To facilitate processing of a fluid sample according to different protocols using the same apparatus to determine the presence or absence of an analyte of the sample.SOLUTION: In a specific embodiment, a fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region coupled fluidically with a fluid displacement chamber 50. The fluid displacement chamber is depressurizable to draw fluid into the chamber and pressurizable to expel fluid from the chamber. The body includes a plurality of external ports 42, 46. The fluid sample processing region is fluidically coupled with at least two of the external ports. The fluid displacement chamber is fluidically coupled with at least one of the external ports. The body is adjustable with respect to at least the plurality of chambers to place one of the external ports in selective fluidic communication with the plurality of chambers.
摘要翻译：要解决的问题：为了便于使用相同装置根据不同方案处理流体样品以确定样品的分析物的存在或不存在。解决方案：在具体实施例中，用于控制多个腔室之间的流体流动的流体控制和处理系统包括主体，该主体包括与流体移动室50流体连接的流体处理区域。流体移动室可减压以绘制流体进入腔室并且可加压以从腔室排出流体。主体包括多个外部端口42,46。流体样本处理区域与至少两个外部端口流体耦合。流体移动室与至少一个外部端口流体耦合。主体相对于至少多个室是可调节的，以使外部端口中的一个选择性地与多个室流体连通。版权所有（C）2012，JPO＆INPIT

52. 发明专利

JP4937904B2 Associated with the controlled flow electroporation chamber method and apparatus 有权
公开(公告)号：JP4937904B2
公开(公告)日：2012-05-23
申请号：JP2007513390
申请日：2005-05-12
申请人：マックスサイトインコーポレーティッド
发明人：セルゲイゼクノブ , ニコラスチョパス , リンホンリ
IPC分类号： C12N13/00 , B01L3/00 , C12M1/42 , C12M3/00 , C12Q1/68
CPC分类号： C12M35/02 , B01L3/502 , B01L3/5027 , C12M41/00

54. 发明专利

JP2012073269A Working device comprising localized zone for capturing liquid of interest 审中-公开
标题翻译：包含利用本地化区域的工作装置
公开(公告)号：JP2012073269A
公开(公告)日：2012-04-12
申请号：JP2011259651
申请日：2011-11-28
申请人： Biomerieux Sa , Commissariat A L'energie Atomique , コミッサリアアレネルジーアトミークCommissariat A L´Energie Atomique , ビオメリユ・エスアーBiomerieux Sa
发明人： MARCHAN GIL , CYRILLE DURAT , PTOE PATRICK , CAILLAT PATRICE
IPC分类号： B01L99/00 , G01N27/28 , B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N27/30 , G01N27/327
CPC分类号： B01L3/502792 , B01J2219/00317 , B01J2219/00527 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L3/50273 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： PROBLEM TO BE SOLVED: To provide a device which is capable of effectively avoiding pollution between drops and can be very flexibly used in all of methods for collective or individual analysis of trace amounts of material, which are currently known by skilled persons, whether chemical, electrical, or optical methods or combinations of these methods are accompanied or not.SOLUTION: A working device is characterized in that it comprises: an active surface (Sa) substantially non wetting with respect to liquid of interest; at least one localized capture zone (Zc) of a drop of the liquid, formed on the active surface; at least one working zone (Zt) arranged with a capture zone such that the working zone is covered at least partly by a drop of the liquid when a drop of the liquid is captured by the capture zone; and means for allowing a drop of the liquid to remain on the capture zone.
摘要翻译：要解决的问题：提供一种能够有效避免液滴之间的污染的装置，并且可以非常灵活地用于对技术人员目前已知的痕量材料的集体或个体分析的所有方法中，无论化学，电或光学方法或这些方法的组合是否伴随。解决方案：一种工作装置的特征在于其包括：相对于目标液体基本上不润湿的活性表面（Sa）形成在活性表面上的一滴液体的至少一个局部捕获区域（Zc）; 至少一个工作区（Zt）布置有捕获区，使得当液滴被捕获区捕获时，工作区至少部分地被一滴液体覆盖; 以及允许一滴液体留在捕获区上的装置。版权所有（C）2012，JPO＆INPIT

55. 发明专利

JP2012058260A Optical lens system and method for microfluidic device 有权
标题翻译：光学透镜系统和微流体器件的方法
公开(公告)号：JP2012058260A
公开(公告)日：2012-03-22
申请号：JP2011269348
申请日：2011-12-08
申请人： Fluidigm Corp , フルイディグムコーポレイション
发明人： UNGER MARC A
IPC分类号： G01N21/64 , B01L3/00 , B01L7/00 , G01N27/447 , G01N35/02 , G02B21/02 , G02B21/16
CPC分类号： C12Q1/686 , B01J2219/00576 , B01J2219/00704 , B01L3/5027 , B01L7/52 , G01N21/64 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/75 , G01N21/8483 , G01N27/44721 , G01N2021/6421 , G01N2201/061 , G02B21/16 , G02B21/36
摘要： PROBLEM TO BE SOLVED: To provide a device for picking up an image of one or more fluorescence index selected from a microfluidic device (205).SOLUTION: The device includes an image pickup path joined to join at least one chamber in at least one microfluidic device (205). The image pickup path prepares for transmission of one or more fluorescence signals from one or more samples in the at least one chamber in the at least one microfluidic device (205). The chamber has a chamber size characterized by a real space size of a normal line of the image pickup path. The devices includes optical lens systems (210, 212) joined to the image pickup path. The optical lens systems transmit one or more fluorescence signals correlated with the chamber.
摘要翻译：要解决的问题：提供一种用于拾取选自微流体装置（205）的一种或多种荧光指数的图像的装置。解决方案：该装置包括被连接以在至少一个微流体装置（205）中连接至少一个室的图像拾取路径。图像拾取路径准备用于从至少一个微流体装置（205）中的至少一个室中的一个或多个样品传输一个或多个荧光信号。该室具有以图像拾取路径的法线的实际空间大小为特征的室尺寸。这些装置包括连接到图像拾取路径的光学透镜系统（210,212）。光学透镜系统透射与室相关的一个或多个荧光信号。版权所有（C）2012，JPO＆INPIT

56. 发明专利

JP4891532B2 Device and manufacturing method and use thereof for handling liquid 有权
公开(公告)号：JP4891532B2
公开(公告)日：2012-03-07
申请号：JP2004176152
申请日：2004-06-14
申请人：ベーリンガーインゲルヘイムマイクロパーツゲーエムベーハーBoehringer Ingelheim microParts GmbH
发明人：バルトス，ホルガー , ブランケンシュタイン，ゲルト , ペーターズ，ラルフ−ペーター
IPC分类号： G01N35/08 , B01J19/00 , B01L3/00 , G01N33/543 , G01N37/00
CPC分类号： G01N33/54386 , B01L3/502746 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/0896 , B01L2400/086 , B82Y30/00
摘要： A medical diagnostics assembly manipulates nano-quantities of fluid. The assembly has a base plate (1) whose surface is sub-divided into zones (6, 7) whose different surface structures have different capillary characteristics. - One or more first zones have structures (6a - 6e) with regular micro- or nano-structures. The base plate and structured zones are formed from a single piece of material. Also claimed is a process to fabricate the medical diagnostics assembly by machining, laser beam cutting, exposure to an ion beam or micro injection-molding. The base plate and other structures are made from a single piece of material e.g. plastic, glass or silicon.

58. 发明专利

JP4878772B2 How to hydrophilizing the surface of the fluid components and systems 有权
公开(公告)号：JP4878772B2
公开(公告)日：2012-02-15
申请号：JP2005126943
申请日：2005-04-25
申请人：エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人：ジーグラーヴェルナー , ヴェルクルディートマー , ジャンピエールライナーマルコ , ヴァイスレオニー
IPC分类号： B05D7/22 , G01N27/327 , B01J19/00 , B01L3/00 , B05D3/04 , B05D3/14 , B05D5/04 , G01N33/49 , G01N37/00
CPC分类号： B05D5/04 , B01L3/502707 , B01L2200/12 , B01L2300/161 , B05D3/14 , B05D3/142 , B05D3/144 , B05D7/22 , B05D7/222 , B05D7/227 , B05D2201/02 , G01N33/4915 , Y10T436/208339
摘要： Sample-contacting surfaces, particularly of plastics components, which: - (a) are physically/chemically prepared e.g. by electric discharge gas-plasma treatment; - (b) are contacted with a solution of hydrophilic polymer e.g. polyether polyurethane in organic solvent; - (c) allow gas displacement of liquid to leave a wet surface; - (d) allow removal of solvent by natural or vacuum drying, leaving a 0.01-50, preferably 0.01-5 micron thick film. - An INDEPENDENT CLAIM is included for analytical apparatus having sample-wetted surfaces coated with hydrophilic polymer.

59. 发明专利

JP4878663B2 Microfabrication sleeve device for chemical reaction 失效
公开(公告)号：JP4878663B2
公开(公告)日：2012-02-15
申请号：JP52705298
申请日：1997-12-03
申请人：ザリージェンツオブザユニヴァーシティーオブカリフォルニア
发明人：ノースラップ，エム．，アレン
IPC分类号： B01J19/00 , C12N15/09 , B01L3/00 , B01L7/00 , B01L9/00 , B81B1/00 , B81C3/00 , C12M1/00 , C12Q1/68 , G01N21/03 , G01N21/05 , G01N21/69 , G01N21/76
CPC分类号： B01L7/52 , B01J19/0046 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00936 , B01J2219/00945 , B01J2219/00952 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0654 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0421 , B01L2400/0439 , B01L2400/0487 , B81C3/00 , G01N21/0332 , G01N21/05 , G01N21/69 , G01N21/76 , G01N2021/0346
摘要： A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and non-silicon based materials to provide the thermal properties desired. For example, the chamber may combine a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.

60. 发明专利

JP4875066B2 Microtiter plates with the removed ambient 有权
公开(公告)号：JP4875066B2
公开(公告)日：2012-02-15
申请号：JP2008510221
申请日：2006-05-04
申请人：カリパー・ライフ・サイエンシズ・インク.
发明人：エドワード・エム．・アルダーマン , フレデリック・ディー．・シモンズ , リチャード・バンチ
IPC分类号： G01N35/02 , B01L3/00
CPC分类号： B01L3/5085 , B01L2200/025 , B01L2300/0829

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