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1. 发明专利

JP2014160075A Fluid control and processing system 有权
标题翻译：流体控制处理系统
公开(公告)号：JP2014160075A
公开(公告)日：2014-09-04
申请号：JP2014037814
申请日：2014-02-28
申请人： Cepheid , セフィードCepheid
发明人： DORITY DOUGLAS B
IPC分类号： G01N35/10 , B01L3/00 , C12M1/34 , G01N1/00 , G01N35/08
CPC分类号： G01N35/1097 , B01L3/502 , B01L2200/16 , B01L2300/0681 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N35/08
摘要： PROBLEM TO BE SOLVED: To provide a fluid control processing system that has variety, being active, and being applicable to a different protocol.SOLUTION: A fluid control processing system controls the flow of a fluid among a plurality of chambers and is provided with a body including a fluid processing region 30 coupled with a fluid movement chamber 50 in a fluid engineering fashion. The fluid movement chamber can reduce pressure to suck a fluid into a chamber and can apply pressure to discharge the fluid out of the chamber. The body includes a plurality of external ports 42. A fluid sample processing region is coupled with at least two external ports in a fluid engineering fashion. The fluid movement chamber is coupled with at least one external port in a fluid engineering fashion. The body is adjustable to at least a plurality of chambers and is arranged such that one external port is selectively communicated with the plurality of chambers by the fluid.
摘要翻译：要解决的问题：提供一种流体控制处理系统，其具有多种，主动和可应用于不同协议。流体控制处理系统控制多个室之间的流体流动，并且设置有主体包括以流体工程方式与流体移动室50联接的流体处理区域30。流体移动室可以减小将流体吸入室中的压力，并且可以施加压力以将流体排出室。主体包括多个外部端口42.流体样品处理区域以流体工程方式与至少两个外部端口耦合。流体移动室以流体工程方式与至少一个外部端口联接。主体可调节至少多个室，并且被布置成使得一个外部端口通过流体与多个室选择性地连通。

2. 发明专利

JP2014064591A Closed-system multi-stage nucleic acid amplification reactions 有权
标题翻译：封闭系统多级核酸放大反应
公开(公告)号：JP2014064591A
公开(公告)日：2014-04-17
申请号：JP2014002146
申请日：2014-01-09
申请人： Cepheid , セフィードCepheid
发明人： CHANG RONALD , CHING JESUS , DORITY DOUGLAS BRYAN , ZHANG JIAN PING , WANG JAMES JIAN QUAN , WONG WENDY WINGKEI , PAUL KENDRA LARA , ATTA REUEL VAN
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68
CPC分类号： G01N21/6428 , B01L3/502 , B01L7/52 , B01L2200/0684 , B01L2300/0654 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q2565/629 , C12Q2563/173 , C12Q2549/119 , C12Q2531/143 , C12Q2537/149
摘要： PROBLEM TO BE SOLVED: To provide systems, methods, and an apparatus for closed multi-stage nucleic acid amplification reactions wherein a portion of a prior-stage reaction mixture serves as the sample for the next stage reaction.SOLUTION: The invention is directed to systems, methods and an apparatus for carrying out multi-stage amplification reactions, especially under fluidly closed conditions. In one aspect, the methods of the invention are carried out in a fluidly closed reaction system that permits the isolation of a portion of a first (or prior) reaction mixture and its use as a sample or specimen in a second (or subsequent) reaction mixture, thereby substantially avoiding interfering effects that first reaction components may have in the second reaction if both reaction mixtures were simply combined together. In the aspect, the systems, methods, and apparatus of the invention may be used with any amplification reaction that permits multiple stages of amplification based on the use of nested primers.
摘要翻译：要解决的问题：提供用于闭合多级核酸扩增反应的系统，方法和装置，其中一部分前期反应混合物用作下一阶段反应的样品。解决方案：本发明涉及系统，方法和用于进行多级扩增反应的装置，特别是在流体封闭的条件下。在一个方面，本发明的方法在流体封闭的反应体系中进行，其允许分离第一（或先前）反应混合物的一部分，并且其在第二次（或随后的）反应中作为样品或样品的用途从而基本上避免了如果两个反应混合物简单地组合在一起，第一反应组分可能在第二反应中可能具有干扰效应。在这方面，本发明的系统，方法和装置可以与基于嵌套引物的使用允许多个扩增阶段的任何扩增反应一起使用。

3. 发明专利

JP2009282041A Cartridge for controlling chemical reaction 有权
标题翻译：用于控制化学反应的墨盒
公开(公告)号：JP2009282041A
公开(公告)日：2009-12-03
申请号：JP2009180791
申请日：2009-08-03
申请人： Cepheid , セフィードCepheid
发明人： PETERSEN KURT E , MCMILLAN WILLIAM A , POURAHMADI FARZAD , CHANG RONALD , DORITY DOUGLAS B
IPC分类号： G01N33/48 , G01N35/02 , B01J19/00 , B01J19/24 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/26 , C12M1/34 , G01N33/483 , G01N35/08 , G01N37/00
CPC分类号： B01L3/502 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644
摘要： PROBLEM TO BE SOLVED: To provide a cartridge which can quickly treat a reactant mixture and improve the detection sensitivity of an analyte in the mixture. SOLUTION: This cartridge (20) for controlling a chemical reaction includes a main body with at least one internally-formed channel The cartridge extends from the main body, and further includes a reaction container (40) for holding the reactant mixture used on the chemical reaction and optical detection. The reaction container (40) has a rigid frame for partitioning sidewalls of a reaction chamber, and the frame has at least one channel for connecting the channel with the reaction chamber. Furthermore, the reaction chamber has flexible films or sheets attached to both sides of the above frame in order to form a main wall opposed to the reaction chamber. Additionally, at least two of the sidewalls are biased with respect to each other so as to be translucent and angular for enabling the real time optical detection of the analyte in the reaction chamber. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可以快速处理反应物混合物并提高混合物中分析物的检测灵敏度的药筒。用于控制化学反应的盒（20）包括具有至少一个内部形成的通道的主体。盒从主体延伸，并且还包括用于保持所使用的反应物混合物的反应容器（40）对化学反应和光学检测。反应容器（40）具有用于分隔反应室侧壁的刚性框架，框架具有用于将通道与反应室连接的至少一个通道。此外，反应室具有附接到上述框架的两侧的柔性膜或片，以形成与反应室相对的主壁。此外，至少两个侧壁相对于彼此被偏置，以便是半透明和有角度的，以便能够对反应室中的分析物进行实时光学检测。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2017116552A 流体制御処理システム有权
公开(公告)号：JP2017116552A
公开(公告)日：2017-06-29
申请号：JP2017023917
申请日：2017-02-13
申请人：セフィードCepheid , Cepheid
发明人： DORITY DOUGLAS B
IPC分类号： G01N35/08 , B01L3/00 , G01N1/00 , G01N35/10
CPC分类号： G01N35/1097 , B01L3/502 , B01L2200/16 , B01L2300/0681 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N35/08
摘要：【課題】新規な流体制御処理システムを提供する。【解決手段】試料の分析物の有無を決定するために、同一の装置を使用する異なるプロトコルにより、流体試料を容易に処理する。複数チャンバ間の流体の流れを制御する流体制御処理システムは、流体移動チャンバ(50)と流体工学的に結合された流体処理領域を含む本体を備える。上記流体移動チャンバは減圧できて流体を上記チャンバに吸引すると共に、加圧できて流体を上記チャンバから放出する。本体は複数の外部ポート(42,46)を含む。流体試料処理領域は少なくとも2つの外部ポートと流体工学的に結合される。流体移動チャンバは少なくとも1つの外部ポートと流体工学的に結合される。本体は少なくとも複数のチャンバに対して調整可能であって1つの外部ポートを複数のチャンバと選択的に流体で連通するように配置する。【選択図】図8

5. 发明专利

JP2014060999A Methods and apparatus for sequential amplification reactions 有权
标题翻译：用于顺序放大反应的方法和装置
公开(公告)号：JP2014060999A
公开(公告)日：2014-04-10
申请号：JP2013245161
申请日：2013-11-27
申请人： Cepheid , セフィードCepheid
发明人： JOSEPH H SMITH , DAVID H PERSING , ALAN WORTMAN , CHANG RONALD , DAVID SWENSON
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09
CPC分类号： C12Q1/686 , B01L3/502738 , B01L7/52 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/0644 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , C12Q2565/629 , C12Q2547/101 , C12Q2537/149 , C12Q2537/143 , C12Q2565/101 , C12Q2527/107
摘要： PROBLEM TO BE SOLVED: To provide methods for conducting multi-stage nucleic acid amplification reactions useful for applications requiring rapid amplification of multiple sequences.SOLUTION: The present invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
摘要翻译：要解决的问题：提供用于进行需要快速扩增多个序列的应用的多级核酸扩增反应的方法。解决方案：本发明提供了通过连续循环在单个反应室中进行多重扩增反应的方法和装置加载反应混合物，在流体封闭的体系中放大和除去废反应混合物。特别地，本发明允许通过在闭环控制下从样品的不同部分连续扩增不同靶多核苷酸而从单个样品扩增多个靶多核苷酸。

6. 发明专利

JP2010104372A Apparatus and method for rapid disruption of cells or viruses 有权
标题翻译：用于快速破坏细胞或病毒的装置和方法
公开(公告)号：JP2010104372A
公开(公告)日：2010-05-13
申请号：JP2009291496
申请日：2009-12-22
申请人： Cepheid , セフィードCepheid
发明人： TAYLOR MICHAEL T
IPC分类号： C12Q1/68 , C12M1/33 , C12M1/42 , C12N1/00 , C12N1/06 , C12N13/00 , C12Q1/02 , C12Q1/70 , G01N1/28
CPC分类号： G01N1/286 , C12M47/06 , C12N1/066
摘要： PROBLEM TO BE SOLVED: To provide an improved apparatus and method for disrupting cells or viruses to release nucleic acids therefrom. SOLUTION: The apparatus 10 for disrupting cells or viruses includes a container 18 having a chamber for holding the cells or viruses. The chamber is defined by at least one wall having an external surface to which is coupled a transducer device 38. The transducer device 38 vibrates at an operating frequency and amplitude sufficient to generate pressure waves or pressure pulses in the chamber. The transducer device 38 is coupled to the wall with a preload force sufficient to create a stress within the wall. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于破坏细胞或病毒以从其释放核酸的改进的装置和方法。解决方案：用于破坏细胞或病毒的装置10包括具有用于保持细胞或病毒的室的容器18。腔室由具有外表面的至少一个壁限定，耦合到换能器装置38.换能器装置38以足以产生腔室中的压力波或压力脉冲的工作频率和振幅振动。换能器装置38以足以在壁内产生应力的预载力联接到壁上。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009236933A Integrated fluid manipulation cartridge 有权
标题翻译：集成液体操作盒
公开(公告)号：JP2009236933A
公开(公告)日：2009-10-15
申请号：JP2009170254
申请日：2009-07-21
申请人： Cepheid , セフィードCepheid
发明人： POURAHMADI FARZAD , MCMILLAN WILLIAM A , CHING JESUS , CHANG RONALD , CHRISTEL LEE A , KOVACS GREGORY T , NORTHRUP M ALLEN , PETERSEN KURT E
IPC分类号： G01N31/20 , G01N35/08 , B01D11/00 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/33 , C12M1/34 , C12Q1/24 , C40B60/14 , G01N1/28 , G01N30/60 , G01N33/50 , G01N37/00
CPC分类号： G01N30/6095 , B01J2219/00432 , B01J2219/00529 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/0621 , B01L2200/0631 , B01L2200/0636 , B01L2200/10 , B01L2300/0816 , B01L2300/1827 , B01L2400/0421 , B01L2400/046 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/086 , C12M47/02 , C12M47/06 , C40B60/14 , G01N30/6091 , Y10T436/25375 , Y10T436/255
摘要： PROBLEM TO BE SOLVED: To provide a fluid manipulation cartridge that permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes. SOLUTION: A cartridge 101 includes a sample port 103 and a sample flow path. The sample flow path includes a component, e.g., filter paper or a microfabricated chip, for capturing the desired analyte from the sample. The cartridge 101 also includes an elution flow path to release captured analyte from the component into the elution fluid. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供允许快速处理体积大于盒内的任何交互区域的流体样品的流体处理盒，允许在检测低拷贝浓度的分析物时提高灵敏度。解决方案：盒101包括样品端口103和样品流动路径。样品流动路径包括用于从样品捕获所需分析物的组分，例如滤纸或微制造芯片。药筒101还包括洗脱流动路径，以将捕获的被分析物从组分释放到洗脱流体中。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2012106242A Heat exchanging, optically interrogated chemical reaction assembly 有权
标题翻译：热交换，光学中间化学反应装置
公开(公告)号：JP2012106242A
公开(公告)日：2012-06-07
申请号：JP2011268248
申请日：2011-12-07
申请人： Cepheid , セフィードCepheid
发明人： CHANG RONALD , CHRISTEL LEE A , KOVACS GREGORY T A , MCMILLAN WILLIAM A , NORTHRUP M ALLEN , PETERSEN KURT E , POURAHMADI FARZAD , YOUNG STEVEN J , YUAN ROBERT , DORITY DOUGLAS B
IPC分类号： B01J19/00 , C12M1/00 , B01L3/00 , B01L7/00 , C12Q1/68 , F28F3/12 , F28F21/04 , G01N21/03 , G01N21/15 , G01N21/64 , G01N21/76 , G01N21/78 , G01N35/00
CPC分类号： G01N21/75 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00871 , B01J2219/00873 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/505 , B01L3/508 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： PROBLEM TO BE SOLVED: To provide a reaction apparatus capable of promptly performing optically interrogating of a sample and capable of controlling heat-exchange.SOLUTION: An assembly for performing controlled heat-exchanging reaction is provided. The assembly includes: a chemical reaction chamber 10 adapted to receive a sample and allow the sample to chemically react; a thermal sleeve having heating elements for making efficient thermal contact with the reaction chamber; and an instrument with a housing comprising an electrical connection, a cooling source, a reaction area adapted to receive the thermal sleeve, an optics assembly in optical communication with the chemical reaction chamber, and a circuit for monitoring and controlling the optics assembly and for collecting the output signal of the optics assembly. Preferably there are a plurality of housings and associated modules, each of which may be independently controlled for heat exchanging operations.
摘要翻译：要解决的问题：提供一种能够及时对样品进行光学询问并能够控制热交换的反应装置。提供了一种用于进行受控热交换反应的组件。组件包括：化学反应室10，其适于接收样品并允许样品发生化学反应; 具有用于与反应室有效热接触的加热元件的热套管; 以及具有壳体的仪器，包括电连接，冷却源，适于接收热套筒的反应区域，与化学反应室光学连通的光学组件，以及用于监测和控制光学组件并用于收集光学组件的输出信号。优选地，存在多个壳体和相关联的模块，每个壳体和相关联的模块可独立地控制用于热交换操作。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2012103265A Fluid control and processing system 审中-公开
标题翻译：流体控制和处理系统
公开(公告)号：JP2012103265A
公开(公告)日：2012-05-31
申请号：JP2011289711
申请日：2011-12-28
申请人： Cepheid , セフィードCepheid
发明人： DORITY DOUGLAS B
IPC分类号： G01N35/08 , B01L3/00 , C12M1/34 , G01N1/00 , G01N35/10
CPC分类号： G01N35/1097 , B01L3/502 , B01L2200/16 , B01L2300/0681 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N35/08
摘要： PROBLEM TO BE SOLVED: To facilitate processing of a fluid sample according to different protocols using the same apparatus to determine the presence or absence of an analyte of the sample.SOLUTION: In a specific embodiment, a fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region coupled fluidically with a fluid displacement chamber 50. The fluid displacement chamber is depressurizable to draw fluid into the chamber and pressurizable to expel fluid from the chamber. The body includes a plurality of external ports 42, 46. The fluid sample processing region is fluidically coupled with at least two of the external ports. The fluid displacement chamber is fluidically coupled with at least one of the external ports. The body is adjustable with respect to at least the plurality of chambers to place one of the external ports in selective fluidic communication with the plurality of chambers.
摘要翻译：要解决的问题：为了便于使用相同装置根据不同方案处理流体样品以确定样品的分析物的存在或不存在。解决方案：在具体实施例中，用于控制多个腔室之间的流体流动的流体控制和处理系统包括主体，该主体包括与流体移动室50流体连接的流体处理区域。流体移动室可减压以绘制流体进入腔室并且可加压以从腔室排出流体。主体包括多个外部端口42,46。流体样本处理区域与至少两个外部端口流体耦合。流体移动室与至少一个外部端口流体耦合。主体相对于至少多个室是可调节的，以使外部端口中的一个选择性地与多个室流体连通。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2012055320A Closed-system multistage nucleic acid amplification reaction 有权
标题翻译：封闭系统多级核酸放大反应
公开(公告)号：JP2012055320A
公开(公告)日：2012-03-22
申请号：JP2011274877
申请日：2011-12-15
申请人： Cepheid , セフィードCepheid
发明人： CHANG RONALD , CHING JESUS , DORITY DOUGLAS BRYAN , ZHANG JIAN PING , WANG JAMES JIAN QUAN , WONG WENDY WINGKEI , PAUL KENDRA LARA , ATTA REUEL VAN
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： G01N21/6428 , B01L3/502 , B01L7/52 , B01L2200/0684 , B01L2300/0654 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q2565/629 , C12Q2563/173 , C12Q2549/119 , C12Q2531/143 , C12Q2537/149
摘要： PROBLEM TO BE SOLVED: To provide systems, methods, and apparatus for closed multistage nucleic acid amplification reactions wherein a part of a prior-stage reaction mixture serves as the sample for the next stage reaction.SOLUTION: There are provided systems, methods, and apparatus for carrying out multistage amplification reactions, especially under fluidly closed conditions. In one embodiment are carried out in a fluidly closed reaction system that permits the isolation of a part of a first (or prior) reaction mixture and its use as a sample or specimen in a second (or subsequent) reaction mixture, thereby substantially avoiding interfering effects that first reaction components may have in the second reaction if both reaction mixtures were simply combined together. In the above embodiment, the systems, the methods, and the apparatus may be used with any amplification reaction that permits multiple stages of amplification based on the use of nested primers.
摘要翻译：要解决的问题：提供封闭多级核酸扩增反应的系统，方法和装置，其中一部分前期反应混合物用作下一阶段反应的样品。解决方案：提供用于进行多级扩增反应的系统，方法和装置，特别是在流体关闭的条件下。在一个实施方案中，在流体封闭的反应体系中进行，其允许在第二（或后续）反应混合物中分离第一（或在先）反应混合物的一部分及其作为样品或样品的用途，从而基本避免干扰如果两个反应混合物简单地组合在一起，第一反应组分可能在第二反应中具有影响。在上述实施方案中，系统，方法和装置可以与允许基于嵌套引物的使用允许多个扩增阶段的任何扩增反应一起使用。版权所有（C）2012，JPO＆INPIT

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