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51. 发明专利

JP2004043588A Gel containing protein, dry gel containing protein, and method for manufacturing gel containing protein 有权
公开(公告)号：JP2004043588A
公开(公告)日：2004-02-12
申请号：JP2002201252
申请日：2002-07-10
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： HARAGUCHI KAZUTOSHI , TAKEHISA KAN
IPC分类号： C12N11/08 , C07K17/08 , C08K3/34 , C08L89/00 , C08L101/14
摘要： PROBLEM TO BE SOLVED: To provide a gel containing a uniformly dispersed protein and having excellent mechanical properties and stability, a method for manufacturing the gel containing a protein, and a dry gel containing a protein, obtained by drying the gel containing a protein.
SOLUTION: The gel containing a protein comprises a gel having a three-dimensional network formed by combining a water-soluble organic polymer with a clay mineral and contains a protein in the three-dimensional network. The dry gel containing a protein is obtained by drying the gel containing a protein. The method for manufacturing a gel containing a protein comprises polymerizing a water-soluble monomer capable of forming a water-soluble organic polymer after polymerization, in a uniform solution containing the water-soluble monomer, a clay mineral, a protein and water.
COPYRIGHT: (C)2004,JPO

52. 发明专利

JP2011072297A Cell culture substrate 审中-公开
标题翻译：细胞培养基质
公开(公告)号：JP2011072297A
公开(公告)日：2011-04-14
申请号：JP2009230454
申请日：2009-10-02
申请人： Asahi Glass Co Ltd , Kawamura Inst Of Chem Res , 旭硝子株式会社 , 財団法人川村理化学研究所
发明人： TAKADA TETSUO , HARAGUCHI KAZUTOSHI , ITO TORU , KONNO KOICHI
IPC分类号： C12M1/00 , C12M1/22
CPC分类号： C12M23/20 , C12M25/00
摘要： PROBLEM TO BE SOLVED: To provide a cell culture substrate having an uncrosslinked polymer contained in the substrate and having a lower limit critical solution temperature, further, which cell culture substrate is rapid in change from hydrophobic one to hydrophilic one relative to the environmental temperature and especially can separate and recover from the culture substrate the macrophage cells differentiated from human peripheral blood monocyte cells, without damaging surface antigen of the cells and at a high yield.
SOLUTION: The culture substrate for peripheral blood monocyte cells and macrophage cells, contains polymethoxyethylacrylate (A), poly(N-isopropylacrylamide) (B), and a water swelling clay mineral (C).
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供具有底物中含有的未交联聚合物并且具有下限临界溶解温度的细胞培养基质，此外，相对于环境温度，特别是可以从培养基质中分离和回收巨噬细胞与人外周血单核细胞分化，而不破坏细胞的表面抗原并以高产率。解决方案：外周血单核细胞和巨噬细胞的培养基质含有聚甲氧基乙基丙烯酸酯（A），聚（N-异丙基丙烯酰胺）（B）和水溶性粘土矿物（C）。版权所有（C）2011，JPO＆INPIT

53. 发明专利

JP2011057962A Organic/inorganic composite hydrogel, and method for producing the same 有权
标题翻译：有机/无机复合水凝胶及其制造方法
公开(公告)号：JP2011057962A
公开(公告)日：2011-03-24
申请号：JP2010110121
申请日：2010-05-12
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： HARAGUCHI KAZUTOSHI , FUKAZAWA MIEKO
IPC分类号： C08L71/02 , C08G65/48 , C08K3/34
CPC分类号： C08L71/02 , A61L27/52 , C08L2203/02
摘要： PROBLEM TO BE SOLVED: To provide a polymeric hydrogel with a polyethylene glycol as an organic component, highly improved in tensile strength and draw ratio or controlled over a wide range.
SOLUTION: The organic/inorganic composite hydrogel is obtained by such a process that a laminarly flaked-off clay mineral is put to composite formation in a crosslinked polyethylene glycol at a ratio, on the polyethylene glycol basis, of 0.03-3 so that these two components forms a three-dimensional network. The thus obtained organic/inorganic composite hydrogel is excellent in mechanical physical properties including tensile strength and draw ratio while retaining uniformity, with the mechanical physical properties controlled over a wide range.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供具有聚乙二醇作为有机组分的聚合物水凝胶，其拉伸强度和拉伸比得到很大改善，或者在宽范围内受控。解决方案：有机/无机复合水凝胶通过以下方式获得：使层状剥落的粘土矿物在交联聚乙二醇中以聚乙二醇为基础以0.03-3的比例复合形成这两个组件形成三维网络。由此获得的有机/无机复合水凝胶在机械物理性能方面具有优异的机械物理性能，包括拉伸强度和拉伸倍率，同时保持均匀性，并且机械物理性质在宽范围内控制。版权所有（C）2011，JPO＆INPIT

54. 发明专利

JP2010018665A Production method of organic-inorganic composite hydrogel 有权
标题翻译：有机无机复合水凝胶的生产方法
公开(公告)号：JP2010018665A
公开(公告)日：2010-01-28
申请号：JP2008178944
申请日：2008-07-09
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： OBAYASHI AKIRA , HARAGUCHI KAZUTOSHI
IPC分类号： C08G77/06 , C08G77/02 , C08K3/34 , C08L33/26 , C08L83/02
摘要： PROBLEM TO BE SOLVED: To provide the production method of a new organic-inorganic composite hydrogel having high dynamic physical properties and low water swelling property.
SOLUTION: The production method of an organic-inorganic composite hydrogel in which water (D) is included in a three-dimensional network mesh formed by compounding a water-soluble organic polymer (A), a water-swelling clay mineral (B) and a siloxane network (C), is characterized in that polymerization of a source monomer (A') of the water-soluble organic polymer compound (A) and hydrolysis and polycondensation of a silicon alkoxide (C') are carried out in parallel, under co-existence of the water-swelling clay mineral and the water (D).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有高动态物理性能和低水溶胀性的新的有机 - 无机复合水凝胶的制备方法。解决方案：一种有机 - 无机复合水凝胶的制备方法，其中水（D）包含在通过将水溶性有机聚合物（A），水溶性粘土矿物（ B）和硅氧烷网络（C）的特征在于，水溶性有机高分子化合物（A）的源单体（A'）和硅醇盐（C'）的水解和缩聚的聚合在在水溶性粘土矿物和水（D）的共存下平行。版权所有（C）2010，JPO＆INPIT

55. 发明专利

JP2009046553A Method for producing organic inorganic composite hydrogel having carboxylic acid group or sulfonic acid group 有权
标题翻译：生产具有羧酸基团或磺酸基团的有机无机复合氢化物的方法
公开(公告)号：JP2009046553A
公开(公告)日：2009-03-05
申请号：JP2007212812
申请日：2007-08-17
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： OBAYASHI AKIRA , HARAGUCHI KAZUTOSHI
IPC分类号： C08F2/44 , C08K3/34 , C08L33/02 , C08L33/26 , C08L35/00 , C08L101/06
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a new organic inorganic composite hydrogel having not only high mechanical properties but also high water swellability. SOLUTION: The method for producing the organic inorganic composite hydrogel in which a three-dimensional network is formed from an organic polymer (A) and a water-swellable clay mineral (B) is provided. The organic polymer (A) is obtained by preparing a uniform solution containing (meth)acrylamide or a derivative thereof, the water-swellable clay mineral (B) and water (C), then adding a polymerizable monomer having a carboxylic acid group or a sulfonic acid group simultaneously with or after addition of a polymerization initiator and polymerizing the (meth)acrylamide or the derivative thereof with the polymerizable monomer having the carboxylic acid group or the sulfonic acid group. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种不仅机械性能高但水溶胀性高的新型有机无机复合水凝胶的制造方法。解决方案：提供由有机聚合物（A）和水溶胀性粘土矿物（B）形成三维网状物的有机无机复合水凝胶的制造方法。有机聚合物（A）通过制备含有（甲基）丙烯酰胺或其衍生物，水溶胀性粘土矿物（B）和水（C）的均匀溶液，然后加入具有羧酸基团或磺酸基团与聚合引发剂同时或加入后，用（甲基）丙烯酰胺或其衍生物与具有羧酸基或磺酸基的可聚合单体聚合。版权所有（C）2009，JPO＆INPIT

56. 发明专利

JP2008222910A Epoxy resin composition 审中-公开
标题翻译：环氧树脂组合物
公开(公告)号：JP2008222910A
公开(公告)日：2008-09-25
申请号：JP2007064982
申请日：2007-03-14
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： OBAYASHI AKIRA , HARAGUCHI KAZUTOSHI
IPC分类号： C08G59/50
摘要： PROBLEM TO BE SOLVED: To provide an epoxy resin composition which has a high glass transition temperature and a low linear expansion coefficient and excels in storage stability.
SOLUTION: It has been found that by simultaneously using an epoxy resin curing agent having a long pot life and a monoamine-condensed boric acid salt, the epoxy resin composition which has a high glass transition temperature and a low linear expansion coefficient and excels in storage stability can be obtained. Specifically, the epoxy resin composition comprises (A) an epoxy resin, (B) a monoamine condensed boric acid salt, (C) an epoxy resin curing agent having a pot life at room temperature for the epoxy resin of 10 days or more, and (D) a solvent.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供具有高玻璃化转变温度和低线膨胀系数并且具有优异的储存稳定性的环氧树脂组合物。解决方案：已经发现，通过同时使用具有长使用期的环氧树脂固化剂和单胺缩合硼酸盐，具有高玻璃化转变温度和低线膨胀系数的环氧树脂组合物和可以获得良好的储存稳定性。具体地，环氧树脂组合物包含（A）环氧树脂，（B）单胺缩合硼酸盐，（C）环氧树脂在室温下的适用期为10天以上的环氧树脂固化剂，以及（D）溶剂。版权所有（C）2008，JPO＆INPIT

57. 发明专利

JP2008074924A Amino group-containing organic/inorganic composite hydrogel and method for producing the same 有权
标题翻译：含氨基的有机/无机复合水凝胶及其制造方法
公开(公告)号：JP2008074924A
公开(公告)日：2008-04-03
申请号：JP2006254178
申请日：2006-09-20
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： OBAYASHI AKIRA , HARAGUCHI KAZUTOSHI
IPC分类号： C08L33/04 , C08F2/44 , C08K3/34 , C08L33/26
摘要： PROBLEM TO BE SOLVED: To provide a new organic/inorganic composite hydrogel having not only high dynamic properties but also rich reactivity and high water swellability, to provide a method for producing the same, to provide a new organic/inorganic composite hydrogel having not only high dynamic properties but also rich reactivity and low surface tackiness, and to provide a method for producing the same. SOLUTION: This amino group-containing organic inorganic composite hydrogel comprises an organic polymer (A) comprising a copolymer of an amino group-containing (meth)acrylate with (meth)acrylamide or its derivative, a water-swelling clay mineral (B), and water (C), wherein the organic polymer (A) and the water-swelling clay mineral (B) forms three-dimensional networks. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供不仅具有高动态性能，而且具有丰富的反应性和高的水溶胀性的新的有机/无机复合水凝胶，以提供其制备方法，以提供新的有机/无机复合水凝胶不仅具有高的动态性能，而且具有丰富的反应性和低的表面粘性，并提供其制备方法。解决方案：该含氨基的有机无机复合水凝胶包含含有氨基的（甲基）丙烯酸酯与（甲基）丙烯酰胺或其衍生物的共聚物的水性膨润性粘土矿物（A）的有机聚合物（A） B）和水（C），其中有机聚合物（A）和水溶性粘土矿物（B）形成三维网络。版权所有（C）2008，JPO＆INPIT

58. 发明专利

JP2007126572A Polymer gel laminated product and its manufacturing method 有权
标题翻译：聚合物胶合层压制品及其制造方法
公开(公告)号：JP2007126572A
公开(公告)日：2007-05-24
申请号：JP2005320802
申请日：2005-11-04
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： TAKEHISA KAN , HARAGUCHI KAZUTOSHI
IPC分类号： C08F292/00 , B32B27/12 , B32B27/30
摘要： PROBLEM TO BE SOLVED: To provide a polymer gel laminated product having a layer composed of a polymer gel having a three-dimensional network structure constituted of a polymer of a water soluble organic monomer and a water swelling clay mineral and a layer composed of cloth.
SOLUTION: The polymer gel laminated product is obtained by well integrating a polymer gel having a three-dimensional network structure constituted of a polymer of a water soluble organic monomer and a water swelling clay mineral with a layer composed of cloth such as a nonwoven fabric, a fabric, a net, and a processed article thereof, and thus both layers are by no means peeled or broken even when elongation and bending are caused. Further, the laminated product has excellent flexibility and surface wetting/drying characteristics of the polymer gel and can exhibit strong breakage resistance and anisotropy such as elongation and swelling by the integrated nonwoven fabric.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种聚合物凝胶层压产品，其具有由具有由水溶性有机单体的聚合物和水溶性粘土矿物构成的三维网状结构的聚合物凝胶构成的层和由的布。解决方案：通过将具有由水溶性有机单体的聚合物和水溶性粘土矿物构成的三维网状结构的聚合物凝胶与由诸如无纺布，织物，网及其加工品，因此即使引起伸长和弯曲，两层也绝不剥离或破损。此外，该层压产品具有优异的聚合物凝胶的柔软性和表面润湿/干燥特性，并且可以表现出强的抗断裂性和各向异性如一体化无纺布的伸长和膨胀。版权所有（C）2007，JPO＆INPIT

59. 发明专利

JP2007070473A Borate group-containing hydrogel and its manufacturing method 有权
标题翻译：含硼氢化合物及其制造方法
公开(公告)号：JP2007070473A
公开(公告)日：2007-03-22
申请号：JP2005259153
申请日：2005-09-07
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： OBAYASHI AKIRA , HARAGUCHI KAZUTOSHI
IPC分类号： C08F30/06 , C08F8/44
摘要： PROBLEM TO BE SOLVED: To provide a new borate group-containing hydrogel which can contain many sugar-chain recognition sites, and a method of easily manufacturing the borate group-containing hydrogel. SOLUTION: By the sterilizing method for sterilizing a polymer hydrogel having a three-dimensional network structure constituted of a polymer of a water soluble organic monomer and a water swelling clay mineral by high-pressure steam treatment, the hydrogel of a water-containing substance can be sterilized while maintaining the safe and original properties without deteriorating properties and water absorption properties as in irradiation sterilization and without leaving a toxic substance behind as in ethylene oxide sterilization. COPYRIGHT: (C)2007,JPO&INPIT

60. 发明专利

JP2006328258A Borate group-containing (meth)acrylate polymer 有权
标题翻译：含甲酸基团（甲基）丙烯酸酯聚合物
公开(公告)号：JP2006328258A
公开(公告)日：2006-12-07
申请号：JP2005155311
申请日：2005-05-27
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： OBAYASHI AKIRA , HARAGUCHI KAZUTOSHI
IPC分类号： C08F30/06 , C08F8/44
摘要： PROBLEM TO BE SOLVED: To obtain a polymer that comprises an amino group-containing (meth)acrylate borate group unit in a polymer skeleton and is useful as a functional material in the field of medical treatment, medicine, agriculture, chemical, analysis, etc., and has a new sugar chain recognition function.
SOLUTION: The borate group-containing (meth)acrylate polymer contains a borate group in the molecule and has 10
3 -10
6 number-average molecular weight, especially the borate group-containing (meth)acrylate polymer has 0.1-20% by mass of a boron content of the borate in the molecule and comprises 1-8 boron atoms per amino group.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了获得在聚合物骨架中含有含氨基的（甲基）丙烯酸酯硼酸酯基单元的聚合物，可用作医疗，医药，农业，化学，分析等，并具有新的糖链识别功能。解决方案：含有硼酸酯基的（甲基）丙烯酸酯聚合物在分子中含有硼酸酯基，具有10个数均分子量，特别是含有硼酸酯基的（甲基）丙烯酸酯聚合物的分子中硼酸的硼含量为0.1-20质量％，每个氨基含有1-8个硼原子。版权所有（C）2007，JPO＆INPIT

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