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    • 55. 发明专利
    • PREPARATION FOR EXTERNAL USE FOR SKIN
    • JPH11302198A
    • 1999-11-02
    • JP10751098
    • 1998-04-17
    • KAO CORP
    • TAMURA TATSUNORIHASEBE KEIKOMATSUMOTO CHIKAKO
    • A61K47/16
    • PROBLEM TO BE SOLVED: To obtain a preparation for external use of skin which possesses excellent lasting therapeutic activity, gives moistness to skin itself, shows reduced irritation to skin, exerts excellent skin-roughening reforming effect and is fine in the touch on use by including a specific component and a specific amide derivative. SOLUTION: The preparation for external use for skin is obtained by including (A) 0.001-20 wt.%, preferably 0.1-10 wt.%, more preferably 0.3-3 wt.%, of at least one kind selected from bendazac, indomethacin, bufexamac, vitamin A oil, methyl salicylate, ibuprofen, lisprofen, orthenone or the like, (B) 0.01-20 wt.%, preferably 0.05-15 wt.%, more preferably 0.1-10 wt.%, of an amide derivative of the formula [R and R are each an (OH substituted) 9-39C (un)saturated hydrocarbon; R and R are each H, a phosphate residue, a sulfate residue or a saccharide residue] and (C), when necessary, 0.01-50 wt.%, preferably 0.01-40 wt.%, more preferably 0.01-20 wt.%, of a sterol (e.g. cholesteryl isostearate).