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41. 发明专利

JPS54116283A ANALYTICAL METHOD OF CHROMOGEN 失效
公开(公告)号：JPS54116283A
公开(公告)日：1979-09-10
申请号：JP32179
申请日：1979-01-08
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI , NOMURA YASUSHI , YABE RIYOUHEI
IPC分类号： G01N21/31 , G01N21/75 , G01N33/49 , G01N35/02
摘要： PURPOSE:To analyze the chromogens optically, such as chylomicron, hemolysis and jaundice contained in biochemical specimen, by performing specified operations by combining the absorbancy measurements in a specific wavelength region. CONSTITUTION:In the figure, 20 is the spectrum of chylomicron reference solution, 22 is that of hemolysis reference solution, and 24 is that of jaundice reference solution. Measuring the absorption spectrum of the sample fluid over the entire wavelength region, the chylomicron rate X is obtained from formula (1) from the difference in absorbancy A20-21 of the longer wavelength regions lambda20 and lambda21 free from disturbance of hemolysis and jaundice. Similarly, the hemolysis rate Y is obtained from formula (2) from the difference in absorbancy A18-19 of medium wavelength regions lambda18 and lambda19 free from disturbance of jaundice. Finally, the jaundice rate Z is obtained from formula (3) from the difference in absorbancy A15-16 of shorter wavelength regions lambda15 and lambda16. In these formulas, Tn-m, Hn-m, and Bn-m are the constants showing the difference in absorbancy per unit chylomicron rate, unit hemolysis rate, and unit jaundice rate, respectively, between the wavelengths lambdan and lambdam obtained from the spectra 20, 22, and 24.

42. 发明专利

JPS5468285A COLORIMETRIC ANALYZING METHOD 失效
公开(公告)号：JPS5468285A
公开(公告)日：1979-06-01
申请号：JP13460077
申请日：1977-11-11
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI , NOMURA YASUSHI , YABE RIYOUHEI
IPC分类号： G01J3/427 , G01N21/25 , G01N21/31
摘要： PURPOSE:To enhance the accuracy of measurements in biochemical inspection, by comparing the analytical values of 1 wavelength colorimetry and 2 wavelength colorimetry and correcting or re-inspecting them in order to eliminate interference due to 3 major obstacle and interference due to air bubbles and solied matter. CONSTITUTION:The reaction liquid of serum is colorimetrically analyzed by 1 wavelength colorimetry and 2 wavelength colorimetry, and the ratio of the two methods is calculated. When the ratio is in the specified range closer to 1, for instance, within 0.95 to 1.05, the one of the analytical values or the mean of the two analytical values is adopted as the result of analysis. At this time, from the spectrum of analytical item in which the analysis of the spectrum is easiest, the chyle index, hemolytic index and icterus index of the obstacle are obtained. If the ratio of the analytical values is beyond the specified range, the both analytical values are corrected according to the mass of the obstacle contained in the specimen, and when the ratio of corrected analytical values is within 0.95 to 1.05, the corrected analytical values are adopted as the result of analysis. If the ratio of corrected analytical values is other than 0.95 to 1.05, the corrected analytical value of 2 wave length colorimetry is adopted, or the measurement is taken again.

43. 发明专利

JPS5367485A DIRECT LIGHT MEASURING ANALYTICAL METHOD USED PLURAL 失效
公开(公告)号：JPS5367485A
公开(公告)日：1978-06-15
申请号：JP14224476
申请日：1976-11-29
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI , NOMURA YASUSHI
IPC分类号： G01J3/427 , G01N21/31 , G01N21/75
摘要： PURPOSE:To decrease measured error based on the dispersion of dimension of reaction vessel, by adding specific absorbency regulating agent in light pervious vessel.

44. 发明专利

JPS52113291A ENZYME ANALYSIS 失效
公开(公告)号：JPS52113291A
公开(公告)日：1977-09-22
申请号：JP2910276
申请日：1976-03-19
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI , NOMURA YASUSHI , OZAWA KIYOUICHI
IPC分类号： C12Q1/52 , G01N31/22
摘要： PURPOSE:To make the accuracy of measurement high, without having on influence on the sample volume error of chemical reagent solution, by using specific chemical reagent solution, regulayed not to change absorbency, at one point measuring method of GOT, GPT enzyme activity, especially in blood serum.

45. 发明专利

JPS5260692A AUTOMATIC MULTIIITEM ANALYZER 失效
公开(公告)号：JPS5260692A
公开(公告)日：1977-05-19
申请号：JP13624475
申请日：1975-11-14
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI , NOMURA YASUSHI , INOMATA HIROSHI , SATOU TAKEHIDE
IPC分类号： G01N33/483 , G01N31/00 , G01N35/08
摘要： PURPOSE:To accurately and rapidly measure absorbancy by intermittently and rapidly moving each flow cell so that each photometric system cincluding each flow cell becomes entirely optically equivalent in a direction perpendicular to the optical axis of one photometer.

46. 发明专利

JPH0854402A AUTOMATIC MULTIITEM ANALYZER 失效
公开(公告)号：JPH0854402A
公开(公告)日：1996-02-27
申请号：JP24575395
申请日：1995-09-25
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI
IPC分类号： G01N33/48 , G01N1/00 , G01N35/02 , G01N35/10
摘要： PURPOSE:To provide a new reagent supply system by which an analysis by a three-liquid method or higher can be executed by using a single reagent dispensing device. CONSTITUTION:A reaction table 5 is subjected to a sample reception stop and to a plurality of halfway stops during one cycle. Containers 3 for a first reagent to a third reagent which are required for measuring items are arranged on a reagent table 2, and reagents which are selected from a container row on the inner circumferential side and from a container row on the outer circumferential side are dispensed to reaction containers 6 by a reagent pipetting mechanism 4. In the reagent table 5, one cycle is constituted of the movement of one rotation plus one container portion, and a reaction liquid is measured by a photometer during rotation.

47. 发明专利

JPS63315955A AUTOMATIC ANALYZER 失效
公开(公告)号：JPS63315955A
公开(公告)日：1988-12-23
申请号：JP15116287
申请日：1987-06-19
申请人： HITACHI LTD
发明人： YOKOSE TAIZO , SAGUSA TOSHIYUKI
IPC分类号： G01N33/49 , G01N35/02
摘要： PURPOSE:To enhance measurement accuracy and to eliminate the need for a dummy operation by providing means for injecting a cleaning liquid having a sterilization effect automatically into reaction vessels and resting the vessels while the vessels are held soaked with the liquid. CONSTITUTION:A reaction table 1 is driven to move the reaction vessels 2 which are cleaned and emptied after the end of routine analyses to the discharge position of a probe 3. The cleaning liquid 5 provided in a part of a reagent cold retaining housing 4 is sucked in a required amt. by the probe 3 and is automatically injected into the reaction vessels 2. A soln. of the lowest possible concn. at which the glass reaction vessels 2 are not damaged and the sterilization effect is obtainable, for example, 0.5% sodium hypochlorite soln. or the like is used. The cleaning liquid 5 is successively injected into the other reaction vessels 2 as well and is rested, by which the miscellaneous bacteria sticking to the inside wall of the reaction vessels 2 are sterilized.

48. 发明专利

JPS6358261A ANALYSIS OF C REACTIVE PROTEIN 失效
公开(公告)号：JPS6358261A
公开(公告)日：1988-03-14
申请号：JP20145986
申请日：1986-08-29
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI
IPC分类号： G01N33/53 , G01N21/82 , G01N33/536 , G01N33/574
摘要： PURPOSE:To improve detection sensitivity by bringing C reactive protein which is an antigen and immune reagent contg. an antibody into reaction, expanding the utilization region of a calibration curve up to the equil. point of an antigen- antibody reaction and allowing the equil. point to coincide with the upper limit value of a concn. range to be measured. CONSTITUTION:At least four standard samples including the concn. region near the upper and lower limit values of the concn. range desired to be measured, and the concn. region between the two concn. regions are drawn into separate reaction vessels. The immune reagent is added to the reaction vessels so as to obtain such a reagent concn. at which the equil. point of the reaction of the antigen and antibody coincides substantially with the upper limit value. The turbidity generated with the antigen-antibody reaction is optically measured and is processed to form the calibration curve. The immune reagent of the same amt. at which said reagent is added to the above-mentioned standard samples is also added to the sample to be examined drawn into the reaction vessel and the reaction liquid thereof is measured. The concn. of the C reactive protein of the sample to be examined is obtd. from the calibration curve.

49. 发明专利

JPS6350743A ANALYSIS OF HEMOLYZED BLOOD SPECIMEN 失效
公开(公告)号：JPS6350743A
公开(公告)日：1988-03-03
申请号：JP19267686
申请日：1986-08-20
申请人： HITACHI LTD
发明人： SAGUSA TOSHIYUKI
IPC分类号： G01N21/75 , G01N33/487
摘要： PURPOSE:To correct the measured value of a hemolyzed blood specimen even with respect to an item to be examined of which the concn. in an erythrocyte is higher than that in serum or plasma, by preliminarily calculating the relation between a grade of hemolysis and the value of an error given to the item to be examined from the values obtained from a large number of actual specimens obtained by destructing the erythrocyte separated from plasma by measurement. CONSTITUTION:At first, the relation between a grade of hemolysis and the value of an error given to an item to be examined brought about by hemolysis is preliminarily calculated with respect to the item to be examined of which the concn. in an erythrocyte is higher than that in serum or plasma. Next, the analytical operation of the item to be examined is carried out with respect to a blood specimen to obtain a measured value before correction. Further, the grade of the hemolysis of the blood specimen is calculated. Then, from the grade of hemolysis of said blood specimen, the measured value before correction is corrected based on the relation previously calculated. Further, the relation between the grade of hemolysis and the error value is set with a gradient and the tolerant width following the same and the value after correction of the measured value before correction is displayed as the value having the tolerant width. The gradient and the tolerant width are calculated for each group classified by a health state, an age and sex.

50. 发明专利

JPS62298765A AUTOMATIC CHEMICAL ANALYSIS 失效
公开(公告)号：JPS62298765A
公开(公告)日：1987-12-25
申请号：JP14158186
申请日：1986-06-18
申请人： HITACHI LTD
发明人： TSUBAKIMOTO HIROKO , SAGUSA TOSHIYUKI
IPC分类号： G01N33/49 , G01N33/53 , G01N33/543 , G01N35/00
摘要： PURPOSE:To achieve a higher accuracy of an end point method, by a method wherein an object to be measured is made to react with a reaction reagent to preset a time range in which the object being measured gives stable reaction data and a statistic processing is performed about a plurality of data obtained within the time range. CONSTITUTION:Curves 1 and 3 indicate actually measured data. When the data between the points M and N is outside an allowable error range epsilon due to bubbles and foreign matters attached at a portion following a point P the data between the points P and N is corrected to obtain a correction data as shown by a curve 2. The data between the points M and N is outside the allowable error epsilon only at a point Q, the data only at this one point is corrected to obtain a correction data as shown by a curve 4. In this manner, a measured data is corrected when considered as subjected to a long-term disturbance such as caused under the influence of bubbles in the range previously specified by M and N. Then, an approximate straight line is determined by the least square method to obtain the most probable value at the final point N as specified from the approximate straight line thus obtained.

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