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    • 37. 发明专利
    • Method for synthesizing buildup type combinatorial library on substrate
    • 在基板上合成建筑类型组合图书馆的方法
    • JP2012116803A
    • 2012-06-21
    • JP2010269482
    • 2010-12-02
    • National Agriculture & Food Research Organization独立行政法人農業・食品産業技術総合研究機構
    • IMABA SHIROTERAUCHI TAKESHIWATANABE SATORU
    • C07H1/00C07H15/04C40B50/08
    • Y02P20/55
    • PROBLEM TO BE SOLVED: To provide a method for forming a sugar chain chip or the like by synthesizing saccharides in a buildup type.SOLUTION: The method for forming the sugar chain chip includes, binding a sugar protected selectively by protective groups of hydroxy groups that is subjected to deprotection, with a substrate, introducing photocleavage-protecting groups W to the hydroxy groups after selectively deprotecting the first desired hydroxy groups, selectively deprotecting the protective groups W present in a desired region of the substrate by exposing the region with light, selectively introducing desired sugar or a capping group thereto, repeating the exposure and the introduction of the sugar or the capping group until the whole protective groups W on the substrate have been converted, selectively deprotecting the second desired hydroxy groups, and repeating the introduction of the W groups, exposure, and the introduction of the sugar or the capping group.
    • 待解决的问题:提供一种通过以积聚型合成糖类形成糖链芯片等的方法。 解决方案:形成糖链芯片的方法包括:将经过去保护的保护基的羟基选择性保护的糖与底物结合,在选择性脱保护之后,将光保护基团W引入羟基 首先需要的羟基,通过用光暴露该区域来选择性地脱保护基团中存在的保护基团W,选择性地将所需的糖或封端基团引入其中,重复曝光和引入糖或封端基团,直到 底物上的整个保护基W已被转化,选择性地脱保护第二个所需的羟基,并重复引入W基团,暴露并引入糖或封端基团。 版权所有(C)2012,JPO&INPIT