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31. 发明专利

JP3771445B2 Anticancer agent containing sulfopyranosylacylglycerol derivative 有权
公开(公告)号：JP3771445B2
公开(公告)日：2006-04-26
申请号：JP2000602289
申请日：2000-02-21
申请人：東洋水産株式会社
发明人：小太郎中山 , 弘益佐原 , 昇志佐藤 , 謙吾坂口 , 慶祐太田 , 隆之山崎 , 和好正木 , 二三男菅原 , 龍哉藤田
IPC分类号： A61K31/7032 , A61P35/00 , A61P43/00 , C07H15/06
CPC分类号： A61K31/70 , A61K31/7032 , C07H15/06

32. 发明专利

JP3388950B2 失效
公开(公告)号：JP3388950B2
公开(公告)日：2003-03-24
申请号：JP20142495
申请日：1995-07-14
IPC分类号： C12N9/99 , A61K8/00 , A61K8/02 , A61K8/37 , A61K8/60 , A61K31/70 , A61K31/7028 , A61K31/7032 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , C07H15/06 , A61K7/00 , A61K7/48

33. 发明专利

JP2001199992A METHOD OF FRACTIONATING SOYBEAN LIPID SACCHARIDE 失效
公开(公告)号：JP2001199992A
公开(公告)日：2001-07-24
申请号：JP2000369630
申请日：2000-12-05
申请人： SHOWA SANGYO CO
发明人： KANEKO TOSHIYUKI , YOSHIZAWA YASUKO
IPC分类号： A23L1/30 , A23D9/007 , C07H1/08 , C07H15/06 , C07H15/10 , C07J9/00 , C07J75/00
摘要： PROBLEM TO BE SOLVED: To obtain physiologically active glycolipid from oil cake. SOLUTION: Oil cake is subjected to the silica gel column chromatography, a chloroform/acetone mixed solvent is used as an elution solvent to fractionate the glycolipid mainly into the fraction mainly containing stearyl acyl glycoside, the fraction mainly containing stearyl glycoside and the fraction mainly containing cerebroside and diglycosylglyceride.

34. 发明专利

JP2000281569A THERAPEUTIC AGENT FOR SPINAL DISORDER 失效
公开(公告)号：JP2000281569A
公开(公告)日：2000-10-10
申请号：JP8191499
申请日：1999-03-25
申请人： NIPPON SHINYAKU CO LTD
发明人： OKAJIMA KENJI , TAOKA YUJI , KOJIMA MASAHIKO
IPC分类号： C07D211/64 , A61K31/00 , A61K31/185 , A61K31/215 , A61K31/27 , A61K31/445 , A61K31/70 , A61K31/7028 , A61K31/7032 , A61P19/00 , C07H15/06 , C07H15/10
摘要： PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for spinal cord diseases having an inhibiting action against cell adhesion and a suppressive action to TNF-α production by bringing the agent to contain a specific aliphatic derivative as an effective ingredient. SOLUTION: This agent for spinal cord diseases contains an aliphatic derivative expressed by formula I or II R1 and R2 are each a 6-30C alkyl or the like; B is (CH2)m, (CH2)n-NRe-CO-O [Re is H or a lower alkyl; (m) and (n) are each 0-12] or the like; R is formula III (R3 is H or OH; R4 is H or sulfo or the like; R5 is H, 3-O-sulfo-β-D-galactopyranosyl or the like), a group expressed by formula IV [R6 is H or OH; R7 is (3-O-sulfo-β-D-galactopyranosy)oxy or the like; R8 is H or 1-fucosyl] or the like} or its pharmaceutically permissible salt as an effective ingredient. Spinal cord disorders are preferably spinal cord injury or spinal cord ischemic recirculation disorder. The aforementioned compound can be administered to animals as a medicinal composition containing 0.1-90%. The dose as a therapeutic agent, 30 mg-2 g/day/person is preferable.

35. 发明专利

JP2000143516A ANTICANCER MEDICINE, NEW SULFOQUINOVOSYLACYLGLYCEROL, NEW INTERMEDIATE FOR PRODUCING THE SAME COMPOUND AND THEIR PRODUCTION 失效
公开(公告)号：JP2000143516A
公开(公告)日：2000-05-23
申请号：JP37348098
申请日：1998-12-28
申请人： TOYO SUISAN KAISHA
发明人： YAMAZAKI TAKAYUKI , SUGAWARA FUMIO , OTA KEISUKE , MASAKI KAZUYOSHI , NAKAYAMA KOTARO , SAKAGUCHI KENGO
IPC分类号： C07H15/06 , A61K31/00 , A61K31/70 , A61K31/7028 , A61K31/7032 , A61P35/00 , C07H13/00 , C07H15/10
摘要： PROBLEM TO BE SOLVED: To prepare an anticancer medicine having carcinostatic activity and useful for the therapy of glandular carcinoma, epithelial cancer, leukemia or the like of mammals including mankind by including a specific sulfoquinovosylacylglycerol derivative as an active principle. SOLUTION: This anticancer medicine is prepared by including at least one kind selected from a compound of the formula (wherein, R101 is an acyl residue of a higher saturated fatty acid; R102 is H or an acyl residue of a higher saturated fatty acid) and its salt. The bond of sulfo-substituted glucose with a glyceride in the compound of the formula is preferably an α-bond from the view point of carcinostatic activity against colon cancer and stomach cancer. The anticancer medicine can be administered e.g. orally or parenterally. The dose of the compound of the formula is 1-10 mg/body weight in kg/day when administered orally, 1-5 mg/body weight in kg/day when administered as parenteral injections and 1-5 mg/body weight in kg/day when administered rectally.

36. 发明专利

JP2862489B2 失效
公开(公告)号：JP2862489B2
公开(公告)日：1999-03-03
申请号：JP372995
申请日：1995-01-13
申请人： EFU HOFUMAN RA ROSHU AG
发明人： AREKUSANDAA KUKOROSUKII , YURUGEN FUINGARII , NITSUJI IBEERUGU , HANSU PEETAA MERUKI , RITA MYUURAA , MIHAERU PETSUHI , MARIANNE RUUJU , JERAARU SHUMATSUDO , TOOMASU CHOTSUPU , HANSU PEETAA UETSUSERU
IPC分类号： C07D307/42 , A61K31/17 , A61K31/225 , A61K31/255 , A61K31/7024 , A61P9/10 , A61P9/14 , C07C31/18 , C07C31/27 , C07C305/04 , C07C305/06 , C07C305/10 , C07C305/16 , C07C309/02 , C07C311/17 , C07C311/23 , C07C317/22 , C07C317/36 , C07C317/44 , C07C335/06 , C07C335/16 , C07D303/46 , C07D307/68 , C07D311/82 , C07H7/00 , C07H11/00 , C07H15/06
摘要： Sugar alcohol sulphate esters (I) and their salts are new: A = tris(hydroxymethyl)methyl or a gp. derived by removing the 1-OH gp. from a sugar alcohol or deriv., with ≥ 1 OH gp. in A being replaced by OSO3H; X = -NR CO-; -NHCONH-; -NHCSNH-; -NHSO2; -NR -; or -O-; R = H; or lower alkyl opt. substd. by OH; B = system of conjugated multiple bonds; m, p = 0 or 1.

37. 发明专利

JP2774429B2 失效
公开(公告)号：JP2774429B2
公开(公告)日：1998-07-09
申请号：JP5583893
申请日：1993-03-16
IPC分类号： A61K9/127 , A61K47/26 , C07H15/04 , C07H15/06

38. 发明专利

JPH07149786A GLYCEROGLYCOLIPID AND CARCINOGENIC PROMOTER INHIBITOR 失效
公开(公告)号：JPH07149786A
公开(公告)日：1995-06-13
申请号：JP31918893
申请日：1993-11-26
申请人： SAGAMI CHEM RES
发明人： YAZAWA KAZUYOSHI , SAKAKIBARA NISAKU , WATANABE MIYAKO , NAGATSU AKITO , TOKUDA HARUKUNI
IPC分类号： C07H15/06 , A61K31/70 , A61K31/7028 , A61P35/00
摘要： PURPOSE:To obtain a new glyceroglycolipid having strong carcinogenic promoter inhibiting action and low cytotoxicity and useful as a carcinogenic promoter inhibitor effective as an active component of a cancer preventing or treating agent, etc. CONSTITUTION:New glyceroglycolipid is expressed by formula I (R is H or a hydroxyl-protecting group; R and R are an acyl residue of a 12-24C fatty acid provided that at least one of R and R is eicosapentaenoyl or docosahexaenoyl) (e.g. 1-O-eicosapentaenoyl-2-O-myristoyl-3-O-beta-D- galacropyranosyl-sn-glycerol), and has strong carcinogenic promoter inhibiting action and low cytotoxicity, and is effective as a cancer preventing or treating agent. The compound can be produced by reacting a brominated alpha-D- galactopyranosyl of formula II (Ac is acetyl) with 1, 2-di-O-benzylglycerol of formula III (Bn is benzyl) and subjecting the reaction product to the deprotection of hydroxyl group, protection and acylation.

39. 发明专利

JPH06336437A CARCINOGENIC PROMOTION-INHIBITING COMPOSITION 失效
公开(公告)号：JPH06336437A
公开(公告)日：1994-12-06
申请号：JP28310193
申请日：1993-11-12
申请人： TAKEDA SHOKUHIN KOGYO KK
发明人： NAGAMINE KOJI , ENDO KATSUMI , KOSHIMIZU KOICHI , DAITO HAJIME , MURAKAMI AKIRA , NISHIDA TSUTOMU
IPC分类号： A23L35/00 , A61K31/70 , A61K31/7028 , A61K36/75 , A61P35/00 , C07H15/06 , A61K35/78 , A23L1/48
摘要： PURPOSE:To obtain a carcinogenic promotion-inhibiting composition containing the extract of Citrus hystrix, an edible plant grown in Thai, as an active ingredient and useful for foods, cosmetics and medicines such as anticancer agents which inhibit the generation of tumors or cancers. CONSTITUTION:This carcinogenic promotion-inhibiting composition contains the extract of Citrus hystrix (especially leaves), an edible plant grown in Thai, especially its extract with a hydrophilic organic solvent (preferably a polar organic solvent), as an active ingredient. The composition can be prepared into foods, cosmetics and medicines such as antitumor agents. The active ingredient of the extract of the Citrus hystrix is a compound of the formula (R , R are alpha-linolenoyl, palmitoyl). The extract of the Citrus hystrix is useful as a carcinogenic promotion-inhibiting ingredient, because of strongly inhibiting the activation of EBV with teleocidin B-4, a promoter, and is highly safe because of being originated from the edible material.

40. 发明专利

JPH0670789A PRODUCTION OF GLYCEROGLYCOLIPID 失效
公开(公告)号：JPH0670789A
公开(公告)日：1994-03-15
申请号：JP23032592
申请日：1992-08-28
申请人： FUJI OIL CO LTD
发明人： KUBOTA YASUSHI , HASHIMOTO YUKIO
IPC分类号： B01F17/56 , C07C69/30 , C07H15/06 , C12P19/44
摘要： PURPOSE:To easily obtain a glyceroglycolipid useful for low-caloric food, etc., by carrying out the condensation and transfer reaction of a fatty acid monoglyceride with a monosaccharide, polysaccharide or its derivative, etc., in a mixture of an organic solvent and an aqueous medium in the presence of a sugar hydrolyzing enzyme. CONSTITUTION:A fatty acid monoglyceride (e.g. monocapryl glycerol) and a monosaccharide (e.g. glucose) or di- or polysaccharide (e.g. lactose) or their derivatives are subjected to condensation and transfer reaction in a mixed solvent capable of dissolving the above compounds and consisting of an organic solvent (e.g. acetone) and an aqueous medium (e.g. buffering solution) in the presence of a sugar hydrolyzing enzyme originated from Escherichia coli (e.g. beta-galactosidase) at 20 deg.C for 48hr. The organic solvent is distilled out, the transfer reaction product is extracted with ethyl acetate, etc., and the obtained solid component is purified by a droplet counter-current partition chromatography to obtain the objective glyceroglycolipid useful as a raw material for low-caloric food, an emulsifier, a detergent, a humectant, a cosmetic base, etc.

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