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31. 发明专利

JP2001029094A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JP2001029094A
公开(公告)日：2001-02-06
申请号：JP20890599
申请日：1999-07-23
申请人： MITSUBISHI CHEM CORP
发明人： WATANABE NAOYUKI , KATO NAOKI
IPC分类号： C12P13/20
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially advantageously producing L- aspartic acid by enzymatic reaction from maleic acid via fumaric acid. SOLUTION: This method comprises the following steps: isomerizing an aqueous solution of maleic acid in the presence of a water-soluble bromine compound and a compound having the standard electrode potential of >=1 V or bromate ion to form fumaric acid slurry where the content of the compound having the standard electrode potential of >=1 V or bromate ion in the aqueous phase is =1 V or bromate ion in the aqueous solution coexisting with fumaric acid crystal to form fumaric acid slurry where the content of the compound having the standard electrode potential of >=1 V or bromate ion is

32. 发明专利

JP2000327665A ALKYLHYDANTOIN COMPOUND 失效
公开(公告)号：JP2000327665A
公开(公告)日：2000-11-28
申请号：JP13860899
申请日：1999-05-19
申请人： MITSUBISHI CHEM CORP
发明人： TAKUMA YUUKI , WATANABE NAOYUKI , YAMAGISHI MASAHIRO
IPC分类号： C07D233/74 , C07C231/10 , C07C233/45 , C07C237/30 , C07D213/40
摘要： PROBLEM TO BE SOLVED: To provide a new alkylhydantoin compound useful as a production intermediate for (L)-BOC-N-methyl-4-chlorophenylalanine, etc., useful as a raw material for pharmaceuticals and agrochemical compounds. SOLUTION: The objective compound is expressed by formula (R1 is a 1-4C alkyl; R2 is a substituted aryl or a 1-4C alkyl), e.g. 5-p-chlorobenzyl-1- methylhydantoin. The compound of formula can be produced by condensing a (substituted)benzaldehyde with an alkylhydantoin in a solvent (e.g. acetic acid) in the presence of a base (e.g. sodium acetate) and reducing the produced 5-(substituted benzal)-1-alkylhydantoin. The amounts of the components based on the alkylhydantoin are 2-100 times volume for the solvent, 0.5-3 times mol for the base and equal amount or excess for the benzaldehyde.

33. 发明专利

JP2000169422A PRODUCTION OF FUMARIC ACID 失效
公开(公告)号：JP2000169422A
公开(公告)日：2000-06-20
申请号：JP34376998
申请日：1998-12-03
申请人： MITSUBISHI CHEM CORP
发明人： WATANABE NAOYUKI , UBUKAWA YOSHIZO , KATO NAOKI
IPC分类号： B01J27/24 , C07B61/00 , C07C51/353 , C07C57/15
摘要： PROBLEM TO BE SOLVED: To produce fumaric acid useful as a production raw material for polyester resin, etc., in high efficiency while preventing the discoloration of the product by keeping the dissolved oxygen concentration in a reaction aqueous solution at a specific level or below. SOLUTION: The dissolved oxygen concentration in the reaction aqueous solution is maintained to =1 V. Preferably, the dissolved oxygen concentration in the reaction aqueous solution is adjusted to

34. 发明专利

JP2000159722A PRODUCTION OF FUMARIC ACID 失效
公开(公告)号：JP2000159722A
公开(公告)日：2000-06-13
申请号：JP21341799
申请日：1999-07-28
申请人： MITSUBISHI CHEM CORP
发明人： WATANABE NAOYUKI , KATO NAOKI
IPC分类号： B01J41/04 , B01J31/02 , C07B61/00 , C07C51/353 , C07C51/43 , C07C51/47 , C07C57/15
摘要： PROBLEM TO BE SOLVED: To provide a method for producing fumaric acid, not lowering the conversion of maleic acid, even when the mother solution is recycled, by isomerizing the maleic acid. SOLUTION: This method for producing fumaric acid from maleic acid as a raw material comprises the following processes (1), (2) and (3). The process (1): a process for isomerizing the maleic acid in the presence of a water-soluble bromine-donating compound and a compound having a standard electrode potential of >=1 V to produce the slurry containing the crystals of the fumaric acid. The process (2): a process for subjecting the fumaric acid crystal-containing slurry obtained in the process (1) to a solid-liquid separation process to recover the fumaric acid crystals. The process (3): a process for treating the mother solution obtained in the process (2) with an ion exchange resin, adding the maleic acid to the treated solution and then recycling the mixture to the process (1).

35. 发明专利

JPH09322792A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH09322792A
公开(公告)日：1997-12-16
申请号：JP14419196
申请日：1996-06-06
申请人： MITSUBISHI CHEM CORP
发明人： KATO NAOKI , MORI YOSHIAKI , WATANABE NAOYUKI , MIURA MIYUKI
IPC分类号： C12P13/20 , C07C229/24
摘要： PROBLEM TO BE SOLVED: To provide a profitable method for producing L-aspartic acid from maleic acid as a raw material by an enzyme-stabilized reaction to enable a stable continuous operation. SOLUTION: This method for producing L-aspartic acid has a characteristic comprising bleeding a solution containing the L-aspartic acid and ammonia at least from a spot in the below-described processes. The process (1): a process for successively or simultaneously executing a reaction for isomerizing maleic acid, etc., in the presence of an enzyme and a reaction for reacting at least a part of the isomerization reaction product with ammonia in the presence of an enzyme in water solvent to produce L-aspartic acid ammonium salt, the process (2): a process for adding maleic acid, etc., to the solution obtained in the process (1) to deposit the L-aspartic acid, and the process (3): a process for recovering the L-aspartic acid obtained in the process (2) and recycling the mother liquor to the process (1).

36. 发明专利

JPH09322791A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH09322791A
公开(公告)日：1997-12-16
申请号：JP14419096
申请日：1996-06-06
申请人： MITSUBISHI CHEM CORP
发明人： KATO NAOKI , MORI YOSHIAKI , WATANABE NAOYUKI , MIURA MIYUKI
IPC分类号： C12P7/46 , C07C229/24 , C12P13/20 , C12P39/00 , C12R1/05 , C12R1/13
摘要： PROBLEM TO BE SOLVED: To provide a method for producing L-aspartic acid from maleic acid as a raw material by an enzymatic reaction, enabling the continuous maintenance in the enzymatic action and the stable continuous operation. SOLUTION: This method for producing L-aspartic acid has a characteristic comprising maintaining the concentration of dissolved oxygen in an aqueous solution as least in an isomerization reaction among the below-described processes to

37. 发明专利

JPH09149792A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH09149792A
公开(公告)日：1997-06-10
申请号：JP31083095
申请日：1995-11-29
申请人： MITSUBISHI CHEM CORP
发明人： MORI YOSHIAKI , KATO NAOKI , WATANABE NAOYUKI , FUJII SEIJI
IPC分类号： C12P13/20 , C07C229/24
摘要： PROBLEM TO BE SOLVED: To inexpensively obtain L-aspartic acid for medicines, food additives, etc., by isomerizing an aqueous solution of ammonium maleate, treating the resultant isomer with aspartases in the presence of NH3 , subjecting the product to acid deposition with maleic acids, removing NH3 and recycling NH3 . SOLUTION: In this method for producing L-aspartic acid comprising using an aqueous solution of ammonium maleate as a raw material and subjecting the aqueous solution of ammonium maleate to isomerization reaction to afford an aqueous solution of ammonium fumarate, then treating the ammonium fumarate with aspartase or a microorganism which produces aspartase to give an aspartic acid ammonium aqueous solution, then subjecting an aqueous solution to acid deposition using maleic acid and/or maleic anhydride to deposit aspartic acid and separating and recovering the aspartic acid, a mother liquid containing monoammonium maleate after acid deposition is used as the following raw material and an aqueous solution of the product after enzymatic treatment is distilled to carry out deammonium and ammonium-containing gas distilled away from the tower top is recycled as a reaction raw material to efficiently and inexpensively obtain the objective L-aspartic acid.

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