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31. 发明专利

JP2008122234A Micro-integrated analysis chip and micro-integrated analysis system 审中-公开
标题翻译：微集成分析芯片和微集成分析系统
公开(公告)号：JP2008122234A
公开(公告)日：2008-05-29
申请号：JP2006306490
申请日：2006-11-13
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , SANTO YASUHIRO , AOKI YOICHI
IPC分类号： G01N35/10 , G01N35/08 , G01N37/00
CPC分类号： F16K99/0017 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0684 , B01L2200/10 , B01L2200/146 , B01L2300/1822 , B01L2400/0439 , B01L2400/0487 , B01L2400/0688 , F16K99/0001 , F16K99/0057 , F16K2099/0074 , F16K2099/0084
摘要： PROBLEM TO BE SOLVED: To provide a micro-integrated analysis chip and a micro-integrated analysis system capable of improving analysis accuracy by stabilizing the liquid sending amount and liquid sending speed of a sample such as a specimen or a reagent. SOLUTION: The sample such as the specimen or the reagent is injected from a sample injection port into a sample injection part, and the sample injected into the sample injection part is sent and stored in a sample storage part, and the sample stored in the sample storage part is sent to the downstream. Hereby, the micro-integrated analysis chip and the micro-integrated analysis system capable of stabilizing the liquid sending amount and the liquid sending speed of the sample, and improving analysis accuracy can be provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种微集成分析芯片和微集成分析系统，其能够通过稳定样品或试剂等样品的送液量和送液速度来提高分析精度。解决方案：将样品或试剂样品从样品注入口注入样品注入部分，并将注入样品注入部分的样品发送并存储在样品储存部分中，并将样品储存在样品储存部分发送到下游。因此，可以提供能够稳定样品的送液量和送液速度的微综合分析芯片和微综合分析系统，并提高分析精度。版权所有（C）2008，JPO＆INPIT

32. 发明专利

JP2007135504A Microreactor used for nucleic acid inspection and holding beads at amplification site 审中-公开
标题翻译：用于核酸检测和控制放大倍数的珠的MICROREACTOR
公开(公告)号：JP2007135504A
公开(公告)日：2007-06-07
申请号：JP2005335663
申请日：2005-11-21
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , SANTO YASUHIRO , AOKI YOICHI
IPC分类号： C12N15/09 , C12M1/00
摘要： PROBLEM TO BE SOLVED: To provide a microreactor used for nucleic acid inspection and capable of quickly, highly reliably and highly sensitively analyze, and to provide an inspection device.
SOLUTION: This nucleic acid inspection device is a system structure which separately has a chip component used for each specimen and loading elements for reagents/liquid-sending systems, and a control/detection component as an inspection device main body. Thereby, cross-contamination, carry-over contamination, and insufficient amplification or error amplification are hardly caused on a fine amount analysis and an amplification reaction. In this microreactor structure, nucleic acid non-adsorbing beads are held in a passage at a nucleic acid amplification site in which the nucleic acid amplification reaction is carried out. When the nucleic acid is amplified, the beads are moved in the passage to enhance the amplification efficiency of the amplification, thereby enabling the highly reliable and highly sensitive analysis in a short time.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供用于核酸检查的微反应器，能够快速，高度可靠和高灵敏度地分析，并提供检查装置。解决方案：该核酸检查装置是分别具有用于每个样品的芯片组件和用于试剂/送液系统的装载元件和作为检查装置主体的控制/检测部件的系统结构。因此，在微量分析和扩增反应中几乎不引起交叉污染，携带污染，扩增不足或误差扩增。在该微反应器结构中，将核酸非吸附珠粒保持在进行核酸扩增反应的核酸扩增位点的通道中。当核酸被扩增时，珠粒在通道中移动以增强扩增的扩增效率，从而在短时间内实现高可靠性和高灵敏度的分析。版权所有（C）2007，JPO＆INPIT

33. 发明专利

JP2006292472A Micro comprehensive analysis system 审中-公开
标题翻译：微型综合分析系统
公开(公告)号：JP2006292472A
公开(公告)日：2006-10-26
申请号：JP2005110967
申请日：2005-04-07
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , SANTO YASUHIRO
IPC分类号： G01N35/08 , C12M1/00 , C12Q1/68 , G01N33/50 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To prevent a biological material in a specimen or in a reagent from non-specifically adsorbing to the wall of a minute flow path in an inspection chip.
SOLUTION: This micro comprehensive analysis system is characterized by including: the inspection chip for analyzing an analyte in the specimen; a micro-pump for sending out a fluid; and the minute flow path which is a flow path with the fluid flowing therethrough, provided in the inspection chip, and whose inner wall is blocking-processed. The blocking-processing is performed by letting flow a solution containing a hydrophilic polymer, etc. adsorbed to the inner wall of the flow path. This analysis system achieves stable and highly accurate mixture of a plurality of fluids by a simple structure and allows efficient and highly sensitive analysis.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了防止检查芯片中的试样或试剂中的生物材料非特异性地吸附在微小流路的壁上。解决方案：该微综合分析系统的特点是：用于分析样品中分析物的检验芯片; 用于发出流体的微型泵; 并且设置在检查芯片中，并且其内壁被阻塞处理的是流体流过其中的流动路径的微小流路。通过使含有亲水性聚合物等的溶液流入流路的内壁来进行阻断处理。该分析系统通过简单的结构实现了多种流体的稳定和高精度的混合，并且允许有效和高度敏感的分析。版权所有（C）2007，JPO＆INPIT

34. 发明专利

JP2006217818A Micro reactor for inspecting gene and method for inspecting gene 审中-公开
标题翻译：用于检测基因的微反应器和检测基因的方法
公开(公告)号：JP2006217818A
公开(公告)日：2006-08-24
申请号：JP2005031748
申请日：2005-02-08
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： NAKAJIMA AKIHISA , AOKI YOICHI , UEDA EIICHI , SANTO YASUHIRO , HIGASHINO KUSUNOKI , ISHIDA NOBUHISA
IPC分类号： C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/28 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a DNA inspection device which can cope many purpose gene inspections by suitably changing a DNA amplification primer loaded on a micro reactor for inspecting genes, a probe hybridizing with an amplification gene.
SOLUTION: This micro reactor can analyze highly sensitively, because of incorporating a DNA amplification process for detection, and can detect an objective gene in good accuracy with a probe DNA specifically hybridizing with an amplified gene. The DNA inspection device hardly causes acute problems such as cross contamination or carryover contamination for microanalysis, amplification analysis, because system-constituting separates a reagent/solution-sending system element-loading component and a control/detection component for each specimen.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种DNA检测装置，其可以通过适当地改变负载在微反应器上的DNA扩增引物来检测基因，以及与扩增基因杂交的探针来处理许多目的基因检查。解决方案：这种微反应器可以高度敏感地分析，因为结合了DNA扩增过程进行检测，并且可以用扩增的基因特异性杂交的探针DNA来检测目标基因的准确性。 DNA检查装置几乎不会引起诸如交叉污染或微量分析的残留污染的急性问题，扩增分析，因为系统构成分离每个样品的试剂/溶液发送系统元件装载部件和控制/检测部件。版权所有（C）2006，JPO＆NCIPI

35. 发明专利

JP2010008145A Microinspection chip, quantitative liquid sending method of microinspection chip and inspection apparatus 审中-公开
标题翻译：微型检验芯片，定量液体检测方法及检验仪器
公开(公告)号：JP2010008145A
公开(公告)日：2010-01-14
申请号：JP2008165836
申请日：2008-06-25
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , SANTO YASUHIRO , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microinspection chip, capable of sending a liquid collectively present at one place to a predetermined flow channel in predetermined timing at a predetermined speed, by quantifying and distributing a predetermined amount of the liquid and also having the high degree of freedom in the arrangement of the flow channel, and to provide a quantitative liquid sending method of the microinspection chip and an inspection apparatus.
SOLUTION: The liquid stored in a liquid storage part is sent to a liquid-quantifying part to be quantified and held, and the liquid held to the liquid-quantifying part is sent, by cutting off from the air, in a state where the downstream flow channel of a liquid sending destination is opened to the outside. This liquid quantifying and sending method is utilized to enable provision for the microinspection chip, capable of sending the liquid collectively present an one place to the predetermined flow channel with a predetermined timing, at a predetermined speed, by quantifying and distributing the predetermined amount of the liquid and also having the high degree of freedom in the arrangement of the flow channel, the quantitative liquid-sending method of the microinspection chip, and the inspection device.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种微检测芯片，其能够以预定速度在预定时间内将一个共同存在于一个位置的液体发送到预定流动通道，通过量化和分配预定量的液体，并且还具有流道布置的高度自由度，提供微检测芯片的定量送液方法和检查装置。解决方案：储存在液体储存部分中的液体被送到待定量和保持的液体定量部件，并且保持在液体定量部件中的液体通过从空气中切断而被送出其中液体送出目的地的下游流动通道向外部打开。这种液体定量和发送方法被用于能够提供微检测芯片，能够以预定的速度以预定的速度将液体集中地呈现给预定流动通道一个位置，通过量化和分配预定量的液体，并且在流动通道的布置中具有高自由度，微检测芯片的定量送液方法和检查装置。版权所有（C）2010，JPO＆INPIT

36. 发明专利

JP2009156741A Opening sealing member, opening sealing method, micro inspection chip, and opening sealing tool 审中-公开
标题翻译：打开密封件，打开密封方法，微型检验芯片和开放式密封工具
公开(公告)号：JP2009156741A
公开(公告)日：2009-07-16
申请号：JP2007336156
申请日：2007-12-27
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , MORI TAKAHIRO , HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： G01N35/02 , G01N35/10 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an opening sealing member, an opening sealing method, a micro inspection chip, and an opening sealing tool, having low cost, capable of sealing easily and surely an opening part of the micro inspection chip. SOLUTION: Concerning the opening sealing member, the opening sealing method, the micro inspection chip, and the opening sealing tool, having low cost, the opening part of the micro inspection chip can be sealed easily and surely, by sealing the opening part of the micro inspection chip by using the opening sealing member comprising a first member and a second member which are separable. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种开口密封构件，开口密封方法，微检查芯片和开口密封工具，其成本低，能够容易且可靠地密封微检查芯片的开口部分。
解决方案：关于开口密封件，开口密封方法，微检查芯片和开口密封工具，成本低，微检查芯片的开口部分可以容易且可靠地密封，通过密封开口通过使用包括可分离的第一构件和第二构件的开口密封构件的微检查芯片的一部分。版权所有（C）2009，JPO＆INPIT

37. 发明专利

JP2009133719A Microinspection chip, liquid quantifying method of microinspection chip and inspection device 审中-公开
标题翻译：微检查液晶微量检测方法及检测装置
公开(公告)号：JP2009133719A
公开(公告)日：2009-06-18
申请号：JP2007310059
申请日：2007-11-30
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , SANTO YASUHIRO , AOKI YOICHI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microinspection chip capable of dividing a specimen or reagent at every channel while individually accurately quantifying the same at every channel by simple operation, also enhanced in the degree of freedom of the arrangement of the channel and also reducing the waste of the specimen or reagent, a liquid quantifying method of the microinspection chip and an inspection device.
SOLUTION: The microinspection chip is constituted so as to be capable of dividing the specimen or reagent while individually accurately quantifying the same at every channel by simple operation by injecting a liquid from a liquid injection port and sucking the same from a downstream channel after the whole of a liquid quantifying part and the region up to the midway of a branch channel are filled with the liquid, also enhanced in the degree of freedom of the arrangement of the channel and also reduces the waste of the specimen or reagent. The liquid quantifying method of the microinspection chip and the inspection device are also disclosed.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够在每个通道上分割样本或试剂的微检测芯片，同时通过简单的操作在每个通道单独精确地量化样品或试剂，还增加了通道的排列的自由度，也减少了样本或试剂的浪费，微检测芯片的液体定量方法和检查装置。解决方案：微检测芯片构成为能够通过简单的操作通过从液体注入口喷射液体并从下游通道吸取样品或试剂，而在每个通道单独精确地定量样品或试剂在整个液体定量部分和直到分支通道中途的区域充满液体之后，还增加了通道排列的自由度，并且还减少了样品或试剂的浪费。还公开了微检测芯片和检查装置的液体定量方法。版权所有（C）2009，JPO＆INPIT

38. 发明专利

JP2009019891A Micro inspection chip and inspection device 审中-公开
标题翻译：微检查芯片和检查设备
公开(公告)号：JP2009019891A
公开(公告)日：2009-01-29
申请号：JP2007180744
申请日：2007-07-10
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/08 , B81B1/00 , C12M1/00 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a micro inspection chip and an inspection device capable of preventing channel air bleeding from becoming impossible caused by blocking an air bleeding high-resistance channel by leakage liquid of a reagent, preventing bubbles from being interposed between driving liquid and the reagent, and stably sending the reagent.
SOLUTION: By having the liquid holding power of a downstream-side water-repellent valve provided on the downstream side of a reagent storage part is adjusted to be weaker than liquid holding power of an upstream-side water-repellent valve provided on the upstream side and leakage reagent always leaks to the downstream side, if such a situation exists, the reagent will not leak to the upstream side, the micro inspection chip and the inspection device can be provided, which is capable of preventing channel air bleeding from becoming disabled caused by blocking the air bleeding high-resistance channel due to the leakage liquid of the reagent, preventing bubbles from being interposed between the driving liquid and the reagent, and stably sending the reagent.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种微检查芯片和检查装置，其能够防止通过试剂的泄漏液阻塞排气高阻通道而引起的通道空气渗出，防止气泡插入在驱动液体和试剂，并稳定地发送试剂。解决方案：通过将设置在试剂储存部下游侧的下游侧防水阀的液体保持力调节为比设置在上游侧防水阀的液体保持力弱上游侧和泄漏试剂总是泄漏到下游侧，如果存在这种情况，则试剂不会泄漏到上游侧，可以提供微检查芯片和检查装置，其能够防止通道空气渗出由于试剂的漏液而阻塞排气高阻通道而导致的阻止，防止气泡插入在驱动液体和试剂之间，稳定地送出试剂。版权所有（C）2009，JPO＆INPIT

39. 发明专利

JP2007289818A Microreactor and micro total analysis system using the same 审中-公开
标题翻译： MICROREACTOR和MICRO TOTAL ANALYSIS SYSTEM SYSTEM THE SAME
公开(公告)号：JP2007289818A
公开(公告)日：2007-11-08
申请号：JP2006118302
申请日：2006-04-21
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , SANTO YASUHIRO
IPC分类号： B01J19/00 , B81B1/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a hard-to-warp microreactor and a micro total analysis system using the microreactor.
SOLUTION: The microreactor is constituted so that a flow passage groove is arranged on one side face of a plate-shaped base material and a flow passage is formed by sticking a covering base material to the plate-shaped base material so as to cover the flow passage groove. A warpage preventing member is fit to the other side face opposite to the flow passage-arranged side face.
COPYRIGHT: (C)2008,JPO&INPIT

40. 发明专利

JP2007289032A Microreactor and integrated microanalytical system using the same 审中-公开
标题翻译： MICROREACTOR和集成微系统使用它
公开(公告)号：JP2007289032A
公开(公告)日：2007-11-08
申请号：JP2006118300
申请日：2006-04-21
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , SANTO YASUHIRO
IPC分类号： C12M1/00 , B01J19/00 , B81B1/00 , C12Q1/68 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microreactor of not unnecessarily enlarged size through securing the amplification part's forming portion even if the microreactor is limited in size, and to provide an integrated microanalytical system using the microreactor.
SOLUTION: The microreactor has the following construction: Flow channels are provided on one and the other sides of a plate-like chip, and there is furnished a through hole making both of the above flow channels communicate with each other, and also there is installed the amplification part functioning to conduct an amplification reaction of a specific substance at least in the above flow channels, wherein the through hole is served as at least part of the amplification part.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：即使微型反应器的尺寸受到限制，通过固定放大部分的成形部分来提供不必要的尺寸的微反应器，并且提供使用该微反应器的集成的微量分析系统。解决方案：微反应器具有以下结构：流通通道设置在板状芯片的一侧和另一侧上，并且设置有使上述流动通道彼此连通的通孔，并且还至少在上述流动通道中安装用于进行特定物质的扩增反应的扩增部分，其中通孔用作扩增部分的至少一部分。版权所有（C）2008，JPO＆INPIT

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