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21. 发明专利

JP5214244B2 To the protein and its substrate, mooring of the functional groups by covalent bond 有权
公开(公告)号：JP5214244B2
公开(公告)日：2013-06-19
申请号：JP2007523888
申请日：2005-07-29
申请人：プロメガコーポレイションPromega Corporation
发明人：ダージンズ，アルディス , ピー．エンセル，ランス , ジョンソン，トニー , クラウバート，ディーター , ブイ．ロス，ジョージー , マクドゥーガル，マーク , ブイ．ウッド，キース , ジー．ウッド，モニカ , ジムプリッチ，チャド
IPC分类号： C12N15/09 , C07K1/22 , C07K14/47 , C07K19/00 , C12N5/10 , C12N9/10 , C12N9/14 , C12N11/00 , C12Q1/02 , C12Q1/26 , C12Q1/34 , C12Q1/37 , C12Q1/48 , G01N21/78
CPC分类号： C12N9/14 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K2299/00 , C12N9/0069 , C12Q1/26 , C12Q1/34 , C12Q1/66 , C12Y113/12005 , C12Y308/01005
摘要： A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.

22. 发明专利

JP2013515462A Sucrose mutase with improved product specificity 审中-公开
公开(公告)号：JP2013515462A
公开(公告)日：2013-05-09
申请号：JP2012545146
申请日：2010-12-18
申请人：ズートツッカーアクチェンゲゼルシャフトマンハイム/オクセンフルト
发明人：エール，ヴォルフガング , エック，ユールゲン , ハルムス，カーステン , クリンゲベルク，ミハエル , ペルツァー，シュテファン , ヴァッハ，ヴォルフガング
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/90 , C12N11/00 , C13K3/00
CPC分类号： C12P19/12 , C12N9/90
摘要：本発明は、ショ糖からのイソマルツロースおよびイソマルツロース含有組成物のバイオテクノロジー的製造のために、改善された手段、特に改善された生成物特異性を有するスクロースムターゼおよび改善されたスクロースムターゼを含む微生物細胞を提供する。
【選択図】なし

23. 发明专利

JP5192700B2 New glycosyltransferase and polynucleotides encoding the same 有权
公开(公告)号：JP5192700B2
公开(公告)日：2013-05-08
申请号：JP2007010759
申请日：2007-01-19
申请人：サントリーホールディングス株式会社
发明人：美佐落合 , 治一深見 , 正宏中尾 , 秋雄野口
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/24 , C12N11/00 , C12Q1/68
CPC分类号： C12N9/1048

24. 发明专利

JP2013049718A Glycomimetic inhibitor of pa-il lectin, pa-iil lectin or both the lectins from pseudomonas 审中-公开
标题翻译： PA-IL LECTIN，PA-IIL LECTIN或来自PSEUDOMONAS的胶囊的GLYCOMIMETIC INHIBITOR
公开(公告)号：JP2013049718A
公开(公告)日：2013-03-14
申请号：JP2012267339
申请日：2012-12-06
申请人： Glycomimetics Inc , グリコミメティクス, インコーポレイテッド
发明人： MAGNANI JOHN L , PATTON JOHN T JR , SARKAR ARUN K
IPC分类号： C07H3/06 , A61K31/702 , A61K45/00 , A61K47/48 , A61P31/04 , A61P43/00 , C12N11/00 , C12Q1/02 , G01N33/569
CPC分类号： C07H17/04 , C07H3/06 , G01N33/56911 , G01N2333/21
摘要： PROBLEM TO BE SOLVED: To provide glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas.SOLUTION: Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
摘要翻译：要解决的问题：提供PA-IL凝集素，PA-IIL凝血素或来自假单胞菌的凝集素两者的模拟抑制剂。提供了与假单胞菌属相关的组合物和方法。组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。通过阻断定植，抑制毒力因子，阻止生长或杀死细菌，可以抑制假单胞菌。版权所有（C）2013，JPO＆INPIT

25. 发明专利

JP2012514586A Means and methods for treating il-21 and il-21 antibody deficiency based diseases mutant 审中-公开
公开(公告)号：JP2012514586A
公开(公告)日：2012-06-28
申请号：JP2011544055
申请日：2010-01-05
申请人：フラウンホーファーゲゼルシャフトツールフォルデルングデルアンゲヴァンテンフォルシユングエー.フアー.
发明人：ザック，ウルリッヒ , ハンマーストローム，レンナールツ , ボルテ，シュテファン
IPC分类号： C07K14/54 , A61K38/00 , A61K38/21 , A61K39/00 , A61K39/395 , A61P37/04 , C12N11/00 , C12N15/09
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54
摘要： The present invention relates to an lnterleukin-21 (IL-21) variant which is capable of increasing the secretion of IgG and/or IgA antibodies in B cells and/or is capable of binding the IL-2 receptor complex and/or the IL-4 receptor complex, comprising stretches of amino acids of lnterleukin-4 (IL-4) or lnterleukin-2 (IL-2) in substitution of amino acids of IL-21. The present invention also relates to a pharmaceutical composition comprising IL-21 and/or an IL-21 variant and at least one compound selected from IgA inducing protein (IGIP), Syntenin-1, Galectin-1 and Galectin-3. The present invention further relates to a pharmaceutical composition for the treatment of a primary humoral immunodeficiency disease comprising IL-21 and/or an IL-21 variant and IL-4 and/or IL-2 and/or IGIP and/or Syntenin-1 and/or Galectin-1 and/or Galectin-3. Furthermore the present invention relates to a kit for the treatment of a primary humoral immunodeficiency disease, comprising IL-21 and/or an IL-21 variant and IL-4 and/or IL-2 and/or IGIP and/or Syntenin-1 and/or Galectin-1 and/or Galectin-3 and optionally at least one element selected from a stimulator of CD40 molecules, a ligand of the tumor necrosis superfamily, a polypeptide with human leukocyte interferon activity, a vaccine protein antigen; and a vaccine polysaccharide antigen.

26. 发明专利

JP4907498B2 Polynucleotide sequencing methods 有权
公开(公告)号：JP4907498B2
公开(公告)日：2012-03-28
申请号：JP2007295468
申请日：2007-11-14
申请人：メディカル・バイオシステムズ・リミテッドMedical Biosystems Ltd.
发明人：ダニエル・ヘンリー・デンシャム
IPC分类号： C12Q1/68 , G01N21/65 , C12M1/34 , C12N11/00 , C12N15/09 , C12Q1/48 , G01N13/16 , G01N21/27 , G01Q30/02
CPC分类号： C12Q1/6869 , C12Q2565/632 , C12Q2533/101 , C12Q2521/543
摘要： The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal.

27. 发明专利

JP4729408B2 Method for producing immobilized enzyme 有权
公开(公告)号：JP4729408B2
公开(公告)日：2011-07-20
申请号：JP2006024346
申请日：2006-02-01
申请人：株式会社日本触媒
发明人：尚仙波 , 龍司相澤
IPC分类号： C12N11/00 , C12N9/88 , C12N9/96 , C12P13/00
CPC分类号： Y02P20/52

28. 发明专利

JP4722998B2 How to grant the ligand binding to a hydrophobic carrier 有权
公开(公告)号：JP4722998B2
公开(公告)日：2011-07-13
申请号：JP2008528695
申请日：2006-12-19
申请人：シャープ株式会社
发明人：アンダーソンサリー , エー．リーヴミハエル
IPC分类号： G01N33/543 , C07K17/00 , C12N11/00 , C12N15/09 , G01N37/00
CPC分类号： C07K17/08 , C07K7/06 , C07K7/08

29. 发明专利

JP2011092185A Method for promoting decomposition of acrylamide 审中-公开
标题翻译：促进丙烯酰胺分解的方法
公开(公告)号：JP2011092185A
公开(公告)日：2011-05-12
申请号：JP2010187380
申请日：2010-08-24
申请人： Kanazawa Inst Of Technology , 学校法人金沢工業大学
发明人： OZEKI KENJI , YAMAMOTO HIROKI , FUJIMOTO NAOKO , WAKAIZUMI MASAKATSU
IPC分类号： C12N1/14 , C12N1/00 , C12N11/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing filamentous fungus induced with acrylamide-decomposing function and the filamentous fungus obtained by the method. SOLUTION: This method for producing the filamentous fungus induced with the acrylamide-decomposing function is provided by culturing the filamentous fungus in an acrylamide-containing medium under the condition of pH 7.5 to 11.0. The method for producing immobilized filamentous fungus induced with the acrylamide-decomposing function is provided by comprising the following processes: (a) performing pre-incubation of a carrier with a nutrition source-containing medium, (b) culturing the filamentous fungus in a medium containing the carrier, and then (c) culturing the immobilized filamentous fungus on the carrier under the condition of pH 7.5 to 11.0 in the acrylamide-containing medium. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供用丙烯酰胺分解功能诱导的丝状真菌的方法和通过该方法获得的丝状真菌的方法。解决方案：通过在pH 7.5〜11.0的条件下，在含丙烯酰胺的培养基中培养丝状真菌来提供用丙烯酰胺分解功能诱导的丝状真菌的制造方法。通过包括以下方法提供用丙烯酰胺分解功能诱导的固定化丝状真菌的方法：（a）使载体与含营养源的培养基进行预温育，（b）在培养基中培养丝状真菌含有载体，然后（c）在含有丙烯酰胺的培养基中，在pH 7.5〜11.0的条件下，在载体上培养固定化的丝状真菌。版权所有（C）2011，JPO＆INPIT

30. 发明专利

JP2011062195A Method for preparing microorganism group-carrying carrier, method for treating substance and method for producing substance by utilizing microorganism 有权
标题翻译：用于制备微生物携带载体的方法，用于处理物质的方法和利用微生物生产物质的方法
公开(公告)号：JP2011062195A
公开(公告)日：2011-03-31
申请号：JP2010083327
申请日：2010-03-31
申请人： Central Res Inst Of Electric Power Ind , 財団法人電力中央研究所
发明人： SASAKI KENGO , MORITA YOSHIHIKO , MATSUMOTO TAKAO , HIRANO SHINICHI , OMURA NAOYA
IPC分类号： C12N11/00 , B09B3/00 , C02F11/04 , C12M1/00 , C12P5/02
CPC分类号： Y02E50/343
摘要： PROBLEM TO BE SOLVED: To prepare a microorganism group-carrying carrier exhibiting an excellent treating capacity even under a high loading condition. SOLUTION: This method for preparing the microorganism group-carrying carrier includes bringing an electroconductive carrier capable of carrying the microorganisms in contact with a microorganism population at least containing an objective microorganism group to be carried and culturing liquid, and controlling the electric potential of the electroconductive carrier in an optimum range of the objective microorganism group to be carried so as to preferentially carry and activate the objective microorganism group to be carried on the electroconductive carrier. Also, the method for preparing the microorganism group-carrying carrier includes bringing a hydrophobic electroconductive carrier capable of carrying the microorganisms in contact with methane fermenting liquid containing an organic substrate material and controlling the electric potential of the electroconductive carrier to an electric potential capable of starting a reducing reaction at the electroconductive carrier, or to +0.3 V based on a silver-silver chloride electrode potential so as to preferentially carry and activate the microorganism group associated with the methane fermentation on the electroconductive carrier. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：为了制备即使在高负载条件下表现出优异处理能力的含微生物组的载体。解决方案：用于制备携带微生物载体的载体的方法包括使能够携带微生物的导电载体与微生物群体接触，所述微生物群体至少含有待携带的目标微生物群和培养液，并控制电位的导电载体在待携带的目标微生物组的最佳范围内，以优先携带和活化待承载在导电载体上的目标微生物组。此外，制备携带微生物组的载体的方法包括使能够携带微生物的疏水性导电载体与包含有机基材的甲烷发酵液接触，并将导电载体的电位控制为能够起始的电位在导电载体上的还原反应，或者基于银 - 氯化银电极电位为+ 0.3V，以优先携带和活化与导电载体上的甲烷发酵相关的微生物组。版权所有（C）2011，JPO＆INPIT

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