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    • 24. 发明专利
    • Rehydratable pharmaceutical product
    • 可再生药品
    • JP2012229248A
    • 2012-11-22
    • JP2012157118
    • 2012-07-13
    • Biocompatibles Uk Ltdバイオコンパティブルズ ユーケー リミテッド
    • WILLIS SEANPALMER ROSEMARY
    • A61K47/32A61K9/10A61K9/19A61K31/4745A61K31/704A61K31/795A61P7/04A61P35/00
    • A61K9/19A61J1/065A61J1/1406A61J1/1412A61K9/0019A61K9/10A61K9/1641A61K9/1676A61K9/1682A61K31/4745A61K31/704A61K45/06B65B31/027B65B63/08B65D81/2015B82Y5/00
    • PROBLEM TO BE SOLVED: To provide a dried pharmaceutical composition to be administered to an animal and used particularly as a chemoembolization composition, capable of being stably stored and easily rehydrated.SOLUTION: The invention is a method for formulating a dried product suitable for direct administration to an animal after rehydration to form a suspension. The method includes: (i) a freezing step of cooling particles of polymer matrix to a temperature below the freezing point of water, the polymer matrix being swollen with water and having absorbed therein a non-volatile biologically active compound; (ii) a lyophilization step of subjecting the cooled particles obtained in step (i) to reduced pressure at which ice sublimes for a period during which at least a portion of the absorbed ice sublimes and water vapor is removed; and (iii) a packaging step of packaging the dried particles. The packaging step is performed under reduced pressure. A packaging container for packaging the particles is substantially airtight, and has an interior under vacuum.
    • 要解决的问题:提供待给予动物并特别用作化学栓塞组合物的干燥药物组合物,其能够稳定储存并容易地再水化。 解决方案:本发明是一种用于配制干物质的方法,其适合于在再水合后直接施用于动物以形成悬浮液。 该方法包括:(i)将聚合物基质的颗粒冷却至低于水凝固点的温度的冷冻步骤,所述聚合物基质用水溶胀并在其中吸收非挥发性生物活性化合物; (ii)冷冻干燥步骤,将步骤(i)中获得的冷却颗粒在减压下进行一段时间,其中至少一部分吸收的升华和水蒸气被除去; 和(iii)包装干燥颗粒的包装步骤。 包装步骤在减压下进行。 用于包装颗粒的包装容器基本上是气密的,并且在真空下具有内部空间。 版权所有(C)2013,JPO&INPIT