专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明专利

JP2006042758A Base material for culturing embryonic stem cell and its use 有权
标题翻译：培养胚胎干细胞的基础材料及其使用
公开(公告)号：JP2006042758A
公开(公告)日：2006-02-16
申请号：JP2004241637
申请日：2004-08-20
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： ASARI AKIRA , OCHITANI TAKAHIRO , TERATANI TAKUMI
IPC分类号： C12M3/00 , C12N5/07 , C12N5/0735
CPC分类号： C12M25/14 , C12M23/20
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently differentiating and inducing hepatic cells from embryonic stem cells, and to provide a raw material therefor.
SOLUTION: The subject base material for culturing the embryonic stem cells contains a sponge form crosslinked polysaccharide as a main ingredient. The polysaccharide is preferably one or more polysaccharides selected from the group consisting of hyaluronic acid, chondroitin sulfate, heparin, heparan sulfate, keratan sulfate, chitin, chitosan, alginic acid, and carboxymethylcellulose. The sponge form crosslinked polysaccharide preferably has (1) ≥760 holes per mm
2 , and (2) ≥50 % of the holes has hole diameters of 10 to 50 μm. The crosslinked polysaccharide is preferably obtained by crosslinking a photoreactive polysaccharide by the irradiation of light. A method for culturing embryonic stem cells preferably uses the culture base material. A method for differentiating and inducing the embryonic stem cells preferably includes at least a step for culturing the embryonic stem cells by the culturing method, and a method for producing hepatic cells comprises the above method.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于从胚胎干细胞中有效地分化和诱导肝细胞并提供其原料的方法。解决方案：用于培养胚胎干细胞的主体基质含有作为主要成分的海绵状交联多糖。多糖优选为选自透明质酸，硫酸软骨素，肝素，硫酸乙酰肝素，硫酸角质素，壳多糖，壳聚糖，海藻酸和羧甲基纤维素中的一种以上的多糖。海绵形式的交联多糖优选具有（1）≥260个/ mm 2的孔，（2）孔的大小的50％具有10〜50μm的孔径。交联多糖优选通过光照射使光反应性多糖交联而获得。培养胚胎干细胞的方法优选使用培养基材。用于分化和诱导胚胎干细胞的方法优选至少包括通过培养方法培养胚胎干细胞的步骤，并且生产肝细胞的方法包括上述方法。版权所有（C）2006，JPO＆NCIPI

22. 发明专利

JP2006016313A Gap junction function inhibitor, cell proliferation promoter and sulfated polyfucose 有权
标题翻译： GAP结功能抑制剂，细胞增殖促进剂和硫酸化多糖
公开(公告)号：JP2006016313A
公开(公告)日：2006-01-19
申请号：JP2004193233
申请日：2004-06-30
申请人： Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho , Seikagaku Kogyo Co Ltd , Toshie Tsuchiya , 国立医薬品食品衛生研究所長 , 利江土屋 , 生化学工業株式会社
发明人： TSUCHIYA TOSHIE , KARIYA YUTAKA
IPC分类号： A61K31/726 , A61K31/727 , A61K31/728 , A61K35/56 , A61K36/02 , A61P7/02 , A61P15/00 , A61P31/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a gap junction (GJ) function inhibitor, etc., using glycosaminoglycan and sulfated polyfucose having branched chain of sulfated fucose residue having strong inhibiting function to GJ function of the surface of human fibroblast. SOLUTION: The GJ function inhibitor comprises a polysaccharide having a sulfated fucose residue, particularly, glycosaminoglycan and sulfated fucose having a branched chain of sulfated fucose residue, their pharmaceutically acceptable salts as active ingredients. The cell proliferation promoter comprises these polysaccharides as active ingredients. A new sulfated polyfucose is also provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：使用具有对人成纤维细胞表面的GJ功能具有强抑制功能的具有支链的硫酸岩藻糖残基支链的糖胺聚糖和硫酸化聚糖糖醇来提供间隙连接（GJ）功能抑制剂等。解决方案：GJ功能抑制剂包括具有硫酸化岩藻糖残基的多糖，特别是具有硫酸化岩藻糖残基支链的糖胺聚糖和硫酸岩藻糖，其药学上可接受的盐作为活性成分。细胞增殖促进剂包含这些多糖作为活性成分。还提供了一种新的硫酸化聚糖蛋白。版权所有（C）2006，JPO＆NCIPI

23. 发明专利

JP2006008692A Artificial complex carbohydrate 审中-公开
标题翻译：人造复合碳水化合物
公开(公告)号：JP2006008692A
公开(公告)日：2006-01-12
申请号：JP2005197650
申请日：2005-07-06
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KUSUMOTO SHOICHI , FUKASE KOICHI
IPC分类号： C07H15/04
摘要： PROBLEM TO BE SOLVED: To provide a readily producible artificial complex carbohydrate in relation to the artificial complex carbohydrate.
SOLUTION: The artificial complex carbohydrate is characterized as follows. A monosaccharide, an oligosaccharide, a polysaccharide or a glycosaminoglycan having the terminal composed of a reducing sugar is bound to a 2-amino group of a 2-amino-6-aminoalkylpyridine residue by a reductive amination reaction. Bovine serum albumin, biotin and acrylic acid or a copolymer of acrylic acid and acrylamide is bound through a 6-aminoalkyl group to form an amide bond. The 2-amino-6-alkylpyridine residue is represented by the formula.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供相对于人造复合碳水化合物容易生产的人造复合碳水化合物。解决方案：人造复合碳水化合物的特征如下。具有由还原糖构成的末端的单糖，寡糖，多糖或糖胺聚糖通过还原胺化反应与2-氨基-6-氨基烷基吡啶残基的2-氨基结合。牛血清白蛋白，生物素和丙烯酸或丙烯酸和丙烯酰胺的共聚物通过6-氨基烷基结合形成酰胺键。 2-氨基-6-烷基吡啶残基用下式表示。版权所有（C）2006，JPO＆NCIPI

24. 发明专利

JP2006006155A New sulfate transferase and gene thereof 审中-公开
标题翻译：新的硫酸盐转移及其基因
公开(公告)号：JP2006006155A
公开(公告)日：2006-01-12
申请号：JP2004185911
申请日：2004-06-24
申请人： National Institute Of Advanced Industrial & Technology , Seikagaku Kogyo Co Ltd , 独立行政法人産業技術総合研究所 , 生化学工業株式会社
发明人： NARIMATSU HISASHI , NAKAMURA MITSURU , ANDO HIDENOBU , YASUGATA TAKASHI , KIKUCHI NORIHIRO , KIMATA HIROHARU
IPC分类号： C12N15/09 , C07K16/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12Q1/48 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a new protein having sulfate transferase activities; to provide a nucleic acid encoding the protein; and to provide applications thereof as a sulfate transferring agent, a method for detecting cancerization, etc. SOLUTION: The protein having a specific amino acid sequence, the nucleic acid encoding the protein, the sulfate transferring agent containing the protein as an effective ingredient, the method for detecting the cancerization of a subject tissue by relating the expressed amount of the protein in the subject tissue with the cancerization of the subject tissue, the antibody specific to the protein, the cell holding the nucleic acid, and the method for identifying the amino acid sequence of the polypeptide reducing the expression thereof in a living tissue by the sulfate-transferring activities and the cancerization, and the base sequence of the nucleic acid encoding the polypeptide, including a step of comparing the specific amino acid sequence or the specified base sequence, with amino acid sequence information of one or more kinds of polypeptides, or base sequence information of the nucleic acids encoding the polypeptides are provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有硫酸转移酶活性的新蛋白质; 以提供编码该蛋白质的核酸; 并提供其作为硫酸盐转移剂的应用，检测癌症化的方法等。解决方案：具有特定氨基酸序列的蛋白质，编码蛋白质的核酸，含有蛋白质的硫酸盐转移剂作为有效的成分，通过将主体组织中的蛋白质的表达量与受试组织的癌化相关的蛋白质特异性抗体，保留核酸的细胞以及用于鉴定通过硫酸盐转移活性和癌化反应减少活组织中表达的多肽的氨基酸序列，以及编码多肽的核酸的碱基序列，包括比较特定氨基酸序列或指定碱基序列，具有一种或多种多肽的氨基酸序列信息或碱基序列信息提供了编码多肽的核酸。版权所有（C）2006，JPO＆NCIPI

25. 发明专利

JP2005338064A Joint information determining method and method for discriminating normal joint from pathologic joint 有权
标题翻译：联合信息确定方法和方法从病理学联合中分离正常关节
公开(公告)号：JP2005338064A
公开(公告)日：2005-12-08
申请号：JP2005118281
申请日：2005-04-15
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAUCHI SATOSHI , HORIE KATSUYUKI
IPC分类号： G01N33/53 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method and a kit for determining joint information.
SOLUTION: In the joint information determining method, information on the amount of normal aglycan and the amount of whole proteoglycan in a specimen is compared with these amounts in synovial fluid derived from a normal joint, to determine whether the information belongs to pathologic joints or to normal joints, on the basis of the presence or absence of a significant difference. The kit for determining joint information includes reagents A-C of the following constitution. A is a reagent for dissolving or removing hyaluronic acid, combined with normal aglycan in the specimen or free hyaluronic acid. B is a solid phase for specifically combining or adsorbing normal aglycan. C is a reagent for detecting normal aglycan, combined with or adsorbed by the solid phase B.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于确定联合信息的方法和工具包。解决方案：在联合信息确定方法中，将来自标准关节的滑液中正常糖苷配基的量和整个蛋白多糖的量的信息与这些量进行比较，以确定信息是否属于病理学关节或正常关节，基于存在或不存在显着性差异。用于确定联合信息的试剂盒包括以下构成的试剂A-C。 A是用于溶解或除去透明质酸的试剂，与样品中的正常糖苷配基或游离透明质酸结合。 B是用于特异性结合或吸附正常糖苷配基的固相。 C是用于检测与固相B结合或吸附的正常糖苷配基的试剂。版权所有（C）2006，JPO＆NCIPI

26. 发明专利

JP2005323506A Protein having hyaluronic acid-synthesizing activity and method for producing hyaluronic acid 审中-公开
标题翻译：具有合成ACA合成活性的蛋白质和产生羟丙酸的方法
公开(公告)号：JP2005323506A
公开(公告)日：2005-11-24
申请号：JP2004141992
申请日：2004-05-12
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： WATANABE MASANORI , ITANO NAOKI , SUGIURA NOBUO
IPC分类号： C12N15/09 , C12N5/10 , C12N7/00 , C12N9/00 , C12P19/26
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a protein having a hyaluronic acid-synthesizing activity, a new nuclear polyhedrosis virus capable of being applied for the efficient production of hyaluronic acid, insect cells useful for the effective production of the protein having the hyaluronic acid-synthesizing activity or hyaluronic acid, an efficient method for producing the protein having the hyaluronic acid-producing activity and an efficient method for producing hyaluronic acid. SOLUTION: The nuclear polyhedrosis virus holding the DNA encoding the protein having the hyaluronic acid-synthesizing activity, insect-derived cells holding the virus and method for producing the protein having the hyaluronic acid-synthesizing activity by using the cells, and method for producing the hyaluronic acid are provided. As "the DNA encoding the protein having the hyaluronic acid-synthesizing activity", to begin with a DNA encoding the protein consisting of an amino acid sequence expressed by sequence number 2 in a table of sequences (in the specification), and the DNAs having a comparable function with the above can be cited. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供具有透明质酸合成活性的蛋白质，能够用于有效生产透明质酸的新的核多角体病毒，可用于有效生产具有透明质酸的蛋白质的昆虫细胞酸合成活性或透明质酸，这是生产具有透明质酸产生活性的蛋白质的有效方法和生产透明质酸的有效方法。解决方案：保持编码具有透明质酸合成活性的蛋白质的DNA的核型多角体病毒，携带病毒的昆虫来源的细胞和使用该细胞产生具有透明质酸合成活性的蛋白质的方法以及方法用于制备透明质酸。作为“编码具有透明质酸合成活性的蛋白质的DNA”，开始于编码由序列号（说明书）中的序列号2表示的氨基酸序列组成的蛋白质的DNA，以及具有可以引用与上述相似的功能。版权所有（C）2006，JPO＆NCIPI

27. 发明专利

JP2005304315A Method for testing periodontal disease and kit for testing 有权
标题翻译：测试周围疾病和试剂盒的方法
公开(公告)号：JP2005304315A
公开(公告)日：2005-11-04
申请号：JP2004122272
申请日：2004-04-16
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： YASUDA TADASHI , ITANO NAOKI , KIMATA HIROHARU , SHIBUYA TOSHIAKI
IPC分类号： G01N33/50 , C12Q1/34 , G01N33/53 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a method for testing periodontal diseases with which hyaluronidase activities in a liquid sample derived from a periodontal tissue of a human or an animal are assayed and the periodontal diseases are judged by correlating the hyaluronidase activities with the periodontal diseases according to a method by which the hyaluronidase activities of a plurality of specimens can be assayed with high sensitivity and high accuracy.
SOLUTION: The hyaluronidase activities in the plurality of specimens can be assayed with the high sensitivity and high accuracy at a time by using a solid phase in which hyaluronic acid is directly or through a spacer substance fixed. Thereby, the hyaluronidase activities thus assayed correlate with the periodontal diseases.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种用于测定来自人或动物的牙周组织的液体样品中的透明质酸酶活性的牙周病的方法，并且通过将透明质酸酶活性与根据通过其可以高灵敏度和高精度测定多个标本的透明质酸酶活性的方法的牙周病。解决方案：通过使用透明质酸直接或通过固定的间隔物物质的固相，可以一次以高灵敏度和高精度测定多个样品中的透明质酸酶活性。因此，这样测定的透明质酸酶活性与牙周病有关。版权所有（C）2006，JPO＆NCIPI

28. 发明专利

JP2005213210A Agent for promoting formation of complex of hyaluronan-associated protein with hyaluronan 审中-公开
标题翻译：促进HYALURONAN相关蛋白复合物与HYALURONAN的代理
公开(公告)号：JP2005213210A
公开(公告)日：2005-08-11
申请号：JP2004022727
申请日：2004-01-30
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： TOIDA TOSHIHIKO , KIMATA HIROHARU
IPC分类号： A61K31/728 , A61P43/00 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To obtain an agent for promoting the formation of a complex (SHAP-HA complex) of a hyaluronan-associated protein with the hyaluronan in the blood; and to obtain an agent for maintaining/sustaining the concentration of the hyaluronan in the blood.
SOLUTION: The former agent for promoting the formation of the complex of the hyaluronan-associated protein with the hyaluronan in the blood contains the hyaluronan for oral administration or a pharmaceutically acceptable salt thereof. The latter agent for maintaining/sustaining the concentration of the hyaluronan in the blood contains also the hyaluronan for the oral administration or the pharmaceutically acceptable salt thereof. The weight average molecular weight of the hyaluronan for the oral administration or the pharmaceutically acceptable salt thereof is preferably about 1,000-6,000,000. The hyaluronan in the blood the concentration of which is maintained by the maintaining/sustaining agent is preferably the one forming the complex with the hyaluronan-associated protein.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：获得促进血液中透明质酸相关蛋白的复合物（SHAP-HA复合物）与透明质酸的形成的试剂; 并获得维持/维持血液中透明质酸浓度的药剂。解决方案：用于促进形成透明质酸相关蛋白质与透明质酸在血液中的复合物的前一种试剂包含用于口服给药的透明质酸或其药学上可接受的盐。用于维持/维持血液中透明质酸浓度的后一种试剂还含有用于口服给药的透明质酸或其药学上可接受的盐。口服给药的透明质酸的重均分子量或其药学上可接受的盐优选为约1,000-6,000,000。维持/维持剂维持浓度的血液中的透明质酸优选是与透明质酸相关蛋白形成复合物的透明质酸。版权所有（C）2005，JPO＆NCIPI

29. 发明专利

JP2005172440A Detection method of purkinje cell and detection kit 审中-公开
标题翻译：胰腺细胞和检测试剂盒的检测方法
公开(公告)号：JP2005172440A
公开(公告)日：2005-06-30
申请号：JP2003408435
申请日：2003-12-08
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KIYOUGASHIMA MAMORU , TAKAHASHI HIBIKI , AKIYOSHI JUNKO
IPC分类号： G01N33/53 , C12Q1/04
摘要： PROBLEM TO BE SOLVED: To provide a method for specifically detecting a Purkinje cell simply, rapidly and inexpensively, and a detection kit using it. SOLUTION: This detection method of the Purkinje cell includes at least a step for immunologically dyeing animal tissue using an anti-prion antibody and the detection kit of the Purkinje cell includes the anti-prion antibody as a constituent. The anti-prion antibody is preferably IgG and one refined as IgG is preferable and one bonded to prion originating from a chicken is preferable. Further, it is preferable to further include a step for treating animal tissue becoming an immunological dyeing object in an autoclave before immunological dyeing. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供简单，快速和廉价地特异性检测浦肯野细胞的方法和使用它的检测试剂盒。解决方案：浦肯野细胞的这种检测方法至少包括使用抗朊病毒抗体免疫染色动物组织的步骤，浦肯野细胞的检测试剂盒包括抗朊病毒抗体作为组分。抗朊病毒抗体优选为IgG，优选为IgG的精制，优选与来自鸡的朊病毒结合的抗体。此外，优选进一步包括在免疫染色之前在高压釜中治疗成为免疫染色对象的动物组织的步骤。版权所有（C）2005，JPO＆NCIPI

30. 发明专利

JP2005036031A Sulfated polyfucose and its manufacturing method 有权
标题翻译：硫化聚糖及其制造方法
公开(公告)号：JP2005036031A
公开(公告)日：2005-02-10
申请号：JP2003197446
申请日：2003-07-15
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KARIYA YUTAKA , IMAI KYOKO
IPC分类号： A61K31/737 , A61P19/08 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To provide a novel sulfated polyfucose for searching for a novel physiological activity.
SOLUTION: The branched sulfated polyfucose is constituted of sugar residues represented by formulae (A), (B) and (C), prepared by a process including a step for removing a solvent from a fraction extracted from an echinoderm using a mixed liquid of chloroform and methanol and dissolving the extract in water, and contains 28-38 mol% of (A), 28-38 mol% of (B) and 28-38 mol% of (C).
COPYRIGHT: (C)2005,JPO&NCIPI

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式