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21. 发明专利

JP2008267842A Organism observation container, biological microscope using the same, and organism observation apparatus 审中-公开
标题翻译：有机体观察容器，使用其的生物显微镜和有机观察装置
公开(公告)号：JP2008267842A
公开(公告)日：2008-11-06
申请号：JP2007107679
申请日：2007-04-17
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI , YOSHIDA TAKASHI
IPC分类号： G01N21/03 , G01N21/64 , G02B21/34
摘要： PROBLEM TO BE SOLVED: To provide a well plate, a biological microscope, and an organism observation apparatus capable of surely acquiring images by facilitating auto-focusing operations.
SOLUTION: With samples mounted inside containers and observed by the biological microscope via a bottom surface 62 in an organism observation container 60, an antireflection film 65 is formed in the surface 63 of the bottom surface 62.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够通过促进自动聚焦操作而可靠地获取图像的孔板，生物显微镜和生物体观察装置。解决方案：将样品安装在容器内并通过生物显微镜通过生物体观察容器60中的底面62观察，在底面62的表面63中形成防反射膜65。版权所有（C） C）2009，JPO＆INPIT

22. 发明专利

JP2008076530A Microscope 审中-公开
标题翻译：显微镜
公开(公告)号：JP2008076530A
公开(公告)日：2008-04-03
申请号：JP2006253097
申请日：2006-09-19
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI
IPC分类号： G02B21/00
摘要： PROBLEM TO BE SOLVED: To provide a microscope for imaging a large number of samples at once.
SOLUTION: The microscope has an objective lens receiving fluorescence generated from the sample and an image forming lens image-forming light after passing through the objective lens. The microscope includes at least two objective lenses and the image forming lens.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供用于一次成像大量样品的显微镜。解决方案：显微镜具有接收从样品产生的荧光的物镜和通过物镜后的成像透镜成像光。显微镜包括至少两个物镜和成像透镜。版权所有（C）2008，JPO＆INPIT

23. 发明专利

JP2008065144A Spectroscopy optical unit 审中-公开
标题翻译：光谱光学单元
公开(公告)号：JP2008065144A
公开(公告)日：2008-03-21
申请号：JP2006244291
申请日：2006-09-08
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI , NEZU TAICHIRO
IPC分类号： G02B21/18 , G01N21/64
摘要： PROBLEM TO BE SOLVED: To provide a spectroscopy optical unit which can eliminate the pixel deviation between monochromatic images, when a polychromatic image is obtained.
SOLUTION: The spectroscopy optical unit is configured so that an optical signal including a plurality of wavelengths is inputted to be separated into images of two wavelengths and the images of each wavelength are taken in two cameras. The spectroscopy optical unit is equipped with a camera driving means for driving at least one of the two cameras in X and Y directions with respect to an optical axis.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供可以消除单色图像之间的像素偏差的光谱学单元，当获得多色图像时。解决方案：光谱光学单元被配置为使得包括多个波长的光信号被输入以分离成两个波长的图像，并且在两个相机中拍摄每个波长的图像。光谱光学单元配备有相机驱动装置，用于相对于光轴在X和Y方向上驱动两个照相机中的至少一个。版权所有（C）2008，JPO＆INPIT

24. 发明专利

JP2008045982A Screening apparatus for drug discovery 有权
标题翻译：用于药物发现的筛选装置
公开(公告)号：JP2008045982A
公开(公告)日：2008-02-28
申请号：JP2006221441
申请日：2006-08-15
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI , YOSHIDA TAKASHI
IPC分类号： G01N21/64 , G02B21/00
摘要： PROBLEM TO BE SOLVED: To provide a screening apparatus for drug discovery, capable of preventing any sample, which serves as a medicinal candidate, from being missed.
SOLUTION: The apparatus for carrying out drug discovery screening which irradiates a sample set on a well plate with excitation light and carries out image processing based on a fluorescence signal from the sample, is characterized in that an image coupling optical path based on light from a light source differing from that of the excitation light is disposed in an optical image separating device having a return light separating means which acquires a confocal image of a Nipkow disk method confocal scanner and separates return light of the sample therefrom.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够防止作为药用候选物的任何样品的药物发现筛选装置。解决方案：用于进行药物发现筛选的装置，其用激发光照射在井板上的样品组，并且基于来自样品的荧光信号进行图像处理，其特征在于，基于来自不同于激发光的光源的光被布置在具有返回光分离装置的光学图像分离装置中，该分离装置获取Nipkow盘方法共聚焦扫描器的共聚焦图像，并分离样品的返回光。版权所有（C）2008，JPO＆INPIT

25. 发明专利

JP2007187945A Confocal microscope 有权
标题翻译： CONFOCAL MICROSCOPE
公开(公告)号：JP2007187945A
公开(公告)日：2007-07-26
申请号：JP2006006931
申请日：2006-01-16
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： MIKURIYA KENTA , KEI KOSHI
IPC分类号： G02B21/00
CPC分类号： G02B21/0044
摘要： PROBLEM TO BE SOLVED: To provide a confocal microscope capable of observing reactions of light stimulation and fluorescence discoloration in real time by adding a function for performing the light stimulation to a Nipkow disk system confocal microscope, and adjusting a focal position in the optical axis direction of the spot of the light beam for stimulation that is concentrated on a sample. SOLUTION: The confocal microscope which is composed of a microscope unit and a Nipkow disk system confocal scanner unit, and observes the sample by the confocal image formed by focusing the return fluorescence of the light beam for image measurement emitted to the sample, comprises a means for outputting a light beam for stimulation that focuses a spot of the light beam on the sample for stimulation that gives stimulation to the sample, and a focus adjusting means that is disposed in the midway of the light beam for stimulation and adjusts the focal position of the spot in the optical axis direction. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提供能够通过添加用于对Nipkow盘系统共聚焦显微镜进行光刺激的功能来实时观察光刺激和荧光变色的反应的共聚焦显微镜，并且调节焦点位置用于聚焦在样品上的刺激用光束的光点的光轴方向。解决方案：由显微镜单元和Nipkow磁盘系统共聚焦扫描器单元组成的共聚焦显微镜，通过聚焦用于发射到样品的图像测量的光束的返回荧光而形成的共焦图像观察样品，包括用于输出用于刺激的光束的装置，其将光束的点聚焦在用于刺激样本的刺激样本上，以及聚焦调节装置，其设置在光束中途用于刺激并调整光点在光轴方向的焦点位置。版权所有（C）2007，JPO＆INPIT

26. 发明专利

JP2006084960A Three-dimensional confocal microscopic system 有权
标题翻译：三维协同微观系统
公开(公告)号：JP2006084960A
公开(公告)日：2006-03-30
申请号：JP2004271503
申请日：2004-09-17
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI , MIKURIYA KENTA
IPC分类号： G02B21/00
摘要： PROBLEM TO BE SOLVED: To realize a three-dimensional confocal microscopic system capable of three-dimensionally exactly performing the observation of a sample after luminous stimulus by performing three-dimensional image measurement by using a confocal microscope obtained by adding a function for radiating a 2nd laser beam for the luminous stimulus to a Nipkow disk type confocal microscope.
SOLUTION: The three-dimensional confocal microscopic system comprises a confocal scanner to acquire the sliced image of the sample as a confocal image through the microscope; a video camera to output the image data of the confocal image; an actuator to move the focal position of the objective of the microscope in an optical axis direction; a control part to generate a scanning waveform signal for making the objective scan in the optical axis direction through the actuator, and an image processing part to form the three-dimensional image of the sample based on the image data acquired by the video camera. It has a laser beam output means connected to the microscope and outputting the laser beam for stimulating the sample, and the sample is stimulated in the optical axis direction by making the objective scan.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了实现三维共焦显微系统，其能够通过使用通过添加功能的功能获得的共聚焦显微镜进行三维图像测量，从而能够三次精确地执行发光刺激后的样品的观察将辐射激光的第二激光束辐射到Nipkow盘式共聚焦显微镜。解决方案：三维共焦显微系统包括共焦扫描仪，通过显微镜获取样品的切片图像作为共焦图像; 摄像机，输出共焦图像的图像数据; 用于沿光轴方向移动显微镜的物镜的焦点位置的致动器; 生成用于通过致动器沿光轴方向进行物镜扫描的扫描波形信号的控制部，以及基于由摄像机获取的图像数据形成样本的三维图像的图像处理部。它具有连接到显微镜的激光束输出装置，并输出用于刺激样品的激光束，并通过进行物镜扫描在光轴方向刺激样品。版权所有（C）2006，JPO＆NCIPI

27. 发明专利

JP2005070689A Three-dimensional confocal laser microscope system 有权
标题翻译：三维共焦激光显微镜系统
公开(公告)号：JP2005070689A
公开(公告)日：2005-03-17
申请号：JP2003303851
申请日：2003-08-28
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI , MIKURIYA KENTA
IPC分类号： G02B21/00
摘要： PROBLEM TO BE SOLVED: To provide a three-dimensional confocal laser microscope system capable of providing the super-depth image of a sample at a real time by scanning an objective lens at high speed.
SOLUTION: The three-dimensional confocal microscope system is provided with a confocal scanner for obtaining sliced images of the sample as confocal images, a video rate camera for converting the confocal image to a video signal, an image processor for converting the video rate signal to image data, an actuator for shifting the focal position of the objective lens for the microscope in an optical axis direction, and a control means for generating a scanning waveform signal for scanning the objective lens in the optical axis direction through the actuator, and the microscope system is constituted so as to provide the sample images sliced in the depth direction, wherein the scanning waveform signal is generated by the control means at least once in a vertical synchronizing signal period of the video signal.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够通过高速扫描物镜实时提供样品的超深度图像的三维共焦激光显微镜系统。解决方案：三维共聚焦显微镜系统设置有共焦扫描器，用于获得样品的切片图像作为共焦图像，用于将共焦图像转换为视频信号的视频速率相机，用于转换视频的图像处理器速度信号到图像数据，用于移动用于显微镜的光轴的物镜的焦点位置的致动器，以及用于产生用于通过致动器沿光轴方向扫描物镜的扫描波形信号的控制装置，并且显微镜系统被构造成提供在深度方向上切片的样本图像，其中扫描波形信号由控制装置在视频信号的垂直同步信号周期中至少产生一次。版权所有（C）2005，JPO＆NCIPI

28. 发明专利

JP2011180411A Confocal microscopic system 有权
标题翻译： CONFOCAL MICROSCOPIC系统
公开(公告)号：JP2011180411A
公开(公告)日：2011-09-15
申请号：JP2010045102
申请日：2010-03-02
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： NEZU TAICHIRO , KEI KOSHI , KUWABARA YOHEI , TAKAI HIRONORI , HIRUKAWA HIDEO
IPC分类号： G02B21/00 , G01N21/64 , G02B1/02
CPC分类号： G02B21/0044 , G02B21/24
摘要： PROBLEM TO BE SOLVED: To constitute a confocal microscopic system which is compact and does not take up much space and to provide the confocal microscopic system which has few parts to be adjusted.
SOLUTION: In the confocal microscopic system, respective apparatuses constituting the confocal microscopic system are integrally housed in a protective cabinet and further a Nipkow scanner section is arranged at a backside of an objective lens when a side of an opening, where a sample arranged to face the objective lens is moved to an outside surface of the protective cabinet and the sample is taken in and out, is a front.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：构成紧凑的并且不占用太多空间的共聚焦微观系统，并提供具有少量要调节的共聚焦显微系统。解决方案：在共焦显微系统中，构成共焦显微系统的各个装置一体地容纳在保护柜中，并且在开口的一侧，另外在开口的一侧设置有Nipkow扫描器部分，其中样品安置在面对物镜的位置被移动到保护柜的外表面，并将样品取出进出，是前方。版权所有（C）2011，JPO＆INPIT

29. 发明专利

JP2011085759A Confocal optical scanner 审中-公开
标题翻译：共焦光学扫描仪
公开(公告)号：JP2011085759A
公开(公告)日：2011-04-28
申请号：JP2009238523
申请日：2009-10-15
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI
IPC分类号： G02B21/00
CPC分类号： G02B21/0044 , G02B21/0032 , G02B21/0076
摘要： PROBLEM TO BE SOLVED: To provide a confocal optical scanner capable of coping with variation of optical system magnification, a bright field image or the like.
SOLUTION: The confocal optical scanner includes a pinhole disc with pinholes formed thereon, and rotation means for rotating the pinhole disc. A confocal image is acquired by rotating the pinhole disc with the use of the rotation means to thereby scan with illumination light and by causing optical feedback from the illumination light passing through the pinholes to form an image. The confocal optical scanner also includes a transfer mechanism for causing the pinhole disc to undergo reciprocating transfer between a position where the pinhole disc resides in an optical path of the illumination light, and a position where the pinhole disc is evacuated from the optical path.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供能够应对光学系统放大率，亮场图像等的变化的共焦光学扫描仪。解决方案：共焦光学扫描器包括其上形成有针孔的针孔盘和用于旋转针孔盘的旋转装置。通过使用旋转装置旋转针孔盘来获得共焦图像，从而用照明光进行扫描，并且通过使来自穿过针孔的照明光的光学反馈形成图像。共焦光学扫描仪还包括用于使针孔盘在针孔盘位于照明光的光路中的位置与针孔从光路排出的位置之间进行往复传送的传送机构。版权所有（C）2011，JPO＆INPIT

30. 发明专利

JP2009288087A Drug development screening device 有权
标题翻译：药物开发筛选装置
公开(公告)号：JP2009288087A
公开(公告)日：2009-12-10
申请号：JP2008141139
申请日：2008-05-29
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： KEI KOSHI
IPC分类号： G01N21/64 , G02B21/00 , G02B21/06
摘要： PROBLEM TO BE SOLVED: To provide a drug development screening device capable of acquiring a multicolored confocal image by a simple optical system, wherein a confocal function is integrated with a spectroscopic function.
SOLUTION: In this drug development screening device for irradiating excitation light to a sample placed on a well plate, and screening by performing image processing, based on a fluorescence signal from the sample, a multicolored confocal scanner is constituted by integrating in a body: a pinhole array disk with a microlens; a first dichroic mirror for transmitting the excitation light, and reflecting multicolored fluorescence; one or more second and third dichroic mirrors for spectrally diffracting the multicolored fluorescence; a plurality of band-pass filters for taking out fluorescence having a single wavelength from a multicolored fluorescence signal; and relay lenses, arranged respectively on the subsequent stage of the plurality of band-pass filters.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够通过简单的光学系统获得多色共焦图像的药物开发筛选装置，其中共焦功能与分光功能整合。解决方案：在用于向放置在孔板上的样品照射激发光的该药物开发筛选装置中，并且通过进行图像处理进行筛选，基于来自样品的荧光信号，多色共焦扫描仪通过将身体：具有微透镜的针孔阵列盘; 用于透射激发光的第一分色镜，并反射多彩荧光; 用于光谱衍射多色荧光的一个或多个第二和第二分色镜; 多个带通滤波器，用于从多彩色荧光信号中取出具有单一波长的荧光; 和分别布置在多个带通滤波器的后续级上的中继透镜。版权所有（C）2010，JPO＆INPIT

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