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21. 发明专利

JP2008128706A Microchip inspection system and program used for the microchip inspection system 审中-公开
标题翻译： MICROCHIP检测系统和微型检测系统使用的程序
公开(公告)号：JP2008128706A
公开(公告)日：2008-06-05
申请号：JP2006311247
申请日：2006-11-17
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： G01M99/00 , G01N35/10 , G01N35/08 , G01N37/00
CPC分类号： G01N35/1016 , B01L3/502715 , B01L3/50273 , B01L2200/143 , B01L2200/147 , B01L2300/0816 , B01L2400/0439 , B01L2400/0487 , B01L2400/082 , G01F1/7086 , G01N11/04 , G01N2011/0013 , G01N2035/1034 , Y10T137/2196 , Y10T137/6416
摘要： PROBLEM TO BE SOLVED: To provide a microchip inspection system accurately performing liquid feed control with the effects due to temperature being corrected, and to provide a program used for the inspection system. SOLUTION: This microchip inspection system comprises a micropump for putting a driving liquid through a flow path into a microchip; a liquid temperature adjustment means for adjusting the liquid temperature of the driving liquid; a driving liquid detection means detecting whether the driving liquid exists at prescribed two points of the flow path to output detection signals; a flow speed calculation means for calculating a flow speed, based on the detection signals obtained from the detection means; and a liquid temperature control means for controlling the adjustment means, based on the flow speed calculated by the calculation means. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种由于温度被校正的效果而精确地执行液体进给控制的微芯片检查系统，并且提供用于检查系统的程序。解决方案：该微芯片检查系统包括：微型泵，用于将驱动液体通过流路通入微芯片; 用于调节驱动液体的液体温度的液体温度调节装置; 驱动液体检测装置，检测所述驱动液是否存在于所述流路的规定的两点，以输出检测信号; 流量计算装置，用于根据从检测装置获得的检测信号计算流速; 以及液体温度控制装置，用于基于由计算装置计算的流速来控制调节装置。版权所有（C）2008，JPO＆INPIT

22. 发明专利

JP2007237021A Microreactor 审中-公开
标题翻译：微反应器
公开(公告)号：JP2007237021A
公开(公告)日：2007-09-20
申请号：JP2006059691
申请日：2006-03-06
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , SANTO YASUHIRO , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： B01J19/00 , C12M1/00 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microreactor in which a part of a reagent is not stayed in a storage chamber and a freedom of arrangement of the reagent storage part is further high when a drive liquid is poured to the storage chamber stored with the reagent and the reagent is pushed out to a downstream to feed the liquid. SOLUTION: Length in the storage chamber 34a of the reagent storage part 33 is made 10 times or more relative to a flow passage width W and a shape of the storage chamber 34a is made to a shape in which at least a part is bent. Further, radius of curvature of a wall surface at a bent portion of the storage chamber 34a is made within a predetermined range. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种微反应器，其中一部分试剂不停留在储存室中，并且当将驱动液体倒入存储室时，试剂储存部件的排列自由度进一步提高试剂和试剂被推出到下游以供给液体。解决方案：试剂储存部33的储存室34a中的长度相对于流路宽度W为10倍以上，储存室34a的形状为至少部分为弯曲。此外，存储室34a的弯曲部分处的壁表面的曲率半径在预定范围内。版权所有（C）2007，JPO＆INPIT

23. 发明专利

JP2007224844A Micropump, liquid feeding method and liquid feeding system 审中-公开
标题翻译： MICROPUMP，液体进料方法和液体进料系统
公开(公告)号：JP2007224844A
公开(公告)日：2007-09-06
申请号：JP2006048545
申请日：2006-02-24
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , SANTO YASUHIRO , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： F04B43/02 , B01J4/00 , B01J19/00 , B81B3/00 , F04B43/04 , F04B49/06 , G01N35/10 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a liquid feeding method and a liquid feeding system capable of increasing liquid feeding speed at a time of liquid feed in a main direction in an embodiment in such a case that liquid to be used for reaction is fed to a downstream in a channel of a micro-reactor, and simultaneously capable of sufficiently preventing formation of bubbles in a pump chamber in a case that liquid is fed in any directions in a micropump capable of feeding liquid in both directions with using change ratio of channel resistance to change of pressure difference. SOLUTION: For an oscillating actuator connected to a pressurizing chamber to which a first channel and a second channel of which change rate of channel resistance to change of pressure difference is smaller than that of the fist channel, voltage rise time T1 of first drive voltage wave form for feeding liquid in a direction toward the second channel from the first channel is set shorter than voltage rise time T7 of a second drive voltage wave form for feeding liquid in a direction toward the first channel from the second channel. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种液体供给方法和液体供给系统，在一个实施方案中，在主要方向上液体供给时，能够提高液体供给速度，在这种情况下，用于反应的液体是进料到微反应器的通道中的下游，同时能够充分防止在液体在两个方向上以两个方向供给液体的微型泵中以任何方向进给的情况下在泵室中形成气泡，使用变化率的通道电阻变化压差。
解决方案：对于连接到加压室的振荡致动器，其中第一通道和第二通道的通道阻力变化率与第一通道的变化相比，第一通道和第二通道的电压上升时间T1 将从第一通道朝向第二通道的方向供给液体的驱动电压波形设定为短于从第二通道朝向第一通道的方向供给液体的第二驱动电压波形的电压上升时间T7。版权所有（C）2007，JPO＆INPIT

24. 发明专利

JP2007139501A Filling method of reagent into microchip 审中-公开
标题翻译：试剂加入MICROCHIP的方法
公开(公告)号：JP2007139501A
公开(公告)日：2007-06-07
申请号：JP2005331501
申请日：2005-11-16
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/10 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of efficiently filling a micro amount of reagents from a small supply port to a reagent storage section of a microchip. SOLUTION: The periphery of an opening of a reagent supply section in the surface of the microchip is surrounded by a frame member that does not cause liquid leakage; a reagent of the liquid to be supplied is input to the inside, and then an air pump joint communicating with the air pump is put on the frame and is sealed. Air is sent from the air pump; a required pressure is applied to the reagent in order that it begins to pass the reagent supply section; then pressure not higher than a liquid holding force of a water-repellent valve disposed at the end of the reagent storage section is applied, thereby supplying the reagent to the reagent storage section. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效地将微量试剂从小供给口填充到微芯片的试剂储存部的方法。解决方案：微芯片表面的试剂供应部分的开口的周围被不会引起液体泄漏的框架部件包围; 将供给液体的试剂输入到内部，然后将与气泵连通的气泵接头放在框架上并被密封。空气从气泵送出; 向试剂施加所需的压力，使其开始通过试剂供应部分; 然后施加不高于设置在试剂储存部分末端的防水阀的液体保持力的压力，从而将试剂供应到试剂储存部分。版权所有（C）2007，JPO＆INPIT

25. 发明专利

JP2006069929A Preparation for treating mycosis and method for producing the same 审中-公开
标题翻译：用于治疗糖皮质激素的制剂及其生产方法
公开(公告)号：JP2006069929A
公开(公告)日：2006-03-16
申请号：JP2004252928
申请日：2004-08-31
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , UEDA EIICHI
IPC分类号： A61K9/127 , A61K31/4174 , A61K31/4196 , A61K31/7048 , A61K47/34 , A61P31/10
摘要： PROBLEM TO BE SOLVED: To provide a preparation for treating mycosis having reduced side effects to a human body and containing a liposome having a high encapsulated rate of an antifungus material by preparing the liposome by using carbon dioxide in a supercritical state; and to provide a method for producing the preparation. SOLUTION: The preparation for treating the mycosis contains the liposome produced by using the carbon dioxide in the supercritical state. The liposome includes the antifungal material. The method for producing the preparation for treating the mycosis comprises mixing a liposome membrane-constituting component, the antifungal material, an aqueous medium and the carbon dioxide in the supercritical state, and distilling off the carbon dioxide by reducing the pressure to prepare the liposome including the antifungus material. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过使用超临界状态的二氧化碳制备脂质体来提供治疗对人体副作用降低的含有具有高密封速率的抗真菌物质的脂质体的制剂，并提供制备该制剂的方法。解决方案：用于治疗真菌病的制剂含有通过使用超临界状态的二氧化碳产生的脂质体。脂质体包括抗真菌材料。制备用于治疗真菌病的制剂的方法包括将脂质体膜构成成分，抗真菌物质，水性介质和超临界状态的二氧化碳混合，并通过降低压力来制备二氧化碳以制备脂质体，包括防霉材料。版权所有（C）2006，JPO＆NCIPI

26. 发明专利

JP2006063009A Antitumor liposome formulation and method for producing the same 有权
标题翻译：抗生素制剂及其制备方法
公开(公告)号：JP2006063009A
公开(公告)日：2006-03-09
申请号：JP2004246737
申请日：2004-08-26
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , UEDA EIICHI
IPC分类号： A61K47/24 , A61K9/127 , A61K9/133 , A61K31/409 , A61K31/704 , A61K41/00 , A61K47/28 , A61K47/34 , A61P35/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a highly safe antitumor liposome formulation stabilizing the structure of the liposome and affording retention stability of an anticancerous compound and achieving efficient delivery of an anticancer agent. SOLUTION: The antitumor liposome formulation comprises a liposome having 0.05-0.7 μm average particle diameter and containing at least one or more kinds of drugs in a phospholipid membrane or an inner aqueous phase thereof without substantially containing an organic solvent. The liposome is prepared by mixing a lipid membrane component composing a phospholipid membrane with carbon dioxide in the supercritical or the subcritical state under conditions in which at least one kind of compound having a hydroxy group, as necessary, may be present. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供稳定脂质体结构的高度安全的抗肿瘤脂质体制剂，并提供抗癌化合物的保留稳定性并实现抗癌剂的有效递送。解决方案：抗肿瘤脂质体制剂包含平均粒径为0.05-0.7μm的脂质体，并且在基本上不含有机溶剂的磷脂膜或其内部水相中含有至少一种或多种药物。通过将构成磷脂膜的脂质膜组分与超临界或亚临界状态的二氧化碳混合，根据需要可以存在至少一种具有羟基的化合物的条件来制备脂质体。版权所有（C）2006，JPO＆NCIPI

27. 发明专利

JP2009250961A Micro inspection chip and liquid-feeding system 审中-公开
标题翻译：微检查芯片和液体进料系统
公开(公告)号：JP2009250961A
公开(公告)日：2009-10-29
申请号：JP2008103451
申请日：2008-04-11
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , SANTO YASUHIRO , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： G01N35/08 , B81B1/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a micro inspection chip and a liquid-feeding system for accurately feeding a liquid, such as specimen and reagent, even when using an inexpensive air pump.
SOLUTION: The micro inspection chip and liquid-feeding system can accurately send the liquid, such as specimen and reagent, even when an inexpensive pump is used, by providing a deceleration means for reducing the liquid-feeding speed of the liquid on a part of a flow channel communicating with a liquid storage part for storing the liquid.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：即使在使用廉价的空气泵的情况下，也可以提供用于准确地供给样品，试剂等液体的微检查片和送液系统。
解决方案：即使使用便宜的泵，微检查芯片和给液系统也可以准确地发送样品和试剂等液体，通过提供减少液体的送液速度的减速装置与用于存储液体的液体存储部分连通的流动通道的一部分。版权所有（C）2010，JPO＆INPIT

28. 发明专利

JP2009222479A Inspection device 审中-公开
标题翻译：检查装置
公开(公告)号：JP2009222479A
公开(公告)日：2009-10-01
申请号：JP2008065536
申请日：2008-03-14
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/00 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an inspection device capable of performing the amplification of a gene by a PCR method using a small-sized microinspection chip.
SOLUTION: A liquid sending part for sending a liquid within the microinspection chip is provided, and a temperature variable part having a plurality of temperature regions and the microinspection chip are relatively moved to repeat a temperature cycle in a state that the liquid is stopped within the microinspection chip. Accordingly, the inspection device is provided, wherein the amplification of the gene by the PCR method can be performed using the small-sized microinspection chip without requiring a long flow channel on the microinspection chip.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供能够通过使用小型微型检测芯片的PCR方法进行基因扩增的检查装置。解决方案：提供一种用于在微检测芯片内发送液体的送液部件，具有多个温度区域的温度可变部分和微检测芯片相对移动，以在液体为停在microinpection芯片内。因此，提供了检查装置，其中可以使用小型微检测芯片通过PCR方法扩增基因，而不需要在微检测芯片上的长流动通道。版权所有（C）2010，JPO＆INPIT

29. 发明专利

JP2008134227A Microchip and microchip inspection system 审中-公开
标题翻译： MICROCHIP和MICROCHIP检查系统
公开(公告)号：JP2008134227A
公开(公告)日：2008-06-12
申请号：JP2007260752
申请日：2007-10-04
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： NAKAJIMA AKIHISA , AOKI YOICHI , SANTO YASUHIRO , HIGASHINO KUSUNOKI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a compact microchip capable of rapidly mixing a reagent when used with no scattering of a stored reagent.
SOLUTION: The microchip includes a reaction section in which at least one of a reagent and a sample from a passage is provided and a reaction thereof is performed by heating, in which a storage section for previously storing a reagent in the reaction section and a reagent previously stored in the storage section are sealed with a matter that changes a phase from a solid to a liquid between a storage temperature and a reaction temperature.
COPYRIGHT: (C)2008,JPO&INPIT

30. 发明专利

JP2008128869A Microchip inspection system and program used for the microchip inspection system 审中-公开
标题翻译： MICROCHIP检测系统和微型检测系统使用的程序
公开(公告)号：JP2008128869A
公开(公告)日：2008-06-05
申请号：JP2006315368
申请日：2006-11-22
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/08 , B01J19/00 , B81C99/00 , G01N37/00
CPC分类号： F04B43/043 , B01L3/50273 , B01L7/00 , B01L2200/14 , B01L2200/143 , B01L2300/0627 , B01L2300/0645 , B01L2300/1822 , B01L2400/0487 , G01N2035/1034 , G01P13/0006 , G05D7/0694
摘要： PROBLEM TO BE SOLVED: To provide a microchip inspection system for accurately performing liquid feed control, by keeping constant the amount of driving liquid filled in a flow path between a micropump and a microchip.
SOLUTION: This microchip inspection system comprises the micropump for putting the driving liquid from a flow path into the microchip; a driving liquid detection means for detecting the presence of the driving liquid at a prescribed position of the flow path to output a detection signal; and a pump drive control part for driving the micropump, based on the detection signal obtained from the detection means to move the driving liquid to a position by using the prescribed position as its reference.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：通过保持填充在微型泵和微型芯片之间的流动路径中的驱动液体的量，来提供用于精确地执行液体进给控制的微芯片检查系统。解决方案：该微芯片检测系统包括用于将驱动液体从流路放入微芯片的微型泵; 驱动液体检测装置，用于检测在流路的规定位置处的驱动液体的存在，以输出检测信号; 以及用于驱动微型泵的泵驱动控制部件，基于从检测装置获得的检测信号，通过使用规定位置作为基准将驱动液体移动到位置。版权所有（C）2008，JPO＆INPIT

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