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21. 发明专利

JPH0971514A EVALUATION OF HAIR TONIC 失效
公开(公告)号：JPH0971514A
公开(公告)日：1997-03-18
申请号：JP25458695
申请日：1995-09-05
申请人： KANEBO LTD
发明人： HAMADA KAZUTO , SUZUKI KEIKO , MIYAMOTO TATSU
IPC分类号： C12Q1/48 , A61K8/00 , A61K8/66 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To evaluate various actions on a hair cycle of each hair tonic in more detail by measuring γ-glutamyl transpeptidase activity in skin. SOLUTION: This method for evaluating a hair tonic comprises evaluation an early induction action in a growth period, an elongating action and a retarding action on a movement to a regression period in a hair cycle in more detail by measuring γ-glutamyl trasnpeptidase activity in skin. γ-Glutamyl transpeptidase activity in skin is measured in detail by culturing 0.05M visine buffer solution (pH 8.6) containing 1mL of 4.4mM γ-glutamyl-p-nitroanilide, 22mM glycylglycine and 11mM magnesium chloride at 37 deg.C for 2 minutes, adding 0.1mL of a measurement specimen to the solution and culturing the resultant solution at 37 deg.C for 45 minutes. The culture solution is mixed with 4mL of 1.1N acetic acid and an absorbance of liberated p-nitroanilide at 405nm is measured.

22. 发明专利

JPH03123720A HAIR TONIC COSMETIC 失效
公开(公告)号：JPH03123720A
公开(公告)日：1991-05-27
申请号：JP26234389
申请日：1989-10-06
申请人： KANEBO LTD
发明人： HAMADA KAZUTO
IPC分类号： A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To obtain a hair tonic cosmetic having inhibitory action on 5alpha-reductase, excellent growing effects on hair and preventing and suppressing effects on fallen hair by blending raw material components with essence extracted from Salvia miltiorrhiza Bunge. CONSTITUTION:A hair tonic cosmetic blended with essence prepared by dried root of Salvia miltiorrhiza Bunge, a perennial weed of the family Labiatae, grinding and extracting with an organic solvent, as an active ingredient. The whole composition is blended with 0.004-0.4wt.%, preferably 0.004-3.2wt.% purified content (calculated as dried weight), properly mixed with a dyestuff, perfume, germicide, antiseptic, keratin solubilizer, anti-androgen agent, hair tonic, antioxidant, etc., and prepared by a conventional procedure to give the objective substance. The substance may be made into a cosmetic such as hair tonic, hair lotion or scalp treatment and quasi-drug.

23. 发明专利

JPH02218604A HAIR-TONIC COSMETIC 失效
公开(公告)号：JPH02218604A
公开(公告)日：1990-08-31
申请号：JP4071389
申请日：1989-02-21
申请人： KANEBO LTD
发明人： HAMADA KAZUTO
IPC分类号： A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To obtain a hair-tonic cosmetic which has ability to inhibit activity of 5alpha-reductase and has excellent effect to grow hair, prevent hairs from falling off and prevent dandruff with reduced skin irritation by using an extract of hawthorn. CONSTITUTION:The hair-tonic cosmetic is hair tonic, hair lotion, hair cream or the like containing 0.004 to 0.4wt.% of essence of hawthorn on the dry base. The essence is obtained by drying and crushing haws and dipping them in aqueous alcohol such as methanol or ethanol or extracting in a extractor such as a Soxhlet's extractor. The extract is appropriately absorbed in percutaneous process to retain the effective concentration of the active ingredients in scalp with reduced skin irritation. In addition, activity of 5alpha-reductase is inhibited to repress the formation of an active type of male hormone and manifest actions to grow hair, prevent hairs from falling off.

24. 发明专利

JP2004115424A Hair tonic 有权
公开(公告)号：JP2004115424A
公开(公告)日：2004-04-15
申请号：JP2002280432
申请日：2002-09-26
申请人： Kanebo Ltd , カネボウ株式会社
发明人： MATSUI JUNICHI , SUGIMOTO KENICHI , HAMADA KAZUTO , KOMIYA AYA
IPC分类号： A61K8/00 , A61K8/30 , A61K31/121 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To prepare a hair tonic which has excellent hair growth, hair-restoring and hair loss preventing effects, excellent solubility in a solvent such as ethanol, hydrated ethanol and improved sense of use.
SOLUTION: This hair tonic contains farnesyl acetone. The hair tonic has excellent promotion effect on hair growth, excellent hair growth and hair loss preventing effects, excellent solubility and sense of use.
COPYRIGHT: (C)2004,JPO

25. 发明专利

JP2002068931A COMPOSITION FOR EXTERNAL USE 失效
公开(公告)号：JP2002068931A
公开(公告)日：2002-03-08
申请号：JP2000251997
申请日：2000-08-23
申请人： KANEBO LTD
发明人： IKEMOTO TAKESHI , MATSUI JUNICHI , KUSUMARU MASAFUMI , NISHIO HIROYUKI , HARATAKE AKINORI , HAMADA KAZUTO , SUDO HIROSHI , TSUBOTA TAKAMIKI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/97 , A61K36/00 , A61P17/00 , A61Q5/00 , A61Q7/00 , A61Q19/10 , A61K7/00 , A61K7/06 , A61K7/50 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To effectively utilize an extraction residue of a crude medicine which has been treated as a waste and, in details, to obtain both an extract of the crude medicine residue having an excellent beautiful skin effect and a composition for external use. SOLUTION: This composition for external use is characterized by comprising an extract extracted from the warm water extraction residue of the crude medicine by using an organic solvent.

26. 发明专利

JPH09229922A METHOD FOR EVALUATING HAIR GROWER 失效
公开(公告)号：JPH09229922A
公开(公告)日：1997-09-05
申请号：JP6007596
申请日：1996-02-21
申请人： KANEBO LTD
发明人： NAKAGAWA NORIAKI , HAMADA KAZUTO
IPC分类号： G01N33/15 , A61K8/00 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To make it possible to evaluate the suppressing action of regression period in a hair cycle by measuring the total amounts of mononucleosome and oligonucleosome in trichocyst-originated cell. SOLUTION: The back skins of C3H mice are shaved, about five mice are used for each sample from about tenth day, the skins of parts for test are continuously coated twice in the morning and evening with about each 0.2ml for ten days. After the coating, they are butchered, the hairs of the parts for test of the samples are collected, and trypsin-treaded. Incubation buffer is added to the obtained cells of predetermined quantity, steadily left to stand for 30min at about 4 deg.C, centrifugally separated, and the part of supernatant is sampled. The sample thinned to about ten times of about 100μl is added to plate coated with antihistone antibody, steadily left to stand for about 90min, and then the plate is cleaned. Then, the same amount of anti-DNA-peroxidase antibody is similarly added, and cleaned. Eventually, the substrate solution of the peroxidase of about 100μl is added, the absorbance is measured in the wavelength of 405nm, and the total amount of mononucleosome and oligonucleosome is obtained.

27. 发明专利

JPH09221414A EVALUATION OF HAIR TONIC 失效
公开(公告)号：JPH09221414A
公开(公告)日：1997-08-26
申请号：JP35202496
申请日：1996-12-10
申请人： KANEBO LTD
发明人： SUZUKI KEIKO , HAMADA KAZUTO
IPC分类号： A61K8/00 , A61K45/00 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q7/00 , G01N33/15 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To provide an evaluation method of a hair tonic capable of detailed evaluation of the hair growth effect such as an early inductive action on stage of growth or extension effect on stage of growth, etc., in hair cycle by applying the hair tonic on a depilated skin of a specific animal and watching the color with time. SOLUTION: This method judges early inductive action on stage of growth, extension effect on stage of growth, delaying effect on transferring to regression period, etc., in hair cycle by utilizing the fact that the skin of C3H mouse, etc., which is a colored mouse, changes from pink to perse caused by the melanin granule produced only in growth period of the mouse and the skin changes from perse to pink in transferring period of growth to regression period. Especially, the early inductive action on stage of hair growth and delaying the transferring of the regression stage is preferably judged by the observation of chroma saturation of the mouse skin.

28. 发明专利

JPH09175948A HAIR TONIC COSMETIC 失效
公开(公告)号：JPH09175948A
公开(公告)日：1997-07-08
申请号：JP35390995
申请日：1995-12-25
申请人： KANEBO LTD
发明人： HAMADA KAZUTO , SUZUKI KEIKO , IKEMOTO TAKESHI , NISHIO HIROYUKI , NAKAGAWA NORIAKI
IPC分类号： A61K8/00 , A61K8/49 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To prepare a hair tonic cosmetic, comprising a tartaric acid nicotinic alcohol and a eugenol glycoside and having hair growth effects and preventing effects on alopecia and dandruff. SOLUTION: This hair tonic cosmetic comprises 0.001-15wt.% tartaric acid nicotinic alcohol and 0.001-15wt.% eugenol glycoside. The tartaric acid nicotinic alcohol is a well-known substance and has promoting actions on peripheral bloodstream. The eugenol glycoside is a compound obtained by bonding saccharides to eugenol through O-glycoside bonds and suitably decomposed into the eugenol having inhibiting activities for 5α-reductases and a saccharide part with a scalp normal bacterial flora and has sustained release hair growth effects and preventing effects on alopecia and dandruff. The cosmetic is prepared as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., for use.

29. 发明专利

JPS6327412A EMULSION COSMETIC 失效
公开(公告)号：JPS6327412A
公开(公告)日：1988-02-05
申请号：JP17233686
申请日：1986-07-21
申请人： KANEBO LTD
发明人： SUGIMOTO KENICHI , SATO KEIICHI , TANNO OSAMU , HAMADA KAZUTO
IPC分类号： A61K8/06 , A61K8/00 , A61K8/25 , A61K8/72 , A61K8/73 , A61K8/92 , A61Q5/00 , A61Q19/00
摘要： PURPOSE:A emulsion cosmetic that is composed of dextrin fatty acid ester, bentonite containing a specific amount of cation-exchangeable sodium ions, oily substances and water or xanthane gum, thus showing excellent storage stability, skin safety and practical performance. CONSTITUTION:The objective O/W or W/O type emulsion cosmetic contains 0.2-5.0wt% of dextrin fatty acid ester such as dextrin palmitate, 0.05-5.0wt% of bentonite containing 100-160mg equivalent/100g of polymer of cation- exchangeable sodium ion, e.g., high-purity sodium montmorilonite, 10-70wt% of oily substance, and 20-85wt% of water or additionally 0.1-2.0wt% of xanthane gum. The resultant cosmetic shows excellent storage stability, skin safety, spreadability, moisture retention and resistance to water.

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