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21. 发明专利

JPH0427397A CELL DIFFERENTIATION INDUCING SUBSTANCE 失效
公开(公告)号：JPH0427397A
公开(公告)日：1992-01-30
申请号：JP13472690
申请日：1990-05-24
申请人： AGENCY IND SCIENCE TECHN
发明人： OKA SHUICHI , TANAKA HIDEOKI , TOMIZUKA NOBORU , MAEDA HIDEKATSU
IPC分类号： C12P21/00 , C12N5/07 , C12N5/0786 , C12N5/0787 , C12R1/91
摘要： PURPOSE:To obtain a monokine such as granulocyte macrophage colony stimulation factor useful as a medicine by adding a cell differentiation-inducing substance containing staurosporine to macrophage and culturing the macrophage. CONSTITUTION:Macrophage is cultured by adding a cell differentiation-inducing substance containing staurosporine. The staurosporine can be separated from a filtrate of a culture liquid obtained e.g. by culturing Streptomyces diastato- chromogenes IFO 13389 at pH6-7 and about 30 deg.C for 48hr.

22. 发明专利

JPH02115198A ANIMAL COLLAGENASE-INHIBITING AGENT 失效
公开(公告)号：JPH02115198A
公开(公告)日：1990-04-27
申请号：JP26611288
申请日：1988-10-24
申请人： AGENCY IND SCIENCE TECHN , SHOWA SANGYO CO
发明人： MARUYAMA SUSUMU , TANAKA HIDEOKI , TOMIZUKA NOBORU , MITSUYOSHI SHINSUKE , FUKUI FUMIO
IPC分类号： C12N9/99 , A61K38/55 , A61P1/02 , A61P29/00 , A61P35/00 , C07K5/10 , C07K14/81
摘要： NEW MATERIAL:Benzylocxycarbonyl-L-Glu-L-Leu-L-Ala-Gly and a salt thereof. USE:An animal collagenase-inhibiting agent. Useful for treating and preventing rheumatic arthritis, dental periostitis, the infiltration of tumor cells, etc. PREPARATION:For example, glycine ethyl ester hydrochloride is condensed with Boc-Ala-OH (Boc is tertiary butyloxycarbonyl) in the presence of activators, N,N'-dicyclohexylcarbodiimide and 1-hydroxybenzotriazole, in a solvent such as DMF and the reaction product is treated with trifluoroacetic acid to give H-Ala-Gly-OEt trifluoroacetic acid salt. The obtained salt is condensed with Boc-Leu-H2O in the same method as the above-mentioned method and further with benzyloxycarbonyl-Glu(OBZl)(r-benzylester) to provide the subject inhibitor.

23. 发明专利

JPH0236195A NOVEL PEPTIDE AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR 失效
公开(公告)号：JPH0236195A
公开(公告)日：1990-02-06
申请号：JP18546788
申请日：1988-07-27
申请人： AGENCY IND SCIENCE TECHN , SHOWA SANGYO CO
发明人： MARUYAMA SUSUMU , TANAKA HIDEOKI , TOMIZUKA NOBORU , MITSUYOSHI SHINSUKE , FUKUI FUMIO
IPC分类号： C12P21/02 , A61K38/55 , A61P9/12 , C07K7/06 , C07K14/425 , C07K14/81
摘要： NEW MATERIAL:A compound expressed by the formula and salts thereof. USE:An angiotensin converting enzyme inhibitor useful for treating or preventing hypertension with ultrahigh safety. PREPARATION:For example, a peptide synthesizer is charged with Boc-L-Pro-O- CH2-phenylacetamidomethyl resin (Boc is tert-butyloxycarbonyl) and Boc-L-pro, Boc-L-Leu, Boc-L-His(Tos) (Tos is tosyl) and Boc-L-Val and the compound expressed by the formula is synthesized in the presence of dicyclohexylcarbodiimide by an anhydrous symmetric method.

24. 发明专利

JPH01172360A PRODUCTION OF BENZOYLFORMIC ACID 失效
公开(公告)号：JPH01172360A
公开(公告)日：1989-07-07
申请号：JP32846787
申请日：1987-12-25
申请人： AGENCY IND SCIENCE TECHN
发明人： MAEDA HIDEKATSU , KAJIWARA SHIGERU , YAMAZAKI YUKINAE , TOMIZUKA NOBORU
IPC分类号： C07C59/84 , C07C51/00 , C07C51/285 , C07C67/00
摘要： PURPOSE:To economically obtain the title compound which is a optically active R-(-)-mandelic acid production raw material of synthetic intermediate for antibiotic, etc., without by-product, by adding emulsified styrene to an electrolytically regenerated permanganic acid alkali solution inexpensively available and oxidizing the styrene. CONSTITUTION:Oxidation reaction is carried out by adding an emulsified suspension of styrene to an electrolytically regenerated permanganic acid alkali solution, preferably sodium permanganate to provide the aimed compound. Method such as supersonic treatment, mechanical stirring by emulsifier is used as a method for emulsifying styrene into water. Regenerated sodium permanganate solution is preferably properly stirred. Furthermore, a method pouring regenerated sodium permanganate into emulsion of styrene little by little is undesirable. Electrolytically regenerated sodium permanganate solution is obtained by subjecting manganese dioxide to electrolytic regeneration with sodium hydroxide.

25. 发明专利

JPS6359896A HYDROLYSIS OF OIL AND FAT WITH IMMOBILIZED LIPASE 失效
公开(公告)号：JPS6359896A
公开(公告)日：1988-03-15
申请号：JP20558886
申请日：1986-09-01
申请人： AGENCY IND SCIENCE TECHN , TSUKISHIMA KIKAI CO
发明人： KOSUGI YOSHIJI , TOMIZUKA NOBORU , SUZUKI HIDEO , NAKABAYASHI AKIRA , HAMAGUCHI TOSHIO
IPC分类号： C12P7/20 , C12P7/62 , C12P7/64
摘要： PURPOSE:To improve the decomposition performance of an immobilized lipase in the hydrolysis of an oily substance using a multistage reactor, by carrying out the mixing and separation, etc., keeping the temperature above a specific level and supplying the oily substance and a water-soluble substance at different feeding rates. CONSTITUTION:The hydrolyzing apparatus is composed of reactors 1A, 1B, 1C and attached separation tanks 2A, 2B, 2C. Each reaction tank is furnished with a screen 3 and a stirrer 4. An oily substance 5 is supplied to the tank 1A and a water-soluble substance 6 is supplied to the tank 1C. The oily substance is made to countercurrently contact with the water-soluble substance in a manner that the average feeding rate of the oily substance becomes higher than that of the water-soluble substance. An immobilized lipase 7 is put into each reaction tank beforehand. The substances are mixed at >=50 deg.C, separated by the screen 3 and separated into the oily substance and the water-soluble substance by a separation tank. The upper layer of the tank 2C is taken out as an oily product 8 and the lower layer of the tank 2A is taken out as a water-soluble product 9.

26. 发明专利

JPS6216425A PYKNIC CELL FUNCTION REGULATOR 失效
公开(公告)号：JPS6216425A
公开(公告)日：1987-01-24
申请号：JP11308085
申请日：1985-05-28
申请人： AGENCY IND SCIENCE TECHN , NIKKA WHISKY
发明人： NAKAGOME KAZUYA , TOMIZUKA NOBORU , SUZUKI HIDEO , MARUYAMA SUSUMU , TAKEUCHI MAKOTO , YASUHARA TADASHI , NAKAJIMA TERUMI
IPC分类号： A61K35/74 , A61P37/00
摘要： PURPOSE:A pyknic cell function regulator, containing a substance consisting of a constituent component of eurocidin and capable of exhibiting an absorption maximum at a specific wavelength as an active constituent and having function regulating action, e.g. degranulating action and inhibitory action on degranulation of pyknic cells. CONSTITUTION:A pyknic cell function regulator containing a substance (hereinafter abbreviated to substance) capable of exhibiting an absorption maximum at about 300-350nm wavelength of an ultraviolet absorption spectrum in a constitutent component of eurocidin [Journal of the Agricultural Chemical Society of Japan, Vol.29, pp. 650-652 (1955)] as an active constituent. The above-mentioned substance is capable of exhibiting inhibitory action on pyknic cell degranulating action taking part in allergy and inflammatory reactions at a low concentration and pyknic cell degranulating action at a high concentration. The above-mentioned substance can be isolated from a cultivation filtrate of Streptoverticillium eurocidicum (IFO No.13491) strain.

27. 发明专利

JPH11246431A ANTI-HIV AGENT 失效
公开(公告)号：JPH11246431A
公开(公告)日：1999-09-14
申请号：JP4742698
申请日：1998-02-27
申请人： AGENCY IND SCIENCE TECHN , OKA SHUICHI , TOKIWA SHOKUBUTSU KAGAKU KENKY
发明人： OKA SHUICHI , YAMAZAKI YUKINAE , TOMIZUKA NOBORU , INOUE MASAMI , OKITA SACHIKO , FUJITA YASUKO , OTAKE TORU , KAWABATA TAKUYA , UCHIDA MASARU , SASAKI TSUTOMU
IPC分类号： A23L2/52 , A23L1/30 , A23L2/38 , A61K36/00 , A61K36/48 , A61P31/12 , A61P31/18 , A61P37/04 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an anti-HIV agent exhibiting an excellent anti-HIV activity and having low toxicity by using the extract of the thin skins of peanut as an active ingredient. SOLUTION: This anti-HIV agent is preferably obtained by extracting the thin skins of peanut (for example, Arachis hypogea) preferably with 40-100 deg.C hot water, allowing Diaion HP20 to adsorb the obtained extract, eluting the adsorbed ingredients with acetone, and further fractionating an ingredient soluble in water and ethanol. The anti-HIV agent may be carried on an organic or inorganic carrier and preferably contains the anti-HIV ingredient in an amount of 0.01-100 wt.%. When orally administered, the anti-HIV ingredient is preferably administered at a daily dose of 0.5 μg to 50 mg/kg body with one or several portions a day.

28. 发明专利

JPH10265399A ANTIALLERGIC AGENT AND ANTIINFLAMMATORY AGENT 失效
公开(公告)号：JPH10265399A
公开(公告)日：1998-10-06
申请号：JP7508597
申请日：1997-03-27
申请人： AGENCY IND SCIENCE TECHN
发明人： OKA SHUICHI , INOUE MASAMI , NAKAGOME KAZUYA , TAKAGI SHINOBU , MARUYAMA SUSUMU , TOMIZUKA NOBORU , ITO SHOTA , HATADA KIYOTAKA
IPC分类号： A23L1/30 , A61K8/00 , A61K8/96 , A61K8/97 , A61K36/02 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q19/00 , A61K35/80 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a medicine, such as an antiallergic agent, high in safety and capable of being easily produced by utilizing the water-soluble ingredient of an alga. SOLUTION: This medicine contains an water extract of an alga as an active ingredient, and can be utilized as an antiallergic agent, an antiinflammatory agent, a hyaluronidase-inhibiting active agent or a mast cell degranulation inhibitor. The active ingredient is obtained e.g. by cutting Cyanophyta, Cryptista, Vaucheriophyta, etc., into a size of about 2-5 mm, and subsequently extraction- treating the cut alga pieces with water at 25-600 deg.C. The medicine can be added not only to the medicines but also to cosmetics and foods.

29. 发明专利

JPH0920672A ANTIALLERGIC SUBSTANCE, ITS PRODUCTION, ANTIALLERGIC AGENT AND FUNCTIONAL FOOD 失效
公开(公告)号：JPH0920672A
公开(公告)日：1997-01-21
申请号：JP19114595
申请日：1995-07-04
申请人： AGENCY IND SCIENCE TECHN , HOKUREN
发明人： OKA SHUICHI , INOUE MASAMI , NAKAGOME KAZUYA , ASADA SHINKO , SUGIE MAKIKO , TOMIZUKA NOBORU , FUKUMORI YASUNORI
IPC分类号： A23L1/30 , A61K36/00 , A61K36/53 , A61P37/08 , A61P43/00 , B01D15/08 , C07G99/00 , A61K35/78 , C07G17/00
摘要： PROBLEM TO BE SOLVED: To obtain an antiallergic substance by purifying matter found in Perilla frutescens crispa and having antiallergic action and specifying the active ingredient therein, to provide a production method for this antiallergic substance, and to obtain an antiallergic agent and functional food each containing this antiallergic substance. SOLUTION: Perilla frutescens crispa leaves are subjected to hot water extraction followed by solid-liquid separation, a precipitant is added to the resultant aqueous solution, water-soluble components are then leached from the resultant precipitate and then subjected to at least one kind of column chromatography to accomplish fractionation and purification, thus obtaining the objective substance having mast cell degranulation-inhibitory activity. This substance contains polysaccharides including amino acids and having a molecular weight of 13500 (antiallergic substance I), polyphenols leachable with 50% acetone by a column chromatography using a DEAE anion column (antiallergic substance II), and polyphenols leachable with 50% acetone containing 0.1N Hcl (antiallergic substance III).

30. 发明专利

JPH089994A PRODUCTION OF OPTICALLY ACTIVE DEXTRO-ROTATORY (+)-(S)-1-HYDROXYETHYLFERROCENE 失效
公开(公告)号：JPH089994A
公开(公告)日：1996-01-16
申请号：JP17362492
申请日：1992-05-21
申请人： AGENCY IND SCIENCE TECHN
发明人： YAMAZAKI YUKINAE , HOSONO KUNIAKI , TOMIZUKA NOBORU
IPC分类号： C12P41/00 , C12R1/365 , C12R1/74 , C12R1/85
摘要： PURPOSE:To obtain the subject optically high-purity compound useful as a synthetic raw material, etc., for physiologically active substances, organometallic polymeric complexes by reducing acetylferrocene with a yeast of the genus Candida, a yeast of the genus Saccharomyces, a bacterium of the genus Nocardia, etc. CONSTITUTION:This method for producing an optically active dextro-rotatory (+)-(S)-1- hydroxyethylferrocene is to use a microbial cell of a yeast of the genus Candida (e.g. Candica tropicalis IFO199), a yeast of the genus Saccharomyces (e.g. Saccharomyces rosei IFO428) or a bacterium of the genus Nocardia (e.g. Nocardia erythropolis IAM12122), inoculate the seed culture into a culture medium, carry out the shaking culture at 28 deg.C for 23hr on a rotary shaker, then centrifuge the resultant cultured product, collect the microbial cell, add the collected microbial cell into a solution prepared by adding a solution of acetylferrocene to a 0.1M phosphoric acid buffer solution (pH 7.5) containing glucose, performing the ultrasonic treatment and uniformly dispersing the acetylferrocene therein, shake the resultant mixture solution at 28 deg.C for 69hr and reduce the acetylferrocene. The obtained opt ically active dextro- rotatory (+)-(S)-1-hydroxyethylferrocene is useful as a synthetic raw material, etc., for physiologically active substances or organometallic polymeric complexes.

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