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21. 发明专利

JP2011229437A Medicinal effect marker of renal cell carcinoma 有权
标题翻译：肾细胞癌的药物效应标记
公开(公告)号：JP2011229437A
公开(公告)日：2011-11-17
申请号：JP2010101608
申请日：2010-04-27
申请人： Shionogi & Co Ltd , Univ Of Tokyo , 国立大学法人東京大学 , 塩野義製薬株式会社
发明人： SAWADA TAKUKO , NAKAMURA YUSUKE , ZENBUTSU HITOSHI , MIZUMORI TADASHI
IPC分类号： C12Q1/68 , A61K38/21 , A61K38/22 , A61P13/12 , A61P35/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method of sorting out patients to whom interleukin-2 (IL-2) and interferon alpha (IFN-alpha) concurrent treatment are effective for treating of renal cell carcinoma, and to provide a useful reagent and a useful reagent kit in order to easily carry out the above method.SOLUTION: Sensitivity of the patient over renal cell carcinoma IL-2 and IFN-alpha concurrent treatment is detected by the expression amount of either or both HLA-DQA1 gene and HLA-DQB1 gene as an indicator.
摘要翻译：要解决的问题：提供一种筛选白细胞介素-2（IL-2）和干扰素α（IFN-α）并发治疗对治疗肾细胞癌有效的患者的方法，并提供有用的试剂和有用的试剂盒，以方便地实施上述方法。解决方案：通过HLA-DQA1基因和HLA-DQB1基因之一或两者的表达量作为指标，检测患者对肾细胞癌IL-2和IFN-α并发治疗的敏感性。版权所有（C）2012，JPO＆INPIT

22. 发明专利

JP2011213713A Combined pharmaceutical preparation of angiotensin ii receptor antagonist 有权
标题翻译：血管紧张素Ⅱ受体拮抗剂的组合药物制备
公开(公告)号：JP2011213713A
公开(公告)日：2011-10-27
申请号：JP2011051303
申请日：2011-03-09
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： SATO YOICHI
IPC分类号： A61K31/5415 , A61K31/4184 , A61K45/00 , A61P9/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a combined pharmaceutical preparation of an angiotensin II receptor antagonist.SOLUTION: A pharmaceutical preparation characterized in the combination of the angiotensin II receptor antagonist and trichlormethiazide is found.
摘要翻译：要解决的问题：提供血管紧张素II受体拮抗剂的组合药物制剂。解决方案：发现特征在于血管紧张素II受体拮抗剂和三氯噻嗪的组合的药物制剂。

23. 发明专利

JP2010214375A Crystallizer, crystallization method, and concentration crystallization system 有权
标题翻译：结晶器，结晶方法和浓度结晶系统
公开(公告)号：JP2010214375A
公开(公告)日：2010-09-30
申请号：JP2010152737
申请日：2010-07-05
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： NAKANISHI ISAO , FURUKAWA HARUO
IPC分类号： B01D9/02
摘要： PROBLEM TO BE SOLVED: To provide a crystallizer for shortening the time required for crystallization by starting the crystal growth process at the point of time when a predetermined amount of a concentrated liquid is stored in a concentrated liquid storage chamber having a small volume.
SOLUTION: The crystallizer includes a crystallization container (14). The crystallization container (14) includes a first concentrated liquid storage chamber (58) and a second concentrated liquid storage chamber (59) which is located below the first concentrated liquid storage chamber (58) and has a volume smaller than the first concentrated liquid storage chamber (58).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种结晶器，用于通过在将预定量的浓缩液体储存在具有小体积的浓缩液体储存室中的时间点开始晶体生长过程来缩短结晶所需的时间。结晶器包括结晶容器（14）。结晶容器（14）包括位于第一浓缩液体储存室（58）下方的第一浓缩液体储存室（58）和第二浓缩液体储存室（59），其容积小于第一浓缩液体存储室（58）。版权所有（C）2010，JPO＆INPIT

24. 发明专利

JP2010174038A Amine derivative having npy y5 receptor antagonist activity 有权
标题翻译：具有NPY Y5受体拮抗剂活性的氨基衍生物
公开(公告)号：JP2010174038A
公开(公告)日：2010-08-12
申请号：JP2010107022
申请日：2010-05-07
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： OKUNO TAKAYUKI , KAMIYAMA NAOKI , SAKAGAMI MASAHIRO
IPC分类号： C07C311/07 , A61K31/18 , A61K31/36 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/455 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/553 , A61P3/04 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D207/27 , C07D207/325 , C07D213/38 , C07D213/74 , C07D213/85 , C07D215/38 , C07D217/22 , C07D231/38 , C07D231/56 , C07D233/61 , C07D237/20 , C07D237/22 , C07D237/34 , C07D239/42 , C07D241/20 , C07D261/14 , C07D261/20 , C07D263/56 , C07D263/58 , C07D265/30 , C07D265/36 , C07D267/14 , C07D271/06 , C07D271/10 , C07D275/02 , C07D277/28 , C07D277/62 , C07D277/82 , C07D295/12 , C07D295/18 , C07D317/46 , C07D403/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D498/04 , C07D513/04
CPC分类号： C07C311/05 , C07C311/07 , C07C311/08 , C07C311/20 , C07C311/21 , C07C311/37 , C07C311/39 , C07C311/43 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D207/27 , C07D207/325 , C07D211/14 , C07D213/38 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/14 , C07D217/22 , C07D219/10 , C07D231/38 , C07D233/58 , C07D233/61 , C07D235/30 , C07D237/20 , C07D237/22 , C07D237/34 , C07D239/42 , C07D241/20 , C07D261/14 , C07D261/20 , C07D263/58 , C07D265/30 , C07D265/36 , C07D267/14 , C07D275/02 , C07D277/28 , C07D277/62 , C07D277/82 , C07D295/12 , C07D295/135 , C07D295/18 , C07D333/36 , C07D333/40 , C07D333/66 , C07D333/72 , C07D403/04 , C07D409/04 , C07D413/04 , C07D417/12 , C07D498/04 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide a new compound having NPY Y5 receptor antagonist activity. SOLUTION: A compound represented by formula (I) below, a pharmaceutically acceptable salt thereof, or a solvate thereof is provided. In formula (I), R 1 represents an optionally substituted lower alkyl group; Y represents -S(O)n- (wherein n is 1 or 2) or -CO-; R 2 represents hydrogen or lower alkyl; R 7 represents hydrogen or lower alkyl; X represents lower alkylene, lower alkenylene, arylene, cycloalkylene or the like; and Z represents lower alkyl, an optionally substituted hydrocarbon ring group, an optionally substituted heterocyclic group or the like. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供具有NPY Y5受体拮抗剂活性的新化合物。解决方案：提供由下式（I）表示的化合物，其药学上可接受的盐或其溶剂合物。在式（I）中，R“SP”表示任选取代的低级烷基; Y表示-S（O）n - （其中n为1或2）或-CO-; R 2表示氢或低级烷基; R 表示氢或低级烷基; X表示低级亚烷基，低级亚烯基，亚芳基，亚环烷基等; Z表示低级烷基，任意取代的烃环基，任意取代的杂环基等。版权所有（C）2010，JPO＆INPIT

25. 发明专利

JP2010046665A Method of purifying/concentrating sugar chain with sugar chain-trapping molecule and method of analyzing sugar chain structure 有权
标题翻译：用糖链捕获分子净化/浓缩糖链的方法和分析糖链结构的方法
公开(公告)号：JP2010046665A
公开(公告)日：2010-03-04
申请号：JP2009266832
申请日：2009-11-24
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： NISHIMURA SHINICHIRO , NIIKURA KENICHI , NAKAGAWA HIROAKI , OKAYAMA MINENOBU
IPC分类号： B01J20/26 , C07C239/20 , C07H1/08 , G01N27/62
CPC分类号： C07H1/08 , C07C239/20 , C07H1/06 , C07H3/06 , C07K1/14 , C07K14/77 , C07K14/79 , C07K16/00 , G01N33/5308 , G01N33/6842 , G01N2333/77 , G01N2333/79 , G01N2400/00 , G01N2560/00
摘要： PROBLEM TO BE SOLVED: To provide a substance capable of specifically interacting with sugar chains. SOLUTION: There is provided a substance capable of specifically interacting with sugar chains. Further, there is provided a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance in a sample, comprising the steps of: (a) bringing a sugar chain-trapping carrier comprising a substance capable of specifically interacting with sugar chains into contact with a sample in a fluid phase under conditions where the sugar chain-trapping carrier can react with the sugar chains or sugar chain-containing substance; (b) isolating a composite of the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance from the fluid phase; and (c) exposing the composite to the conditions where the interaction between the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance is at least partially eliminated. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供能够与糖链特异性相互作用的物质。提供了能够与糖链特异性相互作用的物质。此外，提供了一种用于在样品中分离，浓缩或纯化糖链或含糖链的物质的方法，包括以下步骤：（a）将包含能够特异性相互作用的物质的糖链捕获载体在链条捕获载体可以与糖链或含糖链物质反应的条件下，糖链在液相中与样品接触; （b）从流体相分离捕获糖链的载体和糖链或含糖链的物质的复合物; 和（c）将复合物暴露于糖链捕获载体和糖链或含糖链物质之间的相互作用至少部分消除的条件。版权所有（C）2010，JPO＆INPIT

26. 发明专利

JP2009249377A Water suspensibility-improved fine grain agent 有权
标题翻译：水不溶性改进的细粒剂
公开(公告)号：JP2009249377A
公开(公告)日：2009-10-29
申请号：JP2008285526
申请日：2008-11-06
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： YOSHIOKA KASUAKI , NOAMI MAKOTO , TOMOSHIGE RYUJI
IPC分类号： A61K31/546 , A61K9/10 , A61K9/16 , A61K47/04 , A61K47/34 , A61P31/04
摘要： PROBLEM TO BE SOLVED: To improve water suspensibility of a fine grain agent of cefcapene pivoxil hydrochloride.
SOLUTION: The fine grain agent of cefcapene pivoxil hydrochloride is improved in water wettability and suspensibility by adding polyoxyethylene(160) polyoxypropylene(30) glycol and other additive fine grains thereto.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提高头孢烯酸盐酸盐的精细颗粒剂的水悬浮性。解决方案：通过向其中加入聚氧乙烯（160）聚氧丙烯（30）二醇和其他添加剂微粒，改善了头孢烯酸盐酸盐的细颗粒剂的水润湿性和悬浮性。版权所有（C）2010，JPO＆INPIT

27. 发明专利

JP2009226245A Stirring method, stirrer and adaptor 审中-公开
标题翻译：刺激方法，STIRRER和适配器
公开(公告)号：JP2009226245A
公开(公告)日：2009-10-08
申请号：JP2008071287
申请日：2008-03-19
申请人： ▲榊▼電業株式会社 , Sakaki Dengyo Kk , Shashin Kagaku Co Ltd , Shionogi & Co Ltd , 塩野義製薬株式会社 , 株式会社写真化学
发明人： FUKUNAGA TAKAHIRO , KUMONSHIRO TOSHIO
IPC分类号： B01F9/22
摘要： PROBLEM TO BE SOLVED: To stirr solutions in a plurality of microtubes in a single process.
SOLUTION: A reagent B is put in the microtube and a sample A is adhered to a lid or wall surface. The microtube with a lid is set to the container receiver of a planetary type stirrer subjected to revolution and rotation motions. The sample A adhered to the lid of the microtube is scattered by the centrifugal force to be mixed with the reagent B. At the same time, the sample A and the reagent B are stirred by the revolution and rotation motions. In this way, a process for mixing the reagent B with the sample A and a process for stirring the sample A and the reagent B can be performed by one process.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：在单个过程中对多个微管中的溶液进行搅拌。
解决方案：将试剂B放入微管中，将样品A粘附到盖或壁表面。具有盖子的微管被设置在经受旋转和旋转运动的行星式搅拌器的容器接收器中。附着在微管的盖子上的样品A被离心力分散，与试剂B混合。同时，样品A和试剂B被旋转和旋转运动搅动。以这种方式，可以通过一种方法进行将试剂B与样品A混合的方法和用于搅拌样品A和试剂B的方法。版权所有（C）2010，JPO＆INPIT

28. 发明专利

JP2009161552A Sulfonamide derivatives having Pgd2 receptor antagonist activity 有权
标题翻译：具有PGD2受体拮抗剂活性的磺酰胺衍生物
公开(公告)号：JP2009161552A
公开(公告)日：2009-07-23
申请号：JP2009055298
申请日：2009-03-09
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： KUGIMIYA HIROSHI , FUJIOKA MASAHIKO , TACHIBANA HIROKI , MURASHI TAKAKI , ONODERA KIMIHIRO
IPC分类号： C07D211/46 , A61K31/40 , A61K31/402 , A61K31/445 , A61K31/4545 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/5383 , A61P1/04 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/04 , A61P25/00 , A61P25/20 , A61P27/14 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/12 , C07D207/14 , C07D211/22 , C07D211/58 , C07D213/38 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/20 , C07D277/28 , C07D277/46 , C07D285/12 , C07D285/135 , C07D295/22 , C07D307/52 , C07D307/68 , C07D333/20 , C07D401/12
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition having a DP receptor antagonist activity. SOLUTION: This sulfonamide derivative is a compound expressed by formula (IV) [wherein, ring D is a benzene ring or the like; ring E is a pyrrolidine ring or the like; R 1 is hydroxyalkyl or the like; R 2 is a halogen atom or the like; R 3 is an alkyloxy or the like; R 4 , R 5 are each a halogen atom or the like; M is carbonyl or the like; L 3 , Y are each a single bond or the like: Z is N or the like; and (n), (p), (q) are each a number such as 1 etc.], its pharmaceutically acceptable salt or their hydrates. They can be used as a treating agent of allergic diseases. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有DP受体拮抗剂活性的药物组合物。该解决方案：该磺酰胺衍生物是由式（Ⅳ）表示的化合物[其中，环D为苯环等; 环E是吡咯烷环等; R SP 1是羟烷基等; R 2是卤素原子等; R 3是烷氧基等; R“SP”4，R“SP 5”均为卤素原子等; M是羰基等; L各自为单键或类似物：Z为N等; 和（n），（p），（q）各自为1等的数字]，其药学上可接受的盐或其水合物。它们可以用作过敏性疾病的治疗剂。版权所有（C）2009，JPO＆INPIT

29. 发明专利

JP2008169217A Pyridone derivative having affinity effect for cannabinoid type 2 receptor 审中-公开
标题翻译：对于CANNABINOID 2型受体具有亲和力的吡啶酮衍生物
公开(公告)号：JP2008169217A
公开(公告)日：2008-07-24
申请号：JP2008021092
申请日：2008-01-31
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： TADA YUKIO , ISO YASUYOSHI , HANAZAKI KOJI
IPC分类号： C07D213/69 , A61K31/4412 , A61K31/4439 , A61K31/4709 , A61K31/4738 , A61K31/506 , A61K31/5377 , A61P13/12 , A61P25/00 , A61P25/04 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/54 , C07D217/22 , C07D217/26 , C07D221/04 , C07D221/10 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D455/06 , C07D471/04 , C07D491/04 , C07D491/052 , C07D521/00 , C40B40/04
CPC分类号： C07D213/69 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/227 , C07D215/38 , C07D215/54 , C07D217/22 , C07D217/26 , C07D221/10 , C07D221/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D455/06 , C07D471/04 , C07D491/04
摘要： PROBLEM TO BE SOLVED: To provide a compound having the affinity for a cannabinoid type 2 receptor. SOLUTION: There is provided a compound represented by formula (I) [wherein R 1 is a group of the formula: -Y 1 -Y 2 -Y 3 -Ra (Y 1 is a single bond or the like, Y 2 is -C(=O)-NH- or the like and Y 3 is an optionally substituted aryl group or the like); R 2 is H or the like; R 3 is alkyl or the like; R 4 is alkyl or the like; R 5 is an optionally substituted alkyl or the like; and R 3 and R 4 may form a ring together with adjacent atoms], its prodrug, its pharmaceutically acceptable salt or the solvate thereof. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供对大麻素2型受体具有亲和性的化合物。解决方案：提供由式（I）表示的化合物[其中R 1 是下式的基团：-Y 1 -Y 2 -Y 3 -Ra（Y 1 是单键等，Y 2 是-C（= O） -NH-等，Y 3是任选取代的芳基等）; R 2 是H等; R 3是烷基等; R 4是烷基等; R 5是任选取代的烷基等; 和R 3 和R 4 可与相邻原子一起形成环，其前药，其药学上可接受的盐或其溶剂合物。版权所有（C）2008，JPO＆INPIT

30. 发明专利

JP2008156366A 3-carbamoyl-2-pyridone derivative 有权
标题翻译： 3-卡巴酰基-2-吡啶酮衍生物
公开(公告)号：JP2008156366A
公开(公告)日：2008-07-10
申请号：JP2008010009
申请日：2008-01-21
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： ISHIZUKA NATSUKI , SASAYA TAKASHI , HIRAMATSU YOSHIHARU , INAGAKI MASANAO , ODAN MASAHIDE , HASHIZUME HIROSHI , MITSUMORI SUSUMU , FUJII YASUHIKO , FUKUI KIICHI , WATABE HIDEAKI , SATO JUN
IPC分类号： C07D213/82 , A61K31/435 , A61K31/4365 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P17/00 , A61P17/04 , A61P43/00 , C07D221/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D495/04
CPC分类号： C07D213/82
摘要： PROBLEM TO BE SOLVED: To provide a 3-carbamoyl-2-pyridone derivative having a cannabinoid receptor agonist action, and to provide a pharmaceutical composition containing the compound as an active ingredient. SOLUTION: The 3-carbamoyl-2-pyridone derivative is represented by general formula (I) [R 1 is a 1 to 8C alkyl, or the like; R 2 is a 1 to 6C alkyl; R 3 is a 1 to 6C alkyl or the like, or R 2 and R 3 may together form a five- to ten-membered non-aromatic carbon ring; R 4 is H or the like; G is a group represented by formula (A) (R 5 is H or the like; X 1 is a single bond or the like; X 2 is a 1 to 8C alkylene or the like; X 3 is a single bond or the like)], and its pharmaceutically acceptable salt or their solvates are disclosed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供具有大麻素受体激动剂作用的3-氨基甲酰基-2-吡啶酮衍生物，并提供含有该化合物作为活性成分的药物组合物。解决方案：3-氨基甲酰基-2-吡啶酮衍生物由通式（I）表示[R 1 SP 1是1至8烷基等; R 2是1至6个烷基; R 3是1至6个烷基等，或者R 2和R 3可以一起形成5至10元非 - 芳环碳环; R 4 是H等; G是由式（A）表示的基团（R 5 是H等; X 1 是单键等; X SP>为1〜8C亚烷基等; X 3 为单键等）]及其药学上可接受的盐或其溶剂化物。版权所有（C）2008，JPO＆INPIT

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