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21. 发明专利

JP2010148426A Method for evaluating risk of developing hepatoma and method for forecasting prognosis by using bac clone 审中-公开
标题翻译：用于评估发展中的风险的方法和使用BAC克隆预测预防的方法
公开(公告)号：JP2010148426A
公开(公告)日：2010-07-08
申请号：JP2008329872
申请日：2008-12-25
申请人： Japan Health Science Foundation , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学 , 財団法人ヒューマンサイエンス振興財団
发明人： KANAI YAE , ARAI SHIGESATO , INASAWA JOJI
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a new method for deciding the risk of developing hepatoma and risk of poor prognosis.
SOLUTION: This method for detecting the risk of developing the hepatoma or risk of the poor prognosis is provided by comprising (a) the step of preparing a genomic DNA originated from the liver tissue of a subject, (b) the step of checking the presence or absence of DNA methylation in the associated region of the hepatoma development or associated region of the hepatoma prognosis on the genomic DNA prepared in the (a), and (c) the step of deciding whether the subject is classified into a high risk carcinogenesis group or a poor prognosis group, or not from the DNA methylation pattern clarified by the step (b).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种决定发展肝癌风险的新方法和预后不良的风险。解决方案：通过包括（a）制备源自受试者的肝脏组织的基因组DNA的步骤，（b）用于检测发生肝癌的风险或风险不良的预后的方法，检查在（a）中制备的基因组DNA上的肝癌发生或肝癌预后相关区域中DNA甲基化的存在或不存在，以及（c）决定受试者是否被分类为高风险致癌组或不良预后组，或不是来自步骤（b）所澄清的DNA甲基化模式。版权所有（C）2010，JPO＆INPIT

22. 发明专利

JP2010077045A New transporter molecule of sphingosine-1-phosphate 有权
标题翻译：新型运输分子磷酸1-磷酸盐
公开(公告)号：JP2010077045A
公开(公告)日：2010-04-08
申请号：JP2008245177
申请日：2008-09-25
申请人： Japan Health Science Foundation , Osaka Univ , 国立大学法人大阪大学 , 財団法人ヒューマンサイエンス振興財団
发明人： MOCHIZUKI NAOKI , KAWAHARA ATSUO , NISHI TAKESHI , YAMAGUCHI AKITO
IPC分类号： C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/60
摘要： PROBLEM TO BE SOLVED: To provide a new transporter molecule which migrates S1P (sphingosine-1-phosphate) from cell inside to cell outside, to provide a cell which can express the S1P transporter molecule, and to provide a method for screening the antagonist and/or agonist of the S1P transporter. SOLUTION: Vertebrate Spin2 acts as a new transporter molecule of S1P. The method for screening the antagonist and/or agonist of the S1P transporter comprises interacting a test substance with the transporter molecule to detect a substance reinforcing or reducing the functions of the transporter. By the screening method, an agent for improving diseases caused by the function potentiation or attenuation of S1P or diseases potentiating or attenuating the functions of S1P as symptoms can be screened. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供将S1P（鞘氨醇-1-磷酸）从细胞内部迁移到细胞外的新的转运蛋白分子，以提供能够表达S1P转运蛋白分子的细胞，并提供筛选方法 S1P转运蛋白的拮抗剂和/或激动剂。解决方案：脊椎动物Spin2作为S1P的新转运蛋白分子。用于筛选S1P转运蛋白的拮抗剂和/或激动剂的方法包括将测试物质与转运蛋白分子相互作用以检测加强或降低转运蛋白功能的物质。通过筛选方法，可以筛选用于改善由S1P的功能增强或减弱引起的疾病或增强或减弱S1P作为症状的功能的疾病。版权所有（C）2010，JPO＆INPIT

23. 发明专利

JP2010068884A Focused ultrasonic wave automatic irradiation system by ultrasonic image processing, focused ultrasonic wave automatic irradiation method, focused ultrasonic wave automatic irradiation program, and computer readable recording medium with the same recorded thereon 有权
标题翻译：通过超声波图像处理，聚焦超声波自动辐射方法，聚焦超声波自动辐射方案和与其记录的计算机可读记录介质聚焦超声波自动辐射系统
公开(公告)号：JP2010068884A
公开(公告)日：2010-04-02
申请号：JP2008237241
申请日：2008-09-17
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： CHIBA TOSHIO , KITAKADO KENTARO , YAMASHITA HIROMASA , KATSUIKE KOIN
IPC分类号： A61B18/00 , A61B8/08
摘要： PROBLEM TO BE SOLVED: To provide an HIFU automatic irradiation system for safely and accurately performing automatic irradiation.
SOLUTION: The HIFU automatic irradiation system 10 specifies a tracking object and an irradiation object in the ultrasonic image of an object (S230), and follows the tracking object on the basis of a feature parameter obtained by extracting the feature of the tracking object in real time (S240). Simultaneously, the irradiation object is followed indirectly by calculating the relative position of the irradiation object from the position information of the tracking object (S240), and the automatic irradiation of HIFU is performed only when the irradiation object is within a focus effective range (S260-S280).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于安全，准确地执行自动照射的HIFU自动照射系统。解决方案：HIFU自动照射系统10在对象的超声波图像中指定跟踪对象和照射对象（S230），并且基于通过提取跟踪的特征而获得的特征参数跟踪跟踪对象实时对象（S240）。同时，通过从跟踪对象的位置信息计算照射对象的相对位置来间接照射物体（S240），并且仅当照射对象在聚焦有效范围内时执行HIFU的自动照射（S260 -S280）。版权所有（C）2010，JPO＆INPIT

24. 发明专利

JP2010015360A Control system and control method 有权
标题翻译：控制系统与控制方法
公开(公告)号：JP2010015360A
公开(公告)日：2010-01-21
申请号：JP2008174402
申请日：2008-07-03
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： KAMITSUKURI KENJI , KOMATSU TOMOAKI , HATA NAOTERU
IPC分类号： G06F3/01 , G06F3/02 , G06F3/048
摘要： PROBLEM TO BE SOLVED: To perform necessary switch operation according to a situation even if a living environment changes.
SOLUTION: A switch 17 of an operation target is incorporated with a wireless receiver and a controller, and an identification tag 18 drawn with an identification graphic is disposed near it. The periphery is photographed by an imaging device 15. An information processor 13 analyzes an imaged image, distinguishes whether the identification graphic is present or not, generates an icon corresponding to the identification graphic when detecting the identification graphic, displays it on a display device 12, and sequentially performs emphasis display. The icon to which a user pays attention is distinguished from the bioinformation of brain waves, a view line or the like of a user, and a control signal corresponding to the distinguished icon is transmitted to the wireless receiver of the switch 17 from an wireless communication device 16. In response to the control signal, the controller controls the switch 17.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：即使生活环境发生变化，也可以根据情况执行必要的开关操作。解决方案：操作对象的开关17与无线接收器和控制器结合，并且在其附近设置用识别图形绘制的识别标签18。周边由成像装置15拍摄。信息处理器13分析成像图像，区分识别图形是否存在，当检测到识别图形时生成与识别图形相对应的图标，将其显示在显示装置12上，顺序进行强调显示。用户注意的图标与用户的脑电波，视线等的生物信息不同，对应于识别图标的控制信号从无线通信发送到交换机17的无线接收机设备16.响应于控制信号，控制器控制开关17.版权所有：（C）2010，JPO＆INPIT

25. 发明专利

JP2009278922A Primer and probe for detecting bases of cytochromes p450, 2c9 and 2c19 in single nucleotide polymorphism, kit having the primer and the probe, detecting device having the kit and detection method 审中-公开
标题翻译：用于检测单核苷酸多态体中的细胞色素P450,2C9和2C19的基础和检测方法，具有引物和探针的试剂盒，检测具有试剂盒和检测方法的装置
公开(公告)号：JP2009278922A
公开(公告)日：2009-12-03
申请号：JP2008134753
申请日：2008-05-22
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： TAKAHASHI YUKITOSHI , NISHIMURA SHIGEKO , NOGUCHI HIRONORI , IKUMI YASUHIRO
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a kit or the like suitable for rapidly detecting bases of cytochromes P450, 2C9 and 2C19 in single nucleotide polymorphism. SOLUTION: The base sequence of a gene in the single nucleotide polymorphism is detected by the kit comprising a probe having a DNA comprising a base sequence equal to, complementary to or reverse complementary to a base sequence represented in a prescribed region of a cytochrome P450, 2C9 or 2C19 gene, and a probe having a DNA hybridizing with a base sequence equal to, complementary to or reverse complementary to the base sequence represented by the prescribed region of the gene. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供适合于以单核苷酸多态性快速检测细胞色素P450,2C9和2C19的碱基的试剂盒等。解决方案：通过试剂盒检测单核苷酸多态性中的基因的碱基序列，所述试剂盒包含探针，所述探针具有包含碱基序列的碱基序列，所述碱基序列等同于与SEQ ID NO：细胞色素P450,2C9或2C19基因的探针，以及具有与基因的规定区域所表示的碱基序列互补或互补的碱基序列杂交的DNA的探针。版权所有（C）2010，JPO＆INPIT

26. 发明专利

JP2009215280A New hcv entry inhibitor 有权
标题翻译：新型HCV入门抑制剂
公开(公告)号：JP2009215280A
公开(公告)日：2009-09-24
申请号：JP2008300937
申请日：2008-11-26
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： TAKEBE YUTAKA , HAKAMATA KO , UENISHI RIE
IPC分类号： A61K31/473 , A61K31/496 , A61K31/55 , A61P1/16 , A61P31/14 , A61P35/00 , A61P43/00 , C07D221/16 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To provide an HCV entry inhibitor having excellent HCV inhibiting activity against HCV proliferation by investigation based on a coupling inhibition mechanism of CD81 with E2 protein of the HCV. SOLUTION: The HCV entry inhibitor contains a hexahydro-cyclopenta-quinolyl amine derivative expressed by general formula (I) [wherein R 1 represents H or the like] or a physiologically permissible salt of the same as an active ingredient. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过基于CD81与HCV的E2蛋白的偶联抑制机制的研究来提供对HCV增殖具有优异的HCV抑制活性的HCV进入抑制剂。方案：HCV入口抑制剂含有通式（I）表示的六氢 - 环戊基 - 喹啉基胺衍生物[其中R 1 表示H等]或其生理上允许的盐作为活性成分。版权所有（C）2009，JPO＆INPIT

27. 发明专利

JP2009149534A Trpv2 inhibitor, prophylactic or therapeutic agent for disease, lead compound for drug discovery, and drug discovery method 审中-公开
标题翻译： TRPV2抑制剂，疾病预防药物或治疗药物，用于药物发现的铅化合物和药物发现方法
公开(公告)号：JP2009149534A
公开(公告)日：2009-07-09
申请号：JP2007326606
申请日：2007-12-18
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： IWATA HIROKO , WAKABAYASHI SHIGEO
IPC分类号： A61K31/167 , A61K31/196 , A61K31/277 , A61K31/4196 , A61K31/4709 , A61P9/00 , A61P9/04 , A61P9/10 , A61P21/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a TRPV2 inhibitor that uses a compound capable of specifically inhibiting TRPV2 in the TRPV family, a prophylactic or therapeutic agent for muscle degenerative diseases or other diseases caused by TRPV2 activation, lead compounds for such drugs, and a drug discovery method.
SOLUTION: The TRPV2 inhibitor and the prophylactic or therapeutic agent each comprise at least one compound chosen from the group consisting of compounds of formulas (I) to (V). The lead compounds for drug discovery comprise these compounds and are used in the drug discovery method.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种TRPV2抑制剂，其使用能够特异性抑制TRPV家族中的TRPV2的化合物，用于由TRPV2激活引起的肌肉退行性疾病或其它疾病的预防或治疗剂，用于该药物的铅化合物，和药物发现方法。解决方案：TRPV2抑制剂和预防或治疗剂各自包含至少一种选自式（I）至（V）的化合物的化合物。用于药物发现的铅化合物包括这些化合物并用于药物发现方法中。版权所有（C）2009，JPO＆INPIT

28. 发明专利

JP2009142239A Method for examining type 2 diabetes using genetic polymorphism 有权
标题翻译：使用遗传多态性检查2型糖尿病的方法
公开(公告)号：JP2009142239A
公开(公告)日：2009-07-02
申请号：JP2007325366
申请日：2007-12-18
申请人： Ehime Univ , Gifu Univ , Japan Health Science Foundation , Kobe Univ , Univ Of Tokyo , 国立大学法人東京大学 , 国立大学法人岐阜大学 , 国立大学法人愛媛大学 , 国立大学法人神戸大学 , 財団法人ヒューマンサイエンス振興財団
发明人： YASUDA KAZUMOTO , KASUGA MASAHITO , KADOWAKI TAKASHI , FURUTA HIROTO , MAKINO HIDEKAZU , IWASAKI NAOKO , HORIKAWA YUKIO , YAMAGATA KAZUYA , OKA HOCHI
IPC分类号： C12Q1/68 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N2500/04 , G01N2500/10 , G01N2800/042
摘要： PROBLEM TO BE SOLVED: To provide a method for examining the genetic sensitivity of a subject to type 2 diabetes exactly, easily and swiftly through aiming at a decisive genetic factor judging the genetic sensitivity to type 2 diabetes. SOLUTION: The method for examining the genetic sensitivity of a subject to type 2 diabetes comprises detecting one or more polymorphisms present in KCNQ1 gene and/or EIF2KA4 gene in a DNA-containing specimen taken from the subject. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过针对判断对2型糖尿病的遗传敏感性的决定性遗传因素来准确，容易和迅速地检查受试者对2型糖尿病的遗传敏感性的方法。检查受试者对2型糖尿病的遗传敏感性的方法包括检测从受试者取得的含有DNA的标本中存在于KCNQ1基因和/或EIF2KA4基因中的一个或多个多态性。版权所有（C）2009，JPO＆INPIT

29. 发明专利

JP2009031017A Penetration type pipe strain meter 有权
标题翻译：渗透式管道应变仪
公开(公告)号：JP2009031017A
公开(公告)日：2009-02-12
申请号：JP2007192559
申请日：2007-07-24
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： TAMATE SATOSHI
IPC分类号： G01B7/16 , E02D1/00 , E02D17/20
摘要： PROBLEM TO BE SOLVED: To provide a technology of an inexpensive, easily-conveyable and easily-placeable penetration type pipe strain meter, capable of informing many people of a precursory phenomenon of a landslide easily and quickly, and preventing beforehand a damage caused by the landslide.
SOLUTION: An excavation screw 18 is provided on the tip part of a pipe strain meter body 11 integrated by inserting an inner pipe 12 having a plurality of strain gages 27 mounted on the outer circumferential surface into an outer pipe 13. After burying the strain meter body 11 into an underground shallow layer by rotating implements 20, 21 mounted on the rear end of the strain meter body 11, the rotating implements 20, 21 are dismounted, and an alarm device 31 for issuing an alarm for informing of generation of a precursory phenomenon showing danger of a landslide is mounted on the rear end of the strain meter body 11.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种便宜，易于携带和易于使用的渗透型管应变计的技术，能够容易且快速地通知许多人滑坡的前兆现象，并预先防止损坏造成的滑坡。解决方案：通过将安装在外圆周表面上的具有多个应变计27的内管12插入外管13中，在管应变计主体11的末端部分上设置挖掘螺钉18。应变计主体11通过旋转安装在应变计主体11的后端上的工具20,21，旋转工具20,21进入地下浅层，并且发出用于通知发电的报警器的报警装置31 在应变计主体11的后端安装有表现出滑坡危险的前兆现象。（C）2009年，JPO＆INPIT

30. 发明专利

JP2009029731A New tumor marker of pancreatic cancer 有权
标题翻译：胰腺癌新肿瘤标志物
公开(公告)号：JP2009029731A
公开(公告)日：2009-02-12
申请号：JP2007193328
申请日：2007-07-25
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： ONO MASAYA , YAMADA TETSUJI , HIROHASHI AKIO
IPC分类号： C07K14/75 , C12N15/09
CPC分类号： C07K14/4748 , C07K14/75
摘要： PROBLEM TO BE SOLVED: To provide a modified α-fibrinogen protein and a fragment thereof, useful as a tumor marker of pancreatic cancer.
SOLUTION: The modified α-fibrinogen protein containing an oxidized amino acid residue or the fragment thereof containing the amino acid residue is provided. The oxidized amino acid residue is one or more amino acid residues selected from the group consisting of a specific proline residue in a specified amino acid sequence, and a specific proline residue in another specified amino acid sequence.
COPYRIGHT: (C)2009,JPO&INPIT

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