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11. 发明专利

JP2011244760A Treated cell for producing medicament for accelerating regeneration of biotissue 审中-公开
标题翻译：生产用于促进生物再生的药物的治疗细胞
公开(公告)号：JP2011244760A
公开(公告)日：2011-12-08
申请号：JP2010122501
申请日：2010-05-28
申请人： Sumitomo Chemical Co Ltd , Tokai Univ , 住友化学株式会社 , 学校法人東海大学
发明人： AZUMA SEISHI , SAITO KOICHI , INAGAKI YUTAKA , HIGASHIYAMA REIICHI
IPC分类号： C12N5/10 , A61K35/28 , A61K38/22 , A61K48/00 , A61P1/16 , A61P3/10 , A61P9/10 , A61P9/12 , A61P11/00 , A61P19/00 , A61P25/00 , C07K14/47 , C12N5/0775 , C12N15/09
CPC分类号： C07K14/47 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide a treated cell or the like for producing a medicament for accelerating regeneration of a biotissue.SOLUTION: The treated cell or the like is obtained by separating a cell from a biotissue and subjecting the separated cell to one of : (1) a treatment for introducing a protein having a specific amino acid sequence or a gene having a specified base sequence to the cell; and (2) a treatment for bringing the cell into contact with a substance that induces the expression of the gene having the specified base sequence to produce a protein having the specific amino acid sequence.
摘要翻译：待解决的问题：提供一种处理过的细胞等以产生用于促进生物组织再生的药物。解决方案：通过从生物组织中分离细胞并对分离的细胞进行以下处理之一获得处理的细胞等：（1）用于引入具有特定氨基酸序列的蛋白质的处理或具有指定碱基序列的基因; 和（2）使细胞与诱导具有特定碱基序列的基因表达的物质接触以产生具有特定氨基酸序列的蛋白质的处理。版权所有（C）2012，JPO＆INPIT

12. 发明专利

JP2011006409A Therapeutic or prophylactic drug for disease associated with activity of neurotrophic factor 审中-公开
标题翻译：与神经营养因子活性相关的疾病的治疗药物或预防药物
公开(公告)号：JP2011006409A
公开(公告)日：2011-01-13
申请号：JP2010123614
申请日：2010-05-28
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： ISHIKAWA JUNICHI , SAITO KOICHI , OE NORIHISA , KOBAYASHI KENTARO
IPC分类号： C07D405/14 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/541 , A61P1/02 , A61P1/04 , A61P1/10 , A61P1/12 , A61P3/10 , A61P9/04 , A61P9/06 , A61P9/10 , A61P13/10 , A61P15/10 , A61P19/02 , A61P19/10 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a compound that enhances the activity of a neurotrophic factor and exhibits a protective action on a nerve cell.SOLUTION: The compound is represented by the formula shown herein [in the formula, Z represents N or C-R; X represents N-R, O, or S; Y represents C-Ror N; Rrepresents a hydrogen atom, a noncyclic hydrocarbon group that may be substituted or a cyclic group that may be substituted; Rrepresents a hydrogen atom, a noncyclic hydrocarbon group that may be substituted or a cyclic group that may be substituted; Rrepresents a hydrogen atom or a substituent; Rrepresents a hydrogen atom or a substituent; ring A represents a benzene ring that may be substituted; and ring B represents a benzene ring that may be substituted]. A pharmacologically acceptable salt thereof and a solvate thereof are disclosed.
摘要翻译：要解决的问题：提供增强神经营养因子的活性并对神经细胞表现出保护作用的化合物。解决方案：该化合物由本文所示的式表示[在该式中，Z表示N或C-R; X表示N-R，O或S; Y表示C-Ror N; R表示氢原子，可被取代的非环状烃基或可被取代的环状基团; R表示氢原子，可被取代的非环状烃基或可被取代的环状基团; R表示氢原子或取代基; R表示氢原子或取代基; 环A表示可被取代的苯环; 环B表示可被取代的苯环]。公开了其药理学上可接受的盐及其溶剂合物。

13. 发明专利

JP2010148480A Method for predicting carcinogenicity of test substance in rodent liver 审中-公开
标题翻译：预测肝脏中测试物质致癌性的方法
公开(公告)号：JP2010148480A
公开(公告)日：2010-07-08
申请号：JP2008332370
申请日：2008-12-26
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： SAITO KOICHI , SUMIDA KAYO , YAMADA FUMIHIRO , KATAOKA MASAKI
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new method for predicting carcinogenicity of a test substance without a need for a long term animal experiment.
SOLUTION: The method includes obtaining measurements of mRNA expression of at least one gene specified by a designated unigene number in a rat administered with a test substance and predicting liver carcinogenicity in rodents by discriminant analysis of the mRNA expression measurements.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于预测测试物质的致癌性的新方法，而不需要长期的动物实验。解决方案：该方法包括获得在给予受试物质的大鼠中由指定的unigene编号指定的至少一个基因的mRNA表达的测量值，并通过mRNA表达测量的判别分析预测啮齿动物的肝脏致癌性。版权所有（C）2010，JPO＆INPIT

14. 发明专利

JP2009173594A MEDICINAL COMPOSITION FOR INHIBITING ACCUMULATION OF AMYLOID β PROTEIN 审中-公开
标题翻译：抑制AMYLOIDβ蛋白积累的药物组合物
公开(公告)号：JP2009173594A
公开(公告)日：2009-08-06
申请号：JP2008014914
申请日：2008-01-25
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： MOTONAGA KOZO , SAITO KOICHI , HARADA KOICHIRO
IPC分类号： A61K31/4184 , A61P25/28 , A61P43/00 , C07D235/12
CPC分类号： C07D235/12 , A61K31/404 , A61K31/4184
摘要： PROBLEM TO BE SOLVED: To provide a compound inhibiting accumulation of an amyloid β protein. SOLUTION: A medicinal composition for inhibiting accumulation of an amyloid β protein comprises a compound represented by formula (I) or the like, or a pharmacologically acceptable salt thereof. An inhibitor of accumulation of an amyloid β protein comprises the compound represented by formula (I) or the like, or the pharmacologically acceptable salt thereof. Use, for inhibiting accumulation of an amyloid β protein, of the compound represented by formula (I) or the like, or the pharmacologically acceptable salt thereof is provided. A method for inhibiting accumulation of an amyloid β protein comprises a step of administering an effective amount of the compound represented by formula (I) or the like, or the pharmacologically acceptable salt thereof to a mammal diagnosable as suffering from an amyloid β protein-related disease. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供抑制淀粉样蛋白β蛋白积累的化合物。解决方案：用于抑制淀粉样蛋白β蛋白积累的药物组合物包含由式（I）等表示的化合物或其药理学上可接受的盐。淀粉样蛋白β蛋白的积累抑制剂包含式（I）等表示的化合物或其药理学上可接受的盐。提供了用于抑制淀粉样蛋白β蛋白的积累，由式（I）等表示的化合物或其药理学上可接受的盐。抑制淀粉样蛋白β蛋白积累的方法包括将有效量的由式（I）等表示的化合物或其药理学上可接受的盐给予可被诊断为患有淀粉样β蛋白相关的哺乳动物的哺乳动物的步骤疾病。版权所有（C）2009，JPO＆INPIT

15. 发明专利

JP2007282501A Method for testing apoptosis control ability 审中-公开
标题翻译：测试疫苗控制能力的方法
公开(公告)号：JP2007282501A
公开(公告)日：2007-11-01
申请号：JP2006087342
申请日：2006-03-28
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： OE MOROHISA , MOTONAGA KOZO , KOBAYASHI KENTARO , SAITO KOICHI
IPC分类号： C12Q1/68 , A61K45/00 , A61P25/00 , A61P25/28 , A61P43/00 , C12N15/09 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a method, etc., for testing an apoptosis control ability which is useful in searching for a substance usable as an active ingredient of a drug for controlling the apoptosis in a mammal or a tissue or a cell thereof (hereinafter referred to as a mammal, etc.). SOLUTION: The method for testing the apoptosis control ability dependent on a transcription regulatory factor having an amino acid sequence, etc., composed of a plurality of specific sequences. The method for testing comprises (1) a first step of independently bringing a test substance into contact with both the mammal, etc., expressing the transcriptional regulatory factor and the mammal, etc., without substantially expressing the transcriptional regulatory factor, respectively, (2) a second step of measuring the presence, absence, etc., of activation of a glial cell in the mammals, etc., after the first step and (3) a third step of evaluating the ability possessed by the test substance on the basis of the presence, absence, etc., of the activation measured in the second step. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于检测可用于寻找可用作控制哺乳动物或组织或组织中的细胞凋亡的药物的活性成分的物质的凋亡控制能力的方法等细胞（以下简称哺乳动物等）。解决方案：依赖于具有由多个特定序列组成的氨基酸序列等的转录调节因子来测试凋亡控制能力的方法。测试方法包括（1）独立地使测试物质与表达转录调节因子和哺乳动物等的哺乳动物等接触的第一步骤，而不分别基本上表达转录调节因子（ 2）在第一步骤之后测量哺乳动物等中的神经胶质细胞活化的存在，不存在等的第二步骤，以及（3）评估受试物质对其的能力的第三步骤在第二步测量的激活的存在，不存在等的基础。版权所有（C）2008，JPO＆INPIT

16. 发明专利

JP2012254049A Method for testing phototoxicity with human retinal pigment epithelial cell 审中-公开
标题翻译：用人体细胞色素上皮细胞测试人体毒性的方法
公开(公告)号：JP2012254049A
公开(公告)日：2012-12-27
申请号：JP2011129912
申请日：2011-06-10
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： ANDO MANABU , SAITO KOICHI
IPC分类号： C12Q1/02
CPC分类号： G01N33/5014 , G01N33/5044
摘要： PROBLEM TO BE SOLVED: To provide a method for testing phototoxicity, by which the phototoxicity expression ability of a test substance can effectively be tested.SOLUTION: The method for testing phototoxicity is characterized by including the following processes (1)-(4), and the like: (1) The first process for contacting human retinal pigment epithelial cells with a test substance; (2) the second process for culturing the human retinal pigment epithelial cells made contact with the test substance in the first process, while irradiating it with artificial light containing a wavelength distribution in a range of 340-380 nm within 24 hours after the start of the contact in the first process; (3) the third process for recovering the human retinal pigment epithelial cells cultured in the second process and measuring the cytotoxicity of the recovered cultured cells or an index value correlated thereto; and (4) the fourth process for evaluating the presence or absence of the phototoxicity-expressing ability of the test substance or an extent thereof by the measurement result of the third process to test the phototoxicity expression ability of the test substance.
摘要翻译：要解决的问题：提供一种测试光毒性的方法，通过该方法可以有效地测试测试物质的光毒性表达能力。（1） - （4）等：（1）将人视网膜色素上皮细胞与检测物质接触的第一种方法，其特征在于，（2）在第一过程中培养人视网膜色素上皮细胞的第二种方法与待测物质接触，同时在开始后24小时内用波长分布在340-380nm范围内的人造光照射第一个过程中的联系人; （3）回收第二过程中培养的人视网膜色素上皮细胞并测定回收的培养细胞的细胞毒性的第三过程或与其相关的指标值; 和（4）通过测试被测物质的光毒性表达能力的第三种方法的测量结果来评估被测物质的光毒性表达能力的存在或不存在或其程度的第四种方法。版权所有（C）2013，JPO＆INPIT

17. 发明专利

JP2011006408A Therapeutic or prophylactic drug for disease associated with activity of neurotrophic factor 审中-公开
标题翻译：与神经营养因子活性相关的疾病的治疗药物或预防药物
公开(公告)号：JP2011006408A
公开(公告)日：2011-01-13
申请号：JP2010123613
申请日：2010-05-28
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： ISHIKAWA JUNICHI , SAITO KOICHI , OE NORIHISA , KOBAYASHI KENTARO
IPC分类号： C07D285/16 , A61K31/54 , A61K31/541 , A61P9/10 , A61P25/00 , C07D417/04 , C07D417/14 , C07D471/06
CPC分类号： C07D417/04 , C07D285/16 , C07D417/10 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a compound that enhances the activity of a neurotrophic factor and exhibits a protective action on a nerve cell.SOLUTION: The compound is represented by formula (1a) or by formula (1b) [in the formula, Rand Reach independently represents a hydrogen atom or the like; and Ar represents a 5 to 6 membered ring group or a condensed ring group]. A pharmacologically acceptable salt thereof and a solvate thereof are disclosed.
摘要翻译：要解决的问题：提供增强神经营养因子的活性并对神经细胞表现出保护作用的化合物。解决方案：该化合物由式（1a）或式（1b）表示[在式中，Rand 独立地表示氢原子等; Ar表示5〜6元环或稠环基]。公开了其药理学上可接受的盐及其溶剂合物。

18. 发明专利

JP2010259382A Method for predicting inherent carcinogenicity of substance in rodent mammal tissue 审中-公开
标题翻译：用于预测体重组织中物质致死性致癌性的方法
公开(公告)号：JP2010259382A
公开(公告)日：2010-11-18
申请号：JP2009113361
申请日：2009-05-08
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： YAMADA FUMIHIRO , SUMIDA KAYO , SAITO KOICHI , KATAOKA MASAKI
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a new method for predicting the inherent carcinogenicity of a substance in a rodent mammal tissue, without requiring the performance of testing in mammals requiring a large sum of expenses and a long testing period of time.
SOLUTION: This method for predicting the inherent carcinogenicity of the test substance in the rodent mammal tissue, etc., is provided by comprising (i) a process of administering the test substance to the rodent mammals for a fixed period of within 1 to 90 day range, after the process (i), (ii) a process of measuring the expressed amount value T of mRNA of a predetermined gene or a gene having substantially the same base sequence to the base sequence in the rodent mammal tissue, (iii) a process of preparing the expressed amount value C of the mRNA in the rodent mammal tissue without being administered with the test substance, (iv) a process of preparing a predicting formula for predicting the carcinogenicity of the test substance in the rodent mammal tissue based on the ratio of the expressed amount value T to the expressed amount value C and (v) a process of inputting the ratio of the expressed amount value T to the expressed amount value C into the formula and predicting the carcinogenicity of the test substance in the rodent mammal tissue.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于预测啮齿动物哺乳动物组织中物质的固有致癌性的新方法，而不需要在需要大量费用和长的测试时间的哺乳动物中进行测试。解决方案：用于预测受试物质在啮齿动物哺乳动物组织等中的固有致癌性的方法是通过包括（i）向啮齿动物哺乳动物施用测试物质一定时间内的方法（i），（ii）测定预定基因的mRNA的表达量值T或与啮齿动物哺乳动物组织中的碱基序列具有基本相同碱基序列的基因的过程（i），（ii） iii）制备啮齿动物哺乳动物组织中的mRNA的表达量值C而不施用测试物质的方法，（iv）制备用于预测啮齿动物哺乳动物组织中测试物质的致癌性的预测公式的方法基于表示量值T与表示量值C的比率，（v）将表示量值T与表示量值C的比率输入到公式中并预测carc 测试物质在啮齿动物哺乳动物组织中的不成体性。版权所有（C）2011，JPO＆INPIT

19. 发明专利

JP2010047517A Treating or preventing agent for disease associated with activity of neurotropic factor, and method for producing the same 审中-公开
标题翻译：治疗或预防与神经营养因子活性有关的疾病的药物及其生产方法
公开(公告)号：JP2010047517A
公开(公告)日：2010-03-04
申请号：JP2008213171
申请日：2008-08-21
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： ISHIKAWA JUNICHI , SAITO KOICHI , OE NORIHISA , KAKIMIZU AKIKO , MIYAMURA SATOSHI
IPC分类号： C07D279/16 , A61K31/5415 , A61K31/542 , A61P1/02 , A61P1/04 , A61P1/12 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/50 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/10 , A61P13/12 , A61P15/06 , A61P15/08 , A61P17/14 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/10 , A61P25/12 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00 , A61P35/04 , A61P37/04 , A61P43/00 , C07D417/06 , C07D417/14 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide a low-molecular weight compound effective for treatment, prevention and the like of a disease associated with activity of a neurotropic factor. SOLUTION: The treating or preventing agent for a disease associated with activity of a neurotropic factor comprises as an effective ingredient a compound represented by general formula Ia or Ib [wherein A 1 is a ring optionally substituted with at least one Y a ; A 2 is an alkylene chain; A 3 is an aromatic group optionally substituted with at least one Y b ; A 4 is a hydrogen atom or an alkyl group, or may be linked to one Y a to form a bivalent chain group; X 1 is S, SO, SO 2 , NH or O; n1 is an integer of 0-4; Y 1 's and Y b 's are each independently a hydroxy group or the like in each appearance; and Y a 's are each independently a hydroxy group or the like in each appearance], a pharmacologically acceptable salt thereof, or a hydrate thereof. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供对与神经营养因子的活性相关的疾病的治疗，预防等有效的低分子量化合物。解决方案：与神经营养因子的活性相关的疾病的治疗或预防剂包含作为有效成分的由通式Ia或Ib表示的化合物[其中A 1 是任选取代的环与至少一个Y a ; A 2 是亚烷基链; A 3 是任选被至少一个Y SB取代的芳基; A 4 是氢原子或烷基，或可以连接到一个Y a 以形成二价链基团; X 1 是S，SO，SO 2 SB，NH或O; n1为0-4的整数; 在每种外观中，Y 1 和Y b 各自独立地为羟基等; 和Y a 各自独立地为羟基等，其药理学上可接受的盐或其水合物。版权所有（C）2010，JPO＆INPIT

20. 发明专利

JP2009159852A Method for predicting carcinogenesis of test substance to rodents 有权
标题翻译：用于预测试验物质对人体造血的方法
公开(公告)号：JP2009159852A
公开(公告)日：2009-07-23
申请号：JP2007340406
申请日：2007-12-28
申请人： Chemicals Evaluation & Research Institute , Mitsubishi Chemical Safety Institute Ltd , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 株式会社三菱化学安全科学研究所 , 財団法人化学物質評価研究機構
发明人： YAKABE YOSHIKUNI , MATSUMOTO HIROSHI , SAITO FUMIYO , SAITO KOICHI , SUMIDA KAYO , NAKAYAMA KOJI , SEKIJIMA MASARU
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6876 , C12Q2600/142 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a simple method for predicting carcinogenesis, which predicts carcinogenesis of a test substance to rodents in a short period based on difference in gene expression.
SOLUTION: The method for predicting carcinogenesis of a test substance to rodents has a step for administering a test substance solution to a test group and its solvent to a control group, a step for collecting mRNAs from each group and measuring the expression amount of mRNA from genes containing base sequences having specific sequences for each of one or more selected genes, a step for determining whether a significant difference exists in the expression amount of mRNA expressed from the gene between the test group and the control group, and a step for determining that the test substance has carcinogenesis, when a significant difference exists in the expression amount expressed from any one gene between the test group and the control group, and the increase or decrease direction of the expression amount of the mRNA is expressed in a predetermined direction for each gene.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种预测癌症发生的简单方法，其基于基因表达的差异预测测试物质在短时间内对啮齿动物的致癌作用。解决方案：用于预测测试物质对啮齿动物的致癌作用的方法具有将测试物质溶液施用于测试组及其溶剂至对照组的步骤，用于从每组中收集mRNA的步骤和测量表达量来自含有对于一个或多个选择的基因中的每一个具有特定序列的碱基序列的基因的mRNA的步骤，确定在测试组和对照组之间的基因表达的mRNA的表达量中是否存在显着性差异的步骤，以及步骤用于确定测试物质具有致癌作用时，当从测试组和对照组之间的任何一个基因表达的表达量存在显着差异时，mRNA的表达量的增加或减少方向以预定的方向为每个基因。版权所有（C）2009，JPO＆INPIT

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