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1. 发明专利

JP2014073131A Method for predicting developmental toxicity possessed by chemical substance 有权
标题翻译：预防化学物质发展毒性的方法
公开(公告)号：JP2014073131A
公开(公告)日：2014-04-24
申请号：JP2013250834
申请日：2013-12-04
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： SUZUKI NORIYUKI , SAITO KOICHI , ANDO MANABU , HORIE NOBUYUKI
IPC分类号： C12N15/09 , C12N5/10 , C12Q1/02 , C12Q1/66 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6883 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , C12N5/0603 , C12Q1/6809 , C12Q2600/142 , G01N33/5014 , C12Q2545/113
摘要： PROBLEM TO BE SOLVED: To provide an easy and highly-versatile method for predicting developmental toxicity possessed by a chemical substance.SOLUTION: A method for predicting developmental toxicity possessed by a chemical substance comprises: (1) a first step of measuring an expression level of one or more genes selected from a gene including any one of specific base sequence groups or orthologue genes thereof in a specimen derived from a nonhuman mammal individual or mammalian cell having come into contact with a target chemical substance; and (2) a second step of comparing the measurement value of the expression level of the gene in the specimen obtained by the first step with the reference value of the expression level of the gene, and evaluating the level of developmental toxicity possessed by the target chemical substance in the specimen based on the compared difference. In the method for predicting the developmental toxicity possessed by the chemical substance, the gene is -mya1 gene and the expression level of the gene is measured by measuring an amount of transcription product or translation product.
摘要翻译：要解决的问题：提供一种用于预测化学物质所具有的发育毒性的简单和高度通用的方法。解决方案：用于预测化学物质具有的发育毒性的方法包括：（1）测量表达水平的第一步骤在来源于与目标化学物质接触的非人类哺乳动物个体或哺乳动物细胞的样品中选自包括特定碱基序列组或直系同源基因中的任一种的基因的一种或多种基因; 和（2）将第一步骤获得的标本中的基因的表达水平的测定值与该基因的表达水平的基准值进行比较的第2工序，对该靶基因的发育毒性水平进行评价基于化学物质的样本中的差异进行比较。在用于预测化学物质所具有的发育毒性的方法中，该基因是-mya1基因，并且通过测量转录产物或翻译产物的量来测量该基因的表达水平。

2. 发明专利

JP2010275304A Thiophene derivative 审中-公开
标题翻译：三苯衍生物
公开(公告)号：JP2010275304A
公开(公告)日：2010-12-09
申请号：JP2010103130
申请日：2010-04-28
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： HARADA KOICHIRO , MOTONAGA KOZO , SAITO KOICHI , TANAKA AKIO
IPC分类号： C07D333/36 , A61K31/381 , A61K31/4025 , A61K31/4535 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/26 , A61P9/10 , A61P13/00 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/14 , A61P19/10 , A61P21/00 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07D333/38 , C07D409/04 , C07D409/12
CPC分类号： C07D333/36 , C07D333/38 , C07D409/04 , C07D409/12
摘要： PROBLEM TO BE SOLVED: To provide a new thiophene derivative which is a selective androgen receptor modulator (SARM) and a pharmaceutically acceptable salt thereof, and to further provide a pharmaceutical composition including the derivative and pharmaceutically acceptable salt thereof as an active ingredient, and useful for the treatment and prevention of conditions or disorders that are sensitive to selective androgen receptor modulation. SOLUTION: There are provided the compound of formula (I) or a salt, a solvate, or a physiologically functional derivative thereof; and the pharmaceutical composition including the compound or salt, solvate, or physiologically functional derivative thereof, and useful for the treatment and prevention of the conditions or disorders that are sensitive to the selective androgen receptor modulation. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供作为选择性雄激素受体调节剂（SARM）的新的噻吩衍生物及其药学上可接受的盐，并且还提供包含其衍生物和药学上可接受的盐作为活性成分的药物组合物并且可用于治疗和预防对选择性雄激素受体调节敏感的病症或病症。提供式（I）化合物或其盐，溶剂合物或其生理功能衍生物; 以及包含其化合物或其盐，溶剂合物或生理功能衍生物的药物组合物，可用于治疗和预防对选择性雄激素受体调节敏感的病症或病症。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2010011843A Method for predicting developmental toxicity possessed by chemical substance 有权
标题翻译：预防化学物质发展毒性的方法
公开(公告)号：JP2010011843A
公开(公告)日：2010-01-21
申请号：JP2009125077
申请日：2009-05-25
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： SUZUKI NORIYUKI , SAITO KOICHI , ANDO MANABU , HORIE NOBUYUKI
IPC分类号： C12N15/09 , A01K67/027 , C12N5/10 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , C12N5/0603 , C12Q1/6809 , C12Q2600/142 , G01N33/5014 , C12Q2545/113
摘要： PROBLEM TO BE SOLVED: To provide a simple and versatile method for predicting developmental toxicity possessed by a chemical substance.
SOLUTION: The method for predicting the developmental toxicity possessed by the chemical substance includes (1) a first step for measuring the expression level of one or more genes selected from a gene having one of specific base sequences in a non-human mammal individual having contacted with the subject chemical substance or a specimen derived from the mammal cell, or its orthologous gene, and (2) a second step for comparing the measured value of the expression level of the gene in the specimen obtained at the first step with a control value of the expression level of the gene, and evaluating the level of the developmental toxicity possessed by the subject chemical substance in the specimen based on the difference thereof.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于预测化学物质所具有的发育毒性的简单而通用的方法。解决方案：用于预测化学物质具有的发育毒性的方法包括（1）用于测量在非人哺乳动物中选自具有一个特定碱基序列的基因的一种或多种基因的表达水平的第一步骤与本发明化学物质接触的个体或源自哺乳动物细胞或其直系同源基因的标本，和（2）将第一步骤获得的样品中基因表达水平的测定值与基于该基因的表达水平的对照值，并根据其差异来评价被检物质在试样中具有的发育毒性的水平。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2007282502A Method for testing cell degeneration control ability 审中-公开
标题翻译：测试细胞变性控制能力的方法
公开(公告)号：JP2007282502A
公开(公告)日：2007-11-01
申请号：JP2006087343
申请日：2006-03-28
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： OE MOROHISA , KOBAYASHI KENTARO , MOTONAGA KOZO , SAITO KOICHI
IPC分类号： C12Q1/02 , A61K31/711 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , A61P43/00 , C12N15/09 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method, etc., for testing a cell degeneration control ability used in searching for a substance usable as an active ingredient of a drug for controlling the cell degeneration in a mammal. SOLUTION: The method for testing the cell degeneration control ability dependent on a transcriptional regulatory factor having an amino acid sequence such as an amino acid sequence, etc., which are represented by any of sequence numbers 1-3. The method for testing, etc., are characterized as comprising (1) a first step of bringing a test substance into contact with a mammalian cell expressing the transcriptional regulatory factor, (2) a second step of measuring an index value having a correlation with the presence or absence of phosphorylation of the transcriptional regulatory factor or a degree thereof in the mammalian cell after the first step and (3) a third step of evaluating the ability possessed by the test substance on the basis of the index value having the correlation with the presence or absence of the phosphorylation or the degree thereof measured in the second step. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于检测用于寻找可用作用于控制哺乳动物细胞变性的药物的活性成分的物质的细胞变性控制能力的方法等。解决方案：依赖于具有氨基酸序列等氨基酸序列等的由序列号1-3中任一个表示的转录调节因子的细胞变性控制能力的检测方法。测试方法等的特征在于包括：（1）使测试物质与表达转录调节因子的哺乳动物细胞接触的第一步骤，（2）测量与在第一步骤之后，哺乳动物细胞中转录调节因子或其程度的磷酸化的存在或不存在;（3）第三步，根据与第磷酸化的存在或不存在或其在第二步中测量的程度。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2005318842A Method for testing androgenic activity possessed by chemical substance 审中-公开
标题翻译：化学物质测试和生物活性的方法
公开(公告)号：JP2005318842A
公开(公告)日：2005-11-17
申请号：JP2004139516
申请日：2004-05-10
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： YAMADA TOMOYA , SAITO KOICHI
IPC分类号： C12N15/09 , A61K45/00 , A61P5/26 , A61P43/00 , C12Q1/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for accurately and simply testing androgenic activity as much as possible. SOLUTION: This method for testing the androgenic activity possessed by a chemical substance has (1) a first step for measuring an expression level of a gene, etc., having a specific base sequence in a specimen derived from a mammalian which is preliminarily brought into contact with the chemical substance and (2) a second step for comparing a measured value of the expression level of the gene in the specimen obtained in the first step with a control value of the expression level of the gene, and then evaluating existence or nonexistence of the androgenic activity possessed by the chemical substance in the specimen, or a degree of generation of the activity, based on a difference between the values. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供尽可能准确和简单地测试雄激素活性的方法。测定化学物质所具有的雄激素活性的方法有：（1）测定来自哺乳动物的试样中具有特定碱基序列的基因等的表达水平的第一步骤，初步与化学物质接触，（2）将第一步骤获得的标本中的基因的表达水平的测定值与基因的表达水平的对照值进行比较的第2工序，基于这些值之间的差异，存在或不存在样品中化学物质所具有的雄激素活性或活性的产生程度。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005245201A Method for examining ability of substance to regulate expression of neprilysin activity 审中-公开
标题翻译：检查物质能够调节NEPRILYSIN活性表达的方法
公开(公告)号：JP2005245201A
公开(公告)日：2005-09-15
申请号：JP2004039525
申请日：2004-02-17
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： MOTONAGA KOZO , SAITO KOICHI
IPC分类号： G01N33/50 , A61K45/00 , A61P25/28 , A61P43/00 , C12N5/16 , C12N15/09 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/15
CPC分类号： C12Q1/37
摘要： PROBLEM TO BE SOLVED: To provide a method for examining the ability of a substance to regulate the expression of neprilysin activity, which is simple and effective for searching a substance having the ability of a substance to regulate the expression of neprilysin activity.
SOLUTION: The method for examining the ability of a substance to regulate the expression of neprilysin activity comprises (1) a first step of measuring the ability of a test substance to control the expression of androgen receptor activity with the use of an expression indication which occurs depending on the binding-conditions of the androgen receptor to the test substance in a system wherein the androgen receptor is in contact with the test substance and (2) a second step of comparing the ability measured in the first step with the ability of a control and, based on the difference thus obtained, evaluating the ability of the test substance to regulate the expression of neprilysin activity.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种用于检查物质调节去蛋白酶活性表达的能力的方法，其简单且有效地用于搜索具有物质能力的物质来调节去蛋白酶活性的表达。解决方案：用于检查物质调节去蛋白酶活性表达的能力的方法包括：（1）测量受试物质通过使用表达来控制雄激素受体活性的表达的能力的第一步骤在雄激素受体与被检物质接触的系统中，取决于雄激素受体对被检物质的结合条件而发生的适应症，以及（2）将第一步骤测定的能力与第一步骤中测定的能力进行比较的第二步骤并根据所获得的差异，评估测试物质调节尿素活性表达的能力。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2005160341A LIVER RECEPTOR X β SPLICING MUTANT PROTEIN, ITS GENE AND THEIR UTILIZATION 有权
标题翻译：肝脏受体Xβ分离突变蛋白，其基因及其利用
公开(公告)号：JP2005160341A
公开(公告)日：2005-06-23
申请号：JP2003401240
申请日：2003-12-01
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： NAITO GIICHI , FUJIMORI ISAO , SAITO KOICHI , OITA KENJI
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To obtain a new liver receptor X isoform (for example, a liver receptor X β splicing mutant protein of new liver receptor X β isoform), to provide its gene, and to utilize them, because the liver receptor X β splicing mutant protein, its gene or their partial portion domain is highly useful for developing medicines for clarifying the relation of pathogenic symptoms / diseases directly or indirectly participating on the functions of the liver receptor Xβ splicing mutant protein and for preventing or treating their pathogenic symptoms / diseases. SOLUTION: This liver receptor X β isoform is a liver receptor X β splicing mutant protein which lacks at least the partial domain of an exon 5 and has eight cysteine residues constituting the zinc finger motif of a DNA-bound domain in an exon 3. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了获得新的肝脏受体X同种型（例如，新的肝脏受体Xβ同种型的肝脏受体Xβ剪接突变蛋白），提供其基因并利用它们，因为肝脏受体Xβ剪接突变蛋白，其基因或其部分部分结构域对于开发用于澄清直接或间接参与肝脏受体Xβ剪接突变蛋白的功能的病原性症状/疾病的关系以及用于预防或治疗致病性症状/疾病。解决方案：这种肝脏受体Xβ同种型是一种肝脏受体Xβ剪接突变蛋白，其至少缺乏外显子5的部分结构域，并且具有构成外显子中DNA结合结构域的锌指基序的八个半胱氨酸残基 3.版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2014207878A 細胞培養基材、細胞の製造方法および細胞の取得方法审中-公开
标题翻译：细胞培养基质材料，细胞的生产方法和细胞的获取方法
公开(公告)号：JP2014207878A
公开(公告)日：2014-11-06
申请号：JP2013235704
申请日：2013-11-14
申请人：住友化学株式会社 , Sumitomo Chemical Co Ltd
发明人： TANAKA KENTA , HIGASHIMURA HIDEYUKI , EHASHI TOMO , ANDO MANABU , SAITO KOICHI
IPC分类号： C12N5/0735 , C12N1/00 , C12N5/10
CPC分类号： C12N1/00 , C12N5/00
摘要：【課題】ip細胞及びES細胞等の細胞が培養可能な新規な基材を提供する。【解決手段】基板と、その表面上に形成された、以下の要件(a)および(b)を満たす構造単位並びに以下の要件(a)および(c)を満たす構造単位からなる群から選ばれる1種以上の構造単位を含む膜とを有することを特徴とする細胞培養基材。(a)下記式(21)で表される基、−N=C=S基、-COOR基、−COOH基および−COO-M基からなる群から選ばれる1種以上の基を有すること。(b)前記構造単位と、前記基板とが2つ以上の化学結合により連結していること。(c)前記構造単位と、前記基板とが1つの化学結合により連結しており、且つ、前記構造単位と、他の構造単位とが化学結合により連結していること。【選択図】なし
摘要翻译：要解决的问题：提供一种能够培养细胞如ip细胞和ES细胞的新型基质。解决方案：细胞培养基材具有基材和在表面上形成的膜，该膜包含一个或多个结构单元选自满足以下要求（a）和（b）的结构单元的组和满足以下要求（a）和（c）的结构单元：（a）选自由以下组成的组中的一个或多个基团：通过式（21），-N = C = S基团，-COOR基团，-COOH基团和-COOM基团; （b）结构单元和基板通过两个或多个化学键连接; 和（c）结构单元和基板通过一个化学键连接，并且结构单元和另一个结构单元通过化学键连接。

9. 发明专利

JP2007252277A Method for predicting carcinogenicity of tested material 有权
标题翻译：预测材料致癌性的方法
公开(公告)号：JP2007252277A
公开(公告)日：2007-10-04
申请号：JP2006081537
申请日：2006-03-23
申请人： Chemicals Evaluation & Research Institute , Mitsubishi Chemical Safety Institute Ltd , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 株式会社三菱化学安全科学研究所 , 財団法人化学物質評価研究機構
发明人： MATSUMOTO HIROSHI , YAKABE YOSHIKUNI , SAITO KOICHI , SUMITA YOSHIYO , NAKAYAMA KOJI , SEKIJIMA MASARU , SHIRAI TOMOYUKI
IPC分类号： C12Q1/68 , C12N15/09 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting the carcinogenicity of a tested material. SOLUTION: The method for predicting the carcinogenicity of the tested material includes the following first to third steps at the prediction of the carcinogenicity of the tested material, after previously preparing expression patterns by administering a carcinogen (C+M+) positive to the Ames test and a carcinogen (C+M-) negative to the Ames test to test animals, and collecting mRNAs from the test animals after a prescribed time passes: the first step for subjecting the test material to the Ames test and determining whether the test material belongs to the positive or negative in the Ames test; the second step for obtaining the expression pattern by collecting the mRNA from a test animal to which the tested material is administered; and the third step for predicting the carcinogenicity of the tested material by calculating the identity frequency with the expression pattern of the mRNA of the carcinogen positive to the Ames test when the tested material is positive to the Ames test at the first step, and with the expression pattern of the mRNA of the carcinogen negative to the Ames test when the tested material is negative to the Ames test at the first step. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种预测被测材料的致癌性的方法。
解决方案：预测测试材料的致癌性的方法包括以下第一至第三步骤，在预测测试材料的致癌性之前，先前通过将致癌物（C + M +）施用于 Ames测试和对Ames测试阴性的致癌物（C + M-）进行测试，并在规定的时间过后从测试动物收集mRNA：第一步，将测试材料进行Ames测试，并确定测试材料属于Ames测试中的正或负值; 通过从施用被测试材料的测试动物中收集mRNA获得表达模式的第二步骤; 以及第三步，通过在第一步对Ames测试测试材料为阳性时，通过计算与Ames测试阳性的致癌物质mRNA表达模式的身份频率来预测测试材料的致癌性，并与当测试材料在第一步对Ames测试为阴性时，对Ames测试阴性的致癌物的mRNA的表达模式。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2006180712A Vascular cell-specific expression promoter and its use 审中-公开
标题翻译：血管细胞特异性表达促进剂及其用途
公开(公告)号：JP2006180712A
公开(公告)日：2006-07-13
申请号：JP2004350944
申请日：2004-12-03
申请人： National Institutes Of Natural Sciences , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 大学共同利用機関法人自然科学研究機構
发明人： MOROHASHI KENICHIRO , SATO YUKO , SAITO KOICHI , FUJIMORI ISAO
IPC分类号： C12N15/09 , A01K67/027 , A61K45/00 , A61K48/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a cell-specific expression promoter, more concretely, a promoter capable of specifically expressing a polypeptide in a vascular cell and further provide an expression controlling technique, etc., for expressing an object polypeptide specifically and exclusively in a vascular cell by using the promoter. SOLUTION: The polynucleotide is composed of a base sequence positioned at 3'-region of a gene Fkh3 encoding a mouse forkhead homolog and capable of controlling the specific expression of a polypeptide in a vascular cell. A vector or a plasmid contain the polynucleotide. Transformed cell etc. are composed of them that is transduced the polynucleotide, the vector or the plasmid. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供细胞特异性表达启动子，更具体地，提供能够在血管细胞中特异性表达多肽的启动子，并进一步提供用于特异性表达目的多肽的表达控制技术等，以及仅通过使用启动子在血管细胞中。解决方案：多核苷酸由位于编码小鼠叉头同源基因的基因Fkh3的3'区的碱基序列组成，能够控制血管细胞中多肽的特异性表达。载体或质粒含有多核苷酸。转化细胞等由转染多核苷酸，载体或质粒的组成。版权所有（C）2006，JPO＆NCIPI

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