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11. 发明专利

JPH0261960B2 失效
公开(公告)号：JPH0261960B2
公开(公告)日：1990-12-21
申请号：JP14666382
申请日：1982-08-24
申请人： RIKAGAKU KENKYUSHO
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00

12. 发明专利

JPS5936691A Novel oligomannoside and its preparation 失效
标题翻译：新的寡核苷酸及其制备
公开(公告)号：JPS5936691A
公开(公告)日：1984-02-28
申请号：JP14666382
申请日：1982-08-24
申请人： Rikagaku Kenkyusho , Sapporo Breweries Ltd
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00
摘要： NEW MATERIAL:An oligomannoside shown by the formula I (R is H, or benzyl; R' is H, or acetyl; n is 1W5).
USE: Useful as an intermediate for synthesizing mannan having an antitumor activity and a reagent for elucidating biologial significance of the mannan.
PROCESS: A novel compound shown by the formula II (Bn is benzyl) as a saccharide acceptor is reacted with a novel compound shown by the formula III(Ac is acetyl; X is halogen) as a saccharide donor in the presence of both a silver salt (e.g., Ag
2 CO
3 , AgClO
4 , etc.) or a mercury salt [e.g., HgBr
2 , Hg(CN)
2 , etc.], and a dehydrohalogenating agent to give a disaccharide compound shown by the formula IV (R is H, or Ac). If necessary, this compound is deacetylated to give a compound, which as a new saccharide acceptor is reacted with the saccharide donor compound shown by the formula III, the prepared compound is deacetylated, the reaction product as a new saccharide acceptor is subjected to the repetition of the above-mentioned reactions so that the saccharide chain is extended, and, if necessary, the resultant compound is deacetylated, debenzylated to give a compound shown by the formula I .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I所示的寡甘露糖苷（R为H或苄基; R'为H或乙酰基; n为1-5）。用途：可用作合成具有抗肿瘤活性的甘露聚糖的中间体和用于阐明甘露聚糖的生物学意义的试剂。方法：作为糖受体的通式II（Bn是苄基）所示的新化合物与式III所示的新化合物（Ac是乙酰基; X是卤素）作为糖供体在存在两银的情况下反应盐（例如Ag 2 CO 3，AgClO 4等）或汞盐[例如HgBr 2，Hg（CN）2等]和脱卤化氢剂，得到式IV所示的二糖化合物（R为H，或 AC）。如果需要，该化合物脱乙酰化得到化合物，其作为新的糖受体与式III所示的糖供体化合物反应，所制备的化合物脱乙酰化，作为新糖受体的反应产物经受重复的上述反应，使得糖链延长，并且如果需要，所得化合物脱乙酰，脱苄基化，得到式I所示的化合物。

13. 发明专利

JPS57146797A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS57146797A
公开(公告)日：1982-09-10
申请号：JP3331981
申请日：1981-03-09
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , KARAKAWA TAKUROU
IPC分类号： C07H15/18 , C07H3/04 , C07H3/06 , C07H13/06 , C08B37/00
摘要： NEW MATERIAL:The compound of formulaI(R and R are H or acetyl; R is H or benzyl; R is H, benzyl or halogen; m is 0-2; n is 0-4; m+n is 2-6). USE:Intermediate for the synthesis of mannan useful as an antitumor agent. PROCESS:For example, the compound of formula II is converted to the compound of formula III by deacetylation followed by benzylation. the compound of formala III is heated in the presence of a catalyst, and then deacetylated to obtain the compound of formula IV (Bn is benzyl), which is made to react with the compound of formula V (X is halogen) and subjected to the deacetylation and debenzylation to afford the compound of formula VI (R =R H).

14. 发明专利

JPS5936690A Novel oligomannoside and its preparation 失效
标题翻译：新的寡核苷酸及其制备
公开(公告)号：JPS5936690A
公开(公告)日：1984-02-28
申请号：JP14666282
申请日：1982-08-24
申请人： Rikagaku Kenkyusho , Sapporo Breweries Ltd
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18
摘要： NEW MATERIAL:An oligomannoside shown by the formula I (R is H, or benzyl; R
1 WR
4 are H, benzyl, or acetyl).
USE: Useful as an intermediate for synthesizing mannan having an antitumor activity and a reagent for elucidating biological significance of the mannan.
PROCESS: A compound shown by the formula II (R is benzyl) is reacted with a novel saccharide donor compound shown by the formula III (Ac is acetyl; X is halogen) to give a compound, which is deacetylated, and reacted with a compound shown by the formula VI (R
1 WR
4 are acetyl, or benzyl), and, if necessary, the reaction product is deacetylated and/or debenzylated to give a compound shown by the formula I . The novel compound shown by the formula III, for example, is obtained by converting α-D-mannose into allyl α-D-mannopyranoside, tritylating the reaction product at 6-position, allylating it at 3-position, detritylating it, benzylating it 2-, 4-, and 6-positions, deallylating it, acetylating it to give a halide.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I所示的寡聚糖苷（R为H或苄基; R 1 -R 4为H，苄基或乙酰基）。用途：可用作合成具有抗肿瘤活性的甘露聚糖的中间体和用于阐明甘露聚糖的生物学意义的试剂。方法：将式II化合物（R为苄基）与式III所示的新型糖供体化合物（Ac为乙酰基; X为卤素）反应，得到脱乙酰化的化合物，并与化合物由式VI（R 1 -R 4）表示的是乙酰基或苄基），如果需要，反应产物被脱乙酰化和/或脱苄基化，得到式I所示的化合物。式III所示的新化合物，例如通过将α-D-甘露糖转化成烯丙基-α-D-吡喃甘露糖苷获得，将反应产物在6-位三苯甲基化，在3-位上烯丙基化，使其脱苄基化，使其苄化 2-，4-和6-位，脱气，乙酰化得到卤化物。

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