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11. 发明专利

JP2796925B2 失效
公开(公告)号：JP2796925B2
公开(公告)日：1998-09-10
申请号：JP23163093
申请日：1993-09-17
申请人： NITSUSHIN SEIYU KK , MEITO SANGYO KK
发明人： NEGISHI SATOSHI , SHIRASAWA SEIICHI , SUZUKI JUNKO , MURUI TAKEO , KOKUSHO SUMITAKA , TSUNODA AKIRA , OOSHIMA AKIO
IPC分类号： C12P7/62

12. 发明专利

JPH0656856A PHOSPHOLIPID DERIVATIVE 失效
公开(公告)号：JPH0656856A
公开(公告)日：1994-03-01
申请号：JP11388593
申请日：1993-04-16
申请人： MEITO SANGYO KK
发明人： KOKUSHO SUMITAKA , NAKAYAMA MINEO , TSUNODA AKIRA , KATO SHIGEAKI , MACHIDA HARUO , IWASAKI SHINJIRO
IPC分类号： A61K47/24 , B01F17/14 , B01J13/02 , C07F9/10 , C07F9/655 , C12N9/16 , C12P17/04 , C12P17/06 , C12R1/01 , C12R1/03
摘要： PURPOSE:To provide the phospholipid derivative useful as a base material for formation of a liposome, an emulsifier, a bioactive substance and its carrier, etc. CONSTITUTION:A compound of formula I [A is formula II (R1 and R2 are each a 7 to 21C fatty acid residue), etc.; A' is OH or O; C is formula III, etc.]. In addition, the compound of formula I can be obtained by reacting a phospholipid of formula IV [B is (CH2)2N (CH3)3, (CH2)2NH, etc.] with ascorbic acid or kojic acid in the presence of phospholipase D exhibiting a catalytic effect on a transfer reaction between a phospholipid and a heterocyclic alcohol.

13. 发明专利

JPH0412111B2 失效
公开(公告)号：JPH0412111B2
公开(公告)日：1992-03-03
申请号：JP20999183
申请日：1983-11-10
申请人： MEITO SANGYO KK
发明人： KOKUSHO SUMITAKA , MACHIDA HARUO , IWASAKI SHINJIRO
IPC分类号： C12P7/62 , C12P7/64

14. 发明专利

JPH028717B2 失效
公开(公告)号：JPH028717B2
公开(公告)日：1990-02-26
申请号：JP6330783
申请日：1983-04-11
申请人： MEITO SANGYO KK
发明人： KOKUSHO SUMITAKA , KATO SHIGEAKI , MACHIDA HARUO
IPC分类号： C07F9/10 , C07H11/04 , C07H15/10 , C07H19/06 , C07H19/16 , C12N9/16 , C12P7/20 , C12P9/00 , C12P13/00 , C12P13/02 , C12P17/10 , C12P17/12 , C12P17/16 , C12P19/02 , C12P19/30 , C12P19/32 , C12R1/01 , C12R1/03

15. 发明专利

JPH028716B2 失效
公开(公告)号：JPH028716B2
公开(公告)日：1990-02-26
申请号：JP6330583
申请日：1983-04-11
申请人： MEITO SANGYO KK
发明人： KOKUSHO SUMITAKA , KATO SHIGEAKI , MACHIDA HARUO
IPC分类号： C12P9/00 , C12N9/16 , C12P7/20 , C12P13/00 , C12P17/04 , C12R1/01 , C12R1/03

16. 发明专利

JPS63263092A PRODUCTION OF HALOGEN-CONTAINING HETEROCYCLIC COMPOUND 失效
公开(公告)号：JPS63263092A
公开(公告)日：1988-10-31
申请号：JP9909887
申请日：1987-04-22
申请人： MEITO SANGYO KK
发明人： KITATSUME TOMOYA , KOKUSHO SUMITAKA
IPC分类号： C12P17/14
摘要： PURPOSE:To efficiently produce an optically active halogen-containing heterocyclic compound useful as drugs and agricultural chemicals, by using a bifunctional aromatic compound as a substrate and carrying out addition reaction in an organic phase in the presence of an enzyme. CONSTITUTION:A compound shown by formula I or formula II [R is halogen- containing alkyl; R is H, (substituted) alkyl, (substituted) cycloalkyl or (substituted) aryl] and a compound shown by formula III [s is substituted group; n is 0 or positive integer; Z is group or atomic group necessary for forming aromatic ring; X and Y are -NR -, -S- or -O- (R3 is H, substituted or unsubstituted alkyl or aryl)] are subjected to addition-condensation reaction in an organic phase such as n-hexane or benzene in the presence of an enzyme, preferably a macromolecular lipase such as PL-679, PL-266 or AL at 0-50 deg.C, preferably >=25 deg.C to give the aimed compound shown by formula IV or formula V.

17. 发明专利

JPS63123389A PRODUCTION OF PHOSPHOLIPID-D-SERINE DERIVATIVE BY ENZYMATIC METHOD 失效
公开(公告)号：JPS63123389A
公开(公告)日：1988-05-27
申请号：JP26972386
申请日：1986-11-14
申请人： MEITO SANGYO KK
发明人： KOKUSHO SUMITAKA , TSUNODA AKIRA , MACHIDA HARUO , IWASAKI SHINJIRO
IPC分类号： C12P13/00 , C12P13/06
摘要： PURPOSE:To efficiently produce a phospholipid-d-serine derivative which does not exist in the natural world conventionally and whose enzymatic synthesis is unknown at all, by reacting a phospholipid with d-serine in the presence of phospholipase DM. CONSTITUTION:1mol phospholipid shown by formula I {A is group shown by formula II - formula IV [R1-R3 are OCOR11 or OR12 are aliphatic hydrocarbon group)]; A' is oxide anion or OH; B is (CH2)2NH2, CH2CH2NH(CH3), etc.} is reacted with about 1-100mol synthetic d-serine in the presence of about 10-1,000 units based on 1g phospholipid of phospholipase DM derived from Nocardiopsis No.779 strain (FERM-BP512) or Actinomadura No.362 (FERM-BP 511) by using preferably about 2-500 times as much as aqueous solution as the phospholipid by volume at 20-60 deg.C for 1-96hr to give a phospholipid d-serine derivative shown by formula V (M is H , NH3 , etc.; S is d-serine residue).

18. 发明专利

JPS6391089A PRODUCTION OF PHOSPHOLIPID DERIVATIVE BY IMMOBILIZED ENZYME METHOD 失效
公开(公告)号：JPS6391089A
公开(公告)日：1988-04-21
申请号：JP23451686
申请日：1986-10-03
申请人： MEITO SANGYO KK
发明人： TSUNODA AKIRA , KOKUSHO SUMITAKA , MACHIDA HARUO , IWASAKI SHINJIRO
IPC分类号： C12P7/62 , C12P17/16 , C12P19/00 , C12P19/02
摘要： PURPOSE:To efficiently produce a phospholipid derivative, by bringing a phospholipid and alcoholic OH compound into contact with entrapped and immobilized phospholipase D or DM in the presence of water. CONSTITUTION:Phospholipase D or DM produced by the genera Nocardiopsis No.779 strain (FERM-BP-512), etc., are adsorbed on the surface of a solid support such as an activated charcoal, zeolite, etc., to provide entrapped and immobilized phospholipase D or DM. Then, 1mol phospholipid (e.g. lecithin) and 1-100mol alcoholic OH group-containing compound (e.g. ethanol) are brought into contact with 1-1,000 units of the entrapped and immobilized phospholipase D or DM per 1g phospholipid in the presence (or absence) of salts (e.g. sodium oxalate) and/or an organic solvent (e.g. benzene) in the presence of water at 20-60 deg.C for 1-96hr.

19. 发明专利

JPS62104589A PRODUCTION OF FATTY ACID ESTER 失效
公开(公告)号：JPS62104589A
公开(公告)日：1987-05-15
申请号：JP23753785
申请日：1985-10-25
申请人： MEITO SANGYO KK
发明人： KOKUSHO SUMITAKA , TSUNODA AKIRA , MACHIDA HARUO , IWASAKI SHINJIRO
IPC分类号： C12P7/62
摘要： PURPOSE:To readily obtain the titled ester with a high ultimate synthesis ratio at a low cost, by dehydrating a mixture of a substituted or unsubstituted alcohol having one or more hydroxyl groups with a saturated or unsaturated fatty acid in the presence of an organic solvent and reacting the dehydrated mixture with a microbial alkaline lipase. CONSTITUTION:A mixture of 1mol alcohol, e.g. alcohol having one hydroxyl group such as 1-30C aliphatic primary alcohol, 2-20C aliphatic secondary alcohol or 4-10C alicyclic alcohol (which may have a substituent group, e.g. amino, halogen, phenyl, pyridyl, etc.) or a substituted or unsubstituted alcohol having >=2 hydroxyl groups such as >=2C aliphatic polyhydric alcohol except propylene glycol, (poly)glycerol and sugar (alcohol) or 4-10C alicyclic polyhydric alcohol with (B) 0.01-100mol 2-22C (un)saturated fatty acid which may have a substituent group, e.g. OH, COOH or C6H5, etc., is dehydrated in the presence of 1-99wt%, based on the reaction system, organic solvent without adding water to give

20. 发明专利

JPS6188886A Preparation of phospholipid long-chain alcohol derivative by enzymatic process 失效
标题翻译：通过酶法制备磷脂长链醇衍生物
公开(公告)号：JPS6188886A
公开(公告)日：1986-05-07
申请号：JP20993184
申请日：1984-10-08
申请人： Meito Sangyo Kk
发明人： KOKUSHO SUMITAKA , NAKAYAMA MINEO , TSUNODA AKIRA , KATO SHIGEAKI , MACHIDA HARUO , IWASAKI SHINJIRO
IPC分类号： C07F9/10 , A61K9/127 , C12P7/02 , C12P7/40 , C12P7/62 , C12P9/00 , C12P13/00 , C12P13/02
CPC分类号： A61K9/1271
摘要： PURPOSE: To obtain the titled phospholipid alcohol derivative such as phospholipid polyethylene glycol derivative, in high yield, by reacting a phospholipid with an alcohol in the presence of a phospholipase DM at specific temperature and pH.
CONSTITUTION: A phospholipid of formula I {A is group of formula II or formu la III [R
1 and R
2 or -O-COR
11 or -O-R
12 (R
11 and R
12 are 1W21C aliphatic hydro carbon residue)]; A' is oxide anion or OH; B is -(CH
2 )
2 N
+ (CH
3 )
3 , -(CH
2 )
2 NH
2 , etc.} is made to react with an alcohol compound at 60W70°C and about 7pH in the presence of a phospholipase DM. The alcoholic compound is a primary alcohol having ≥27C aliphatic or aromatic hydrocarbon residue (which may have substituent group such as halogen or an ether bond, etc. in the molecule) or a secondary alcohol compound having ≥11C alkyl residue which may be substituted with halogen, amino, etc.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过在磷脂酶DM的存在下，在特定温度和pH下使磷脂与醇反应，以高产率获得标题磷脂醇衍生物如磷脂聚乙二醇衍生物。构型：式I的磷脂（A是式II或式IIIIII的基团[R1和R2或-O-COR11或-O-R12（R11和R12是1-21C脂肪族氢碳残基）]; A'是氧化物阴离子或OH; 在磷脂酶DM存在下，B为 - （CH 2）2 N +（CH 3）3， - （CH 2）2 NH 2等）与醇化合物在60-70℃和约7pH反应。醇化合物是具有> = 27C脂族或芳族烃残基（其分子中可具有取代基如卤素或醚键等）的伯醇或具有> = 11C烷基残基的仲醇化合物，其可以是被卤素，氨基等取代

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