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11. 发明专利

JP2007222120A Automatic culturing apparatus 有权
标题翻译：自动文化设备
公开(公告)号：JP2007222120A
公开(公告)日：2007-09-06
申请号：JP2006049601
申请日：2006-02-27
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： SUZUKI TSUTOMU , IESHIMA DAISUKE
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M41/36 , C12M29/26 , C12M41/48
摘要： PROBLEM TO BE SOLVED: To provide an automatic culturing apparatus capable of smoothly carrying out injection and discharge of chemicals, etc., even when forming an incubator in a sealing structure and capable of avoiding problems of contamination. SOLUTION: The automatic culturing apparatus is equipped with an incubator 1 stored in a thermostatic chamber 3 retained in culturing environment, a plurality of chemical containers 5, 7 and 9 in which a plurality of chemicals are each stored, a feed pump 35 for feeding chemicals through a pipe line 29 made to communicate with the incubator 1 to the incubator 1 and a discharge pump 61 for discharging a liquid in the incubator 1 through a pipe line 59 made to communicate with the incubator 1. The incubator 1 is formed in sealed state and equipped with a nozzle 69 to which a discharge pipe line 29 of the feed pump 35 is connected, a nozzle 71 to which a suction pipe line 59 of the discharge pump 61 is connected and a nozzle 73 opened in the thermostatic chamber 3, and a suction filter 81 and a discharge filter 77 are each provided through pinch valves 87 and 85 in the open end of the nozzle 73. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：即使在密封结构中形成培养箱并且能够避免污染问题的同时，提供能够平稳地进行化学品等的喷射和排出的自动培养装置。解决方案：自动培养装置配备有储存在保存在培养环境的恒温槽3中的培养箱1，多个储存有多种化学物质的多个化学容器5,7和9，进料泵35 用于通过与孵化器1连通的管路29将化学品送入培养箱1;以及排出泵61，用于通过与培养箱1连通的管道59排出培养箱1中的液体。形成培养箱1 在密封状态下配备有供给泵35的排出管路29连接的喷嘴69，排出泵61的吸入管路59连接的喷嘴71和在恒温室内开口的喷嘴73 在喷嘴73的开口端分别通过夹管阀87和85设置吸入过滤器81和排出过滤器77.（C）2007，JPO＆INPIT

12. 发明专利

JP2006141328A Culturing container and culturing device 审中-公开
标题翻译：文化集装箱和文化设备
公开(公告)号：JP2006141328A
公开(公告)日：2006-06-08
申请号：JP2004338039
申请日：2004-11-22
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： SUZUKI TSUTOMU , TACHIKUI HIROSHI
IPC分类号： C12M3/00
CPC分类号： C12M23/10 , C12M23/38 , C12M27/16 , C12M29/00
摘要： PROBLEM TO BE SOLVED: To reduce the risks of contamination in culturing and cross contamination between the containers. SOLUTION: This culturing container main body is constituted so as to culture cells along a horizontal surface. A lid member closing an opening part of the culturing container main body and equipped with at least 2 port parts at the peripheral edge part of the culturing container main body is installed. At one of the port parts installed at the lid member, a tubular member protruding so as to touch its tip end part with an inside bottom surface part of the culturing container main body is installed. Liquid at the inside of the culturing container main body is sucked through the tubular member, and also by relatively lifting up one side of the container main body without having the tubular member, the liquid in the culturing container main body becomes to be sucked easier. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：减少容器间培养和交叉污染的污染风险。解决方案：该培养容器主体构成为沿水平面培养细胞。安装关闭培养容器主体的开口部并且在培养容器主体的周缘部配置有至少2个口部的盖构件。在安装在盖构件上的一个端口部分中，安装有以与培养容器主体的内底面部分相接触其顶端部分的管状构件。培养容器主体内侧的液体通过管状部件被吸入，也可以通过相对提升容器主体的一侧而不需要管状部件，使培养容器主体内的液体变得容易吸引。版权所有（C）2006，JPO＆NCIPI

13. 发明专利

JP2005295969A Cellular segregation device 审中-公开
标题翻译：细胞分离装置
公开(公告)号：JP2005295969A
公开(公告)日：2005-10-27
申请号：JP2004121250
申请日：2004-04-16
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： TACHIKUI HIROSHI , SUZUKI TSUTOMU , KOMORI YOSHIHIRO , MIYAUCHI AKIHIRO , KUWABARA KOSUKE
IPC分类号： C12M1/00 , B01D43/00
CPC分类号： C12M47/04 , C12M25/00 , C12M33/00
摘要： PROBLEM TO BE SOLVED: To provide a cellular segregation device capable of reducing the occurrence of contamination in the segregation operation to be carried out for several times.
SOLUTION: This cellular segregation device is constituted of two or more cellular segregation chambers 1, 3 for storing a cell-containing liquid containing different two or more kinds of cells, and segregating a target cell from the cells contained in the cell-containing liquid, transfer passages 5 for transferring the cells between two or more cellular segregation chambers, injection passages 7, 17 formed in each of the cellular segregation chambers 1, 3, and for injecting the liquid to the cellular segregation chambers, and deriving passages 9, 19, 21 for deriving the liquid in the cellular segregation chambers 1, 3. The cellular segregation chambers 1, 3 have attaching parts 35, 37 for attaching a cell having an adhesive properties or a cell having the adhesive properties stronger than those of other cells in the cells contained in the stored cell-containing liquid, and the transfer passage 5 is constituted so as to have a transfer passage-opening and closing means 5a for opening and closing the transfer passage 5.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决的问题：提供一种能够减少分离操作中污染发生多次的细胞分离装置。解决方案：该细胞分离装置由两个或多个细胞分离室1,3构成，用于储存含有不同的两种或更多种细胞的含细胞液体，并将靶细胞与细胞内含有的细胞分离，用于在两个或多个细胞分离室之间转移细胞的转移通道5，在每个细胞分离室1,3中形成的注射通道7,17和用于将液体注入细胞分离室，以及导出通道9 ，19,21，用于导出细胞分离室1,3中的液体。细胞分离室1,3具有用于附着具有粘合性的细胞的附着部分35,37或具有比其它粘合性更强的粘合性的细胞包含在储存的含细胞液体中的细胞中的细胞，并且传送通道5构成为具有用于打开的传送通道 - 开闭装置5a 并关闭转运通道5.版权所有（C）2006，JPO＆NCIPI

14. 发明专利

JP2005218404A Cell culture apparatus 审中-公开
标题翻译：细胞培养装置
公开(公告)号：JP2005218404A
公开(公告)日：2005-08-18
申请号：JP2004031892
申请日：2004-02-09
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： WATABE SHIGEO , MATSUZAWA MITSUHIRO , SUZUKI TSUTOMU
IPC分类号： C12M1/10 , C12M3/00
摘要： PROBLEM TO BE SOLVED: To provide a cell culture vessel for culturing adhesion-dependent cells automatically without relying on hand work despite of easy simple structure, and provide a cell culture apparatus using the same.
SOLUTION: This cell culture apparatus is equipped with a disk (2000) that is driven with a motor to rotate around the rotation axis, one or more of the primary culture vessels (2100a to d) that are fixed to the disk and are formed on the prescribed radial position to the rotation axis, a plurality of secondary culture vessels (2200a to d, 2201a to d, 2202a to d, 2203a to d) that are formed more outer than the primary culture vessels (2100a to d) and a plurality of flow channels that start from the primary culture vessel, branch at the branching points (2180a to d) on the outer sides in the radial direction and connect to at least two or more of the secondary culture vessels.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种细胞培养容器，用于自动培养粘附依赖性细胞，而不依赖于手工制作，尽管结构简单，并提供使用该细胞培养装置的细胞培养装置。解决方案：该细胞培养装置配备有用马达驱动以绕旋转轴线旋转的盘（2000），固定到盘的一个或多个主培养容器（2100a至d）形成在与旋转轴线相关的规定的径向位置上，形成为比主培养容器（2100a〜d）更外侧的多个第二培养容器（2200a〜d，2201a〜d，2202a〜d，2203a〜d）以及从初级培养容器开始的多个流路，在径向外侧的分支点（2180a〜d）处分支，并与至少两个以上的二次培养容器连接。版权所有（C）2005，JPO＆NCIPI

15. 发明专利

JP2007295827A Automatic culturing device 审中-公开
标题翻译：自动文化装置
公开(公告)号：JP2007295827A
公开(公告)日：2007-11-15
申请号：JP2006125317
申请日：2006-04-28
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： SUZUKI TSUTOMU , IESHIMA DAISUKE
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： C12M41/48 , C12M23/00 , C12M29/26 , C12M41/14
摘要： PROBLEM TO BE SOLVED: To improve the traceability of a culturing equipment used in an automatic culturing device. SOLUTION: This automatic culturing device is constituted by being equipped with a multiple number of culturing equipment 21 to 24 and 40 including a culturing tool 1 used for cell culture, a reading means 46 for reading a discrimination label attached to at least one of the culturing equipment and a memory means for memorizing the discriminating label read by the reading means as associated with the information related to the cultured cells, and therefore, in the case that there occurs any inconvenience in the cells after the culture, it becomes possible to investigate whether the presence of the inconvenience is in the culturing equipment such as the culturing tool, etc., or not. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提高自动培养装置中使用的培养设备的追溯性。解决方案：该自动培养装置由多个培养装置21至24和40构成，包括用于细胞培养的培养工具1，读取装置46，用于读取附于至少一个的鉴别标签的培养装置和用于记忆由阅读装置读取的识别标签与记录与培养细胞有关的信息的记忆装置，因此，在培养后细胞发生任何不便的情况下，以调查是否存在不便之处在培养设备如培养工具等中。版权所有（C）2008，JPO＆INPIT

16. 发明专利

JP2007110996A Cell culture container and cell culture device 审中-公开
标题翻译：细胞培养容器和细胞培养装置
公开(公告)号：JP2007110996A
公开(公告)日：2007-05-10
申请号：JP2005307405
申请日：2005-10-21
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： MATSUZAWA MITSUHIRO , MOMOI YASUYUKI , TOGASHI MORINORI , ISHIKAWA MASANORI , SUZUKI TSUTOMU
IPC分类号： C12M3/00
CPC分类号： C12M23/50 , C12M23/10 , C12M23/34 , C12M29/00
摘要： PROBLEM TO BE SOLVED: To provide a means which can suppress the loss of cells and stresses given to the cells and can carry out the successive operations of culture containers by a simple method.
SOLUTION: This cell culture container has a primary culture container having a relatively small culture surface and a secondary culture container having a relatively large culture surface. The cell culture container is inclined to transfer a solution in the primary culture container to the secondary culture container. The present cell culture container further has a third culture container having a larger culture surface, and the cell culture container is inclined to transfer a solution in the secondary culture container to the third culture container.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供能够抑制细胞损失和赋予细胞的应力的手段，并且可以通过简单的方法进行培养容器的连续操作。解决方案：该细胞培养容器具有培养面较小的原代培养容器和培养面较大的二次培养容器。细胞培养容器倾向于将初级培养容器中的溶液转移到第二培养容器。本细胞培养容器还具有培养面较大的第三培养容器，细胞培养容器倾向于将第二培养容器中的溶液转移至第三培养容器。版权所有（C）2007，JPO＆INPIT

17. 发明专利

JP2006288311A Monitoring system for cultivation vessel 审中-公开
标题翻译：培养船舶监测系统
公开(公告)号：JP2006288311A
公开(公告)日：2006-10-26
申请号：JP2005115294
申请日：2005-04-13
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： TACHIKUI HIROSHI , SUZUKI TSUTOMU
IPC分类号： C12M1/00
CPC分类号： C12M41/40
摘要： PROBLEM TO BE SOLVED: To provide a monitoring system for cultivation vessel that can confirm the shut tightness of the culture system.
SOLUTION: This culture vessel-monitoring system is equipped with a means for measuring the shut tightness of the whole culture vessel system comprising the reagent vessel, the cultivation vessel and the waste fluid vessel at discontinuous different time and the measurement of shut tightness of the whole vessel system is carried out at least once. The measurement is carried out by measuring the amount of the air injected into the vessels and these operations are backed up with a pressure sensor set at the culture apparatus and with the gas charging.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供可以确认培养系统的紧密性的栽培容器的监测系统。解决方案：该培养容器监测系统配备有用于测量不连续不同时间的包括试剂容器，培养容器和废液容器的整个培养容器系统的闭合性的装置，并且关闭密封度的测量的整个船舶系统至少进行一次。通过测量注入容器的空气量进行测量，并且用设置在培养装置处的压力传感器和气体充注来备份测量。版权所有（C）2007，JPO＆INPIT

18. 发明专利

JP2005295818A Device for culturing cell 有权
标题翻译：文化细胞装置
公开(公告)号：JP2005295818A
公开(公告)日：2005-10-27
申请号：JP2004112792
申请日：2004-04-07
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO , SUZUKI TSUTOMU
IPC分类号： C12M1/00 , C12M1/34
CPC分类号： C12M41/36
摘要： PROBLEM TO BE SOLVED: To provide a device for culturing cells, capable of minutely observing the cultured state of the cells in an optional colony in performing the cell culture, and also easily recognizing the presence or absence of the colony of the cultured cells and its size by the scanning of a camera and an image-processing by keeping the use of a highly magnifying lens and the camera for observing the details in the cultured state without performing the exchanging work of the lenses.
SOLUTION: This device for culturing cells, having a flat plane-formed culturing container for culturing the cells, an image-taking device having its optical axis in the direction of crossing at right angle with the plane and a narrower sight range than the surface of the culturing device and a driving means for relatively moving at least one of the culturing device surface and the image-taking device while maintaining a state that the culturing device surface crosses the optical axis of the image-taking device at the right angle is provided with that, when the driving means moves relatively to the surface part of the culturing device which is not under the sight range of the image-taking device so as to enter the sight range, the image-taking device takes the photographs of the culturing device surface.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种培养细胞的装置，其能够在进行细胞培养时细小地观察可选菌落中的细胞的培养状态，并且还容易识别培养的菌落的存在或不存在通过使用高度放大的镜头和相机来观察细节，在不执行透镜的交换的情况下，通过相机的扫描和图像处理来进行细胞的尺寸和图像处理。解决方案：这种用于培养细胞的装置，具有用于培养细胞的平面形成培养容器，其光轴在与平面成直角交叉的方向上的摄像装置，并且视线范围比培养装置的表面和用于相对移动培养装置表面和摄像装置中的至少一个的驱动装置，同时保持培养装置表面与摄像装置的光轴成直角的状态设置有，当驱动装置相对于不在摄像装置的视野范围内的培养装置的表面部分移动以进入视线范围时，拍摄装置拍摄照片培养装置表面。版权所有（C）2006，JPO＆NCIPI

19. 发明专利

JP2004121717A X-ray ct apparatus 审中-公开
标题翻译： X射线CT装置
公开(公告)号：JP2004121717A
公开(公告)日：2004-04-22
申请号：JP2002293403
申请日：2002-10-07
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： SUZUKI TSUTOMU , ISOJIMA NORIYUKI , MATSUI NOBUHIKO
IPC分类号： A61B6/03
摘要： PROBLEM TO BE SOLVED: To provide an X-ray CT apparatus having a cooling structure to keep the temperature of an X-ray detector to be not more than a prescribed value even when an heat generation amount in a mount is increased.
SOLUTION: The X-ray CT apparatus includes: a rotary member 10 to be rotated around the subject 1 by mounting an X-ray tube 3, a cooler 5, the X-ray detector 4, a high voltage generator, etc. so as to surround the outer periphery of an opening 39 where a subject 1 is inserted; a mount 14 for storing the rotary member 10, and comprising an outer air intake port 21 and a cooling fan 15 for radiating heat to an outer part; and a bed 2 on which the subject 1 is laid. A duct 17 for introducing the outer air is arranged on the inner peripheral surface of the rotary member 10. The passage surface of the X-ray detector 4 in a rotation state is positioned between the rotary center axis of the rotary member and the inlet of the duct 17. The duct main body 17 is arranged at the inner surface side of a rack front surface cover fixing part 19, and the duct inlet is at the front side of the rack front surface cover fixing part 19.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：即使当安装座中的发热量增加时，提供具有将X射线检测器的温度保持在规定值以下的冷却结构的X射线CT装置。解决方案：X射线CT装置包括：通过安装X射线管3，冷却器5，X射线检测器4，高压发生器等，围绕被检体1旋转的旋转部件10 围绕被检体1插入的开口39的外周; 用于存储旋转构件10的安装件14，并且包括用于向外部散热的外部空气吸入口21和冷却风扇15; 以及铺设被检体1的床2。用于引入外部空气的管道17布置在旋转构件10的内周面上.X旋转状态的X射线检测器4的通过面位于旋转构件的旋转中心轴线和旋转构件的入口之间管道主体17布置在齿条前表面盖固定部分19的内表面侧，导管入口位于齿条前表面盖固定部分19的前侧。版权所有：（C）2004，JPO

20. 发明专利

JP2004016194A Cell culture apparatus 审中-公开
标题翻译：细胞培养装置
公开(公告)号：JP2004016194A
公开(公告)日：2004-01-22
申请号：JP2002180120
申请日：2002-06-20
申请人： Hitachi Medical Corp , Minoru Ueda , 上田実 , 株式会社日立メディコ
发明人： SUZUKI TSUTOMU , UEDA MINORU
IPC分类号： C12M3/00
CPC分类号： C12M23/50 , C12M41/14 , C12M41/36 , C12M41/46
摘要： PROBLEM TO BE SOLVED: To provide a cell culture apparatus, further improving the working property of a subculture.
SOLUTION: This cell culture apparatus is equipped with a culturing means 15 housing at least one culturing container 1 of which inner environment can be adjustable, containing a medium inoculated with cells and performing the cell culture, a medium-exchanging means 9 for performing an exchange of the medium in the culturing apparatus 1, a cell state-measuring means 5 for measuring the state of the cells in the culturing apparatus 1, a cell-inoculation means 11 for inoculating the cells cultured by the culturing means 15 in the culturing apparatus 1 to another medium not inoculated with the cells, a conveying means for conveying the culturing apparatus 1 and a box body 17 housing the culturing means 15, medium-exchanging means 9, cell state-measuring means 5, cell-inoculating means 11 and conveying means 6, and formed as air tight. The box body 17 has at least one opening and closing parts 19a, 19b and the conveying means 6 is constituted for conveying the culturing container 1 at least between the opening and closing parts 19a, 19b and the cell-inoculating means 11.
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：为了提供细胞培养装置，进一步提高亚培养物的加工性能。解决方案：该细胞培养装置装备有容纳至少一个可以调节内部环境的培养容器1的培养装置15，其中含有接种细胞的培养基并进行细胞培养，介质交换装置9用于在培养装置1中进行培养基的交换，用于测定培养装置1中的细胞的状态的细胞状态测定装置5，将由培养装置15培养的细胞接种在培养装置1中的细胞接种装置11 培养装置1到没有接种细胞的另一培养基，用于输送培养装置1的输送装置和容纳培养装置15的箱体17，中等交换装置9，细胞状态测定装置5，细胞接种装置11 和输送装置6，并形成为气密的。盒体17具有至少一个开闭部分19a，19b，输送装置6构成用于至少在打开和关闭部分19a，19b和细胞接种装置11之间输送培养容器1。版权所有（C）2004，JPO

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