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11. 发明专利

JP2008249444A Mass spectrometry data analysis method 有权
标题翻译：质谱分析数据分析方法
公开(公告)号：JP2008249444A
公开(公告)日：2008-10-16
申请号：JP2007090129
申请日：2007-03-30
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： KOBAYASHI NORIKO , YOSHIOKA SHINJI , MOCHIZUKI KOHEI
IPC分类号： G01N27/62
摘要： PROBLEM TO BE SOLVED: To acquire data having higher reliability by performing re-determination of a valence number of MS
n+1 (n is an integer under the condition of n≥1) spectrums and MS
n spectrums, whereas, concerning mass spectrometry acquired data, in a domain wherein MS
n spectrums originated in a plurality of components are intermingled adjacently, there is a probability of performing simultaneously MS
n+1 analysis of the adjacent MS
n spectrums, and determination of the valence number becomes sometimes complicated.
SOLUTION: A domain wherein MS
n+1 spectrums are intermingled adjacently is extracted, and a domain wherein re-determination of the valence number is performed is determined. Then, each spectrum intensity in a prescribed extracted interminglement domain is listed in each scan, and spectrum intensity fluctuation between lists in each scan is calculated, and each spectrum group fluctuating in the same way is grouped. Analysis of mass spectrometry data including a step for performing re-determination of the valence number is performed based on the grouped data.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过重新确定MS n + 1 的价数（n是n≥1的整数）频谱，获得具有较高可靠性的数据，以及 MS n 光谱，而关于质谱采集数据，在其中源自多个分量的MS中的MS 光谱相互相互混合的域中，存在同时执行的概率相邻MS n 光谱的MS n + 1 分析，并且价数的确定有时变得复杂。解决方案：提取其中MS n + 1个频谱相邻的域，并确定执行价数的重新确定的域。然后，在每个扫描中列出规定的提取的混合域中的每个频谱强度，并且计算每个扫描中的列表之间的频谱强度波动，并且以相同的方式对每个频谱组进行波动分组。基于分组数据进行包括执行价数重新确定步骤的质谱数据的分析。版权所有（C）2009，JPO＆INPIT

12. 发明专利

JP2005055370A Liquid chromatograph mass-spectrometric analytical data analyzer 审中-公开
标题翻译：液相色谱质谱分析数据分析仪
公开(公告)号：JP2005055370A
公开(公告)日：2005-03-03
申请号：JP2003288220
申请日：2003-08-06
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , SHIZUKUISHI KENICHI
IPC分类号： G01N27/62 , G01N30/72 , G01N30/86
摘要： PROBLEM TO BE SOLVED: To provide a mass-spectrometric analytical data analyzer for enhancing reliability for determining a molecular ion peak in an estimated sample or objective component by a liquid chromatograph mass spectrometer.
SOLUTION: A detectable ion peak mass number is calculated based on an ion source species used for ionization in steps 100-102, polarity and a mobile phase solvent species, and the presence of consistent ion within a storage measured data is retrieved in a step 103. Returning to the step 100 is carried out when no consistent peak exists. When the consistent peak exists, a mass chromatogram data is computed by the mass number of the consistent ion peak in a step 104, the peak is determined in a step 105, and peak detection is determined when a fixed value or more of peak intensity is found with respect to a base line noise value of the chromatogram. Returning to the step 100 is carried out when no peak is determined in the step 105. When the peak is determined in the step 105, it is stored as a report together with a mass spectrometric data in steps 106, 107.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种质谱分析数据分析仪，用于提高通过液相色谱质谱仪测定估计样品或目标成分中的分子离子峰的可靠性。解决方案：基于在步骤100-102，极性和流动相溶剂种类中用于电离的离子源种类计算可检测的离子峰质量数，并且在存储中测量数据中存在一致的离子返回到步骤100，当没有一致的峰值时，进行步骤100。当存在一致的峰时，通过步骤104中一致的离子峰的质量数计算质谱图数据，在步骤105中确定峰，并且当峰强度的固定值或更高的峰值强度为发现相对于色谱图的基线噪声值。当在步骤105中没有确定峰值时，执行步骤100.当在步骤105中确定峰值时，在步骤106,107中将其作为报告与质谱数据一起存储。COPYRIGHT （C）2005，JPO＆NCIPI

13. 发明专利

JP2010032227A Mass analyzer and mass analyzing method 有权
标题翻译：质量分析仪和质量分析方法
公开(公告)号：JP2010032227A
公开(公告)日：2010-02-12
申请号：JP2008191580
申请日：2008-07-25
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , TAKEDA AKIHIRO , SHISHIKA TSUKASA
IPC分类号： G01N27/64 , H01J49/06 , H01J49/40 , H01J49/42
CPC分类号： H01J49/0054
摘要： PROBLEM TO BE SOLVED: To provide a mass analyzer increased in the number of the peaks of detectable fragment ions and using electron capture dissociation. SOLUTION: The mass analyzer is equipped with an ion source 2 for forming ions from a sample, an ion trapping part 3 for performing the accumulation and selection of the ions, an ion dissociation part 4 for performing the electron capture dissociation of the ions and a flight time mass analyzing part 7 for performing the mass analysis of the ions. The reaction time of electron capture dissociation is variable according to the valency of the ions subjected to mass analysis. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供质量分析仪增加可检测的碎片离子的峰的数量并使用电子俘获解离。质量分析仪配备有用于从样品形成离子的离子源2，用于进行离子的积聚和选择的离子捕获部分3，用于进行离子的电子俘获解离的离子解离部分4 离子和飞行时间质量分析部分7进行离子的质量分析。电子俘获解离的反应时间根据进行质量分析的离子的化合价而变化。版权所有（C）2010，JPO＆INPIT

14. 发明专利

JP2009031201A Liquid chromatography/mass spectrometer 有权
标题翻译：液相色谱/质谱仪
公开(公告)号：JP2009031201A
公开(公告)日：2009-02-12
申请号：JP2007197500
申请日：2007-07-30
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , MOCHIZUKI KOHEI
IPC分类号： G01N27/62 , G01N30/04 , G01N30/24 , G01N30/34 , G01N30/72 , H01J49/32 , H01J49/38 , H01J49/40
摘要： PROBLEM TO BE SOLVED: To solve the problem that it is difficult to introduce an interior standard sample and to perform mass calibration because a plurality of sample components are continuously introduced to the mass spectrometer in a short time when a mass spectrometer is connected to a liquid chromatograph.
SOLUTION: The precision mass number measurement of ions uses a mass analysis method combined with a mass spectrometer which, as an analysis means for separating objective components in a sample, ionizes sample components separated from the liquid chromatograph and obtains mass spectra of corresponding components continuously. In this measurement, the invention includes the steps of mixing the interior standard sample with a known mass number for performing the mass calibration in a mobile phase solvent by a liquid feed pump of the liquid chromatograph, introducing it to the mass spectrometer continuously or intermittently, referencing the mass spectrum derived from the interior standard sample, and performing the mass calibration of the mass spectra of the corresponding objective components by the interior standard method.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了解决难以引入内部标准样品并进行质量校准的问题，因为当连接质谱仪时，在短时间内将多个样品组分连续引入质谱仪到液相色谱仪。解决方案：离子的精密质量数测量采用与质谱联用的质量分析方法，作为分析样品中的目标成分的分析手段，将与液相色谱仪分离的样品成分离子化，得到相应的质谱图组件不断。在该测定中，本发明包括将内标样品与已知质量数混合的步骤，用于通过液相色谱仪的液体进料泵在流动相溶剂中进行质量校准，将其连续或间歇地引入质谱仪，参考从内部标准样品得到的质谱，并通过内部标准方法对相应的目标成分的质谱进行质量校准。版权所有（C）2009，JPO＆INPIT

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