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11. 发明专利

JP2009080010A Mass analyzing system 有权
标题翻译：质量分析系统
公开(公告)号：JP2009080010A
公开(公告)日：2009-04-16
申请号：JP2007249572
申请日：2007-09-26
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： MORISHIMA DAISUKE , SHISHIKA TSUKASA , NISHIDA TETSUYA , KUROSAWA TOMOYUKI
IPC分类号： G01N27/62 , H01J49/04 , H01J49/26
摘要： PROBLEM TO BE SOLVED: To enhance quantitative reliability by discriminating mass spectrum data especially lowered in the reliability of a quantitative result by the effect of ion suppression in the mass spectrum data.
SOLUTION: This mass analyzing system includes a separation means for separating a sample so that the spectra of components are arranged in the elapse order of time and a mass analyzing means for analyzing the components of the respective spectra so that the spectra are arranged in the order of a mass-to-charge ratio (M/Z) and has the function of selecting the peak of the constant mass-to-charge ratio present in the respective spectra from the analyzing data of all of mass spectra reaching the whole of spectra, the function of calculating the statistical index of the peak in the analyzing data of the respective spectra from the analyzing data of all of the mass spectra and the function of determining the quantitative reliability of the analyzing data of the respective spectra using the statistical index as a decision standard.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过在质谱数据中通过离子抑制的作用，通过区分质谱数据特别降低定量结果的可靠性来提高定量可靠性。解决方案：该质量分析系统包括分离装置，用于分离样品，使得组分的光谱按时间排列;以及质量分析装置，用于分析各个光谱的分量，使得光谱布置按质量比（M / Z）的顺序，并且具有从所有质谱的分析数据到达整个数据的各个光谱中选择存在的恒定质荷比的峰值的功能的光谱，从所有质谱的分析数据计算各光谱分析数据中峰的统计指标的功能以及使用统计学方法确定各光谱分析数据的定量可靠性的功能指标作为决策标准。版权所有（C）2009，JPO＆INPIT

12. 发明专利

JP2006236795A Mass spectroscope and mass spectrometry 有权
标题翻译：质谱和质谱
公开(公告)号：JP2006236795A
公开(公告)日：2006-09-07
申请号：JP2005050102
申请日：2005-02-25
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： ONISHI FUJIO , SHINPO KENICHI , ORIHASHI RITSURO , TERUI YASUSHI , SHISHIKA TSUKASA
IPC分类号： H01J49/40 , G01N27/62
CPC分类号： H01J49/0036 , H01J49/40
摘要： PROBLEM TO BE SOLVED: To reduce a data transfer time and to remove noise data at the same time in a data processing function of an ADC method in a time-of-flight mass spectroscope; and to provide a mass spectroscopy technique capable of improving analysis efficiency.
SOLUTION: A data collection circuit 5 in this mass spectroscope includes: an A/D converter 51; a signal integration memory 53 for executing the storing and integrating processes of data of predetermined time range and measurement number of ion signals; a voltage value frequency integration memory 54 for integrating and storing the frequencies of voltage values of predetermined time range and measured number in parallel with it; a threshold value calculation circuit 56 for calculating a predetermined threshold value from the storage result of the memory; a compression memory 55 for extracting only data above the threshold value within the data stored in the signal integration memory; and a counter 52 for controlling a measurement time of data collection and the operation of each circuit.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：在飞行时间质谱仪中的ADC方法的数据处理功能中同时减少数据传送时间和消除噪声数据; 并提供能够提高分析效率的质谱技术。解决方案：该质谱仪中的数据采集电路5包括：A / D转换器51; 用于执行预定时间范围的数据和离子信号的测量数量的存储和积分处理的信号积分存储器53; 电压值频率积分存储器54，用于对预定时间范围和测量数字的电压值的频率进行积分和存储; 阈值计算电路56，用于根据存储器的存储结果计算预定阈值; 压缩存储器55，用于仅在存储在信号积分存储器中的数据中提取高于阈值的数据; 以及用于控制数据采集的测量时间和每个电路的操作的计数器52。版权所有（C）2006，JPO＆NCIPI

13. 发明专利

JP2005353428A Ion trap/time of flight mass spectrometer and mass spectrometry 有权
标题翻译：离子捕捉/飞行时间质谱仪和大质量分光光度计
公开(公告)号：JP2005353428A
公开(公告)日：2005-12-22
申请号：JP2004173340
申请日：2004-06-11
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： TERUI YASUSHI , OKUMOTO TOYOJI , SHISHIKA TSUKASA , NAGAI SHINJI , TOMIOKA MASARU
IPC分类号： G01N27/62 , B01D59/44 , H01J49/40 , H01J49/42
CPC分类号： H01J49/424 , H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/40 , H01J49/427
摘要： PROBLEM TO BE SOLVED: To provide an ion trap TOF/MS enabling an observation output correction of the ion trap and the TOF. SOLUTION: Sample ion with a known mass number ionized by an ion source is trapped by the ion trap, a subsidiary alternate current voltage having a frequency component ω is impressed on an end-cap electrode of the ion trap to exhaust unnecessary ion inside the ion trap, and the ion remaining inside the ion trap is exhausted by impressing direct current voltage on a ring electrode and the end-cap electrode to carry out a measurement treatment measuring with the time-of-flight mass spectrometer. By repeating the measurement treatment by varying the frequency component ω and comparing a signal strength measured by the time-of-flight mass spectrometer with a pre-recorded threshold value, correction of the frequency component is carried out against the ion of the known mass number. In doing so, the observation mass correction of the TOF and the ion trap can be carried out. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够进行离子阱和TOF的观察输出校正的离子阱TOF / MS。解决方案：通过离子源离子化已知质量数的样品离子被离子阱捕获，具有频率分量ω的辅助交流电压施加在离子阱的端盖电极上以排出不必要的离子离子阱内部留下的离子通过施加环状电极和端盖电极上的直流电压来进行利用飞行时间质谱仪进行测量处理而被排出。通过重复测量处理，通过改变频率分量ω并将由飞行时间质谱仪测量的信号强度与预先记录的阈值进行比较，对已知质量数的离子进行频率分量的校正。在这样做时，可以进行TOF和离子阱的观察质量校正。版权所有（C）2006，JPO＆NCIPI

14. 发明专利

JP2005093152A Mass spectrometer 审中-公开
标题翻译：质谱仪
公开(公告)号：JP2005093152A
公开(公告)日：2005-04-07
申请号：JP2003322560
申请日：2003-09-16
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIE MASAKI , YOKOKURA TAKEFUMI , SHISHIKA TSUKASA
IPC分类号： G01N27/62 , G01N27/64 , H01J49/42
CPC分类号： H01J49/424 , H01J49/147 , H01J49/162
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometer, capable of obtaining a plural kinds of spectra at one measurement and improving identification accuracy or the structural analysis of an object sample.
SOLUTION: An sample introduced from GC1 is guided by a column 2 to an ionizing and trap space surrounded by a ring electrode 3 and an end-cap electrode 4, together with a carrier gas. In this space, not only thermion are discharged from a filament 5, but also laser beam is irradiated from a laser light source 6, and the sample is ionized. The ionized sample is held and stored selectively in the space by a voltage impressed on each electrode 3, 4, and is introduced to a detector 7 for each mass number, by the sweeping of a high-frequency voltage impressed on the electrode 3 corresponding to the mass number. By a combination of EI and PI as the ionization method, the ion trap space can be made an ionization space, and it becomes unnecessary to arrange the ionizing space separately, and most suitable data among both EI and PI data can be used for quantitative calculation with respect to identical sample.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够在一次测量时获得多种光谱并提高目标样品的识别精度或结构分析的质谱仪。解决方案：从GC1引入的样品由载体气体一起由柱2引导到由环形电极3和端盖电极4包围的电离和捕获空间。在该空间中，不仅热电偶从灯丝5排出，而且从激光光源6照射激光束，使样品离子化。电离样品通过施加在每个电极3,4上的电压选择性地保存并存储在空间中，并且通过扫描施加在对应于电极3的电极3上的高频电压而被引入到每个质量数的检测器7 质量数。通过EI和PI的组合作为离子化方法，离子阱空间可以形成电离空间，不需要分离排列电离空间，EI和PI数据中最适合的数据可用于定量计算对于相同的样品。版权所有（C）2005，JPO＆NCIPI

15. 发明专利

JP2012127771A Mass spectrometer 审中-公开
标题翻译：质谱仪
公开(公告)号：JP2012127771A
公开(公告)日：2012-07-05
申请号：JP2010278739
申请日：2010-12-15
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YANOKURA TOSHIAKI , SHISHIKA TSUKASA , SAWAHATA HIROYUKI
IPC分类号： G01N27/62 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To dispense with a highly accurate measuring and a preprocessing to a specimen including individual difference and, even if a person having no special knowledge and experience of a mass spectrometry performs an analysis, capable of performing a stable identification, and allowing an on-site analysis.SOLUTION: The mass spectrometer according to the present invention includes: an ionization unit 5 for ionizing a specimen; a mass spectrometric unit 6 for separating ions according to a mass-to-charge ratio (m/z); an ion detecting unit 7 for detecting the ions separated by the mass spectrometric unit 6; and a measuring/detecting conditions storing memory unit 8 for previously storing the mass number of a target ion and a threshold of an ionic strength of the ion. In a case where the ion strength of the peak mass number exceeds the above-mentioned ion strength when performing the mass spectrometry (MS1), the mass spectrometer disassociates the ion as a parent ion and performs the mass spectrometry (MS2).
摘要翻译：要解决的问题：为了免除对包括个体差异的样本的高精度测量和预处理，并且即使没有特殊知识和质量经验的人进行分析，能够执行稳定的识别，并进行现场分析。解决方案：根据本发明的质谱仪包括：用于电离样品的电离单元5; 用于根据质荷比（m / z）分离离子的质谱单元6; 离子检测单元7，用于检测由质谱分析单元6分离的离子; 以及存储存储单元8的测量/检测条件，用于预先存储目标离子的质量数和离子的离子强度的阈值。在进行质谱分析（MS1）时，峰值质量数的离子强度超过上述离子强度的情况下，质谱仪分离离子作为母离子，进行质谱（MS2）。版权所有（C）2012，JPO＆INPIT

16. 发明专利

JP2011147403A Bacterial test apparatus and bacterial test method 审中-公开
标题翻译：细菌试验装置和细菌试验方法
公开(公告)号：JP2011147403A
公开(公告)日：2011-08-04
申请号：JP2010012211
申请日：2010-01-22
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： SHISHIKA TSUKASA , MAEJIMA MUNEO , FUJITA HIROKO , HIYAMA TOSHIYUKI
IPC分类号： C12M1/34 , C12Q1/04
摘要： PROBLEM TO BE SOLVED: To provide a method for accurately determining drug resistance when using a specimen containing plural kinds of bacteria, and a method for determining the drug resistance of the plural kinds of bacteria at the same time.
SOLUTION: The bacterial test method includes a step to ionize a mixed liquid by an ionization part, wherein the mixed liquid is obtained by mixing the specimen 221 containing plural kinds of bacteria with at least one drug liquid, a step to perform mass spectrometry of the ionized mixed liquid with a mass analyzer, and a step to identify the bacteria in the specimen by a data analyzing part based on the result of mass spectrometry and determine resistance of each identified bacteria to the drug liquid.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种在使用含有多种细菌的试样时精确测定耐药性的方法，以及同时测定多种细菌的耐药性的方法。解决方案：细菌测试方法包括通过电离部分离子化混合液体的步骤，其中混合液体通过将含有多种细菌的样品221与至少一种药液混合而获得，以进行质量用质量分析仪进行离子化混合液的光谱测定，以及通过基于质谱分析结果的数据分析部分鉴定样品中细菌的步骤，并确定每种鉴定的细菌对药液的耐药性。版权所有（C）2011，JPO＆INPIT

17. 发明专利

JP2010219053A Mass spectrometer and mass spectrometry 审中-公开
标题翻译：质谱仪和质谱仪
公开(公告)号：JP2010219053A
公开(公告)日：2010-09-30
申请号：JP2010107858
申请日：2010-05-10
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： ONISHI FUJIO , SHINPO KENICHI , ORIHASHI RITSURO , TERUI YASUSHI , SHISHIKA TSUKASA
IPC分类号： H01J49/40 , G01N27/62
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometry technology which reduces the data transfer time and simultaneously removes noise data, and improves the analysis efficiency in the data processing function of ADC system in a flight-time type mass spectrometer. SOLUTION: A data collection circuit 5 in the mass spectrometer includes an A/D converter 51, a signal integration memory 53 to store data of a predetermined time range of ion signals and the number of times of the measurement, and perform the integration process, a voltage value frequency integration memory 54 to integrate and store the predetermined time and the frequency of the voltage value of the number of times of the measurement simultaneously with the storage and integration of the data, a threshold operation circuit 56 to operate a predetermined threshold from the stored results of the memory, a compression memory 55 to extract only data higher than the threshold out of the data stored in the signal integration memory, and a counter 52 to control the measurement time of the data collection and the operation of the each circuit. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种减少数据传输时间并同时消除噪声数据的质谱技术，提高飞行时间型质谱仪中ADC系统的数据处理功能的分析效率。解决方案：质谱仪中的数据采集电路5包括A / D转换器51，用于存储预定时间范围的离子信号的数据和测量次数的信号积分存储器53，并执行积分处理，电压值频率积分存储器54，与数据的存储和积分同时整合并存储预定时间和测量次数的电压值的频率;阈值运算电路56，用于操作来自存储器的存储结果的预定阈值;压缩存储器55，其仅从存储在信号积分存储器中的数据中提取高于阈值的数据;以及计数器52，用于控制数据收集和操作的测量时间每个电路。版权所有（C）2010，JPO＆INPIT

18. 发明专利

JP2008190898A Quadruple mass spectrometer and mass calibration method therefor 审中-公开
标题翻译： QUADRUPLE质谱仪及其大量校准方法
公开(公告)号：JP2008190898A
公开(公告)日：2008-08-21
申请号：JP2007022932
申请日：2007-02-01
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： OWADA AKIRA , SHISHIKA TSUKASA , TERUI YASUSHI
IPC分类号： G01N27/62 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide a quadruple mass spectrometer capable of performing high-precision mass spectrometry, even with respect to a high-frequency power supply that is not equipped with high linearity of precision. SOLUTION: In a mass calibration method for the quadruple electrode type mass analyzer that has a mass separation part equipped with a DC bias and quadruple electrodes to which a high frequency is applied, processes are carried out that includes an ion source for ionizing a measuring sample to generate ions and a detection part for detecting the ions separated in the mass separation part, the measured mass range of ions to be detected is divided into a plurality of sections and the errors between the mass index value of a mass number to be detected, with respect to the respective sections and the actually detected mass number is calculated; and the mass index value of the mass number is calibrated on the basis of the error calculated at each section. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：即使对于没有高精度线性化的高频电源，也可以提供能够进行高精度质谱分析的四重质谱仪。解决方案：在具有配备有直流偏压的质量分离部件和施加高频的四极电极的四极电极型质量分析器的质量校准方法中，进行包括用于电离的离子源用于产生离子的测量样品和用于检测在质量分离部分中分离的离子的检测部件，将被测量的离子的测量质量范围分成多个部分，质量数的质量指数值与对各部分进行检测，并计算实际检测到的质量数; 并且基于在每个部分计算的误差来校准质量数量的质量指数值。版权所有（C）2008，JPO＆INPIT

19. 发明专利

JP2008084850A Ion trap time-of-flight mass spectroscope 有权
标题翻译：离子捕捉时间飞行质谱
公开(公告)号：JP2008084850A
公开(公告)日：2008-04-10
申请号：JP2007221374
申请日：2007-08-28
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： NAKAMURA HIROSHI , SHISHIKA TSUKASA , TERUI YASUSHI , SAEKI TAKUYA
IPC分类号： H01J49/40 , G01N27/62 , H01J49/24 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide an ion trap time-of-flight mass spectroscope of high sensitivity. SOLUTION: Ions fly in a time-of-flight mass spectrometry section 9 (time-of-flight mass spectrometry means) and are transported to an MCP (detector) 8 efficiently by varying the period of high-voltage pulses applied to a PUSH electrode 6 according to the distribution of the number of ions at a multi-pole section 5. Ions are transported to the MCP (detector) 8 efficiently, thus achieving the ion trap time-of-flight mass spectroscope for obtaining high-sensitivity mass spectra. COPYRIGHT: (C)2008,JPO&INPIT

20. 发明专利

JP2006292542A Liquid chromatograph mass spectrometer 审中-公开
标题翻译：液相色谱质谱仪
公开(公告)号：JP2006292542A
公开(公告)日：2006-10-26
申请号：JP2005113487
申请日：2005-04-11
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , MOCHIZUKI KOHEI , KODA MASAYOSHI , SHISHIKA TSUKASA
IPC分类号： G01N30/34 , G01N27/62 , G01N30/72
摘要： PROBLEM TO BE SOLVED: To provide a liquid chromatograph mass spectrometer, constituted so as to use a water-organic solvent mixture type eluate to change the composition of the eluant with the lapse of time, capable of optimizing spray ionizing conditions, while ensuring proper separation and capable of stabilizing spray ionization to high-accuracy analysis.
SOLUTION: An inverse gradient pump 6 for sending an addition liquid, of which the mixture ratio is inverse to the eluate sent from a gradient pump 1, is installed in the liquid chromatograph mass spectrometer. In the additive liquid joint 7 provided in between a column 3 and an emitter 4, the additive liquid from the inverse gradient pump 6 is mixed with the eluant, containing the sample components that have eluted from the column 3 and the mixture liquid is held to a constant mixture ratio. Since the mixture liquid has a constant mixture ratio, ionization efficiency can be made substantially constant.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种液相色谱质谱仪，其构造为使用水 - 有机溶剂混合型洗脱液以随时间改变洗脱剂的组成，能够优化喷雾电离条件，同时确保适当的分离，并能够将喷雾电离稳定到高精度分析。解决方案：用于发送与梯度泵1发送的洗脱液相反的混合比的反相梯度泵6安装在液相色谱质谱仪中。在设置在塔3和发射体4之间的添加液体接头7中，将来自反向梯度泵6的添加剂液与含有从塔3洗脱的样品成分和混合液保持的洗脱液混合恒定混合比。由于混合液具有恒定的混合比，电离效率可以基本上恒定。版权所有（C）2007，JPO＆INPIT

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