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11. 发明专利

JPS6344728B2 失效
公开(公告)号：JPS6344728B2
公开(公告)日：1988-09-06
申请号：JP3327979
申请日：1979-03-23
申请人： EISAI CO LTD
发明人： YAMATSU ISAO , INAI JUICHI , ABE SHINYA , IGARASHI SHUNJI , SHIOJIRI HIROYUKI , TANABE YOSHIO , HARA KUNIKO
IPC分类号： A61K31/23 , A61P1/16 , C07C69/587

12. 发明专利

JPS6328050B2 失效
公开(公告)号：JPS6328050B2
公开(公告)日：1988-06-07
申请号：JP11845280
申请日：1980-08-29
申请人： EISAI CO LTD
发明人： YAMATSU ISAO , INAI JUICHI , ABE SHINYA , SUZUKI TAKESHI , OOSATO TOSHIJI , MURAKAMI MANABU , OKETANI KYOSHI , FUJISAKI HIDEAKI
IPC分类号： A61K31/045 , A61P1/04 , A61P35/00 , C07C27/00 , C07C29/143 , C07C33/02 , C07C67/00

13. 发明专利

JPS63119461A 2-PYRROLIDONE DERIVATIVE 失效
公开(公告)号：JPS63119461A
公开(公告)日：1988-05-24
申请号：JP26465386
申请日：1986-11-06
申请人： EISAI CO LTD
发明人： IKUTA HIRONORI , YAMAGISHI YOJI , AKASAKA KOZO , YAMATSU ISAO , KOBAYASHI SEIICHI , SHIROTA HIROSHI , KATAYAMA KOICHI
IPC分类号： C07D207/273
摘要： NEW MATERIAL:The 2-pyrrolidone derivative of formula I {R is H, lower alkyl, lower alkoxy, lower alkynyl or -(CH2)n-Y [Y is phenyl, OH or group of formula II (R and R are H or lower alkyl); n is 1 or 2]; X is halogen} and its salt. EXAMPLE:N-methoxy-3-bromo-2-pyrrolidone. USE:An intermediate for anti-inflammatory agent. PREPARATION:The compound of formula I can be produced e.g. by condensing a compound of formula III (Z is halogen or organic sulfonyloxy) with a compound of formula RNH2 and cyclizing the resultant compound of formula IV in the presence of a base.

14. 发明专利

JPS61254546A QUINONE COMPOUND 失效
公开(公告)号：JPS61254546A
公开(公告)日：1986-11-12
申请号：JP9608485
申请日：1985-05-08
申请人： EISAI CO LTD
发明人： YAMATSU ISAO , SUZUKI TAKESHI , ABE SHINYA , NAKAMOTO KOJI , HAYASHI KENJI , KAJIWARA SHOJI , KATAYAMA KOICHI , KATAYAMA SATOSHI , SAKUMA YOSHINORI
IPC分类号： A61K31/16 , A61K31/165 , A61K31/22 , A61P11/00 , A61P37/08 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/30 , C07C235/34 , C07C235/78
摘要： NEW MATERIAL:The compound of formula I [A is group of formula II or formula III (X and Y are OH, methoxy or H); R is H or acyl; n is 1-5]. EXAMPLE:6-{7-(2'-Hydroxyethylaminocarbonyl)-3-methyl-2,6-octadienyl}-2 ,3,4-tri methoxy-5-methylphenol. USE:An antiallergic agent and antiasthmatic agent. It suppresses the isolation of SRS-A which is an allergy-inducing substance. PREPARATION:The compound of formula I wherein A is group of formula III can be produced by reacting the compound of formula IV with the compound of formula V. Another compound of formula I wherein A is group of formula II is obtained by treating the obtained compound of formula I wherein A is group of formula III with an oxidizing agent.

15. 发明专利

JPS6135169B2 失效
公开(公告)号：JPS6135169B2
公开(公告)日：1986-08-12
申请号：JP6058376
申请日：1976-05-27
申请人： EISAI CO LTD
发明人： KIJIMA SHIZUMASA , IGARASHI SHUNJI , YAMATSU ISAO , HAMAMURA KICHISABURO , NAKAJIMA YOSHIAKI , MINAMI NORIO , YAMAGISHI YOJI , INAI JUICHI
IPC分类号： C07C69/587 , A61K31/19 , A61K31/20 , A61K31/22 , A61K31/23 , A61P9/12 , C07C51/00 , C07C51/353 , C07C57/03 , C07C67/00

16. 发明专利

JPS6058209B2 失效
公开(公告)号：JPS6058209B2
公开(公告)日：1985-12-19
申请号：JP14785878
申请日：1978-12-01
申请人： EISAI CO LTD
发明人： YAMATSU ISAO , ABE SHINYA , INAI JUICHI , IGARASHI SHUNJI , NAKAJIMA YOSHIAKI
IPC分类号： A61K31/045 , A61P9/12 , C07C27/00 , C07C29/00 , C07C29/147 , C07C33/02 , C07C33/025 , C07C51/08 , C07C57/03 , C07C67/00 , C07C253/00 , C07C255/07 , C07C255/23

17. 发明专利

JPS60244293A PREPARATION OF DOLICHOL 失效
公开(公告)号：JPS60244293A
公开(公告)日：1985-12-04
申请号：JP9982184
申请日：1984-05-18
申请人： EISAI CO LTD
发明人： IKEDA YASUNORI , IWAMA KIYOSHI , YAMADA KOUJI , YOKOHAMA HIROMITSU , YAMATSU ISAO , ABE SHINYA
IPC分类号： C12P7/04 , C12R1/645
摘要： PURPOSE:To obtain dolichol useful as medicines, by cultivating a microorganism belonging to the genus Saccharomycopsis or Stephenoascus, and having the ability to produce the dolichol, and collecting the resultant microbial cells. CONSTITUTION:A microorganism, e.g. Saccharomycopsis fibuligera, Saccharomycopsis capsularis or Stephanoascus cifferrii, belonging to the genus Saccharomycopsis or Stephanoascus, and having the ability to produce dolichol consisting essentially of dolichol of the formula (n is 16-20) in the dolichol of the formula is cultivated. After completing the cultivation, microbial cells are separated from the culture fluid, and the dolichol which is the aimed substance is extracted from the culture fluid with an organic solvent.

18. 发明专利

JPS60136510A REMEDY AND PREVENTIVE FOR HEPATIC DISEASE 失效
公开(公告)号：JPS60136510A
公开(公告)日：1985-07-20
申请号：JP24422783
申请日：1983-12-26
申请人： EISAI CO LTD
发明人： YAMATSU ISAO , SUZUKI TAKESHI , ABE SHINYA , NAKAMOTO KOUJI , KAJIWARA SHIYOUJI , KATAYAMA KOUICHI , TSUNODA SOU , MURAKAMI MANABU , ONO HIDEKI , YAMADA KOUJI
IPC分类号： A61K31/045 , A61K31/66 , A61P1/16
摘要： PURPOSE:To provide the titled agent containing dolichol or dolichol phosphate as an active component. CONSTITUTION:A remedy and preventive for hepatic diseases is produced by using a dolichol of formula I (n is 14-24) (a single compound having a specific n value or a mixture of compounds having different n values) or a dolichol phosphate of formula II (n is 14-24; m is 1-3). The dolichol used as the active component is a polyprenol existing in yeast or the tissue of mammalian, and can be produced by extracting the liver of pig or by the fermentation with microorganisms. Dose: 10-1,000mg, preferably 50-300mg daily, in the form of tablet, granule, powder, capsule, injection, suppository, etc. The above active component has extremely high safety, and accordingly, it can be administered continuously.

19. 发明专利

JPS6020368B2 失效
公开(公告)号：JPS6020368B2
公开(公告)日：1985-05-21
申请号：JP11618474
申请日：1974-10-11
申请人： EISAI CO LTD
发明人： KIJIMA SHIZUMASA , YAMATSU ISAO , HAMAMURA KICHISABURO , MINAMI NORIO , YAMAGISHI YOJI , INAI JUICHI
IPC分类号： C07C69/035 , B01J27/00 , B01J31/00 , C07C41/00 , C07C43/23 , C07C46/06 , C07C50/28 , C07C67/00

20. 发明专利

JPS59163375A Polyprenyl compound 失效
标题翻译：聚丙烯化合物
公开(公告)号：JPS59163375A
公开(公告)日：1984-09-14
申请号：JP3656783
申请日：1983-03-08
申请人： Eisai Co Ltd
发明人： YAMATSU ISAO , SUZUKI TAKESHI , ABE SHINYA , NAKAMOTO KOUJI , KAJIWARA SHIYOUJI , TADANO KIYOUICHI
IPC分类号： C07D295/18 , A61K31/535 , A61K31/5375 , A61P1/16
摘要： NEW MATERIAL:A polyprenyl compound shown by the formula I (X is -CH
2 OH-, or -COOH).
EXAMPLE: 4-(15-Carboxy-3,7,11-trimethyl-6,10,14-hexadecatrienoyl)morpholine.
USE: A remedy for hepatic diseases. Activating liver function, having saccarometabolism, detoxication action, bile forming and secretive action, etc.
PREPARATION: For example, N-(3,7,11,15-tetramethyl-6,10-14-hexadecatrienoyl)morpholine shown by the formula II is epoxidized to give a compound shown by the formula III, which is oxidized with HIO
4 , etc. in a solvent to give an aldehyde shown by the formula IV. This compound is reacted with a Witting reagent to give a compound shown by the formula V, which is hydrolyzed to give a compound shown by the formula I where X is -COOH. This compound is reduced to give the compound shown by the formula I where X is -CH
2 OH.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I所示的聚异戊烯基化合物（X为-CH 2 OH-或-COOH）。实施例：4-（15-羧基-3,7,11-三甲基-6,10,14-十六碳三烯酰基）吗啉。用途：治疗肝病。活化肝功能，具有神经代谢，解毒作用，胆汁形成和分泌作用等。制备：例如式II所示的N-（3,7,11,15-四甲基-6,10-十四碳三烯酰基）吗啉环氧化得到式III所示的化合物，其在溶剂中用HIO4等氧化，得到式IV所示的醛。使该化合物与Witting试剂反应，得到式V所示的化合物，将其水解，得到其中X为-COOH的式I化合物。将该化合物还原，得到其中X为-CH 2 OH的式I化合物。

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