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11. 发明专利

JP2003126053A ARTERIOSCLEROTIC ASSESSMENT SYSTEM 审中-公开
公开(公告)号：JP2003126053A
公开(公告)日：2003-05-07
申请号：JP2001325967
申请日：2001-10-24
申请人： NIPPON COLIN CO LTD
发明人： NAKAGAWA TSUNEO
IPC分类号： A61B5/0245 , A61B5/022 , A61B5/0285
摘要： PROBLEM TO BE SOLVED: To provide a system which is capable of assessing arteriosclerosis by rapidly measuring a variation of pulse wave propagation velocities depending on the blood pressure levels. SOLUTION: The arteriosclerotic assessment system consists of a means 102 for continually determining blood pressure levels which continually determines monitoring blood pressures MBP according to pressure pulse waves to be detected by a pressure pulse wave sensor 70, a means 106 for obtaining an information of pulse wave propagation velocities to calculate pulse wave propagation velocities and 2-dimensional graphs indicating monitoring blood pressure axes and pulse wave propagation velocities displayed on an indicator 86, where an outputting means 108 that shows a mark on a position to be decided depending on the monitoring blood pressure level and the pulse wave propagation velocity PWV is provided, and when the arteriosclerotic assessment device is used in a duration of lowered blood pressures immediately after an exercise load is given to a patient, a variation of pulse wave propagation velocities PWV in relation to the monitoring blood pressure MBP can be promtly determined from a variation tendency of the mark to be indicated on the two-dimensional graph. Thus, rapid diagnosis of arteriosclerosis is avalable.

12. 发明专利

JP2003111737A BLOOD PRESSURE DETERMINING APPARATUS 审中-公开
公开(公告)号：JP2003111737A
公开(公告)日：2003-04-15
申请号：JP2001311535
申请日：2001-10-09
申请人： NIPPON COLIN CO LTD
发明人： NISHIBAYASHI HIDEO
IPC分类号： A61B5/022 , A61B5/021 , A61B5/0225
摘要： PROBLEM TO BE SOLVED: To provide a blood pressure determining apparatus with which a highest blood pressure value is determined without giving much pain to a patient. SOLUTION: An average blood pressure value BP (MEAN) is determined based on a cuff pulse wave CW detected in the process of slowly raising cuff pressure Pc. when determining the average blood pressure value BP (MEAN), the cuff pressure Pc is lowered to a pulse wave detection pressure PM lower than a lowest blood pressure value BP (DIA) to detect the cuff pulse wave CW by the pulse wave detection pressure PM to determine the lowest pulse wave value Imin, an area centroid pulse wave value Ig and the highest pulse wave value Imax of the cuff pulse wave. Then, based on the fact that the lowest pulse wave value Imin, the area centroid pulse wave value Ig and the highest pulse wave value Imax correspond respectively to the lowest blood pressure value BP (DIA)m, the average blood pressure value BP (MEAN) and a highest blood pressure value BP (SYS), the highest blood pressure value BP (SYS) is determined from formula 1. (formula 1) (Imax-Imin):(Ig-Imin)= BP(SYS)-BP(DIA)}: BP(MEAN)-BP(DIA)}.

13. 发明专利

JP2003010319A Dialyzer 审中-公开
标题翻译： DIALYZER
公开(公告)号：JP2003010319A
公开(公告)日：2003-01-14
申请号：JP2001202720
申请日：2001-07-03
申请人： Nippon Colin Co Ltd , 日本コーリン株式会社
发明人： KAWAGUCHI KEIZO
IPC分类号： A61M1/14
CPC分类号： A61M1/14 , A61M2230/04 , A61M2230/20 , A61M2230/005
摘要： PROBLEM TO BE SOLVED: To provide a dialyzer which automatically controls dewatering velocity so as to perform efficient dewatering without rapid dropping of the blood pressure of a patient.
SOLUTION: A blood pressure variation related information detection means 110 detects a plurality of kinds of information related with blood pressure variation giving influence to the blood pressure variation (blood pressure dropping) of the patient in the middle of dialysis. A dewatering velocity control means 108 controls the dewatering velocity of the dialyzer 70 by a previously stored control formula, that is an assessment formula based on the plurality of kinds of information related with the blood pressure variation. Thus, the dewatering velocity is controlled automatically so as to perform efficient dewatering without rapid dropping of the blood pressure of the patient. Thus the adjusting operation of the dewatering velocity corresponding to the state of the patient by medical expert/specialists such as doctors is reduced and a smaller number of the medical expert/specialists are required than those in the case of a conventional device. Thus, dialysis equipment can easily be increased and medical costs for analysis can be reduced.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种自动控制脱水速度的透析器，以便在不使患者的血压快速下降的情况下进行有效的脱水。解决方案：血压变化相关信息检测装置110检测与透析中期患者血压变化（血压下降）的血压变化有关的多种信息。脱水速度控制装置108通过预先存储的控制公式来控制透析器70的脱水速度，该控制公式是基于与血压变化相关的多种信息的评估公式。因此，自动控制脱水速度，以便在不迅速降低患者血压的情况下进行有效的脱水。因此，医疗专家/专家如医生对应于患者状态的脱水速度的调节操作减少，并且需要较少数量的医疗专家/专家，而不是常规装置的情况。因此，可以容易地增加透析设备，并且可以降低用于分析的医疗成本。

14. 发明专利

JP2003010139A Measuring device for information on pulse wave propagation speed 有权
标题翻译：用于脉冲波传播速度信息的测量装置
公开(公告)号：JP2003010139A
公开(公告)日：2003-01-14
申请号：JP2001200503
申请日：2001-07-02
申请人： Nippon Colin Co Ltd , 日本コーリン株式会社
发明人： NARIMATSU KIYOYUKI
IPC分类号： A61B5/0245 , A61B5/02 , A61B5/021 , A61B5/0285
CPC分类号： A61B5/6822 , A61B5/02 , A61B5/02007 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/7239
摘要： PROBLEM TO BE SOLVED: To provide a measuring device of information on a pulse wave propagation speed capable of measuring pulse wave propagation speed information only by installing one heartbeat synchronizing signal detecting device.
SOLUTION: The peak pi of a traveling wave component wi and the peak pr of a reflected wave component wr of a carotid pulse wc detected by a pressure pulse wave detecting probe are determined, and a time difference between the peak pi of the traveling wave component wi and the peak pr of the reflected wave component wr is calculated as pulse wave propagation time DT (sec). The pulse wave propagation time DT is subjected in a formula 1 to obtain a pulse wave propagation speed PWV (m/sec); (formula 1) PWV=L/DT (wherein L(m) is a distance reaching a pulse wave detecting part via a reflection point positioned in the vicinity of the iliatic artery from an aortic valve). Thus, the pulse wave propagation speed PWV can be calculated only by installing one pressure pulse wave detecting probe (the heartbeat synchronizing signal detecting device).
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：仅通过安装一个心跳同步信号检测装置来提供能够测量脉搏波传播速度信息的脉搏波传播速度信息的测量装置。解决方案：确定由压力脉搏波检测探测器检测到的行波分量wi的峰值pi和由颈动脉脉搏wc的反射波分量wrc的峰值pr，并且确定行波成分的峰值pi之间的时间差 wi，反射波分量wr的峰值pr被计算为脉波传播时间DT（秒）。脉冲波传播时间DT在式1中进行，得到脉波传播速度PWV（m / sec）。（公式1）PWV = L / DT（其中L（m）是经由位于主动脉瓣的髂动脉附近的反射点到达脉搏波检测部的距离）。因此，仅通过安装一个压力脉搏波检测探头（心跳同步信号检测装置）即可计算出脉搏波传播速度PWV。

15. 发明专利

JP2002303576A OXYGEN SATURATION MEASURING DEVICE 失效
公开(公告)号：JP2002303576A
公开(公告)日：2002-10-18
申请号：JP2001107298
申请日：2001-04-05
申请人： NIPPON COLIN CO LTD
发明人： TAKATANI SETSUO
IPC分类号： G01N33/72 , A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/35 , G01N21/3577 , G01N21/359 , G01N33/84
摘要： PROBLEM TO BE SOLVED: To provide an oxygen saturation measuring device with high measuring accuracy. SOLUTION: The oxygen saturation measuring device is provided with a first light emitting device and a second light emitting device respectively applying irradiation light of a first wavelength λ1 with an extinction coefficient of hemoglobin changed by oxygen saturation and irradiation light of a second wavelength λ2 with an extinction coefficient of hemoglobin unchanged by the oxygen saturation to an organic tissue. The oxygen saturation is determined from a preset linear expression on the basis of an intensity ratio between back scattered light of the first wavelength λ1 and back scattered light of the second wavelength λ2. The first wavelength λ1 is 730 nm and the second wavelength λ2 is 830 nm. By this, since linearity of the oxygen saturation to the intensity ratio between the back scattered light of the first wavelength λ1 and the back scattered light of the second wavelength λ2 is improved, accuracy of the oxygen saturation is improved.

16. 发明专利

JP2001224564A CARDIAC SOUND DETECTOR AND PULSE WAVE PROPAGATING SPEED INFORMATION MEASURING INSTRUMENT USING IT 失效
公开(公告)号：JP2001224564A
公开(公告)日：2001-08-21
申请号：JP2000041609
申请日：2000-02-18
申请人： NIPPON COLIN CO LTD
发明人： KAWAGUCHI KEIZO
IPC分类号： A61B5/025 , A61B5/0245 , A61B5/026 , A61B5/0285 , A61B5/0452 , A61B5/0456 , A61B7/04
摘要： PROBLEM TO BE SOLVED: To provide a cardiac sound detector capable of precisely determining the start point of a first sound. SOLUTION: When a cardiac sound signal SH detected from a microphone 12 is smoothly differentiated by a smooth differentiation processing means 40 (S3), the cardiac sound signal SH is smoothed and made into a differential waveform to clarify the change of the signal. When the amplitude strength to the base line of the waveform processed by the smoothing processing means 40 (S3) is squared, the waveform emphasized on only the positive side of the base line and the amplitude is formed. Since the point of time when the amplitude intensity of the waveform processed by the square processing means 42 (S4) exceeds a preset threshold TH is determined as the start point of the first sound by a start point determining means 44 (S5), the start point of the first sound can be precisely determined.

17. 发明专利

JP2001190510A PERIODIC ORGANISMIC INFORMATION MEASURING DEVICE 失效
公开(公告)号：JP2001190510A
公开(公告)日：2001-07-17
申请号：JP2000004117
申请日：2000-01-13
申请人： NIPPON COLIN CO LTD
发明人： HONDA TAKASHI , OGURA TOSHIHIKO
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/025 , A61B5/0285 , A61B5/0402 , A61B5/0452 , A61B5/0456 , A61B5/05
摘要： PROBLEM TO BE SOLVED: To provide a periodic organismic information measuring device capable of easily eliminating an abnormal value from plural periodic organismic information. SOLUTION: An R-II period is successively measured during 30 beats by an electrocardiographic wave-II sound period measuring means 50 (S4), and when a respiratory synchronous component wave M for expressing a respiratory synchronous component of the R-II period on the basis of a respiratory pulse wave f (t) measured by a respiratory pulse wave measuring means 64 (S2) by a respiratory synchronous component wave deciding means 66 (S6) is decided, an amplitude difference ΔA between amplitude of the R-II period and amplitude of the respiratory synchronous component wave M at the R-II measured period is calculated by an amplitude difference calculating means 68 (S7), and since an abnormal value is eliminated from the R-II period measured by the electrocardiographic wave-II sound period measuring means 50 (S4) on the basis of the amplitude difference ΔA by an abnormal value eliminating means 72 (S10), the abnormal value can be easily eliminated from plural R-II periods.

18. 发明专利

JP2001190506A ARTERIAL SCLEROSIS EVALUATING DEVICE 失效
公开(公告)号：JP2001190506A
公开(公告)日：2001-07-17
申请号：JP2000007682
申请日：2000-01-17
申请人： NIPPON COLIN CO LTD
发明人： OGURA TOSHIHIKO , HONDA TAKASHI , NARIMATSU KIYOYUKI
IPC分类号： A61B5/02 , A61B5/022 , A61B5/0245
摘要： PROBLEM TO BE SOLVED: To provide an arterial sclerosis evaluating device capable of easily evaluating arterial sclerosis. SOLUTION: The actual age A of an organism and the actual lowest blood pressure value BPDIA measured by a blood pressure measuring means 80 are substituted in a preset normal pulse wave propagation speed calculating expression by a normal pulse wave propagation speed information calculating means 90 to calculate a normal pulse wave propagation speed PWVno in the age A and the lowest blood pressure value BPDIA when the organism is normal to calculate an actual pulse wave propagation speed PWVac on the basis of an actually measured pulse wave by an actual pulse wave propagation speed information calculating means 88 to calculate a difference ΔPWV(=PWVac-PWVno) between the actual pulse wave propagation speed PWVac and the normal pulse wave propagation speed PWVno as an arterial sclerosis index Ia by an arterial sclerosis index calculating means 92. Since the actual pulse wave propagation speed PWVac becomes a value separate from the normal pulse wave propagation speed PWVno as arterial sclerosis makes progress on the organism, even an unexperienced person can easily evaluate the arterial sclerosis by the arterial sclerosis index Ia calculated as the difference ΔPWV between the actual pulse wave propagation speed PWVac and the normal pulse wave propagation speed PWVno.

19. 发明专利

JP2001157668A PULSE WAVE DETECTING DEVICE FOR MEASURING PULSE WAVE PROPAGATION VELOCITY INFORMATION AND DEVICE FOR MEASURING PULSE WAVE PROPAGATION VELOCITY INFORMATION 失效
公开(公告)号：JP2001157668A
公开(公告)日：2001-06-12
申请号：JP34418299
申请日：1999-12-03
申请人： NIPPON COLIN CO LTD
发明人： NARIMATSU KIYOYUKI , HONDA TAKASHI , OGURA TOSHIHIKO
IPC分类号： A61B5/0245 , A61B5/022
摘要： PROBLEM TO BE SOLVED: To provide a device for measuring pulse wave propagation velocity information with which highly accurate pulse wave propagation velocity information may be obtained. SOLUTION: Period mean pulse pressure PMav for each pressure sensitive element E of pulse pressure PM calculated by a pulse pressure calculating means 72 is calculated by a period mean pulse pressure calculating means 82, a reference pulse pressure PST is calculated on the basis of the maximum period mean pulse pressure MAXP in the period mean pulse pressure PMav for each of the pressure sensitive elements E by a reference pulse pressure determining means 84, and the period mean pulse wave propagation time Dtav calculated in the pressure sensitive element E detecting the period mean pulse pressure Pmav over the reference pulse pressure PST is determined as a candidate for normal pulse wave propagation time TDT by a candidate determining means 88. Then, since, by a normal pulse wave propagation velocity information determining means 92, a candidate for normal pulse wave propagation time TDT determined by a candidate determining means 88 which has a minimum standard deviation σis determined as the normal pulse wave propagation time TDT, highly accurate pulse wave propagation time DT may be obtained.

20. 发明专利

JP2001070262A SPHYGMOMANOMETER 失效
公开(公告)号：JP2001070262A
公开(公告)日：2001-03-21
申请号：JP25117799
申请日：1999-09-06
申请人： NIPPON COLIN CO LTD
发明人： NISHIBAYASHI HIDEO , NUNOME TOMOHIRO
IPC分类号： A61B5/022
摘要： PROBLEM TO BE SOLVED: To provide a sphygmomanometer to acquire a precise value of blood pressure. SOLUTION: A second amplitude A2 detected by a pressure pulse wave detecting device 45 is corrected by an amplitude correcting means 68 so that the second amplitude A2 and a first amplitude A1 generated in a first rubber pouch 18 in the section where the blood flow is blocked in an artery 21 of the part where a cuff 12 is wound are almost equal to each other, and the difference ΔA in amplitude between the amplitude A2-1 corrected by the amplitude correcting means 68 and the first amplitude A1 generated in the first rubber pouch 18 is calculated by an amplitude difference calculating means 70. Therefore, the difference ΔA in amplitude clearly indicates the start-up point. Then a blood pressure value BP of a subject is determined by a blood pressure determining means 72 based on the variation of the difference ΔA in amplitude calculated by the amplitude difference calculating means 70, so that a precise blood pressure value can be acquired.

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