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151. 发明专利

JPH0632803A HCG-RELATING HEPTOSE HAPTEN 失效
公开(公告)号：JPH0632803A
公开(公告)日：1994-02-08
申请号：JP21071692
申请日：1992-07-16
申请人： TOWA KASEI KOGYO KK
发明人： KITAJIMA TORU , KOMIYA SHINICHI , OGAWA TOMOYA , KATAURA KOICHI , KATO KAZUAKI
IPC分类号： C08B37/00
摘要： PURPOSE:To provide a heptose hapten having a specific molecular structure, enabling the determination of epitope recognizable by an antibody and necessary for the preparation of monoclonal antibody for the diagnosis of urinary or serological diagnosis of chorionic carcinoma. CONSTITUTION:The heptose hapten expressed by formula (R is methyl; R , R , R and R are H; R is acetyl), the compound of formula wherein R is ethyl, R and R are phthaloyl, R is benzyl, R is H and R is acetyl or the compound of formula wherein R is ethyl, R and R are phthaloyl, R is benzyl, R is p-methoxyphenyl and R is acetyl.

152. 发明专利

JPH05301905A 失效
公开(公告)号：JPH05301905A
公开(公告)日：1993-11-16
申请号：JP21318792
申请日：1992-07-20
申请人： TOWA KASEI KOGYO KK
发明人： KITAJIMA TORU , KOMIYA SHINICHI , OGAWA TOMOYA , KATAURA KOICHI , ISHII YOSHIFUMI , KATO KAZUAKI
IPC分类号： C08B37/00
摘要： PURPOSE:To obtain a nonasaccharine hapten originated from chorionic carcinoma and useful as an immunogen suitable for the preparation of monoclonal antibody for the diagnosis of chorionic carcinoma with urine or serum by designing a molecular form containing a spacer introduced in a natural-type sugar chain structure. CONSTITUTION:The compound of formula I (R is methyl, R and R to R are H and R is acetyl: compound A), (R is ethyl, R and R are phthaloyl, R is benzyl, R is H and R is acetyl: compound B) or (R is ethyl, R and R are phthaloyl, R is benzyl, R is p-methoxyphenyl and R is acetyl: compound C) and the compound of formula II (Ac is acetyl; Bn is benzyl; Et is ethyl; MP is p-methoxyphenyl; Phth is phthaloyl) which is an intermediate for the above compounds. The compound C can be produced by glycosylating the compound of formula II with a compound obtained from pentaacetylmannose via two steps. The de-p-methoxyphenylation of the compound C gives the compound B, which is subjected to debenzylation, deacetylation, transesterification, dephthaloylation and N-acetylation to get the compound A.

153. 发明专利

JPH0425277B2 失效
公开(公告)号：JPH0425277B2
公开(公告)日：1992-04-30
申请号：JP23204383
申请日：1983-12-08
申请人： RIKAGAKU KENKYUSHO , TOWA KASEI KOGYO KK , MEKUTO KK
发明人： OGAWA TOMOYA , NUKADA YASUO , KITAJIMA TOORU , SUGIMOTO MAMORU , TAKEMURA MOTOHIRO , SHIDORI YOSHASU
IPC分类号： C07H7/02 , C07H3/06 , C07H7/027 , C07H15/18

154. 发明专利

JPH02257848A FOOD CONTAINING MALTITOL AS SWEETENER OR FAT SUBSTITUTE 失效
公开(公告)号：JPH02257848A
公开(公告)日：1990-10-18
申请号：JP3168490
申请日：1990-02-14
申请人： TOWA KASEI KOGYO KK
发明人： ABURAHAMU AI BAKAARU , NANBU SHOICHI , MURAOKA TOSHIAKI
IPC分类号： A21D2/18 , A23D7/005 , A23D9/007 , A23G3/00 , A23G3/42 , A23G9/32 , A23G9/34 , A23G9/44 , A23G9/52 , A23L1/00 , A23L1/09 , A23L1/30 , A23L13/40 , A23L27/30 , A23L27/60 , A23L29/00
摘要： PURPOSE:To obtain a food having extremely low calorie without damaging fat-containing tasty palatability by partially or wholly replacing fats in food with maltitol. CONSTITUTION:Fat such as BRAUNI, spread or cake in fat containing food having

155. 发明专利

JPH02215353A ARBINOGALACTAN-CONTAINING LIQUID COMPOSITION AND ITS PRODUCTION 失效
公开(公告)号：JPH02215353A
公开(公告)日：1990-08-28
申请号：JP3608989
申请日：1989-02-17
申请人： TOWA KASEI KOGYO KK
发明人： FUSE MASAAKI , SAKATA KATSUMI , KATAURA KOICHI , ISHII YOSHIFUMI , KATO KAZUAKI
IPC分类号： A23L2/00 , A23L1/09 , A23L3/349 , A23L29/00 , A23L29/20 , A23L29/206 , A23L1/052 , A23L1/03
摘要： PURPOSE:To obtain arabinogalactan-containing liquid composition which is inexpensive and easy to handle, and resists to putrefaction and deterioration by mixing a sugar alcohol and arabinogalactan so that the solid concentration is adjusted to a specific one. CONSTITUTION:A sugar alcohol and arabinogalactan is mixed so that the solid composition contains 1 to 70wt.% of arabinogalactan, then the solid concentration is adjusted to 60 to 85wt.% to give the subject composition. The sugar alcohol may have such a quality as it can be generally used in food products and food additives and reduced maltose syrup, reduced starch syrup, lactitol, sorbitol. mannitol and others can be cited, because they are readily available and inexpensive, and has suitable properties for the purposes of the present invention. The arabinogalactan used may originate from Japanese larch or tamarack, or other trees or from soybeans.

156. 发明专利

JPH02109991A PRODUCTION OF BETA-D-XYLOSIDE 失效
公开(公告)号：JPH02109991A
公开(公告)日：1990-04-23
申请号：JP26272988
申请日：1988-10-20
申请人： TOWA KASEI KOGYO KK
发明人： YASUI TSUNEO , SHINOYAMA HIROFUMI , KATO KAZUAKI
IPC分类号： C12P19/44 , C12R1/685
摘要： PURPOSE:To enable commercially advantageous production of '-D-xyloside by allowing beta-xylosidase to act on a mixed solution containing a xylobiose or oligomeric xylose mixture, water and a compound of a general formula: R-OH. CONSTITUTION:The reaction system is composed of a mixture mainly composed of xylobiose or oligomeric xylose which is obtained by hydrolysis of hemi- cellulose from wood, water and 10 to 300 units/ml of beta-xylosidase originating from Aspergillus niger, and an alcohol of a general formula: R-OH where R corresponds to the R in the objective compound such as methanol or ethanol. They are allowed to react at 30 to 55 deg.C under stirring whereby beta-D-xylosides are obtained selectively in high yield. The products are subjected to a usual isolation and a purification such as column chromato-graphy, concentration, crystallization or the like to obtain the purified product. The process according to the present invention makes it possible to produce beta-D-xylosides from an economically advantageous raw materials.

157. 发明专利

JPH0279994A PRODUCTION OF MONOCLONAL ANTIBODY 失效
公开(公告)号：JPH0279994A
公开(公告)日：1990-03-20
申请号：JP23426088
申请日：1988-09-19
申请人： NICHIREI KK , TOWA KASEI KOGYO KK
发明人： KOBATA AKIRA , OGAWA TOMOYA , KITAJIMA TORU , OBAYASHI KOICHI
IPC分类号： G01N33/574 , A61K39/395 , C12N5/10 , C12N5/16 , C12N15/02 , C12N15/06 , C12P21/08 , C12R1/91 , G01N33/577
摘要： PURPOSE:To obtain the title antibody to sugar chain antigen, for e.g., diagnostic drugs for carcinoma by fusing with myeloma cells antibody-productive cells of an animal with sugar chain antigen immunized by linking it to a carrier, followed by screening the resultant product using antigen linked to another carrier and by putting the selected hybridoma to culture. CONSTITUTION:Firstly, hybridoma is produced by fusing (A) myeloma cells with (B) antibody-productive cells of an animal with sugar chain to be an antigen immunized by linking it to the first carrier so as to possess immunogenicity. Thence, the sugar chain to be the antigen is linked to the second carrier. The reactivity is then screened to select those hybridoma having produced monoclonal antibody with the sugar chain as an antigen, and the hybridoma thus selected is put to culture to recover the product from the resulting cultured product, thereby obtaining the objective monoclonal antibody with sugar chain as an antigen.

158. 发明专利

JPH0223881A PRODUCTION OF MALTOSE HAVING LOW OLIGOSACCHARIDE CONTENT AND ITS REDUCTION PRODUCT 失效
公开(公告)号：JPH0223881A
公开(公告)日：1990-01-26
申请号：JP17176388
申请日：1988-07-12
申请人： TOWA KASEI KOGYO KK
发明人： NIIMI MASAHIRO , HARIO YUKARI , ISHII YOSHIFUMI , KATAURA KOICHI , KATO KAZUAKI
IPC分类号： C12P19/12 , C07H15/04 , C12N15/00 , C12N15/09 , C12N15/56 , C12P19/14 , C12P19/16 , C12P19/22 , C12R1/07 , C12R1/125
摘要： PURPOSE:To obtain easily pulverizable maltose having low oligosaccharide content and its reduction product by saccharifying liquefied starch with maltogenic-alpha-amylase under specific condition. CONSTITUTION:An aqueous solution of starch having a concentration of 5-40wt.% is liquefied with a liquefaction enzyme and the enzyme is inactivated at a dextrose-equivalent of

159. 发明专利

JPS6411273B2 失效
公开(公告)号：JPS6411273B2
公开(公告)日：1989-02-23
申请号：JP13009780
申请日：1980-09-20
申请人： TOWA KASEI KOGYO KK
发明人： TAKEMURA MOTOHIRO , EBISU TAKASHI , TATENO YOSHIAKI , KATO KAZUAKI
IPC分类号： A23L13/60 , A23L13/00 , A23L17/00

160. 发明专利

JPS63270695A SACCHARIDE CHAIN-BIOTIN COMPLEX AND PRODUCTION THEREOF 失效
公开(公告)号：JPS63270695A
公开(公告)日：1988-11-08
申请号：JP10459687
申请日：1987-04-30
申请人： TOWA KASEI KOGYO KK
发明人： TAKEMURA MOTOHIRO , KITAJIMA TORU , YAMAZAKI MASAYOSHI , OGAWA TOMOYA , KOBATA AKIRA , TATENO YOSHIAKI
IPC分类号： C07H15/04 , G01N33/53
摘要： NEW MATERIAL:A compound shown by formula I (R is H or group shown by formula II; R is H or acetyl; R is H, acetyl or group shown by formula III; n is 0-8). USE:Useful for searching existing site of a receptor to recognize human chorionic gonadotropic hormone (HCG) related saccharides or as a ligand for affinity chromatography related to HCG. PREPARATION:A compound shown by formula IV (R is lower alkyl; R is H or group shown by formula III) is reacted with a compound shown by formula H2N(CH2)nNH2.

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