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    • 148. 发明专利
    • JPH0360839B2
    • 1991-09-17
    • JP5900182
    • 1982-04-10
    • MERCK & CO INC
    • ROJAA EMU FUREIDEINGAADANIERU EFU UEEBAA
    • C07K7/64A61K38/00A61K38/04A61P1/04A61P3/08A61P3/10A61P5/00A61P5/02A61P27/02C07K1/04C07K1/113C07K7/06C07K14/575C07K14/655
    • The compounds are best summarized by formula: … … wherein… Y is (CH2)m wherein m is 0, 1 or 2 or sulfur such that the sulfur may be in any position along the chain;… R1 and R2 are independently loweralkyl, benzyl, substituted benzyl where the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and loweralkyl substituted with a 5- or 6-membered hetercyclic ring;… R3 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy, or halogen;… R4 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro;… R5 is hydrogen, loweralkyl, benzyl, or substituted benzyl wherein the substituent is loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro; and the two asymmetric centers marked with an asterisk (*) may be either D or L, provided the two centers of asymmetry are not the same, while the other asymmetric centers are D. … The term "loweralkyl" when used in the instant application is intended to represent those alkyl groups either straight or branched chain, which have from 1-5 carbon atoms. Examples of such alkyl groups are methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, pentyl and the like.
    • 149. 发明专利
    • DOUBLE TIP DOSING AND METERING DEVICE
    • JPH03212383A
    • 1991-09-17
    • JP28602590
    • 1990-10-25
    • MERCK & CO INC
    • JIYON II AREGURETSUTEITOMASU II SHIYURAUDETSUKAA
    • B65D81/32A61F9/00A61J1/00A61J1/05A61J1/20B65D47/18
    • PURPOSE: To enable holding at least two substances in solution which are required to be separated until just prior to their dispensing by including an upper dropper tip and a lower dropper tip which are split by a bellows or squeeze storage chamber, by including a plugging means which selectively seals a lower dropper tip, and by including a device for dispensing of the substances from the devices. CONSTITUTION: The tip of a metering dropper has an orifice 3 which is connected to a dropper chamber 4 and has a screw thread 5 for attaching an upper cap covering an upper tip. The upper tip connects a lower part-attaching arm 6 to an upper bellows 8 by so connecting both of an upper and a lower dropper tip are connected together. A lower part (bottom part) dropper tip has a squeeze or bellows wall 9, an inverse thread-cut screw 10 for attaching a bottom cap, and a conveyance tip passage 11 for the entry of drugs into a storage bellows chamber 9 through a sealed tip orifice 12. A bottom part conveyance-dropper tip 12 is an inverse screw cap having an inverse thread-cut screw 13, designed, after conveying drugs to the storage chamber 9, to be covered by a tip seal 14 in order to hermetically close the tip of the lower part permanently.