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131. 发明专利

JPS631937B2 失效
公开(公告)号：JPS631937B2
公开(公告)日：1988-01-14
申请号：JP17155679
申请日：1979-12-28
申请人： NISSHIN FLOUR MILLING CO
发明人： SUEDA NORYOSHI , KIKUCHI HARUHIKO
IPC分类号： C07D309/12 , C07C67/00 , C07C213/00 , C07C217/30 , C07C239/00 , C07C275/70 , C07D209/04

132. 发明专利

JPS62265261A PRODUCTION OF INDOLE 失效
公开(公告)号：JPS62265261A
公开(公告)日：1987-11-18
申请号：JP10995586
申请日：1986-05-14
申请人： KAWASAKI STEEL CO
发明人： TANAKA MAKOTO , TAKEO SETSU , SAKOTA NAOICHI
IPC分类号： C07D209/04 , C07D209/06
摘要： PURPOSE:To obtain indole from an indole-containing oil in high recovery, by contacting an indole-containing oil with an acid to form an oligomer salt of indole, separating and dissolving the salt in an alcohol, removing acid from the solution with a basic substance and thermally decomposing the deacidified oligomer. CONSTITUTION:An indole-containing oil having an indole content of as low as =-10 deg.C to form an oligomer salt of indole, which is separated by filtration, etc. The separated oligomer is dissolved in an alcohol (e.g. methanol, ethylene glycol, etc.) and deacidified with a basic substance to obtain a mixture of the oligomer and alcohol. After removing the alcohol, the oligomer is thermally decomposed at 100-350 deg.C to recover indole. USE:Raw material for pharmaceuticals and agricultural chemicals.

133. 发明专利

JPS6254281B2 失效
公开(公告)号：JPS6254281B2
公开(公告)日：1987-11-13
申请号：JP11843579
申请日：1979-09-14
申请人： MEIJI SEIKA CO
发明人： IWATA MICHIAKI , KAI FUMIO , SUZUKI YUKIO , WATANABE TETSUO , SEKIZAWA TAIJI
IPC分类号： C07D209/34 , A01N43/38 , C07D209/04 , C07D209/46 , E05B65/08

134. 发明专利

JPS61151171A PRODUCTION OF INDOLE 失效
公开(公告)号：JPS61151171A
公开(公告)日：1986-07-09
申请号：JP27274884
申请日：1984-12-26
申请人： MITSUI TOATSU CHEMICALS
发明人： YAMAUCHI ATSURO , IGUCHI SEIYA , ONO YUZO , KIMURA HIROSHI , MORITA SATOSHI
IPC分类号： C07D209/04 , C07D209/08
摘要： PURPOSE:To obtain high-purity indole by a simple process, by subjecting aniline and ethylene glycol to gaseous-phase contact reaction in the presence of a catalyst, separating and removing previously a high-boiling impurity, etc. from the prepared reaction product, and carrying out rectification. CONSTITUTION:Aniline which is previously vaporized by an evaporator is brought into contact with ethylene glycol in the presence of a solid acid catalyst or a metallic catalyst (supported on a carrier) at 0.01-10hr10 liquid space velocity (LHSV) at 200-600 deg.C at 1.1X10 -1.0X10 Pa pressure to give a reaction product, from which a high-boiling impurity and an nonvolatile substance are separated and removed, and rectification is carried out to give high-purity indole. EFFECT:In rectification of indole, a high-boiling impurity and a nonvolatile substance which remain in a rectification column after distillation of aniline and produce aniline gradually by thermal decomposition are previously removed, so occurrence of aniline is prevented, and purification is easily carried out. USE:An industrial raw material for perfume, dye, etc., a raw material for synthesizing amino acid, etc.

135. 发明专利

JPS6036423B2 失效
公开(公告)号：JPS6036423B2
公开(公告)日：1985-08-20
申请号：JP3701475
申请日：1975-03-28
申请人： SIEGFRIED AG
发明人： FURANTSU SHATSUTSU , KURISUTEIAN SHUTAMUBATSUHA , KURUTO TEIIRE , TEODOORU UAAGUNERU YAUREEKU , RUUTOITSUHI TSUIRUNGIIPURU , YOHANNA FUITSUSHERU , URURITSUHI YAAN
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P25/24 , A61P25/26 , A61P31/04 , C07D209/04 , C07D209/08 , C07D209/10 , C07D209/12 , C07D231/56 , C07D249/18

136. 发明专利

JPS6014023B2 失效
公开(公告)号：JPS6014023B2
公开(公告)日：1985-04-11
申请号：JP9669375
申请日：1975-08-11
申请人： NIPPON SODA CO
发明人： SUZUKI JUNJI
IPC分类号： C07D295/14 , A01N37/52 , A01N41/12 , A01N43/38 , A01N43/40 , A01N43/60 , A01N47/38 , A01N47/42 , C07C67/00 , C07C325/00 , C07C327/58 , C07C335/30 , C07C381/00 , C07D209/04 , C07D209/08 , C07D213/75 , C07D265/30

138. 发明专利

JPS5862160A SEPARATION OF INDOLE 失效
公开(公告)号：JPS5862160A
公开(公告)日：1983-04-13
申请号：JP15944181
申请日：1981-10-08
申请人： MITSUI TOATSU CHEMICALS
发明人： HONDA TADATOSHI
IPC分类号： C07D209/08 , C07C209/04 , C07D209/04
摘要： PURPOSE:To prevent the degradation loss of indole in the separation of indole by the distillation of indole synthesis reaction liquid derived from N-(beta-hydroxyethyl)aniline or aniline and ethylene glycol, by carrying out the distillation in the presence of a basic substance. CONSTITUTION:Indole is separated from the indole synthesis reaction liquid derived from N-(beta-hydroxyethyl)aniline or aniline and ethylene glycol. In the above distillation process, the reaction liquid is treated with a basic substance (e.g. oxide or hydroxide of alkali metal or alkaline earth metal, alkai metal carbonate, etc.). The amount of the basic substance added to the liquid is 0.001- 0.2mol per 1mol of indole. The distillation is carried out preferably under reduced pressure.

139. 发明专利

JPS5829748A RECOVERY OF ANILINE 失效
公开(公告)号：JPS5829748A
公开(公告)日：1983-02-22
申请号：JP12813681
申请日：1981-08-18
申请人： MITSUI TOATSU CHEMICALS
发明人： HONDA TADATOSHI
IPC分类号： C07D209/04 , C07C67/00 , C07C209/00 , C07C209/86 , C07C211/46
摘要： PURPOSE:A nitrogen-containing organic compound that boils at a higher temperature than aniline and is separable from aniline by distillation is added to a solution containing aniline and indole and the aniline is distilled off for recovery without causing the change of properties in indole. CONSTITUTION:Indole is synthesized from N-(beta-hydroxyethyl)aniline or from a combination of aniline and ethylene glycol and the reaction mixture is combined with a nitrogen-containing organic compound boiling at a higher temperature than 230 deg.C, aniline's boiling point, such as 4-phenylmorpholine or 1-phenylpyrrolidine or N-phenylpipirazine. Then, they are subjected to distillation under reduced pressure to recover the objective compound. The amount of the nitrogen-containing compound is more than 0.1, preferably 0.5-1mol% based on the indole. Less than 0.1mol% of the compound is less effective in preventing indole from changing in properties.

140. 发明专利

JPS5732254A Novel preparation of (s)-(-)-1-alkylamino-3-aryl- oxypropane-2-ol 失效
标题翻译：（S） - （ - ） - 1-氨基亚氨基-3-亚甲基氧基-2-醇的新制备
公开(公告)号：JPS5732254A
公开(公告)日：1982-02-20
申请号：JP10712880
申请日：1980-08-06
申请人： Paamakemu Asia:Kk
发明人： TSUDA YOSHINORI , YOKOGOE KIYONORI
IPC分类号： A61K31/135 , A61P25/02 , B01J23/44 , B01J31/02 , C07C67/00 , C07C213/00 , C07C213/08 , C07C217/30 , C07D209/04
摘要： PURPOSE: To obtain the titled compound useful as a blocking agent for β-accetor in improved optical purity, by reacting a novel optically active compound with naphthol, etc., followed by hydrolysis, hydrogenation decomposition and/or decarboxylation.
CONSTITUTION: A novel optically active compound shown by the formula II (X is halogen, alkyl or arylsulfonyloxy; R
1 is H, alkyl, aryl, alkyl or aralkyl; R is lower alkyl) is reacted with a compound shown by the formula ArOH (Ar is aryl or indolyl which may be substituted.) to give a reaction product shown by the formula IV, which is hydrolyzed, subjected to hydrogenation decomposition and/or decarboxylated, or reacted with an alkylsulfonic acid, to give the desired compound shown by the formula I. The compound shown by the formula II is obtained easily by reacting a compound shown by the formula V with a halogenating agent.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：目的：通过使新颖的光学活性化合物与萘酚等反应，然后进行水解，氢化分解和/或脱羧，得到可用作β-加成剂的阻聚剂的标题化合物，以提高光学纯度。构成：由式II表示的新型光学活性化合物（X为卤素，烷基或芳基磺酰氧基; R 1为H，烷基，芳基，烷基或芳烷基; R为低级烷基）与式 ArOH（Ar是可被取代的芳基或吲哚基），得到式IV所示的反应产物，其被水解，进行氢化分解和/或脱羧，或与烷基磺酸反应，得到所需化合物通式I所示的化合物可以通过使式V所示的化合物与卤化剂反应而容易地得到。

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