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111. 发明专利

JP2003156442A METHOD OF COLLECTING DATA ON BIO-MOLECULE MICRO ARRAY 审中-公开
公开(公告)号：JP2003156442A
公开(公告)日：2003-05-30
申请号：JP2001358581
申请日：2001-11-22
申请人： RIKAGAKU KENKYUSHO
发明人： TASHIRO HIDEO , KONDO YASUMITSU , KITSUNAI TOKUJI
IPC分类号： G01N21/64 , C12N15/09 , C12Q1/68 , C40B40/02 , C40B50/06 , G01N21/55 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a data collection method for DNA micro array capable of collecting automatically fluorescent data from the DNA micro array without troubling a person. SOLUTION: This invention provides the method for collecting data on bio-molecule micro array. A fluorescence-labeled target bio-molecule is interacted with the bio-molecule micro array having a plurality of bio-molecule probe immobilized spots on a light reflecting layer spot on a substrate surface, in the method. The obtained bio-molecule micro array is irradiated with an excitation ray, reflected light and fluorescence from the bio-molecule micro array are measured concurrently, the bio-molecule probe immobilized spots having the light reflecting layer spot is specified based on a difference in intensity of the reflected light on the bio-molecule micro array, and the fluorescent data from a specified spot range is provided. Alternatively, the obtained bio-molecule micro array is irradiated with light, the reflected light from the bio-molecule micro array is measured, the bio-molecule probe immobilized spots having the light reflecting layer spot is specified based on a difference in intensity of the reflected light on the bio-molecule micro array, only a specified bio-molecule probe immobilized spot range is irradiated with an excitation light to measure the fluorescence, and the fluorescent data from the specified spot range are obtained thereby.

112. 发明专利

JP2003101111A METHOD FOR CORRECTING WAVELENGTH OF LIGHT SOURCE WITH CONTINUOUSLY VARIABLE WAVELENGTH 审中-公开
公开(公告)号：JP2003101111A
公开(公告)日：2003-04-04
申请号：JP2001293054
申请日：2001-09-26
申请人： RIKAGAKU KENKYUSHO
发明人： SUNOUCHI HIROSHI , TASHIRO HIDEO
IPC分类号： H01S3/137
摘要： PROBLEM TO BE SOLVED: To provide a method for correcting the wavelength of a light source with continuously variable wavelength in which the wavelength of a light emitted from a continuously variable wavelength light source, e.g. a variable wavelength laser, can be corrected with high accuracy. SOLUTION: The method for correcting the wavelength of a light emitted from a continuously variable wavelength light source comprises a first step for measuring interference fringes of a standard sample while scanning the wavelength of a light being emitted from the continuously variable wavelength light source, a second step for measuring the frequency distribution of an interference fringes measured in the first step using a short time Fourier transform method, and a third step for decreasing the feed width in the scanning of wavelength at a part of high frequency based on a frequency distribution measured in the second step and correcting the wavelength of a light being emitted from the continuously variable wavelength light source such that the feed width in the scanning of wavelength is increased at a part of low frequency.

113. 发明专利

JP2002181816A REAGENT AND METHOD FOR DETECTING DUPLEX NUCLEIC ACID 失效
公开(公告)号：JP2002181816A
公开(公告)日：2002-06-26
申请号：JP2000374626
申请日：2000-12-08
申请人： UNIV WASEDA , RIKAGAKU KENKYUSHO
发明人： NOJIMA TAKAHIKO , MATSUMOTO KAZUKO , KONDO YASUMITSU , TASHIRO HIDEO , TAKENAKA SHIGEORI
IPC分类号： G01N33/53 , C09B57/08 , C09B57/10 , C12Q1/68 , G01N21/75 , G01N33/566 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a new reagent for detecting a duplex nucleic acid and a method using this reagent for detecting the duplex nucleic acid formed by hybridization with a probe without labeling any target nucleic acid. SOLUTION: One molecule of this duplex nucleic acid detecting reagent includes a naphthalenediimide group capable of being intercalated in the duplex nucleic acid and a β-diketone group capable of forming a lanthanoid metal complex.

114. 发明专利

JP2002153272A BIOMOLECULE MICROARRAY 失效
公开(公告)号：JP2002153272A
公开(公告)日：2002-05-28
申请号：JP2000358121
申请日：2000-11-24
申请人： RIKAGAKU KENKYUSHO , UNIV WASEDA
发明人： TASHIRO HIDEO , KONDO YASUMITSU , KITSUNAI TOKUJI , TAKENAKA SHIGEORI , MATSUMOTO KAZUKO , NOJIMA TAKAHIKO
IPC分类号： G01N31/22 , B01J19/00 , C07K1/04 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N37/00 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a biomolecule microarray which can be used for quantitative analyses and has a high S/N ratio. SOLUTION: A photolithography technique and an etching technique are used to form an immobilizing film 14 in which avidin molecules are immobilized in a single layer at only specific probe biomolecule adhesion-desired sites 101 on the surface of a slide glass substrate 11, thus obtaining the surface-treated substrate 100. Since the areas and shapes of the specific sites all are uniform, the numbers of the biotin molecules immobilized on the specific sites 101 are also approximately uniform. Thereby, the numbers of the avidin molecoles bound to the specific sites 101 are identical. The specific sites 101 of the surface- treated substrate 100 are spotted with a solution containing probe DNA treated with biotin to obtain the DNA microarray. Since the numbers of the avidin molecules immobilized on the specific sites 101 are identical in the DNA microarrays, the number of probe DNAs 21 bound to the specific sites 101 is also identical.

115. 发明专利

JP2002098696A INTEGRATED BIOMOLECULE SENSOR 失效
公开(公告)号：JP2002098696A
公开(公告)日：2002-04-05
申请号：JP2000292832
申请日：2000-09-26
申请人： RIKAGAKU KENKYUSHO , TASHIRO HIDEO , KONDO YASUMITSU , KITSUNAI TOKUJI , TASHIRO TOMOKO
发明人： TASHIRO HIDEO , KONDO YASUMITSU , KITSUNAI TOKUJI , TASHIRO TOMOKO
IPC分类号： G01N33/53 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/58 , G01N37/00 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a method of manufacturing integrated biomolecule sensor by which a researcher, etc., can easily make its own biomolecule micro-array without requiring any expensive manufacturing device. SOLUTION: Solutions containing different kinds of probe DNAs are respectively poured in the 96 solution tanks 5a of a titer plate 5. The optical fibers 2 of an optical fiber bundle unit 4 are respectively dipped in the solutions contained in the solution tanks 5a of the titer plate 5 by inserting the front ends 2c into the tanks 5a after passing through the holes 6a of an auxiliary plate 6. When the front ends 2c are dipped in the solutions, the probe DNAs contained in the solutions adhere to the end faces of the cores 7a of the front ends 2c. Then the optical fiber bundle unit 4 is removed from the titer plate 5 and the front ends 2c of the fibers 2 are dried. Consequently, an integrated DNA sensor 1 constituted by fixing the different probe DNAs to the end faces of the cores 7a of the optical fibers 2 is obtained.

116. 发明专利

JP2002048524A METHOD AND DEVICE FOR PLANE INTERPOLATION OF MEASURED DATA 失效
公开(公告)号：JP2002048524A
公开(公告)日：2002-02-15
申请号：JP2000237533
申请日：2000-08-04
申请人： RIKAGAKU KENKYUSHO
发明人： KASE KIWAMU , TASHIRO HIDEO
IPC分类号： G01B11/24 , G06T17/00
摘要： PROBLEM TO BE SOLVED: To allow interpolation processing and rendering based on a large number of three-dimensional data x, y, z under a condition where measured precision of resolution is kept, without changing coordinate values of measured data, to compress the measured data efficiently to reduce a calculation load, and to allow thereby the interpolation processing and the rendering in a short time even in a small-sized computer of a low speed. SOLUTION: This method has a three-dimensional data obtaining step A for obtaining the three-dimensional data of a measured object as two-dimensional coordinates x, y and a height data z, a contour-line processing step B for processing the height data z out of the three-dimensional data by a boundary tracing method to store the data having the same value as a contour line comprising a chain code, a plane interpolation step C for interpolating a space between the contour line in a horizontal face and a vertical face divided into triangles, and a sloped face interpolation step D for substituting a sloped face divided into triangles for an area formed regularly repeatedly with the horizontal faces and the vertical faces at a fixed period.

117. 发明专利

JP2001244530A ULTRA-SHORT PULSE LASER OSCILLATION DEVICE 失效
公开(公告)号：JP2001244530A
公开(公告)日：2001-09-07
申请号：JP2000051650
申请日：2000-02-28
申请人： RIKAGAKU KENKYUSHO , KO NORIHIRO , WADA TOMOYUKI , TASHIRO HIDEO
发明人： KO NORIHIRO , WADA TOMOYUKI , TASHIRO HIDEO
IPC分类号： H01S3/117 , H01S3/081 , H01S3/094 , H01S3/098 , H01S3/106
摘要： PROBLEM TO BE SOLVED: To realize stable ultra-short pulse laser oscillation by eliminating the need for providing a mechanical operation part such as a rotation mechanism. SOLUTION: The device has a laser resonator constituted of an emission side mirror 10 and a total reflection mirror 12, a continuous oscillation laser 32 which injects excitation laser light A, a wavelength variable laser medium 18 which enables laser oscillation, a birefringence optical acousto-optic crystal 20 as a wavelength selecting crystal whereto emission light B from a wavelength variable laser medium is injected, a piezoelectric element which inputs acoustic wave, whose frequency is in accordance with strain caused by application of a voltage, to the optical acousto-optic crystal, a power supply 24 for applying a voltage and a control means for controlling the frequency of a voltage applied to a piezoelectric element by a power supply. The frequency of a voltage is controlled by a control means, a voltage, whose frequency is matched with the distance between a emission side mirror and a total reflection mirror, is applied to a piezoelectric element by a power supply, and laser beam emitted from the emission side mirror 10 is made emission laser beam C from a laser resonator.

118. 发明专利

JP2001053371A METHOD AND APPARATUS FOR GENERATING VACUUM ULTRAVIOLET LIGHT AND APPARATUS FOR UTILIZING THE SAME 失效
公开(公告)号：JP2001053371A
公开(公告)日：2001-02-23
申请号：JP22796799
申请日：1999-08-11
申请人： RIKAGAKU KENKYUSHO
发明人： WADA TOMOYUKI , TASHIRO HIDEO
IPC分类号： H01S3/30 , G02F1/35 , G02F1/37 , H01S3/108 , H01S3/16
摘要： PROBLEM TO BE SOLVED: To stably generate vacuum ultraviolet light, having wavelength of 157 nm using a compact arrangement. SOLUTION: A laser beam 11, having wavelength of 1,046 nm generated from a solid-state laser 10 utilizing active ions of Nd or Yb is converted by nonlinear optical crystals 35-37 into a fifth higher harmonic laser beam 31, having a wavelength of 213 nm. The laser light 31 having converted wavelength of 213 nm is projected into hydrogen gas 40 to produce laser light 21 having wavelength of 157 nm by a fourth order anti-Stokes stimulated Raman scattering.

119. 发明专利

JP2000337862A SYNTHESIZING METHOD FOR PARTIAL MEASURED DATA 失效
公开(公告)号：JP2000337862A
公开(公告)日：2000-12-08
申请号：JP14775699
申请日：1999-05-27
申请人： RIKAGAKU KENKYUSHO
发明人： KASE KIWAMU , TASHIRO HIDEO
IPC分类号： G01B21/20 , G01B11/24 , G06F17/50 , G06T17/00
摘要： PROBLEM TO BE SOLVED: To provide a synthesizing method for partial measured data, in which high-accuracy composed data can be prepared by a small number of repetitive calculations on the basis of a plurality of partial measured data. SOLUTION: The shape on the surface of an object 1 is measured while its position and/or its direction are changed. A plurality of partial measured data 2 which contain common parts 2a are acquired. Regarding all the partial measured data 2, overlap ranges 3a of measuring error ranges 3 in the adjacent common parts 2a are found. When the overlap ranges 3a do not exist, it is judged that the common parts in the partial measured data cannot be composed. When the overlap ranges 3a exist, the common parts in the partial measured data are synthesized within the ranges.

120. 发明专利

JP2000022254A LASER OSCILLATION CONTROL METHOD AND ITS DEVICE 失效
公开(公告)号：JP2000022254A
公开(公告)日：2000-01-21
申请号：JP18395398
申请日：1998-06-30
申请人： RIKAGAKU KENKYUSHO
发明人： SATO HIDETOSHI , WADA TOMOYUKI , TASHIRO HIDEO
IPC分类号： H01S3/117 , H01S3/136 , H01S3/137
摘要： PROBLEM TO BE SOLVED: To prevent emitting laser beams from being affected by a temperature change of an acoustic optical element, by a method wherein an input intensity value of first acoustic waves is set as an input intensity value capable of oscillating a laser, and the input intensity value of second acoustic waves is a value obtained by subtracting the input intensity value of the first acoustic waves from a predetermined value. SOLUTION: A first frequency input from a first RF power source 10 to a piezoelectric element 22 is set as a frequency capable of oscillating a laser in a Ti:Al2O3 laser crystal 14 in response to a frequency of emissive laser beams, and a second RF frequency input from a second power source 12 to the piezoelectric element 22 is set as a frequency incapable of oscillating the laser. And, it is preferable that a first RF input intensity is set to be an intensity most optimal to a laser oscillation of the first RF frequency, but the second RF frequency is controlled so that the total value of the first RF input intensity is always set to be constant. Thus, the emissive laser beams are not affected by a temperature change of a photoacoustic optical element 100.

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