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1. 发明专利

JPH0522180B2 失效
公开(公告)号：JPH0522180B2
公开(公告)日：1993-03-26
申请号：JP12627682
申请日：1982-07-20
申请人： OLYMPUS OPTICAL CO
发明人： KANEKO NOBUTAKA
IPC分类号： G01N27/26 , G01D9/02 , G01N27/447

2. 发明专利

JPH03191855A ELECTROPHORESIS APPARATUS 失效
公开(公告)号：JPH03191855A
公开(公告)日：1991-08-21
申请号：JP33237089
申请日：1989-12-21
申请人： OLYMPUS OPTICAL CO
发明人： SUZUKI HIDEO , KANEKO NOBUTAKA , YAMAMOTO AKIHIKO , WATANABE SADAHIRO
IPC分类号： G01N21/15 , G01N21/41 , G01N27/447
摘要： PURPOSE:To make it possible to measure each division rate and the total protein quantity by measuring the total protein quantity of a sample, and operating the measured data. CONSTITUTION:Samples 2 which are contained in receiving parts 1a - 1j of a sample container 1 are sequentially picked up with a pickup mechanism 4. The sample 2 is dropped and applied on an application surface 5a1 of a head 5a of the refractive-index meter of a measuring mechanism 5. The total protein quantity of the applied sample 2 is measured, computed and stored in this mechanism 5. The quantity is multiplied by the division rate obtained in a migration- division measuring part. Thus the protein quantity with respect to each division is automatically obtained. When the measurement of the smaple 2 is finished, the application surface 5a1 of the head 5a is immersed in a cleaning liquid cell 5d and cleaned. The other samples 2 are sequentially picked up from the receiving parts 1a - 1j with the mechanism 4 and applied on the application surface 5a1 of the head 5a. In this way, the total protein quantities of the samples 2 are measured, computed and stored.

3. 发明专利

JPH0313545B2 失效
公开(公告)号：JPH0313545B2
公开(公告)日：1991-02-22
申请号：JP12627882
申请日：1982-07-20
申请人： OLYMPUS OPTICAL CO
发明人： KANEKO NOBUTAKA
IPC分类号： G01N21/17 , G01N21/25 , G01N21/59 , G01N21/86 , G01N27/26 , G01N27/447
摘要： A densitometer comprises a first carrier supporter for supporting a carrier formed of a cellulose acetate film for carrying a blood serum specimen after an electrophoresis process is completed and a second carrier supporter for supporting a carrier for a blood serum which is formed of a gel or the like and reinforced with a transparent plate. The first and second carrier supporters are disposed between a light projector and a light receiver in such a manner that the density measurement of fractionated patterns of a blood serum may be effected upon occasion by supporting either the carrier formed of a cellulose acetate film or the carrier formed of a gel or the like.

4. 发明专利

JPS61271460A IMMUNOLOGICAL ANALYSIS 失效
公开(公告)号：JPS61271460A
公开(公告)日：1986-12-01
申请号：JP11305185
申请日：1985-05-28
申请人： OLYMPUS OPTICAL CO
发明人： YAMADA TAKASHI , KANEKO NOBUTAKA , TAWARA TAKASHI , TAKAHASHI TAKEO
IPC分类号： G01N21/21 , G01N33/542 , G01N33/543 , G01N33/544
摘要： PURPOSE:To enable accurate assay and analysis with a limited analysis process, by arranging an antibody or an antigen prone to an antigen-antibody reaction specifically with a substant to be inspected on a liquid crystal molecule as converted to a solid phase to lead it to an antigen-antibody reaction with a sample. CONSTITUTION:A liquid crystal is used in place of an insoluble carrier and a liquid crystal molecule 10 is made to react with a sample 12 after an antibody or an antigen 11 allowed to an immunological reaction specifically with a substance 20 to be inspected is converted to the phase the same as the molecule. As a result, the liquid crystal molecule 10 bonded to the substance 20 being inspected by the immunological reaction changes in the orientation characteristic according to the substance 20 being inspected thus bonded thereto. Luminous flux emitted from a light source 18 is transmitted with a polarization plate 17 to be converted to a linearly polarized light and made incident into a reactor 13. As being at a random state, the liquid crystal molecule 10 in the reactor 13 acts on the incident polarized light as photodetector or work to turn the rotary surface of the incident polarized light. This enables direct assay of the substance 20 being inspected bonded to the liquid crystal molecule 10 by measuring the quantity of the polarized light passing through the reactor 13 thereby simplifying the analysis process.

5. 发明专利

JPS59212868A Supplying method of buffer solution 失效
标题翻译：缓冲解决方案的供应方法
公开(公告)号：JPS59212868A
公开(公告)日：1984-12-01
申请号：JP8593083
申请日：1983-05-18
申请人： Olympus Optical Co Ltd
发明人： ABE KENICHI , KANEKO NOBUTAKA
IPC分类号： G01N27/447 , G03G17/04
CPC分类号： G03G17/04
摘要： PURPOSE:To automate the discharge and supply of a migration vessel and a buffer solution vessel and hold the degrees of fatigue in both vessels invariably constant by supplying the buffer solution which is used in the buffer solution vessel communicating with the migration vessel to the migration vessel. CONSTITUTION:The ion concentration detector 9 in the buffer solution vessel 6 operates all the time. When the ion concentration of a detecting circuit 10 exceeds some specific value, a cross valve 4 forms the flow passage between the vessel 6 and migration vessel 14 and a pump 12 sends the solution in the vessel 6 to reservoir parts 14a and 14b of the vessel 14 to make a solution exchange. The capacity of the vessel 6 is equal to or a little bit larger than the sum of the capacities of the reservoir parts 14a and 14b, so a waste solution is exchanged from above through filter paper 16. Then, the solution is sent from a supply vessel 1 to the vessel 6 through the valve 4 to supply the fresh solution up to the level of a reducing valve 2. Thus, a support 7 is sent from a roller 8 to the vessel 6 again and a specific treatment is carried out.
摘要翻译：目的：为了使迁移容器和缓冲溶液容器的放电和供应自动化并且通过将与迁移容器连通的缓冲溶液容器中使用的缓冲溶液提供给迁移容器来保持两个容器中的疲劳程度恒定不变。构成：缓冲溶液容器6中的离子浓度检测器9一直运行。当检测电路10的离子浓度超过某一特定值时，交叉阀4形成容器6和迁移容器14之间的流动通道，并且泵12将容器6中的溶液送到容器的储存部分14a和14b 14进行解决交换。容器6的容量等于或稍大于储存部分14a和14b的容量的总和，因此从上方通过滤纸16更换废液。然后，将溶液从供应源容器1通过阀4送到容器6，以将新鲜溶液供应到减压阀2的水平面上。因此，支撑件7再次从辊8送到容器6，并进行特定的处理。

6. 发明专利

JPS5917142A Recording method of densitogram 失效
标题翻译：密度记录方法
公开(公告)号：JPS5917142A
公开(公告)日：1984-01-28
申请号：JP12627682
申请日：1982-07-20
申请人： Olympus Optical Co Ltd
发明人： KANEKO NOBUTAKA
IPC分类号： G01N27/26 , G01D9/02 , G01N27/447
CPC分类号： G01N27/44721 , G01D9/02
摘要： PURPOSE: To make always both changes in concentration of plural substances in a sample to be tested, and changes in fractions of the said substances in a densitogram correspond to each other, by recording a densitographic curve so that an area surrounded by a base line may satisfy a prescribed relationship.
CONSTITUTION: A fractional image of serum protein of a supporting material 4 is optically scanned, and the detected value of concentration sent from a photodetector 5 and a concentration converting part 6 is stored in a concentration storing part 7. Then, the stored contents are treated by an arithmetic part 11 to which the total protein concentration T coming through a concentration accumulator 8 or through an input part 9 and a storage part 10 for total concentration, is impressed, and a calculation is conducted so that an area S sur- rounded by a base line may satisfy the relationship on S=KT, where K is a constant. Based on the calculation results, a densitographic curve using a storage meter 13 is recorded. Thus, even if the amount of a sample to be coated changes, both changes in concentration of plural substances incorporated in the sample, and changes in fractions of the said substances on the densitogram always correspond to each other, and the changes in concentration are visually judged with ease.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：为了使待测样品中的多种物质的浓度总是变化，并且致密图中的所述物质的分数变化相互对应，通过记录密度曲线使得由基线包围的区域可以满足规定的关系。构成：对支撑材料4的血清蛋白质的分数图像进行光学扫描，将从光电检测器5和浓度转换部6发送的浓度的检测值存储在浓度存储部7中。然后对存储的内容物进行处理通过运算部11将通过浓度积存器8或通过输入部9的总蛋白浓度T和总浓度的存储部10印刷，并进行计算，使得通过基线可以满足S = KT的关系，其中K是常数。基于计算结果，记录使用存储计13的密度曲线。因此，即使要涂覆的样品的量发生变化，包含在样品中的多种物质的浓度变化和浓度图上的所述物质的分数变化总是相对应，并且目测浓度的变化轻松判断

7. 发明专利

JP2533845B2 失效
公开(公告)号：JP2533845B2
公开(公告)日：1996-09-11
申请号：JP11305285
申请日：1985-05-28
申请人： OLYMPUS OPTICAL CO
发明人： YAMADA TAKASHI , KANEKO NOBUTAKA , TAWARA TAKASHI , TAKAHASHI TAKEO
IPC分类号： G01N21/17 , A61K39/00 , G01N21/03 , G01N33/543

8. 发明专利

JPH0629848B2 失效
公开(公告)号：JPH0629848B2
公开(公告)日：1994-04-20
申请号：JP18653385
申请日：1985-08-27
申请人： OLYMPUS OPTICAL CO
发明人： KANEKO NOBUTAKA
IPC分类号： G01N21/17 , G01N27/26 , G01N27/447 , G01N30/95

9. 发明专利

JPS6247534A AUTOMATIC ANALYSIS BY ELECTROPHORETIC IMAGE 失效
公开(公告)号：JPS6247534A
公开(公告)日：1987-03-02
申请号：JP18653385
申请日：1985-08-27
申请人： OLYMPUS OPTICAL CO
发明人： KANEKO NOBUTAKA
IPC分类号： G01N21/17 , G01N27/26 , G01N27/447 , G01N30/95
摘要： PURPOSE:To enable an automatic and exact analysis even if variance exists in a coating amt. and migration length by normalizing the data obtd. by photometrically measuring the electrophoretic image of a measuring specimen and analyzing the measuring specimen in accordance with the reference data associated to the normal electrophoretic image. CONSTITUTION:A data processor of a photometric instrument is constituted of a logarithmic amplifier 12, an A/D converter 13, a CPU 14, a memory 15, a keyboard 16, a CRT 17, a floppy disk 18 and a printer 19, etc. The photoelectrical conversion output obtd. from a photodetector 5b of the photometric instrument 5 by photometric scanning is logarithmically amplified and is then converted to a digital signal which is stored in a memory 15 and is subjected to smoothing processing; at the same time, the signal is subjected to auto-zero processing for removing the base floating component by the quantity of light then to normalizing processing. The processed signal is stored on the floppy disk 18. The measuring specimen is automatically analyzed in accordance with the normalized data and the normal electrophorectic image.

10. 发明专利

JPS6242034A TREATMENT OF ELECTROPHORESIS PATTERN 失效
公开(公告)号：JPS6242034A
公开(公告)日：1987-02-24
申请号：JP18003285
申请日：1985-08-17
申请人： OLYMPUS OPTICAL CO
发明人： KANEKO NOBUTAKA
IPC分类号： G01N21/17 , G01N27/26 , G01N27/447
摘要： PURPOSE:To easily and exactly know the density change of each fraction and to easily and exactly analyze a disease condition by normalizing sampling data in such a manner that two reference points coincide respectively with the prescribed data positions to be associated to the predetermined migration length. CONSTITUTION:A photometric instrument 5 having a light source 5a and a photodetector 5b is moved in the scanning direction intersecting orthogonally with the conveying direction of a base 1, by which the electrophoresis image formed on the base 1 is subjected to photometric scanning. The photoelectrically converted output obtd. from the element 5b by the photometric scanning is logarithmically amplifier 12 and is converted to absorbancy; thereafter the absorbancy is sampled and converted to a digital signal by an A/D converter 13. The digital signal is subjected to the normalization treatment under the control of a CPU14 and is stored into a memory 15. The data exceeding such prescribed threshold value at which both end points come to both end points of the migration image is extracted from the sampling data of a specimen to be measured and the presence or absence of a peak in the prescribed range is detected from both end points of the extracted data. The reference point is detected from the detected peak position.

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