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1. 发明专利

JP2014172839A Process for producing optically active tertiary alcohol derivative 有权
标题翻译：用于生产光学活性醇类衍生物的方法
公开(公告)号：JP2014172839A
公开(公告)日：2014-09-22
申请号：JP2013045569
申请日：2013-03-07
申请人： Hokkaido Univ , 国立大学法人北海道大学 , Nippon Soda Co Ltd , 日本曹達株式会社
发明人： OKUMA TAKESHI , UEMIYA NOBUHITO , OOOKA HIROHITO
IPC分类号： C07C67/313 , C07B53/00 , C07B57/00 , C07B61/00 , C07C69/675 , C07C269/02 , C07C271/12 , C07D263/28
摘要： PROBLEM TO BE SOLVED: To provide a process for producing a tertiary alcohol derivative of high optical purity from a racemic tertiary alcohol derivative or a tertiary alcohol derivative of low optical purity.SOLUTION: Provided is a method for producing an optically active tertiary alcohol, comprising: reacting a tertiary alcohol derivative such as (±)-methyl 2-hydroxy-3,3-dimethylbutanoate and an isocyanic acid ester such as isocyanic acid n-propyl isocyanate to convert a portion of the tertiary alcohol derivative into a carbamate in the presence of a metallic compound and a compound such as (s)-2,2-isopropylidene-bis(4-t-butyl-2-oxazoline) which can coordinate with a metallic compound; and separating the tertiary alcohol derivative which is not converted into a carbamate from the tertiary alcohol derivative which is converted into a carbamate.
摘要翻译：要解决的问题：提供从外消旋叔醇衍生物或低光学纯度的叔醇衍生物制备高光学纯度的叔醇衍生物的方法。解决方案：提供一种光学活性叔醇的制备方法，包括：使叔醇衍生物如（±） - 2-羟基-3,3-二甲基丁酸甲酯和异氰酸酯如异氰酸正丙酯异氰酸酯反应，将一部分叔醇衍生物转化为氨基甲酸酯，的金属化合物和可与金属化合物配位的（s）-2,2-异亚丙基 - 双（4-叔丁基-2-恶唑啉）的化合物; 并将未转化成氨基甲酸酯的叔醇衍生物与转化成氨基甲酸酯的叔醇衍生物分离。

2. 发明专利

JP2008031132A METHOD FOR PREPARING β,β-BISHETERO-SUBSTITUTED OPTICALLY ACTIVE ALCOHOL 有权
标题翻译：制备β，β-双（异构取代）光学活性醇的方法
公开(公告)号：JP2008031132A
公开(公告)日：2008-02-14
申请号：JP2006209433
申请日：2006-08-01
申请人： Hokkaido Univ , Nippon Soda Co Ltd , 国立大学法人北海道大学 , 日本曹達株式会社
发明人： OKUMA TAKESHI , ARAI NORIYOSHI , INOUE TSUTOMU , OOOKA HIROHITO
IPC分类号： C07C41/18 , B01J31/24 , C07B53/00 , C07B61/00 , C07C43/315 , C07D319/06
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for commercially advantageously preparing a β,β-bishetero-substituted optically active alcohol from the corresponding α,α-bishetero-substituted carbonyl compound by using an easily available ruthenium compound as an asymmetric hydrogenation catalyst and hydrogen. SOLUTION: The method for preparing a β,β-bishetero-substituted optically active alcohol (III) (wherein R 1 is an aryl group or the like; R 21 and R 22 are each a 1-20C alkyl group or the like; and X 1 and X 2 are each oxygen or the like) comprises bringing a carbonyl compound (I) (wherein R 1 , R 21 , R 22 , X 1 , and X 2 are the same as defined above) into contact with hydrogen in the presence of a ruthenium compound (II) (wherein Y is an anionic ligand; Px is a phosphine ligand; and A is a diamine ligand) and a base. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过使用容易获得的钌化合物作为不对称氢化从相应的α，α-双杂杂取代的羰基化合物商业上有利地制备β，β-双杂杂取代的光学活性醇的方法催化剂和氢气。解决方案：制备β，β-双杂杂取代的光学活性醇（III）（其中R 1 为芳基等的方法; R SP SP 21 >和R“SP”22各自为1-20C烷基等; X 1 和X 2 分别为氧等）包括使羰基化合物（I）（其中R 1，R 2，R 2，R 2，SP 2，X SP 1，和X 2 与上述相同）在钌化合物（II）（其中Y是阴离子配体; Px是膦配体; A是二胺）的存在下与氢接触配体）和碱。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2005239601A Method for producing n-acylamino acids 审中-公开
标题翻译：生产N-酰氨基酸的方法
公开(公告)号：JP2005239601A
公开(公告)日：2005-09-08
申请号：JP2004049110
申请日：2004-02-25
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： SAKAE TAKAHIRO , HAYASHI KENICHI , INOUE TSUTOMU , OOOKA HIROHITO
IPC分类号： C07C231/08 , C07B61/00 , C07C233/47
摘要： PROBLEM TO BE SOLVED: To provide a practical method for producing an N-acylamino acid, by which amidocarbonylation reaction is efficiently advanced while controlling reduction in catalytic activity and leaching of palladium even by repeated use by using both a polymer-immobilized palladium catalyst and a solid acid catalyst.
SOLUTION: The N-acylamino acid is obtained by reacting an aldehyde with an amide in the presence of a halogen compound, a polymer fixed palladium catalyst and a solid acid catalyst in an organic solvent under pressure of carbon monoxide.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了提供一种生产N-酰基氨基酸的实用方法，其中通过酰胺基羰基化反应有效地进行，同时控制催化活性的降低和钯的浸出，甚至通过使用聚合物固定的钯催化剂和固体酸催化剂。解决方案：通过在一氧化碳压力下，在有机溶剂中，在卤素化合物，聚合物固定钯催化剂和固体酸催化剂的存在下，使醛与酰胺反应，得到N-酰基氨基酸。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004331540A Method for producing bisphosphine 有权
公开(公告)号：JP2004331540A
公开(公告)日：2004-11-25
申请号：JP2003127900
申请日：2003-05-06
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： OOOKA HIROHITO
IPC分类号： C07F5/02 , C07F9/50 , C07F19/00
摘要： PROBLEM TO BE SOLVED: To provide a useful method for producing a phosphine compound which is useful as a component for catalyst systems capable of being used for carbonylating olefins.
SOLUTION: This method for producing a compound represented by formula [1] (R
1 , R
2 and R
3 may be identical with or different from each other and are hydrocarbon groups, respectively, which may be bound to each other to form a ring; L
1 and L
2 are each a 1 to 6C hydrocarbon group which may be substituted; X is an aryl which may be substituted) is characterized by (the first process) reacting a compound represented by formula [2](Y is a releasing group) with a compound represented by formula [3] (M is a metal atom) to produce a borane complex represented by formula [4] and (the second process) removing the borane from the borane complex. The objective compound is obtained in a good yield.
COPYRIGHT: (C)2005,JPO&NCIPI

5. 发明专利

JP2007283302A Catalyst composition 有权
标题翻译：催化剂组合物
公开(公告)号：JP2007283302A
公开(公告)日：2007-11-01
申请号：JP2007165566
申请日：2007-06-22
申请人： Japan Science & Technology Agency , Jfe Steel Kk , Jfeスチール株式会社 , Kanto Chem Co Inc , Nippon Soda Co Ltd , Takasago Internatl Corp , Takeda Chem Ind Ltd , 日本曹達株式会社 , 武田薬品工業株式会社 , 独立行政法人科学技術振興機構 , 関東化学株式会社 , 高砂香料工業株式会社
发明人： IKARIYA TAKAO , IKEHIRA HIDEYUKI , MURATA KUNIHIKO , KIYOFUJI NOBUO , OOOKA HIROHITO , HASHIGUCHI SHOHEI , OKUMA TAKESHI , NOYORI RYOJI
IPC分类号： B01J31/22
摘要： PROBLEM TO BE SOLVED: To provide a catalyst composition for obtaining an optically-active alcohol compound in a high yield and a high selectivity.
SOLUTION: The catalyst composition is composed of a ruthenium complex represented by general formula (1) (wherein, X and Y each represent a hydrogen atom, halogen atom, carboxyl group, or other anion group, R
1 , R
2 , and R
3 each represent a hydrocarbon group which may have a substituent, both the R
1 and the R
2 may form a carbon chain ring which may have a substituent, n is an integer of 1 to 4, R
6 , R
7 , and R
8 each represent a hydrocarbon group which may have a hydrogen atom or a substituent, m is an integer of 1 to 4, and both of PR
1 R
2 R
3 and NR
6 R
7 R
8 are an optically-active group).
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供以高产率和高选择性获得光学活性醇化合物的催化剂组合物。解决方案：催化剂组合物由通式（1）表示的钌络合物（其中X和Y各自表示氢原子，卤素原子，羧基或其它阴离子基团，R 1， / SP>，R 2 和R 3 各自表示可以具有取代基的烃基，R 1 SP> 2可以形成可以具有取代基的碳链环，n为1〜4的整数，R SP 6，R SP 7，和R 各自表示可以具有氢原子或取代基的烃基，m为1〜4的整数，PR 1 2 < / SP> R 3 和NR 6 R 7 R 8 是光学活性基团）。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2009057299A Substituted phenoxyazabicyclooctane derivative and method for producing the same 有权
标题翻译：取代的苯氧基羰基衍生物及其制备方法
公开(公告)号：JP2009057299A
公开(公告)日：2009-03-19
申请号：JP2007224234
申请日：2007-08-30
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： SUGA SHIGEMI , OOOKA HIROHITO , HIROKAWA KENICHI , IMAGAWA TSUTOMU
IPC分类号： C07D221/22
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a substituted phenoxyazabicyclooctane derivative [compound (V)] in a high yield by using readily available raw materials and to provide a new 2-halogenophenoxyazabicyclooctane derivative [compound (III) and compound (V)]. SOLUTION: The method for producing a substituted phenoxyazabicyclooctane derivative represented by the formula (V) comprises reacting an azabicyclool derivative represented by formula (I) with a halogenobenzene compound represented by the formula (II) in the presence of a base at ≤20°C to give a 2-halogenophenoxyazabicyclooctane derivative represented by the formula (III) and reacting the obtained 2-halogenophenoxyazabicyclooctane derivative represented by the formula (III) with an alcohol compound represented by the formula (IV), wherein R 1 and R 2 are each a substituent group-containing 1-20C alkyl group or the like; n is 1 or 2; R 3 is a 1-20C haloalkyl group or the like; and X is a halogen. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过使用容易获得的原料以高产率制备取代的苯氧基偶氮二环辛烷衍生物[化合物（V）]的方法，并提供新的2-卤代苯氧基氮杂双环辛烷衍生物[化合物（III）和化合物（V）]。解决方案：用于制备由式（Ⅴ）表示的取代的苯氧基氮杂双环辛烷衍生物的方法包括使式（I）表示的氮杂双环衍生物与式（II）表示的卤代苯化合物在碱的存在下， 20℃，得到式（III）表示的2-卤代苯氧基氮杂双环辛烷衍生物，将得到的式（III）表示的2-卤代苯氧基氮杂双环辛烷衍生物与式（IV）表示的醇化合物反应，其中R SB ＆lt; / SB＆gt;和R＆lt; SB＆gt; 2＆lt; / SB＆gt;各自为含有取代基的1-20C烷基等; n为1或2; R SB 3是1-20C卤代烷基等; X是卤素。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2005068113A Ruthenium compound and method for producing optically active alcohol compound 有权
标题翻译：用于生产光学活性醇的化合物的方法和方法
公开(公告)号：JP2005068113A
公开(公告)日：2005-03-17
申请号：JP2003303471
申请日：2003-08-27
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： OOOKA HIROHITO , INOUE TSUTOMU
IPC分类号： B01J31/24 , C07B53/00 , C07B61/00 , C07C29/145 , C07C33/20 , C07C33/22 , C07C33/30 , C07C211/65 , C07C231/18 , C07C233/73 , C07C269/06 , C07C271/16 , C07F9/50 , C07F15/00
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new ruthenium compound that is readily available and useful as an asymmetric hydrogenation catalyst and provide a method for producing optically active alcohol compound by using the ruthenium compound as an asymmetric hydrogenation catalyst.
SOLUTION: The ruthenium compound is represented by formula (I) [wherein X and Y are each H or a halogen, or the like; Px is a phosphine ligand; n is 1 or 2; A is a diamine ligand represented by formula (1) or formula (2) (wherein R
1 is a 1-20C alkyl, an aryl or the like; R
2 and R
3 are each H or a 1-20C alkyl which may be substituted)]. In the presence of the ruthenium compound, a carbonyl compound is brought into contact with hydrogen to produce an optically active alcohol compound.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种容易获得并用作不对称氢化催化剂的新的钌化合物，并提供通过使用钌化合物作为不对称氢化催化剂制备光学活性醇化合物的方法。解决方案：钌化合物由式（I）表示[其中X和Y各自为H或卤素等; Px是膦配体; n为1或2; A是由式（1）或式（2）表示的二胺配体（其中R 1 = 1〜C 2烷基，芳基等; R 2 SP 2， R 3各自为H或可被取代的1-20C烷基]]。在钌化合物的存在下，使羰基化合物与氢接触以产生光学活性的醇化合物。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2008094744A Process for producing piperidin-4-one derivative using bisaminol ether compound 有权
标题翻译：使用双嘧啶醇醚化合物生产哌啶-4-酮衍生物的方法
公开(公告)号：JP2008094744A
公开(公告)日：2008-04-24
申请号：JP2006277088
申请日：2006-10-11
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： OOOKA HIROHITO , INOUE HIROO
IPC分类号： C07D491/113 , C07B61/00 , C07D221/22
摘要： PROBLEM TO BE SOLVED: To provide a process for producing a piperidin-4-one derivative useful as an agricultural and pharmaceutical intermediate.
SOLUTION: The piperidin-4-one derivative represented by the formula (III-1) or (III-2) is produced by reaction of a bisaminol ether compound represented by the formula (I) and an acetone derivative represented by the formula (II) in the presence of a metal iodide to function as a Lewis acid, or a Lewis acid and an alkali metal iodide or an alkaline earth metal iodide.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供用作农药和中间体的哌啶-4-酮衍生物的制备方法。解决方案：由式（III-1）或（III-2）表示的哌啶-4-酮衍生物通过由式（I）表示的双氨基醚醚化合物和由式式（II）的化合物在金属碘化物的存在下，作为路易斯酸，路易斯酸和碱金属碘化物或碱土金属碘化物起作用。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2006036729A Method for producing optically active alcohol derivative 有权
标题翻译：生产光学活性醇衍生物的方法
公开(公告)号：JP2006036729A
公开(公告)日：2006-02-09
申请号：JP2004222685
申请日：2004-07-30
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： OOOKA HIROHITO
IPC分类号： C07C67/60 , B01J31/22 , C07B57/00 , C07B61/00 , C07C45/85 , C07C49/245 , C07C69/67 , C07C69/68 , C07C69/732 , C07C231/20 , C07C235/34 , C07C269/02 , C07C271/18 , C07C271/22 , C07D307/33
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an optically active carbonyl-containing alcohol derivative useful as an intermediate for pharmaceuticals and agricultural chemicals from a racemic or lowly optically pure alcohol compound by industrially advantageous kinetic resolution.
SOLUTION: This method for stereoselectively producing the carbonyl-containing optically active alcohol derivative comprises reacting a carbonyl-containing alcohol compound with an isocyanic acid ester in the presence of a metal complex composed of a metal compound and asymmetric ligands to effect kinetic resolution into carbamate compounds.
COPYRIGHT: (C)2006,JPO&NCIPI

10. 发明专利

JP2005247703A Method for producing propionic ester derivative, and macromolecular sulfonic acid compound 审中-公开
标题翻译：生产丙酸酯衍生物的方法和大分子磺酸化合物
公开(公告)号：JP2005247703A
公开(公告)日：2005-09-15
申请号：JP2004056489
申请日：2004-03-01
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： IZUNO SHINICHI , OOOKA HIROHITO , SAKAE TAKAHIRO , INOUE TSUTOMU
IPC分类号： C07C67/38 , C07B61/00 , C07C69/612 , C07C69/67 , C07C69/675 , C07C69/68
摘要： PROBLEM TO BE SOLVED: To provide a method for easily producing in high yield propionic ester derivative(s) by hydroesterification reaction of a substituted vinyl compound, and to provide a new macromolecular sulfonic acid compound suitable for the method.
SOLUTION: The method for producing the propionic ester derivative(s) of formula(3) and/or formula(4) comprises carrying out a reaction between the substituted vinyl compound of formula(1), an alcohol compound of the formula:R
2 OH and carbon monoxide in the presence of a group 8 metal compound, a phosphorus ligand and the macromolecular sulfonic acid compound. In the above formulas, R
1 is H or the like; X is an alkylcarbonyloxy or the like; and R
2 is an alkyl or the like. The macromolecular sulfonic acid compound is also provided.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过取代的乙烯基化合物的加氢酯化反应容易地生产高产率丙酸酯衍生物的方法，并提供适用于该方法的新的大分子磺酸化合物。解决方案：制备式（3）和/或式（4）的丙酸酯衍生物的方法包括在式（1）的取代的乙烯基化合物与式（1）的醇化合物之间进行反应，：在第8族金属化合物，磷配位体和大分子磺酸化合物的存在下，R 2 SP 2 OH和一氧化碳。在上式中，R 1 为H等; X是烷基羰基氧基等; R 2是烷基等。还提供了大分子磺酸化合物。版权所有（C）2005，JPO＆NCIPI

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