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1. 发明专利

JP2007186435A Nicotinamide derivative 审中-公开
标题翻译： NICOTINAMIDE DERIVATIVE
公开(公告)号：JP2007186435A
公开(公告)日：2007-07-26
申请号：JP2006004305
申请日：2006-01-12
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： KAMIKUBO TAKASHI , MUKAI HANA , IBUKA RYOTARO , KOSHIO HIROYUKI , ISHIKAWA NORIKO , SHIBATA HIROSHI , SOGA YUMIKO
IPC分类号： C07D213/81 , A61K31/437 , A61K31/4409 , A61K31/4439 , A61K31/465 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/5377 , A61P9/00 , A61P25/28 , A61P43/00 , C07D213/82 , C07D237/24 , C07D239/28 , C07D241/24 , C07D401/04 , C07D471/04
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as a nitrogen monoxide production enhancer and/or endothelial nitrogen monoxide synthetase activator.
SOLUTION: The nicotinamide derivative used as an active component of the medicine has blood circulation improving action based on excellent vascular endothelial nitrogen monoxide production enhancing action and/or endothelial nitrogen monoxide synthetase activating action. The medicine is useful as an agent for ameliorating diseases or pathological states caused by vascular endothelial function insufficiency, especially as a treating agent for peripheral artery obstruction, arteriosclerosis, ischemic heart disease, etc. It is useful also as a preventing or treating agent for dementia and an agent for the enhancement and/or promotion of the functional disorder recovery enhancing action or functional recovery exercising effect including the motility disorder caused by central neurodegeneration diseases such as cerebral apoplexy, brain injury and spinal cord injury.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供可用作一氧化氮生产增强剂和/或内皮一氧化氮合成酶激活剂的化合物。解决方案：用作药物活性成分的烟酰胺衍生物具有基于优异的血管内皮一氧化氮产生增强作用和/或内皮一氧化氮合成酶激活作用的血液循环改善作用。该药可用作改善由血管内皮功能不全引起的疾病或病理状态，特别是作为外周动脉阻塞，动脉硬化，缺血性心脏病等的治疗剂。它也可用作痴呆的预防或治疗剂以及用于增强和/或促进功能障碍恢复增强作用或功能恢复运动效果的试剂，包括由中枢神经变性疾病如脑中风，脑损伤和脊髓损伤引起的运动障碍。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2007186434A Medicinal composition 审中-公开
标题翻译：药物组合物
公开(公告)号：JP2007186434A
公开(公告)日：2007-07-26
申请号：JP2006004279
申请日：2006-01-12
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： TAKAHASHI MASAYASU , TAKAMI SHINYA , NAGAKURA AKIRA , KAMIKUBO TAKASHI , MUKAI HANA , IBUKA RYOTARO , KOSHIO HIROYUKI , ISHIKAWA NORIKO , SHIBATA HIROSHI , SOGA YUMIKO
IPC分类号： A61K31/455 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/5377 , A61P1/16 , A61P3/10 , A61P5/14 , A61P5/18 , A61P9/00 , A61P9/10 , A61P13/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P25/32 , A61P31/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P43/00 , C07D213/82 , C07D213/84 , C07D213/89 , C07D237/24 , C07D239/28 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as a nitrogen monoxide production enhancer and/or endothelial nitrogen monoxide synthetase activator.
SOLUTION: The phenethyl nicotinamide compound used as an active component of the medicine has blood circulation improving action based on excellent vascular endothelial nitrogen monoxide production enhancing action and/or endothelial nitrogen monoxide synthetase activating action. The medicine is useful as an agent for ameliorating diseases or pathological states caused by vascular endothelial function insufficiency, especially as a treating agent for peripheral artery obstruction, arteriosclerosis, ischemic heart disease, etc. It is useful also as a preventing or treating agent for dementia and an agent for the enhancement and/or promotion of the functional disorder recovery enhancing action or functional recovery exercising effect including the motility disorder caused by central neurodegeneration diseases such as cerebral apoplexy, brain injury and spinal cord injury.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供可用作一氧化氮生产增强剂和/或内皮一氧化氮合成酶激活剂的化合物。解决方案：用作药物活性成分的苯乙基烟酰胺化合物具有基于优异的血管内皮一氧化氮产生增强作用和/或内皮一氧化氮合成酶激活作用的血液循环改善作用。该药可用作改善由血管内皮功能不全引起的疾病或病理状态，特别是作为外周动脉阻塞，动脉硬化，缺血性心脏病等的治疗剂。它也可用作痴呆的预防或治疗剂以及用于增强和/或促进功能障碍恢复增强作用或功能恢复运动效果的试剂，包括由中枢神经变性疾病如脑中风，脑损伤和脊髓损伤引起的运动障碍。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2007277096A Medicine containing phenethyl-nicotinamide derivative 审中-公开
标题翻译：含有苯乙烯衍生物的药物
公开(公告)号：JP2007277096A
公开(公告)日：2007-10-25
申请号：JP2004208547
申请日：2004-07-15
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： KAMIKUBO TAKASHI , MUKAI HANA , IBUKA RYOTARO , KOSHIO HIROYUKI , ISHIKAWA NORIKO , SHIBATA HIROSHI , SOGA YUMIKO
IPC分类号： A61K31/455 , A61P7/02 , A61P9/00 , A61P9/10 , A61P29/00 , A61P43/00 , C07D213/82
CPC分类号： C07D213/82 , C07D213/89
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as an NO-production accelerator and/or eNOS (endothelial NO-synthesizing enzyme) activator.
SOLUTION: This phenethyl-nicotinamide derivative which is an active ingredient of a medicine has a blood stream circulation-improving effect by its excellent blood vessel endothelial NO production acceleration and/or eNOS-activation activity, and further has platelet agglutination inhibition, anti-thrombotic effect, anti-proliferation effect, anti-inflammatory effect, etc. The disclosed medicine is useful for improving diseases or pathological states having causes of blood vessel endothelium function failure caused by the reduction of the blood vessel endothelial NO production and/or the reduction of the eNOS function, and especially useful as the treating agent of diseases such as circulation failure, etc., such as peripheral artery obstructive disease (PAOD), arteriosclelosis, ischemic heart failure, etc.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供可用作NO生成促进剂和/或eNOS（内皮NO合成酶）活化剂的化合物。解决方案：作为药物的活性成分的苯乙基 - 烟酰胺衍生物通过其优异的血管内皮NO生成加速和/或eNOS活化活性具有血流循环改善作用，并且还具有血小板凝集抑制，抗血栓形成作用，抗增殖作用，抗炎作用等。所公开的药物可用于改善由血管内皮细胞NO产生减少引起的血管内皮功能衰竭的病因或病理状态，和/或 eNOS功能的降低，特别适用于周围动脉阻塞性疾病（PAOD），动脉硬化性疾病，缺血性心力衰竭等循环衰竭等疾病的治疗剂。版权所有（C） 2008年，日本特许厅和INPIT

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