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1. 发明公开

EP4341411A1 GENETICALLY MODIFIED PLANTS WITH IMPROVED YIELD AND DROUGHT TOLERANCE AND METHOD FOR OBTAINING SUCH PLANTS 审中-实审
公开(公告)号：EP4341411A1
公开(公告)日：2024-03-27
申请号：EP22805079.5
申请日：2022-05-20
申请人： Swetree Technologies AB
发明人： FUNK, Christiane , MISHRA, Laxmi
IPC分类号： C12N15/82 , A01H1/00 , C12N15/57

2. 发明公开

EP4219547A3 FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION 审中-实审
公开(公告)号：EP4219547A3
公开(公告)日：2023-10-18
申请号：EP22214327.3
申请日：2009-09-15
申请人： uniQure biopharma B.V.
发明人： Simioni, Paolo
IPC分类号： C12N9/64 , C12N15/57 , A61K38/48 , A61P7/04
摘要： Disclosed are a modified FIX (factor IX) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or tyrosine in position 338; pharmaceutical preparations containing said modified FIX polypeptide; a nucleotide sequence coding for the modified FIX polypeptide; and a method for producing the modified FIX polypeptide.

3. 发明公开

EP4239071A1 MUTATED PROTEASE AND USE THEREOF 审中-实审
公开(公告)号：EP4239071A1
公开(公告)日：2023-09-06
申请号：EP21885842.1
申请日：2021-10-06
申请人： Kao Corporation
发明人： HIOKI, Takahiro , YAMASHITA, Daichi , KAWAHARA, Akihito
IPC分类号： C12N15/57 , C12N1/15 , C12N1/19 , C12N1/20 , C12N1/21 , C12N9/52 , C12N15/63
摘要： Provided are a polypeptide having a glycine-glycine bond-degrading activity and an improved microbicidal activity, and a method for using the same. A polypeptide consisting of the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having at least 80% identity thereto, the polypeptide having any modification selected from the group consisting of: a modification of an amino acid residue at position 116 in the amino acid sequence of SEQ ID NO: 2 or a position corresponding thereto; a modification of amino acid residues at position 170 in the amino acid sequence of SEQ ID NO: 2 or a position corresponding thereto, position 172 or a position corresponding thereto, position 173 or a position corresponding thereto, position 174 or a position corresponding thereto, position 178 or a position corresponding thereto, and position 179 or a position corresponding thereto; a modification of amino acid residues at position 170 in the amino acid sequence of SEQ ID NO: 2 or a position corresponding thereto, position 172 or a position corresponding thereto, position 173 or a position corresponding thereto, and position 174 or a position corresponding thereto; and a modification of amino acid residues at position 116 in the amino acid sequence of SEQ ID NO: 2 or a position corresponding thereto, position 170 or a position corresponding thereto, position 172 or a position corresponding thereto, position 173 or a position corresponding thereto, position 174 or a position corresponding thereto, position 178 or a position corresponding thereto, and position 179 or a position corresponding thereto, and the polypeptide having a glycine-glycine bond-degrading activity.

4. 发明授权

EP3310914B1 VARIANTS OF CHYMOSIN WITH IMPROVED PROPERTIES 有权
公开(公告)号：EP3310914B1
公开(公告)日：2022-04-06
申请号：EP16751481.9
申请日：2016-06-22
发明人： JAECKEL, Christian , LUND, Martin , HANSEN, Enikö Fodor , RIISBERG, Lone , JEPPESEN, Iben , VAN DEN BRINK, Johannes Maarten
IPC分类号： C12N9/64 , C12N15/57

5. 发明公开

EP3957728A1 COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER 审中-实审
公开(公告)号：EP3957728A1
公开(公告)日：2022-02-23
申请号：EP21182887.6
申请日：2009-11-02
申请人： AERase, Inc.
发明人： GEORGIOU, George , STONE, Everett
IPC分类号： C12N9/50 , C12N15/57 , C07K19/00 , C12N15/62 , A61K38/48 , A61P35/00
摘要： Described are pharmaceutical compositions and medical uses of engineered human arginases, and particularly, among others, a pharmaceutical formulation comprising a protein comprising an amino acid sequence of human Arginase I and a non-native metal cofactor, wherein the non-native metal cofactor is cobalt.

6. 发明公开

EP3940050A1 MUTANT PROTEASE 审中-实审
公开(公告)号：EP3940050A1
公开(公告)日：2022-01-19
申请号：EP20771003.9
申请日：2020-03-06
申请人： Kao Corporation
发明人： TOHATA, Masatoshi
IPC分类号： C11D3/386 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/57 , C12N9/54
摘要： Provided is a mutant protease with improved stability under acidic condition. A mutant protease that consists of the amino acid sequence as shown in SEQ ID NO:2 or an amino acid sequence having an identity of at least 90% thereto, in which the amino acid residue at a position corresponding to position 303 in the amino acid sequence as shown in SEQ ID NO:2 is substituted with another amino acid residue.

7. 发明公开

EP3778885A1 COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER 有权
公开(公告)号：EP3778885A1
公开(公告)日：2021-02-17
申请号：EP20171935.8
申请日：2009-11-02
申请人： AERase, Inc.
发明人： GEORGIOU, George , STONE, Everett
IPC分类号： C12N9/50 , C12N15/57 , C07K19/00 , C12N15/62 , A61K38/48 , A61P35/00
摘要： Described are pharmaceutical compositions and medical uses of engineered human arginases, and particularly, among others, a pharmaceutical formulation comprising a protein comprising an amino acid sequence of human Arginase I and a non-native metal cofactor, wherein the non-native metal cofactor is cobalt; a pharmaceutical formulation comprising a human Arginase I protein having a metal binding site and comprising at least one amino acid substitution at the metal binding site, wherein the protein displays an increase in the hydrolysis of Arginine that results in a kcat /Km of at least two fold greater than that of a native human Arginase I; a pharmaceutical formulation comprising a fusion protein comprising any of the said proteins; as well as medical uses related to the above.

8. 发明公开

EP3634145A1 POLYPEPTIDE, USE AND METHOD FOR HYDROLYSING PROTEIN 审中-公开
公开(公告)号：EP3634145A1
公开(公告)日：2020-04-15
申请号：EP18813701.2
申请日：2018-06-08
申请人： Novozymes A/S
发明人： LIU, Cui , HENDRIKSEN, Hanne, Vang , LYNGLEV, Gitte, Budolfsen , FRISNER, Henrik , LIU, Ye , DELLA PIA, Eduardo, Antonio , HELDT-HANSEN, Hans, Peter , JENSEN, Kenneth , PENG, Wei , LI, Ming
IPC分类号： A23J1/00 , C07K14/37 , C12N9/58 , C12N15/57 , C12N15/63

9. 发明公开

EP3486319A2 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS 有权
公开(公告)号：EP3486319A2
公开(公告)日：2019-05-22
申请号：EP18197362.9
申请日：2012-05-04
申请人： Danisco US Inc. , The Procter & Gamble Company
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David, A. , KELLIS, JR, James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
IPC分类号： C12N9/54 , C12N15/57
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.

10. 发明公开

EP3436578A1 IMPROVED SORTASE 有权
公开(公告)号：EP3436578A1
公开(公告)日：2019-02-06
申请号：EP17713676.9
申请日：2017-03-28
申请人： F. Hoffmann-La Roche AG
发明人： BOENITZ-DULAT, Mara , SCHATTE, Martin
IPC分类号： C12N9/52 , C12N15/57

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