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1. 发明授权

EP3481553B1 USE OF A CELL CO-CULTURE DEVICE IN HIGH THROUGHPUT SCREENING AND A CORRESPONDING METHOD 有权
公开(公告)号：EP3481553B1
公开(公告)日：2024-04-10
申请号：EP17825028.8
申请日：2017-07-07
发明人： BEEBE,David , JOHNSON, Brian , JIMENEZ, Jose
IPC分类号： B01L3/00 , C12M1/28 , C12M1/32 , C12M1/00

2. 发明公开

EP4165406A2 SALIVA TREATMENT DEVICES 审中-实审
公开(公告)号：EP4165406A2
公开(公告)日：2023-04-19
申请号：EP21734528.9
申请日：2021-06-10
申请人： Salignostics Ltd.
发明人： DEUTSCH, Omer , COHEN, Raluca , NEUMANN, Yoav , KRIEF, Guy
IPC分类号： G01N33/53 , G01N33/543 , B01L3/00 , C12M1/26 , C12M1/28

4. 发明公开

EP3149147A1 METHOD AND APPARATUS TO PREPARE CARDIAC ORGANOIDS IN A BIOREACTOR SYSTEM 有权
标题翻译： VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON HERZORGANOIDEN IN EINEM BIOREAKTORSYSTEM
公开(公告)号：EP3149147A1
公开(公告)日：2017-04-05
申请号：EP15800086.9
申请日：2015-05-29
申请人： Icahn School of Medicine at Mount Sinai
发明人： COSTA, Kevin, David , CASHMAN, Timothy, James , BACKERIS, Peter, Constantine
IPC分类号： C12M1/00 , C12M1/28 , C12N5/00
CPC分类号： C12M21/08 , C12M23/00 , C12M23/26 , C12M23/38 , C12M35/02
摘要： A bioreactor system for preparing a cardiac organoid chamber and for subsequent testing thereof is described herein and shown in the exemplary drawing figures. The bioreactor system includes a first vessel having a hollow interior and an open top. A first cover is mated with the open top of the first vessel. The first cover has a first opening formed therein. The system further includes a cannula having a lumen that extends from an open first end to an open second end. The cannula is disposed within the first opening of the first cover such that a portion of the cannula lies below the first cover and for insertion into the hollow interior of the first vessel. A porous ring is coupled to the cannula at or proximate the open second end thereof. The system also includes a balloon catheter having an inflatable balloon at a distal end of a catheter shaft. The balloon catheter is adapted to pass through the lumen of the cannula when the balloon is in a deflated state. The balloon catheter is axially adjustable within the lumen to allow the balloon in an inflated state to be disposed adjacent: (1) the open second end of the cannula; and (2) the porous ring for preparing the cardiac organoid chamber about the inflated balloon and porous ring. The cannula and porous ring construction and combination allows for the balloon to be deflated and removed from the lumen of the cannula while the engineered cardiac organoid chamber remains attached to the porous ring. This permits the testing of organoid pump function, such as organoid pressure and volume characteristics, without having to transfer the engineered cardiac organoid from one tool (e.g., an incubation tool) to another tool (e.g., a functional testing apparatus).
摘要翻译：本文描述了一种用于制备心脏有机体室并用于随后测试的生物反应器系统，并在示例性附图中示出。生物反应器系统包括具有中空内部和开口顶部的第一容器。第一个盖子与第一艘船的敞开的顶部相配。第一盖具有形成在其中的第一开口。该系统还包括具有从开放的第一端延伸到开放的第二端的内腔的套管。套管设置在第一盖的第一开口内，使得套管的一部分位于第一盖下方并用于插入第一容器的中空内部。多孔环在其开口的第二端处或其附近联接到套管。该系统还包括在导管轴的远端具有可膨胀气囊的气囊导管。当气囊处于放气状态时，球囊导管适于穿过套管的内腔。气囊导管可在内腔内轴向调节，以允许处于充气状态的球囊邻近设置：（1）插管的开放的第二端; 和（2）用于在充气球囊和多孔环周围制备心脏有机体腔的多孔环。插管和多孔环结构和组合允许气囊从套管的内腔放气并移除，而工程化的心脏有机体室保持连接到多孔环上。这允许测试有机体泵功能，例如有机体压力和体积特性，而不必将工程心脏器官细胞从一个工具（例如，孵化工具）转移到另一个工具（例如功能测试装置）上。

5. 发明授权

EP2341946B1 SELF-CONTAINED BIOLOGICAL INDICATOR 有权
标题翻译：独立的生物指示剂的
公开(公告)号：EP2341946B1
公开(公告)日：2017-01-18
申请号：EP09792208.2
申请日：2009-09-03
申请人： American Sterilizer Company
发明人： PASMORE, Mark, Edward , FRANCISKOVICH, Phillip, P. , CREGGER, Tricia, A. , SOLOMON, Alan, M.
IPC分类号： A61L2/28 , C12M1/28 , C12Q1/22
CPC分类号： C12Q1/22 , A61L2/28 , C12M37/06

6. 发明公开

EP2836835A2 METHODS, SYSTEMS, AND DEVICES FOR DETECTING AND IDENTIFYING MICROORGANISMS IN MICROBIOLOGICAL CULTURE SAMPLES 有权
标题翻译：方法中，微生物培养样品检测系统和装置及鉴定微生物
公开(公告)号：EP2836835A2
公开(公告)日：2015-02-18
申请号：EP13753216.4
申请日：2013-03-15
申请人： Becton Dickinson and Company
发明人： WEIDEMAIER, Kristin , CAMPBELL, Robert L. , CARRUTHERS, Erin Gooch , CURRY, Adam C. , DOLAN, Kevin G. , LIEBMANN-VINSON, Andrea , WOODLEY, Wendy Dale , KURODA, Melody M.H. , LENTZ, Ammon David , LIVINGSTON, Dwight , LIZZI, Michael Justin , LOCKHART, Artis R. , RITCHEY, Ernie , FALLOWS, Eric A. , GORELICK, Donald E. , KESSLER, Jack , LOVETTE, Spencer , OJALA, Jeffrey S. , TALMER, Mark A. , BARTKOWIAK, Miroslaw , DANHOF, Scott N. , KRAMER, Gregory S. , HAUBERT, Thomas D. , MARSHALL, Michael L. , PRESCOTT, James A. , SOMERVILLE, Randy J. , ULRICH, M. Scott , SEBBA, David S.
IPC分类号： G01N33/569 , C12M1/34 , C12M1/28 , C12M1/26 , C12M1/00
CPC分类号： G01N33/54333 , B01L3/0217 , B01L3/502 , B01L3/50825 , B01L2200/026 , B01L2200/0605 , B01L2200/10 , B03C1/01 , B03C1/288 , B03C2201/26 , C12M23/08 , C12M23/22 , C12M23/38 , C12M33/04 , C12M41/14 , C12M41/36 , G01N33/56911 , G01N35/0098
摘要： Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
摘要翻译：提供在可用于检测和/或培养物样品中鉴定一种或多种特定微生物的方法，系统和装置。指示剂颗粒，颜色：如表面增强拉曼光谱（SERS） - 活性纳米颗粒，每个具有与必须针对感兴趣的一种或多种微生物亲合力的一种或多种特异性结合成员有关那里，可以形成与培养样品中的特定微生物的复合物。此外，搅动磁性捕获粒子，从而具有与具有亲和性的一种或多种特异性结合成员对感兴趣的一种或多种微生物相关联的存在可以被用于捕捉微生物指示器颗粒复合并浓缩复杂在测定容器的局部区域随后的检测和鉴定。复可以分散，沉淀，所以没有再分散培养样品可以在孵育期间被重新测试若干次，以允许培养物样品的实时监测。

7. 发明公开

EP2833793A1 URINE SAMPLING DEVICE 有权
标题翻译： DEVICE尿液样本采集
公开(公告)号：EP2833793A1
公开(公告)日：2015-02-11
申请号：EP12872591.8
申请日：2012-03-30
申请人： SCA HYGIENE PRODUCTS AB
发明人： HUSMARK, Ulrika , GUSTAFSON, Ingrid
IPC分类号： A61B10/00 , A61F13/84 , G01N33/493 , A61F5/451 , C12M1/28
CPC分类号： A61B10/007 , A61F5/4401 , A61F13/84 , A61F17/00 , A61F2013/15146 , A61F2013/8473 , C12Q1/04 , F04C2270/0421 , G01N33/493
摘要： A urine sampling device 1 comprising: a housing 4 comprising a urine sampling chamber 3, the housing 4 of the urine sampling device 1 being arranged such that the urine sampling device 1 can be associated with a hygiene absorbent product, and the urine sampling device 1 comprises an inlet 2 for said fluid, wherein said chamber 3 comprises a dry gel that can be swelled by urine, and wherein said urine sampling device 1 possess the ability to preserve a bacteria content from a urine sampled in the device, either by means of the properties of the dry gel in itself and/or by providing a preservative in the dry gel. Further disclosed are a hygiene absorbent product 15 and a urine examination kit.

8. 发明公开

EP2383331A1 METHOD OF PRODUCING CELL CULTURE SCAFFOLD 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINESZELLKULTURGERÜSTS
公开(公告)号：EP2383331A1
公开(公告)日：2011-11-02
申请号：EP09838804.4
申请日：2009-01-26
申请人： Empire Technology Development LLC
发明人： KUSUURA, Takahisa
IPC分类号： C12M1/00 , C12M1/28
CPC分类号： C12N5/0068 , C12N2535/10
摘要： Problem to be Solved
To provide a simple method for producing a cell culture scaffold material having a nanoporous surface in which the pore density, pore diameter and pore diameter distribution are easily controlled.
Solution
A method for producing a cell culture scaffold material, comprising: providing a substrate; forming a layer comprising a material having a plurality of nanoparticles dispersed in a matrix on the substrate; and selectively removing the nanoparticles from the layer comprising a material having a plurality of nanoparticles dispersed in a matrix.
摘要翻译：要解决的问题提供一种具有纳米多孔表面的细胞培养支架材料的简单方法，其中容易控制孔密度，孔径和孔径分布。溶液制备细胞培养支架材料的方法，包括：提供基材; 形成包含分散在所述基底上的基质中的多个纳米颗粒的材料的层; 以及从包含分散在基质中的多个纳米颗粒的材料的层选择性地除去纳米颗粒。

9. 发明公开

EP1320739A4 REAGENT DELIVERY DEVICE AND METHOD OF USE 审中-公开
标题翻译： REENENTIENABLIEFERUNGSSYSTEM UND VERWENDUNGSVERFAHREN
公开(公告)号：EP1320739A4
公开(公告)日：2008-06-04
申请号：EP01984347
申请日：2001-07-17
申请人： EY LAB INC
发明人： CHU ALBERT E
IPC分类号： G01N33/48 , A61B10/00 , B01L3/00 , B01L3/02 , B01L3/14 , C12M1/28 , C12Q1/04 , G01N1/28 , G01N1/38
CPC分类号： G01N1/4077 , A61B10/0045 , B01L3/0272 , B01L3/502 , B01L3/5082 , B01L2200/16 , B01L2300/0681 , B01L2400/0481 , B01L2400/0683 , Y10S436/808 , Y10S436/81 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： A reagent delivery device includes a reservoir body (12) with a flexible side wall (12c) and a cap (14) which holds a reagent-containing matrix (18) and a filter (16). Sample is placed in the reservoir body (12) and the cap (14) is attached. The flexible side wall (12c) is compressed, rupturing a vessel (20a) to mix the contents with the sample. The mixture is filtered by the filter (16) and reagent diffuses from the reagent matrix (18) to form a reagent-sample mixture.
摘要翻译：试剂传送装置包括具有柔性侧壁（12c）和保持含试剂基质（18）和过滤器（16）的帽（14）的贮存器主体（12）。将样品放置在储液器本体（12）中并且盖（14）被附接。柔性侧壁（12c）被压缩，使容器（20a）破裂以将内容物与样品混合。混合物通过过滤器（16）过滤并且试剂从试剂基质（18）扩散形成试剂 - 样品混合物。

10. 发明授权

EP1637584B1 Beutel mit darin gezüchteter Kultur sowie Probeentnahmeverfahren 有权
标题翻译：袋在文化和抽样程序成长
公开(公告)号：EP1637584B1
公开(公告)日：2007-07-11
申请号：EP05011858.7
申请日：2005-06-01
申请人： Infors AG
发明人： Hawrylenko, Alexander
IPC分类号： C12M1/00 , C12M1/28 , B01L3/00
CPC分类号： B01L3/505 , B01L2200/141 , B01L2300/0864 , C12M23/14 , C12M25/14 , C12M25/16 , C12M33/00

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