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1. 发明公开

EP4357334A2 CONJUGATED OLIGONUCLEOTIDE COMPOUNDS, METHODS OF MAKING AND USES THEREOF 审中-实审
公开(公告)号：EP4357334A2
公开(公告)日：2024-04-24
申请号：EP24160680.5
申请日：2022-01-28
申请人： E-Therapeutics plc
发明人： MANNELLA, Viviana , JAYARAMAN, Muthusamy , MORTAZAVI, Ahmad Ali
IPC分类号： C07D207/404
CPC分类号： C07H15/08 , C07H15/04 , C07H21/00 , C07H21/02 , C07H21/04 , C07D207/404 , A61K47/549
摘要： The present invention relates to novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions

2. 发明授权

EP3233795B1 ALKYD RESIN COMPOSITIONS OF POLYFUNCTIONAL HYDROPHTHALIMIDE MONOMER COMPOUNDS 有权转让
公开(公告)号：EP3233795B1
公开(公告)日：2020-05-13
申请号：EP15813853.7
申请日：2015-12-21
申请人： DSM IP Assets B.V.
发明人： KONING, Cornelis Eme , BUIJSEN, Paulus Franciscus Anna , LANSBERGEN, Adrianus Jozephus Hendricus , PAPEGAAIJ, Alwin , HAYDEN, Douglas
IPC分类号： C07D207/404 , C08G73/16

3. 发明公开

EP2404903A4 METHOD OF SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE 有权
标题翻译： METHOD FOR合成[18 F] SFB的使用微型合成工艺
公开(公告)号：EP2404903A4
公开(公告)日：2012-08-08
申请号：EP10748713
申请日：2010-03-01
申请人： SHIMADZU CORP , UNIV KYOTO
发明人： NAKANISHI HIROAKI , SAIKI HIDEKAZU , SAJI HIDEO , KIMURA HIROYUKI , KAWASHIMA HIDEKAZU , TOMATSU KENJI , KUGE YUJI
IPC分类号： C07D207/404 , A61K51/00 , C07B59/00 , C07B61/00
CPC分类号： C07D207/404 , A61K51/00 , C07B59/001 , C07B59/002

4. 发明公开

EP2379685A4 A POST-TREATED ADDITIVE COMPOSITION AND METHOD OF MAKING THE SAME 有权
标题翻译：返工添加剂组合物及其制造方法
公开(公告)号：EP2379685A4
公开(公告)日：2012-06-20
申请号：EP09835532
申请日：2009-12-11
申请人： CHEVRON ORONITE CO
发明人： HARRISON JAMES J , HOSSEINI MITRA
IPC分类号： C10M133/16 , C07D207/404 , C10M133/56 , C10N30/02
CPC分类号： C08F8/32 , C08F8/00 , C08F2810/20 , C10L1/221 , C10L1/2364 , C10L10/18 , C10M133/56 , C10M177/00 , C10M2215/28 , C10N2230/041 , C10N2230/68 , C10N2240/10 , C10N2260/06 , C10N2260/00 , C08F255/08 , C08F8/48

5. 发明公开

EP2379685A2 A POST-TREATED ADDITIVE COMPOSITION AND METHOD OF MAKING THE SAME 有权
标题翻译：后处理添加剂组合物及其制造方法
公开(公告)号：EP2379685A2
公开(公告)日：2011-10-26
申请号：EP09835532.4
申请日：2009-12-11
申请人： Chevron Oronite Company LLC
发明人： HARRISON, James, J. , HOSSEINI, Mitra
IPC分类号： C10M133/16 , C07D207/404 , C10N30/02
CPC分类号： C08F8/32 , C08F8/00 , C08F2810/20 , C10L1/221 , C10L1/2364 , C10L10/18 , C10M133/56 , C10M177/00 , C10M2215/28 , C10N2230/041 , C10N2230/68 , C10N2240/10 , C10N2260/06 , C10N2260/00 , C08F255/08 , C08F8/48
摘要： An oil-soluble lubricating oil additive composition prepared by the process which comprises reacting (A) reacting a copolymer of an (i) an unsaturated acidic reagent; and (ii) a mono-olefin, with at least one linking hydrocarbyl di-primary amine, thereby producing a hybrid succinic anhydride copolymer having from about 10 % to about 90 % unreacted anhydride groups; and subsequently (B) reacting the hybrid succinic anhydride copolymer with a second amine compound, thereby producing the succinimide; and (C) reacting the succinimide with at least one post-treating agent selected from a cyclic carbonate, a linear mono-carbonate, a linear poly-carbonate, an aromatic polycarboxylic acid, an aromatic polycarboxylic anhydride, an aromatic polycarboxylic acid ester, or mixtures thereof.

6. 发明授权

EP1889834B1 NOVEL ORGANIC COMPOUND AND METHOD FOR PRODUCING RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND USING THE SAME 有权
标题翻译：新的有机化合物和一种用于生产放射性卤素标记的有机化合物使用其
公开(公告)号：EP1889834B1
公开(公告)日：2011-04-20
申请号：EP06746390.1
申请日：2006-05-15
申请人： NIHON MEDI-PHYSICS CO., LTD.
发明人： TOYAMA, Masahito , KUROSAKI, Fumie , HAYASHI, Akio , ITO, Osamu
IPC分类号： C07D209/48 , A61K51/00 , C07D207/404
CPC分类号： C07D209/48 , A61K51/0406 , Y02P20/55
摘要： It is intended to provide a precursor compound to be labeled for selectively producing syn-1-amino-3-cyclobutanecarboxylic acid substituted with a radioactive halogen and a method for producing syn-1-amino-3-cyclobutanecarboxylic acid substituted with a radioactive halogen using the compound. The precursor to be labeled having a phthalimide group as a protecting group for an amino group is used. By labeling the precursor to be labeled with a radioactive halogen and performing deprotection, 1-amino-3-cyclobutanecarboxylic acid substituted with a syn-form radioactive halogen can be selectively produced.

7. 发明公开

EP1889834A4 NOVEL ORGANIC COMPOUND AND METHOD FOR PRODUCING RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND USING THE SAME 有权
标题翻译：新的有机化合物和一种用于生产放射性卤素标记的有机化合物使用其
公开(公告)号：EP1889834A4
公开(公告)日：2010-06-30
申请号：EP06746390
申请日：2006-05-15
申请人： NIHON MEDIPHYSICS CO LTD
发明人： TOYAMA MASAHITO , KUROSAKI FUMIE , HAYASHI AKIO , ITO OSAMU
IPC分类号： C07D209/48 , A61K51/00 , C07D207/404
CPC分类号： C07D209/48 , A61K51/0406 , Y02P20/55

8. 发明公开

EP2008999A1 N-TERT-BUTOXYCARBONYL-2-PYRROLIDINONES AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译： N-TERT.-BUTOXYCARBONYL-2-PYRRIDIDONON VERFAHREN ZUR HERSTELLUNG
公开(公告)号：EP2008999A1
公开(公告)日：2008-12-31
申请号：EP06767864.9
申请日：2006-06-28
申请人： Sumitomo Chemical Company, Limited
发明人： HIRATA, Norihiko , UEMURA, Toshitsugi
IPC分类号： C07D207/27 , C07D207/404 , C07D209/52
CPC分类号： C07D207/27 , C07D207/404 , C07D209/52
摘要： N-tert-butoxycarbonyl-2-pyrrolidinones of the following formula (1):

[wherein, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 represent each independently a hydrogen atom, halogen atom, cyano group, optionally substituted linear, branched or cyclic alkyl group having 1 to 10 carbon atoms, optionally substituted linear, branched or cyclic alkenyl group having 2 to 10 carbon atoms, optionally substituted aryl group having 6 to 20 carbon atoms, optionally substituted amino group, -OR a group, or -SR b group, R a and R b represent each independently a hydrogen atom, alkylcarbonyl group having 2 to 10 carbon atoms, arylcarbonyl group having 7 to 20 carbon atoms, aralkyl group having 7 to 20 carbon atoms, alkoxyalkyl group having 2 to 10 carbon atoms, trialkylsilyl group having 3 to 10 carbon atoms, alkyl group having 1 to 10 carbon atoms, aryl group having 6 to 20 carbon atoms,
alternatively, R 1 and R 2 may be connected to form a >C=O group together with a carbon atom to which they are connected, R 3 and R 4 may be connected to form a >C=O group together with a carbon atom to which they are connected, R 5 and R 6 may be connected to form a >C=O group together with a carbon atom to which they are connected,
any two of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may be connected to form an optionally substituted polymethylene group having 1 to 4 carbon atoms, one or no-mutually-adjacent two methylene groups constituting the polymethylene group may be substituted by an oxygen atom, one or two ethylene groups constituting the polymethylene group may be substituted by a vinylene group, no-mutually-adjacent two methylene groups constituting the polymethylene group may be mutually connected via an oxygen atom, methylene group, ethylene group or vinylene group.].
摘要翻译：下式（1）的N-叔丁氧基羰基-2-吡咯烷酮：[其中，R 1，R 2，R 3，R 4，R 5和R 6各自独立地表示氢原子，卤素原子，氰基，任选取代的具有1-10个碳原子的直链，支链或环状烷基，任选取代的具有2-10个碳原子的直链，支链或环状烯基，任选取代的具有6至20个碳原子的芳基，任选取代的氨基，-OR 基团或-SR b基团，R a和R b各自独立地表示氢原子，具有2〜10个碳原子的烷基羰基，具有7〜20个碳原子的芳基羰基，具有7〜20个碳原子的芳烷基，烷氧基烷基具有2至10个碳原子，具有3至10个碳原子的三烷基甲硅烷基，具有1至10个碳原子的烷基，具有6至20个碳原子的芳基，或者R 1和R 2可以连接形成> C = O基团与它们连接的碳原子一起R 3 R 4可以连接成与其连接的碳原子一起形成> C = O基团，R 5和R 6可以与它们所连接的碳原子一起形成> C = O基团 R 1，R 2，R 3，R 4，R 5和R 6中的任何两个可以连接形成任选取代的具有1至4个碳原子的多亚甲基，一个或不相互相邻的两个亚甲基构成多亚甲基可以被氧原子取代，构成多亚甲基的一个或两个亚乙基可以被亚乙烯基取代，构成多亚甲基的不相邻的两个亚甲基可以通过氧原子相互连接，亚甲基基团，亚乙基或亚乙烯基。

9. 发明公开

EP1666486A4 COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE 审中-公开
标题翻译：甘油衍生物改性CONNECTION
公开(公告)号：EP1666486A4
公开(公告)日：2006-12-06
申请号：EP04772926
申请日：2004-09-03
申请人： KYOWA HAKKO KOGYO KK , TECHNO NETWORK SHIKOKU CO LTD
发明人： NEMOTO H , YAMAUCHI M , KUSANO H , KATO YASUKI , YAMASAKI M , SUZAWA T
IPC分类号： C07K5/08 , A61K9/107 , A61K9/127 , A61K47/00 , A61K47/42 , A61K47/48 , C07C233/47 , C07C323/52 , C07C323/60 , C07D207/404 , C07F9/10 , C07K5/02
CPC分类号： C07D207/452 , A61K47/00 , A61K47/54 , A61K47/6911 , B82Y5/00 , C07C323/60 , C07F9/10 , C07K5/0202
摘要： A compound useful as, e.g., a surface modifier for use in producing, e.g., a drug carrier, or a salt of the compound; and fine particles containing either of these. The compound is one obtained by modifying a substance to be modified which is selected from the group consisting of amphiphatic substances and hydrophobic substances with a glycerol derivative represented by the formula (1) (wherein R represents a residue which comprises a group reactive with either the substance to be modified, which is selected from the group consisting of amphiphatic substances and hydrophobic substances, or a spacer for bonding the substance to be modified, which is selected from the group consisting of amphiphatic substances and hydrophobic substances, to R-X or comprises a group capable of being converted to the reactive group; n is an integer of 3 or larger; and X represents a residue capable of having n groups of the following formula) directly or through the spacer.

10. 发明公开

EP1322597A4 PROCESS AND INTERMEDIATES 有权
标题翻译：过程和中间产品
公开(公告)号：EP1322597A4
公开(公告)日：2005-10-19
申请号：EP01975197
申请日：2001-09-12
申请人： SMITHKLINE BEECHAM CORP
发明人： ELDRIDGE ANN M , HIEBL JOHANN
IPC分类号： C07D207/404 , A61K47/48 , C07C319/22 , C07C319/24 , C07C323/52 , C07C323/60 , C07D207/46 , C07C231/10
CPC分类号： C07D207/46 , A61K47/6803 , C07C319/22 , C07C319/24 , C07C323/60 , C07C323/52
摘要： Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.

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