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1. 发明公开

EP3572392A1 METHOD FOR PRODUCING FLUORENYLIDENE DIALLYLPHENOLS, AND FLUORENYLIDENE DIALLYLPHENOLS 审中-实审
公开(公告)号：EP3572392A1
公开(公告)日：2019-11-27
申请号：EP17892787.7
申请日：2017-10-06
申请人： JFE Chemical Corporation
发明人： KITAHARA, Yoshinori
IPC分类号： C07C37/20 , C07C39/23 , C07C39/42 , C07C41/30 , C07C43/23 , C07C51/377 , C07C65/28 , C07B61/00
摘要： Provided are: a method for producing fluorenylidene diallylphenols represented by formula (1), the method including a reaction step for reacting fluorenones represented by formula (2) and allylphenols represented by formula (3) in the presence of an acid catalyst, excluding compounds having mercapto groups, the amount of acid catalyst being 0.001-20 mol per mol of compound represented by formula (2); and fluorenylidene diallylphenols represented by formula (4) .

2. 发明公开

EP3018118A1 BASE GENERATOR, BASE-REACTIVE COMPOSITION CONTAINING SAID BASE GENERATOR, AND BASE GENERATION METHOD 有权转让
标题翻译： BASERENERATOR，BASENREAKTIVE ZUSAMMENSETZUNG MIT DIESEM BASERENERATOR UND BASENERZEUGUNGSVERFAHREN
公开(公告)号：EP3018118A1
公开(公告)日：2016-05-11
申请号：EP14818139.9
申请日：2014-06-25
申请人： Wako Pure Chemical Industries, Ltd. , Tokyo University of Science Foundation
发明人： SAKAI, Nobuhiko , YANABA, Kosuke , ARIMITSU, Koji
IPC分类号： C07C59/84 , C07C65/28 , C07C279/26 , C07D311/86 , C09K3/00
CPC分类号： C07C279/26 , B01J19/123 , B01J19/127 , B01J19/128 , C07C59/84 , C07C65/28 , C07C2601/14 , C07C2603/24 , C07D209/48 , C07D311/86 , G03F7/0045
摘要： It is a subject of the present invention to provide a base generator which has high solubility to general-purpose organic solvents, can dissolve directly into a base-reactive compound, such as an epoxy-based compound, further is provided with both performance of high heat resistance and low nucleophilicity, and generates a strong base, a base-reactive composition comprising the base generator and a base-reactive compound, as well as a method for generating a base, etc.
The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc.

(wherein R 1 to R 5 each independently represent a hydrogen atom; an alkyl group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, R 6 represents a hydrogen atom; an alkyl group which may have a substituent; an alkenyl group; an alkynyl group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, R 7 represents a hydrogen atom; an alkyl group which may have an amino group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, and Z - represents an anion derived from a carboxylic acid having a specific structure.)
摘要翻译：本发明的主题是提供一种对通用有机溶剂具有高溶解度的碱发生剂，可以直接溶解在诸如环氧基化合物的碱反应性化合物中，进一步具有高的性能耐碱性和低亲核性，并且产生强碱，包含碱产生剂和碱反应性化合物的碱反应性组合物，以及产生碱的方法等。本发明涉及由通式（A），包含该化合物的碱产生剂，包含碱发生剂和碱反应性化合物的碱反应性组合物，以及产生碱的方法等（其中R 1至R 5各自独立地表示氢原子;烷基;可以具有取代基的芳基;或可以具有取代基的芳基烷基，R 6表示氢原子;可以具有取代基的烷基; a 链烯基炔基; 可以具有取代基的芳基; 或可以具有取代基的芳基烷基，R 7表示氢原子; 可以具有氨基的烷基; 可以具有取代基的芳基; 或可以具有取代基的芳烷基，Z-表示衍生自具有特定结构的羧酸的阴离子。）

3. 发明公开

EP2080751A4 CARBOXYLIC ACID DERIVATIVE 审中-公开
标题翻译： CARBONSÄUREDERIVAT
公开(公告)号：EP2080751A4
公开(公告)日：2011-06-22
申请号：EP07829575
申请日：2007-10-11
申请人： INST MED MOLECULAR DESIGN INC
发明人： YAMAGUCHI YOUICHI , YANASE TAKESHI , MUTO SUSUMU , ITAI AKIKO
IPC分类号： C07C59/64 , A61K31/192 , A61K31/194 , A61K31/198 , A61K31/36 , A61P7/02 , A61P43/00 , C07C65/24 , C07C65/28 , C07C233/56
CPC分类号： C07C51/00 , C07C59/64 , C07C65/24 , C07C65/28 , C07C205/06 , C07C205/34 , C07C217/86 , C07C235/80 , C07C255/37

4. 发明公开

EP2142495A1 SUBSTITUIERTE DIBENZOESÄURE-DERIVATE UND IHRE VERWENDUNG 有权
标题翻译：取代dibenzoic衍生物及其
公开(公告)号：EP2142495A1
公开(公告)日：2010-01-13
申请号：EP08716566.8
申请日：2008-03-15
申请人： Bayer Schering Pharma Aktiengesellschaft
发明人： HAHN, Michael , BECKER, Eva-Maria , KNORR, Andreas , SCHNEIDER, Dirk , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , LANG, Dieter
IPC分类号： C07C65/28 , A61K31/194 , A61P9/00
CPC分类号： C07C65/28
摘要： The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.

5. 发明授权

EP1472209B1 LIPOXIN A4 ANALOGS 有权
标题翻译：脂氧素A4类似物
公开(公告)号：EP1472209B1
公开(公告)日：2009-03-04
申请号：EP02784388.7
申请日：2002-11-05
申请人： Bayer Schering Pharma Aktiengesellschaft
发明人： BAUMAN, John, G. , GUILFORD, William, J. , PARKINSON, John, F. , SKUBALLA, Werner , SUBRAMANYAM, Babu
IPC分类号： C07C65/28 , C07C65/40 , C07C59/66 , C07C59/64 , C07C69/734 , C07C69/738 , C07C69/92 , A61P37/00 , A61P31/00 , A61K31/202 , A61K31/216
CPC分类号： C07D317/72 , A61K31/202 , A61K31/216 , C07C59/68 , C07C59/70 , C07C69/708 , C07C69/736 , C07C209/68 , C07C217/46 , C07C229/12 , C07C235/06 , C07C323/52 , C07D317/22
摘要： This invention is directed to lipoxin A4 analogs of the following formulas (I) and (II), wherein R?1, R2, R3, R4 and R5¿ are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.

6. 发明授权

EP1324970B1 RETINOIDS FOR THE TREATMENT OF EMPHYSEMA 有权
标题翻译： RETINOIDE ZUR BEHANDLUNG VON EMPHYSEM
公开(公告)号：EP1324970B1
公开(公告)日：2008-11-05
申请号：EP01969762.2
申请日：2001-09-24
申请人： F. Hoffmann-La Roche AG
发明人： LAPIERRE, Jean-Marc , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian
IPC分类号： C07C65/28 , C07C323/56 , C07D231/12 , C07D207/32 , C07D307/38 , C07C65/19 , C07D295/08 , C07D239/38 , C07D249/12 , A61K31/19 , A61K31/33
CPC分类号： C07D207/27 , C07C65/19 , C07C65/28 , C07C229/38 , C07C233/83 , C07C311/13 , C07C317/44 , C07C323/56 , C07C2602/10 , C07D207/327 , C07D211/76 , C07D231/12 , C07D231/14 , C07D233/56 , C07D233/84 , C07D239/26 , C07D239/38 , C07D249/08 , C07D249/12 , C07D257/04 , C07D277/16 , C07D277/30 , C07D277/74 , C07D285/125 , C07D295/155 , C07D307/38 , C07D333/22 , C07D333/24 , C07D333/60
摘要： The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for such deseases and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.
摘要翻译：本发明提供新型类视黄醇化合物及其合成方法，治疗或预防肺气肿，癌症和皮肤疾病的方法以及适用于治疗或预防肺气肿，癌症和皮肤疾病的药物组合物。

7. 发明公开

EP1174412A4 POLYMERIZABLE COMPOSITION SHOWING LIQUID-CRYSTAL PHASE AND OPTICALLY ANISOTROPIC OBJECT MADE WITH THE SAME 有权
标题翻译：与液晶相聚合制备这样制作的光学各向异性的影响
公开(公告)号：EP1174412A4
公开(公告)日：2006-03-08
申请号：EP01901442
申请日：2001-01-19
申请人： DAINIPPON INK & CHEMICALS
发明人： OBI NAOKI , LEE SEUNGTAEG , HASEBE HIROSHI , KAWARA TATSUO
IPC分类号： C07C59/68 , C07C65/28 , C08F20/30 , C08F20/40 , C08F220/40 , C08F222/10 , C08F222/18 , C08F222/22 , C08F222/26 , C09K19/38 , C09K19/40
CPC分类号： C08F20/30 , C08F20/40 , C08F220/40 , C08F222/26 , C08F2222/102 , C08F2222/185 , C08F2222/225 , C09K19/38 , C09K19/408 , C08F2220/1891
摘要： A polymerizable liquid-crystal composition containing a polymerizable liquid-crystalline compound, which shows a nematic phase at low temperatures, has excellent compatibility with other polymerizable liquid-crystalline compounds to be used in combination therewith, and gives through polymerization a polymer excellent in transparency and mechanical strength. The polymerizable composition shows a liquid-crystal phase and contains a compound (I) having a liquid-crytalline skeleton with two or more rings and a segment structure represented by the general formula P?1-S1-A1-D1-E1¿- [wherein P1 is a polymerizable functional group; S1 is -(CH¿2?)w-, -O(CH2)w-, -(CH2)wO-, -(CH2)wC(=O)O-, -(CH2)wOC(=O)-, -C(=O)O(CH2)w-, or -OC(=O)(CH2)w- (w is 1 to 20); A?1 and E1¿ each is a hydrocarbon ring or heterocycle or E1 is one of the rings contained in the liquid-crystalline skeleton; and D1 is -C(=O)-O-(CH¿2?)m-O-, -O(CH2)m-O-C(=O)-, -O-C(=O)-(CH2)m-O-, or -O-(CH2)m-C(=O)-O- (m is 1 to 15)].

8. 发明授权

EP1045823B1 PROCESS FOR MAKING CERTAIN BENZOIC ACID COMPOUNDS 有权
标题翻译：过程对某些BENZOESAÜREVERBINDUNGEN的制备
公开(公告)号：EP1045823B1
公开(公告)日：2005-11-02
申请号：EP98959112.8
申请日：1998-12-28
申请人： THE PROCTER & GAMBLE COMPANY
发明人： LEDOUSSAL, Benoit , ZHENG, Xiaomin, Sharon , ALMSTEAD, Ji-In, Kim , GRAY, Jeffrey, Lyle
IPC分类号： C07C51/15 , C07C63/04 , C07C65/21 , C07C51/347 , C07C65/28 , C07C201/08 , C07C205/58
CPC分类号： C07C201/08 , C07C51/15 , C07C51/353 , C07C51/363 , C07C51/367 , Y02P20/582 , C07C63/70 , C07C65/21 , C07C63/04 , C07C65/28 , C07C205/58
摘要： The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating with an electrophilic reagent which provides Q1, or a functional moiety which is then transformed to Q1, producing 1-bromo-2,4-difluoro-3-Q1-benzene; (b) treating the 1-bromo-2,4-difluoro-3-Q1-benzene with an alkali or alkaline earth metal or organometallic reagent; then treating with carbon dioxide, or with a formylating agent followed by oxidation, to produce 2,4-difluoro-3-Q1-benzoic acid. The subject invention also involves optional additional steps to further modify Q1, or to substitute a non-hydrogen moiety at the 5-position, at the 6-position, or at both, of the phenyl ring of the 2,4-difluoro-3-Q1-benzoic acid.

9. 发明公开

EP1513793A1 NOVEL LIGANDS THAT ARE INHIBITORS OF THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS 有权转让
标题翻译：对于RAR受体的新的配基作为抑制剂，其制造方法相同，它们在人类药物及化妆品
公开(公告)号：EP1513793A1
公开(公告)日：2005-03-16
申请号：EP03755947.3
申请日：2003-05-27
申请人： Galderma Research & Development, S.N.C.
发明人： BIADATTI, Thibaud , COLLETTE, Pascal
IPC分类号： C07C65/36 , C07C65/40 , C07C65/17 , C07C65/19 , C07C65/26 , C07C65/28 , C07D213/79 , C07C335/06 , C07D405/06 , A61K31/19 , A61K7/48 , A61K7/00 , A61P17/00 , A61P19/00
CPC分类号： C07C65/17 , C07C65/19 , C07C65/26 , C07C65/28 , C07C65/36 , C07C65/40 , C07D213/30 , C07D213/50 , C07D213/80 , C07D295/096 , C07D295/112 , C07D295/15
摘要： The invention relates to novel biaryl compounds corresponding to the general formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.

10. 发明公开

EP1346975A4 AROMATIC CARBOXYLIC ACIDS, ACID HALIDES THEREOF AND PROCESSES FOR PREPARING BOTH 审中-公开
标题翻译：芳族羧酸，制备这些化合物的酰卤和方法
公开(公告)号：EP1346975A4
公开(公告)日：2004-03-31
申请号：EP01997472
申请日：2001-11-26
申请人： SUMITOMO BAKELITE CO
发明人： OKANUMA MASAKO , ISHIDA YUICHI , HASE YOKO , HIGASHIDA NOBUHIRO , ENOKI TAKASHI
IPC分类号： C07C63/64 , C07C65/28 , C07C63/15 , C07C51/09 , C07C51/60 , C07C63/331 , C07C63/66 , C07C63/72 , C07C63/74
CPC分类号： C07C63/64 , C07C65/28
摘要： A novel aromatic carboxylic acid useful as a material for macromolecular compounds and, in particular, for polycondensed macromolecular compounds exhibiting excellent heat resistance, an acid halide derivative thereof and a process for producing these compounds are disclosed. The aromatic carboxylic acid and the acid halide derivative thereof have structures represented general formulae (1) and (2), respectively, and can be efficiently produced from a dialkyl ester derivative of isophthalic acid and an acetylene derivative in accordance with the disclosed process comprising specific steps. In the above formulae, A represents: - C IDENTICAL C-R or (R represents hydrogen atom, an alkyl group or an aromatic group, R represents an alkyl group or an aromatic group) and X represents a halogen atom.

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