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1. 发明公开

EP4363402A1 A PROCESS FOR THE PREPARATION OF 2-NITRO-4-(METHYLSULFONYL)BENZOIC ACID 审中-实审
公开(公告)号：EP4363402A1
公开(公告)日：2024-05-08
申请号：EP22832285.5
申请日：2022-06-23
申请人： Gharda Chemicals Limited
发明人： MATHUR, Suchet Saran , SATHE, Shekhar Vishwanath , MAIRH, Mithilesh Kumar , KSHIRSAGAR, Kedar Parshuram , PRAJAPATI, Vinodkumar Jethuram , SINGH, Vikram Naresh
IPC分类号： C07C315/06
CPC分类号： C07C315/04

2. 发明授权

EP2627627B1 PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS 失效转让
标题翻译：合成手性普通酒精的方法
公开(公告)号：EP2627627B1
公开(公告)日：2017-08-09
申请号：EP11772888.1
申请日：2011-10-14
申请人： Bristol-Myers Squibb Company
发明人： BRENNER, Meinrad , CARREIRA, Erick, M. , CHINKOV, Nicka , LORENZI, Miriam , WARM, Aleksander , ZIMMERMANN, Lothar
IPC分类号： C07C213/00 , C07B53/00 , C07C213/10 , C07C315/06 , C07D265/18
CPC分类号： C07C315/06 , C07B53/00 , C07C213/00 , C07C213/10 , C07D265/18 , C07C215/68

3. 发明授权

EP2459527B1 COMPOSITION DE SOLVANT À BASE D'OXYDE DE SULFURE ORGANIQUE À ODEUR MASQUÉE 有权
标题翻译：溶剂组成基于与蒙面气味的有机硫化物OXID
公开(公告)号：EP2459527B1
公开(公告)日：2016-12-07
申请号：EP10763202.8
申请日：2010-07-29
申请人： Arkema France
发明人： SCHMITT, Paul-Guillaume , MONGUILLON, Bernard , VAUTHRIN, Mélanie
IPC分类号： C07C315/06 , C07C317/04 , C07C319/26 , C07C321/14
CPC分类号： C07C315/06 , C07C317/00 , C07C317/02 , C07C319/26 , C07C317/04 , C07C321/14

4. 发明授权

EP1979310B1 PROCESS FOR THE CRYSTALLISATION OF MESOTRIONE 有权
标题翻译： PROCESS FOR硝磺草酮的结晶
公开(公告)号：EP1979310B1
公开(公告)日：2015-03-04
申请号：EP07700526.2
申请日：2007-01-15
申请人： Syngenta Participations AG
发明人： BINDER, Arthur
IPC分类号： C07C315/06 , C07C317/24
CPC分类号： C07C315/06 , C07B2200/13 , C07C317/24

5. 发明公开

EP2785688A2 A PROCESS FOR THE MANUFACTURE OF CHIRAL CATALYSTS AND THEIR SALTS 有权
标题翻译：用于生产手性催化剂及其盐的
公开(公告)号：EP2785688A2
公开(公告)日：2014-10-08
申请号：EP12853125.8
申请日：2012-11-29
申请人： Scinopharm Taiwan, Ltd.
发明人： WU, Ping-Yu
IPC分类号： C07C315/06 , C07C321/16 , C07D295/00
CPC分类号： C07D265/30 , C07B53/00 , C07C303/36 , C07D295/096 , C07D413/12
摘要： The present invention provides efficient and economical methods for synthesis of (-)-2-
exo -morpholinoisoborne-10-thiol, its enantiomer, and related chiral catalysts. Novel compounds and methods of asymmetric synthesis are also disclosed.

6. 发明公开

EP2679576A2 Procédé de préparation de formes cristallines des énantiomeres optiques du modafinil et leur composition pharmaceutique 审中-公开
标题翻译：一种制备的莫达非尼的旋光对映体的结晶形式，其药物组合物的过程。
公开(公告)号：EP2679576A2
公开(公告)日：2014-01-01
申请号：EP13177648.6
申请日：2003-12-18
申请人： Teva Santé
发明人： Neckebrock, Olivier , Courvoisier, Laurent , Graf, Stéphanie , Serrure, Gilles , Coquerel, Gérard , Rose, Sébastien , Besselievre, Christine , Mallet, Franck , Van Langevelde, Adriaan Jan , Leproust, Pierre
IPC分类号： C07C317/50 , C07C315/06 , A61K31/165 , A61P25/00 , C07C315/04 , C07C317/28
CPC分类号： C07C317/28 , C07B2200/07 , C07B2200/13 , C07C315/04 , C07C315/06 , C07C317/44
摘要： L'invention a pour objet un procédé de préparation de formes cristallines des énantiomères optiques du modafinil, comprenant les étapes consistant à :i) dissoudre l'un des énantiomères optiques du modafinil dans un solvant autre que l'éthanol ;ii) cristalliser l'énantiomère du modafinil ;iii) récupérer la forme cristalline de l'énantiomère du modafinil ainsi obtenue. L'invention vise également un procédé de préparation des énantiomères optiques du modafinil.

7. 发明授权

EP2343275B1 Forme cristalline des énantiomères optiques du modafinil. 有权转让
标题翻译：莫达非尼的旋光对映体的结晶形式
公开(公告)号：EP2343275B1
公开(公告)日：2013-04-24
申请号：EP11163602.3
申请日：2003-12-18
申请人： Teva Santé
发明人： Neckebrock, Olivier , Courvoisier, Laurent , Graf, Stéphanie , Serrure, Gilles , Coquerel, Gérard , Rose, Sébastien , Besselievre, Christine , Mallet, Franck , Van Langevelde, Adriaan Jan , Leproust, Pierre
IPC分类号： C07C315/04 , C07C315/06
CPC分类号： C07C317/28 , C07B2200/07 , C07B2200/13 , C07C315/04 , C07C315/06 , C07C317/44
摘要： Production of crystalline forms (specifically polymorphic forms or solvates) of enantiomers of modafinil (A) involves dissolving an enantiomer of (A) (preferably the levorotatory isomer, (-)-(A)) in a solvent other than ethanol, crystallizing the enantiomer and recovering the obtained crystalline form. Some polymorphic forms and solvates of (-)-(A) are new. Independent claims are included for: (a) the following new polymorphic forms of (-)-(A): (i) Form II, having an X-ray diffraction pattern with maxima corresponding to interplanar spacings of 8.54Å, 7.57Å, 7.44Å, 4.56Å, 3.78Å and 3.71Å; (ii) Form III, having an X-ray diffraction pattern with maxima corresponding to interplanar spacings of 12.58Å, 8.54Å, 5.01Å, 4.10Å, 3.97Å and 3.20Å; and (iii) Form IV, having an X-ray diffraction pattern with maxima corresponding to interplanar spacings of 12.38Å, 8.58Å, 7.34Å, 5.00Å and 4.09Å; (b) a new dimethyl carbonate solvate of (-)-(A), having an X-ray diffraction pattern with maxima corresponding to interplanar spacings of 12.31Å, 9.69Å, 9.09Å, 8.54Å, 7.27Å, 6.21Å, 5.45Å, 5.10Å, 5.00Å, 4.83Å, 4.63Å, 4.46Å, 4.22Å, 4.21Å, 4.09Å, 3.78Å, 3.62Å, 3.53Å, 3.42Å, 3.32Å, 3.24Å, 3.21Å and 3.10Å; (c) a method for converting a first crystalline form of an enantiomer of (A) (specifically Form I of (-)-(A)) into another crystalline form, involving suspending the first crystalline form in a suitable solvent and recovering the second form (the solvate specifically being acetonitrile, with the product being recovered as acetonitrile solvate); (d) a new acetonitrile solvate of (-)-(A), having an X-ray diffraction pattern with maxima corresponding to interplanar spacings of 16.17Å, 14.14Å, 12.32Å, 10.66Å, 9.79Å, 9.29Å, 8.54Å, 8.15Å, 7.80Å, 7.09Å, 6.31Å, 5.83Å, 5.62Å, 5.41Å, 5.10Å, 4.90Å, 4.66Å, 4.58Å, 4.46Å, 4.33Å, 4.20Å, 4.02Å, 3.92Å, 3.835Å, 3.72Å, 3.60Å, 3.57Å, 3.45Å, 3.33Å, 3.24Å, 3.19Å, 3.0Å and 3.03Å; (e) the preparation of optically active (A) from modafinic acid (B) by: (i) optically resolving (+-)-(B) and recovering at least one of the enantiomers; (ii) contacting one of the enantiomers with a lower alkyl haloformate in presence of alcohol and organic base; and (iii) converting the obtained ester into the amide; and (f) the preparation of an enantiomer of (A) by optically resolving (+-)-(B) (or its salt) by preferential crystallization and converting the obtained enantiomer into (A) (optionally via a lower alkyl ester). - ACTIVITY : Nootropic; Antiparkinsonian; Cerebroprotective; Nootropic; Tranquilizer; Neuroprotective; Antidepressant; Neuroleptic; - MECHANISM OF ACTION : None given in the source material.

8. 发明授权

EP1775285B1 METHOD OF CRYSTALLIZING BICALUTAMIDE 有权
标题翻译：比卡鲁胺的方法结晶
公开(公告)号：EP1775285B1
公开(公告)日：2011-08-24
申请号：EP05766195.1
申请日：2005-07-13
申请人： Sumitomo Chemical Company, Limited
发明人： KATSURA, Tadashi , MIZUNO, Tadashi , ITAYA, Nobushige
IPC分类号： C07C315/06 , C07C317/46
CPC分类号： C07C315/06 , C07C317/46
摘要： A method of crystallizing bicalutamide, comprising adding an acetone solution containing bicalutamide to water. There is provided a crystal of bicalutamide obtained by the above method and having a particle size distribution of Dp10=1 to 10 µm, Dp50=10 to 25 µm and Dp90=25 to 100 µm. Further, there is provided a crystal of bicalutamide having a particle size distribution of Dp10=1 to 3 µm, Dp50=2 to 5 µm and Dp90=5 to 15 µm.

9. 发明公开

EP2168946A1 Crystalline form of modafinil, and methods of preparing the crystalline form 审中-公开
标题翻译： Kirstalline Form von Modafinil und Verfahren zu deren Herstellung
公开(公告)号：EP2168946A1
公开(公告)日：2010-03-31
申请号：EP09179990.8
申请日：2001-07-27
申请人： Teva Pharmaceutical Industries Ltd
发明人： Singer, Claude , Gershon, Neomi , Ceausu, Arina , Lieberman, Anita , Aronhime, Judith
IPC分类号： C07C317/44 , A61K31/165 , C07C315/02 , C07C315/06
CPC分类号： C07C317/44 , A61K31/165 , C07B2200/13 , C07C315/02 , C07C315/06 , C30B7/00 , C30B29/54
摘要： The present invention provides a new crystalline form of modafinil and processes for preparing the same.
摘要翻译：本发明提供了莫达非尼的新结晶形式及其制备方法。

10. 发明授权

EP1740534B1 PROCESS FOR PURIFYING MESOTRIONE 有权转让
标题翻译：法提纯硝磺草酮
公开(公告)号：EP1740534B1
公开(公告)日：2008-05-07
申请号：EP05707695.2
申请日：2005-03-03
申请人： Syngenta Participations AG
发明人： BENKE, Alan, Henry , WICHERT, Julie, Marie
IPC分类号： C07C315/06 , C07C317/24
CPC分类号： C07C315/06 , C07C317/24
摘要： A method for reducing the cyanide levels in a mesotrione sample, said method comprising: (i) taking an aqueous solution of the mesotrione sample in an aqueous solvent, (ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and (iii) crystallising the mesotrione out of solution is disclosed.

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