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1. 发明公开

EP3317440A1 BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM 审中-公开
公开(公告)号：EP3317440A1
公开(公告)日：2018-05-09
申请号：EP16818934.8
申请日：2016-07-01
申请人： Edico Genome, Corp.
发明人： VAN ROOYEN, Pieter , RUEHLE, Michael , MEHIO, Rami , HAHM, Mark
IPC分类号： C40B60/10 , G01N33/48 , G06F19/00
CPC分类号： G06F19/28 , G06F19/22
摘要： A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.

2. 发明公开

EP3191840A1 METAL-ANTIBODY TAGGING AND PLASMA-BASED DETECTION 有权
标题翻译：金属抗体标记和基于等离子体的检测
公开(公告)号：EP3191840A1
公开(公告)日：2017-07-19
申请号：EP15840345.1
申请日：2015-09-14
申请人： Purdue Research Foundation
发明人： ROBINSON, Joseph, Paul , RAJWA, Bartolomej, P. , PATSEKIN, Valeri, P. , BAE, Euiwon
IPC分类号： G01N33/53 , G01N33/567 , G01N33/554 , G01N33/569 , C40B30/04 , C40B60/10
摘要： An apparatus and method for characterizing a target, e.g., microbial samples or biological toxins, includes labeling the target with a biomolecular recognition construct and measuring an atomic-spectra signal of the biomolecular recognition construct. The method can include heating the labeled target before measuring the atomic-spectra signal. The atomic-spectra signal can be measured by performing laser-induced breakdown spectroscopy. The atomic-spectra signal can be measured by performing spark induced breakdown spectroscopy. The biomolecular recognition construct can be prepared by tagging a biological scaffolding with a metal atom or ion. In an aspect in which the target includes a microbial sample, the biological scaffolding can include an antibody against epitopes present on bacterial surface, the antibody linked to a heavy metal. In an aspect in which the target includes a biological toxin, the biological scaffolding can include an antibody against the biological toxin linked to heavy metals.
摘要翻译：样本内的目标可以使用被配置为将样本中的金属转化为等离子体的能量源和被配置为检测由等离子体发射的电磁辐射以提供光谱信号的光学光谱检测器来表征。处理器可以使用光谱信号确定样品中金属的存在。目标可以包括微生物或生物毒素。包含金属和支架的识别构建体可以应用于样品。脚手架可以绑定到目标。能量可以用于将至少一些样品转化成等离子体。可以检测等离子体发射的电磁辐射，以提供样本的光谱信号。准备子系统可以将识别构建体添加到样本中，并且清洗子系统可以将未结合的识别构建体从样本中清除。

3. 发明公开

EP1180111A4 METHOD AND APPARATUS FOR COMPOUND LIBRARY PREPARATION USING OPTICAL MODULATOR 审中-公开
标题翻译：方法和装置的化合物库由光调制器是指生产
公开(公告)号：EP1180111A4
公开(公告)日：2003-03-26
申请号：EP00904105
申请日：2000-02-10
申请人： MACROGEN INC
发明人： SEO JEONG-SUN , LEE YOON-SIK , KIM YONG-KWEON
IPC分类号： G01N31/20 , B01J19/00 , C07B61/00 , C07H21/00 , C07H21/04 , C07K1/06 , C12Q1/68 , C40B20/00 , C40B40/02 , C40B40/06 , C40B50/06 , C40B60/10 , C40B60/14 , G01N33/53 , G01N33/566 , G01N37/00 , C07H19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00436 , B01J2219/00439 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B60/14
摘要： The present invention relates to the provision of compound libraries, more particularly it provides a compound library preparation method using an optical modulator and a compound library preparation apparatus used in the same. Furthermore, the present invention provides a compound analyzing method using the preparation method and a compound analyzing apparatus used in the same.

4. 发明公开

EP2611954A1 HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS 有权转让
标题翻译： CHIPS VON HOHER DICHTEFÜRBIOCHEMISCHE ARRAYS
公开(公告)号：EP2611954A1
公开(公告)日：2013-07-10
申请号：EP11822596.0
申请日：2011-08-31
申请人： Complete Genomics, Inc.
发明人： STAKER, Bryan P.
IPC分类号： C40B20/02 , C40B60/10 , C12Q1/68
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , C40B20/02 , G01N21/6428 , G01N21/6458
摘要： An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.
摘要翻译：提供了一种可用于生物化学测定的阵列芯片，其中芯片包括根据第一间距布置有附着位置的场区域和至少一个具有根据第二节距排列的一维点图案的轨迹区域，该第二间距不太密集，第一音调的非整数倍，使得可以在轨道区域中施加一维莫尔平均，从而以更高的附着位置密度实现芯片与光学仪器的对准。

5. 发明公开

EP2611954A4 HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS 有权转让
标题翻译：高密度生化阵列芯片
公开(公告)号：EP2611954A4
公开(公告)日：2015-04-29
申请号：EP11822596
申请日：2011-08-31
申请人： COMPLETE GENOMICS INC
发明人： STAKER BRYAN P
IPC分类号： G01N21/64 , B01J19/00 , C40B20/02 , C40B60/10 , G06T7/00
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , C40B20/02 , G01N21/6428 , G01N21/6458
摘要： An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.

6. 发明公开

EP1451318A4 COMPILATIONS OF NUCLEIC ACIDS AND ARRAYS AND METHODS OF USING THEM 审中-公开
标题翻译： NUCLEIC和阵列组合物及使用方法
公开(公告)号：EP1451318A4
公开(公告)日：2007-06-27
申请号：EP02807317
申请日：2002-10-15
申请人： PERKINELMER LAS INC
发明人： MOHAMMED MANSOOR , KANG JASON SINGH , SHAH SHISHIR , CAI WEI-WEN
IPC分类号： G01N33/53 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B20/04 , C40B30/04 , C40B40/08 , C40B60/10 , G01N33/566 , G01N37/00
CPC分类号： C40B40/08 , C07H21/00 , C40B20/04 , C40B30/04 , C40B60/10
摘要： In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.

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