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1. 发明公开

EP4053292A1 METHODS OF ANALYZING NUCLEIC ACIDS FROM INDIVIDUAL CELLS OR CELL POPULATIONS 审中-公开
公开(公告)号：EP4053292A1
公开(公告)日：2022-09-07
申请号：EP21199180.7
申请日：2015-06-26
申请人： 10X Genomics, Inc.
发明人： HINDSON, Benjamin, J. , HINDSON, Christopher, Martin , SCHNALL-LEVIN, Michael , NESS, Kevin, Dean , JAROSZ, Mirna , SAXONOV, Serge , HARDENBOL, Paul , BHARADWAJ, Rajiv , ZHENG, Xinying , BELGRADER, Philip
IPC分类号： C12Q1/6806 , C12N15/10 , C40B20/04 , C40B50/16
摘要： Methods, compositions and systems for analyzing individual cells or cell populations through the partitioned analysis of contents of individual cells or cell populations. Individual cells or cell populations are co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the contents of a given cell or cell population, and subsequently analyzing the cell's contents and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of the cell's nucleic acids through sequencing.

2. 发明公开

EP3529400A1 CONCEALING INFORMATION PRESENT WITHIN NUCLEIC ACIDS 有权
公开(公告)号：EP3529400A1
公开(公告)日：2019-08-28
申请号：EP17865703.7
申请日：2017-10-24
申请人： Geneinfosec, Inc.
发明人： SAWAYA, Sterling
IPC分类号： C40B70/00 , C40B50/06 , C40B50/16 , C40B40/06 , C12N15/10

3. 发明公开

EP3368208A1 SYSTEM AND METHOD FOR LONGITUDINAL ANALYSIS OF PEPTIDE SYNTHESIS 审中-公开
公开(公告)号：EP3368208A1
公开(公告)日：2018-09-05
申请号：EP16788491.5
申请日：2016-10-26
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： PATEL, Jigar , SULLIVAN, Eric , BARILOVITS, Sarah , BANNEN, Ryan , TAN, John
IPC分类号： B01J19/00 , C07K1/04 , C07K7/06 , C07K17/14 , C40B30/04 , C40B50/16 , G01N21/64 , G01N33/68
CPC分类号： B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00623 , B01J2219/00659 , B01J2219/00693 , B01J2219/00695 , B01J2219/00725 , C07K1/047 , C07K17/14 , C40B50/16 , G01N21/6452 , G01N33/6845
摘要： The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.

4. 发明公开

EP3351631A3 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 有权
公开(公告)号：EP3351631A3
公开(公告)日：2018-08-29
申请号：EP18158771.8
申请日：2012-09-07
申请人： X-Chem, Inc.
发明人： KEEFE, Anthony, D. , WAGNER, Richard, W. , LITOVCHICK, Alexander , CLARK, Matthew , CUOZZO, John, W. , CENTRELLA, Paolo A. , ZHANG, Ying , HUPP, Christopher D.
IPC分类号： C12N15/10 , C40B50/14 , C40B50/16
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2'-substituted nucleotides, such as 2'-O-methyl or 2'-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

5. 发明公开

EP3284851A1 METHOD FOR SOLID-PHASE SYNTHESIS OF DNA-ENCODED CHEMICAL LIBRARY 有权转让
标题翻译：一种编码DNA的化学文库的固相合成方法
公开(公告)号：EP3284851A1
公开(公告)日：2018-02-21
申请号：EP16779596.2
申请日：2016-04-13
申请人： Hitgen Ltd.
发明人： LI, Jin , WAN, Jinqiao , LIU, Guansai , ZHONG, Lina , CHEN, Yang , WANG, Zhi , LIU, Xincheng , MU, Yun , DOU, Dengfeng
IPC分类号： C40B40/06 , C40B20/04 , C40B70/00 , C40B50/04 , C40B50/16
CPC分类号： C12N15/1068 , C12P19/34 , C40B20/04 , C40B40/06 , C40B50/04 , C40B50/16 , C40B70/00
摘要： The present invention provides a method of solid-phase synthesis of DNA-encoded compound library. The method includes following steps: a) reacting solid carrier G-1 with linker molecule L-1 to prepare L-G-1; b) reacting DNA with linker molecule L-0 to prepare L-2; c) reacting L-G-1 with L-2 to prepare L-G-2; d) removing protection group of the L-G-2 and obtaining L-G-2-1; e) reacting the L-G-2-1 with synthetic building block and performing DNA encoding; and f) removing the solid carrier and obtaining the DNA-encoded compound library. Compared with the prior art, the present invention can complete post-treatment purification of the reaction only by filtration and irrigation processes for several times. The present invention is simple to operate, can shorten the production cycle of DNA encoded compound library with more than 50%, significantly increases the production efficiency and the unicity as well as the purity of the final products. Besides, the present invention has a high economic value, which is suitable for industrial application.
摘要翻译：本发明提供了DNA编码的化合物文库的固相合成方法。该方法包括以下步骤：a）使固体载体G-1与接头分子L-1反应以制备L-G-1; b）使DNA与接头分子L-0反应以制备L-2; c）使L-G-1与L-2反应以制备L-G-2; d）除去L-G-2的保护基并得到L-G-2-1; e）使L-G-2-1与合成结构单元反应并进行DNA编码; 和f）除去固体载体并获得DNA编码的化合物文库。与现有技术相比，本发明只需通过过滤和冲洗过程就可以完成反应的后处理纯化数次。本发明操作简单，可将DNA编码化合物文库的生产周期缩短50％以上，大大提高了生产效率和单一性以及最终产品的纯度。此外，本发明具有很高的经济价值，适用于工业应用。

6. 发明公开

EP4370710A1 PRE-TEMPLATED INSTANT PARTITIONING OF DNA-ENCODED LIBRARIES 审中-实审
公开(公告)号：EP4370710A1
公开(公告)日：2024-05-22
申请号：EP22842853.8
申请日：2022-07-14
申请人： Fluent Biosciences, Inc.
发明人： KUGLER, Catherine , MELTZER, Robert
IPC分类号： C12Q1/6844 , C12Q1/6869 , C12Q1/6876 , C40B20/04 , C40B30/04 , C40B30/06 , C40B40/08 , C40B50/16
CPC分类号： C12N15/1065 , C12N15/1075 , C12Q1/6806

7. 发明授权

EP2831268B1 MOLECULAR CODE SYSTEMS 有权
公开(公告)号：EP2831268B1
公开(公告)日：2018-06-20
申请号：EP13713339.3
申请日：2013-03-26
申请人： ETH Zürich
发明人： GRASS, Robert N. , STARK, Wendelin Jan
IPC分类号： B01L3/00 , C40B20/04 , C40B50/16 , C12Q1/68
CPC分类号： C12Q1/686 , B01J2219/00572 , B01L3/54 , C12Q1/68 , C40B20/04 , C40B50/16 , C12Q2527/125 , C12Q2563/149 , C12Q2563/185
摘要： The present invention relates to a method for protecting and recovering nucleic acids. This method may be applied in a verification method of products using molecular code systems or it may be applied in a storage method for nucleic acids. The invention further provides specific particles, their use in secure marking; products suitable for such verification method, to processes for manufacturing such products and methods for reading the information.

8. 发明授权

EP2748357B1 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 有权
标题翻译：标记DNA编码文库的方法
公开(公告)号：EP2748357B1
公开(公告)日：2018-04-04
申请号：EP12830083.7
申请日：2012-09-07
申请人： X-Chem, Inc.
发明人： KEEFE, Anthony, D. , WAGNER, Richard, W. , LITOVCHICK, Alexander , CLARK, Matthew , CUOZZO, John, W. , CENTRELLA, Paolo A. , ZHANG, Ying , HUPP, Christopher D.
IPC分类号： C12N15/10 , C40B50/14 , C40B50/16
CPC分类号： C12N15/1065 , C07B2200/11 , C12N15/10 , C12N15/1068 , C12N15/1093 , C40B50/16
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

10. 发明公开

EP3889325A1 METHODS OF ANALYZING NUCLEIC ACIDS FROM INDIVIDUAL CELLS OR CELL POPULATIONS 审中-公开
公开(公告)号：EP3889325A1
公开(公告)日：2021-10-06
申请号：EP21166784.5
申请日：2015-06-26
申请人： 10X Genomics, Inc.
发明人： HINDSON, Benjamin, J. , HINDSON, Christopher, Martin , SCHNALL-LEVIN, Michael , NESS, Kevin, Dean , JAROSZ, Mirna , SAXONOV, Serge , HARDENBOL, Paul , BHARADWAJ, Rajiv , ZHENG, Xinying , BELGRADER, Philip
IPC分类号： C40B20/04 , C40B50/16 , C12Q1/6806 , C12N15/10
摘要： Methods, compositions and systems for analyzing individual cells or cell populations through the partitioned analysis of contents of individual cells or cell populations. Individual cells or cell populations are co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the contents of a given cell or cell population, and subsequently analyzing the cell's contents and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of the cell's nucleic acids through sequencing.

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