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1. 发明公开

EP0169055A3 Polymeric single layer analytical element 有权转让
标题翻译：聚合物单层分析元素
公开(公告)号：EP0169055A3
公开(公告)日：1987-03-18
申请号：EP85305059
申请日：1985-07-16
申请人： TECHNICON INSTRUMENTS CORPORATION (a New York corporation)
发明人： Kumar, Anand , Koon-Wah, Leong
IPC分类号： G01N33/52 , G01N33/72 , G01N33/84 , C12Q01/60 , C12Q01/54 , C12Q01/62 , G01N33/53
CPC分类号： G01N33/521 , C12Q1/00
摘要： A device (10) for determining an analyte in a fluid sample consists essentially of a dimensionally stable, uniformly porous, diffusely reflective single layer (20) formed of a polymeric non-fibrous matrix and, dispersed throughout said matrix, at least one substance which effects a detectable response to the analyte. Preferably, the polymer is a high density polyethylene treated to be hydrophilic. The optical properties of the device can be further modified by blending in pigments, such as titanium dioxide. The analyte-responsive substance can include a first component which is responsive to the analyte to form a reaction product and a second component separated from the first component binder and responsive to the reaction product to effect a detectable change. The device is completely effective in the absence of other elements or structures to provide a quantitative detectable response to the presence of the analyte under assay.

2. 发明公开

EP0125698A3 A process for screening microorganisms producing glucose-2-oxidase 失效
标题翻译：筛选生产葡萄糖-2-氧化酶的微生物的方法
公开(公告)号：EP0125698A3
公开(公告)日：1986-02-26
申请号：EP84105568
申请日：1984-05-16
申请人： NABISCO BRANDS, Inc.
发明人： Horwath, Robert O.
IPC分类号： C12Q01/04 , C12Q01/26 , C12Q01/54
CPC分类号： C12Q1/54 , C12Q1/04 , C12Q2326/30 , G01N2333/906
摘要： This invention relates to a process for screening of microorganisms for the production of glucose-2-oxidase. Microorganisms capable of glucose-2-oxidase synthesis and growing on the surface of a solid medium are detected by reaction of glucosone (arabino-2-hexosulose), or hydrogen peroxidase surrounding each microorganism with an analytically indicatable reagent. The process is particularly useful for the early detection of glucose-2-oxidase activity in slow growing strains of microorganisms such as Basiciomycetes.

3. 发明公开

EP0057285A3 Method and device for detecting glucose concentration 失效
标题翻译：检测葡萄糖浓度的方法和装置
公开(公告)号：EP0057285A3
公开(公告)日：1982-09-01
申请号：EP81110630
申请日：1981-12-21
申请人： MILES LABORATORIES, INC.
发明人： Bauer, Robert , Rapkin, Myron C.
IPC分类号： C12Q01/54 , G01N33/52
CPC分类号： C12Q1/54 , Y10S435/805
摘要： A method and test device for determining the glucose concentration in a test sample containing from ½ to 5 percent glucose are disclosed. The method and test device involve incorporating urea-formaldehyde resin in a carrier matrix and subsequently impregnating the carrier with an enzymatic testing composition which includes glucose oxidase, a peroxidatively-active compound and a chromogen. Contact of the carrier with a glucose-containing test sample produces a detectable response whereby the glucose concentration can be determined.

4. 发明公开

EP0189388A3 Diagnostic method for diseases having an arthritic component 有权
标题翻译：具有神经元素的疾病诊断方法
公开(公告)号：EP0189388A3
公开(公告)日：1988-11-30
申请号：EP86870007
申请日：1986-01-21
申请人： Monsanto Company
发明人： Dwek, Raymond A. Dep. of Biochemistry , Rademacher, Thomas W. Dep. of Biochemistry
IPC分类号： C12Q01/54 , G01N33/66 , G01N33/50
CPC分类号： G01N33/564 , C12Q1/34 , C12Q1/54 , G01N33/66 , G01N2800/102 , Y10S436/827 , Y10T436/143333
摘要： A method is disclosed for the diagnosis of diseases having an arthritic component such as rheumatoid arthritis and osteoarthritis which comprises determining the deficiency of galactose in a sample of the patient's blood serum or plasma, or synovial fluid, or an Ig component or fragment thereof in comparison with the corresponding normal values of galactose.

5. 发明公开

EP0119722A3 Measuring composition 有权
标题翻译：测量组合物
公开(公告)号：EP0119722A3
公开(公告)日：1986-03-05
申请号：EP84300863
申请日：1984-02-10
申请人： UNITIKA LTD.
发明人： Tomita, Kosuke , Hashimoto, Yasunobu
IPC分类号： C12Q01/48 , C12Q01/32 , C12Q01/54
CPC分类号： C12Q1/48 , C12Q1/008 , C12Q1/32 , C12Q1/54
摘要： A measuring composition for use in determination of glucose, ATP, phosphotransferases such as creatine phosphokinase, and glucosidases is disclosed. The composition is comprised of glucokinase, glucose-6-phosphate dehydrogenase, and potassium or ammonium ions. This composition makes it possible to shorten measuring times even if the amount of enzyme is reduced, and exhibits high stability when stored at room temperature in a solution state.

6. 发明公开

EP0147713A3 Enzymatic ATP and FMN assay 失效
标题翻译：酶促ATP和FMN测定
公开(公告)号：EP0147713A3
公开(公告)日：1986-02-19
申请号：EP84115113
申请日：1984-12-10
申请人： Miles Italiana SpA
发明人： Fossati, Piero
IPC分类号： C12Q01/48 , C12Q01/26 , C12Q01/28 , C12Q01/54
CPC分类号： C12Q1/48 , C12Q1/008 , C12Q1/04
摘要： An enzymatic determination of one of the coenzymes adenosine triphophate (ATP) or flavin mononucleotide (FMN) based on the use of an flavine adenine dinucleotide (FAD) synthetase-active system in conjunction with the other coenzyme to generate FAD. The generated FAD can then be measured to determine the ATP or FMN concentration in the sample. Preferably, the generated FAD is measured by combination with a corresponding apoenzyme, preferably apo(glucose oxidase), and measuring the activity of the enzyme produced. The resultant active enzyme is preferably measured in a manner which results in a colorimetric response. The present invention provides an ATP or FMN assay which combines the sensitivity of bioluminescent assays with the convenience of a colorimetrically detectable response.

7. 发明公开

EP0141648A3 Reflective particle-containing analytical device 有权转让
标题翻译：反射粒子分析装置
公开(公告)号：EP0141648A3
公开(公告)日：1985-07-03
申请号：EP84307507
申请日：1984-10-31
申请人： TECHNICON INSTRUMENTS CORPORATION (a New York corporation)
发明人： Kumar, Anand , Leong, Koon-Wah
IPC分类号： G01N33/52 , G01N33/72 , G01N33/68 , C12Q01/54 , C12Q01/28
CPC分类号： G01N33/521
摘要： @ A device for determining an analyte in a liquid sample consists essentially of a single integral matrix, comprising (a) a plurality of solid, reflective, inorganic particles (22); (b) at least one substance (24) which effects a detectable response to the analyte and is associated with the surface of said particles; and (c) a binder (26) which is permeable to the analyte or a reaction product thereof. Preferably, the particles are non-spherical and have a refractive index greater than about 1.6. The analyte-responsive substance can include a first component which is responsive to the analyte to form a reaction product, and a second component separated from the first component by the binder and responsive to the reaction product to effect a detectable change. It is the second component which is usually associated with the surface of the particles. The device is effective in the absence of other elements or structures to provide a quantitative detectable response to the presence of the analyte under assay.

8. 发明公开

EP0250991A3 Method for the specific determination of serum fructosamine content and suitable reagent mixture 失效
标题翻译：特异性测定血清蛋白内含物和适用试剂混合物的方法
公开(公告)号：EP0250991A3
公开(公告)日：1988-11-17
申请号：EP87108517
申请日：1987-06-12
申请人： BOEHRINGER MANNHEIM GMBH
发明人： Siedel, Joachim, Dr. rer.nat. , Ziegenhorn, Joachim, Dr. rer.nat. , Schellong, Lieselotte , Vogt, Bernd, Dr. med.
IPC分类号： G01N33/66 , C12Q01/26 , C12Q01/54 , G01N33/52
CPC分类号： C12Q1/26 , G01N33/66 , Y10S436/825 , Y10S436/904 , Y10T436/144444 , Y10T436/25125

9. 发明公开

EP0207370A3 Electrochemical sensor and membrane therefor 失效转让
标题翻译：电化学传感器及其膜
公开(公告)号：EP0207370A3
公开(公告)日：1988-11-17
申请号：EP86108293
申请日：1986-06-18
申请人： MILES INC.
发明人： Jones, James E.
IPC分类号： G01N27/40 , C12M01/40 , C12Q01/54
CPC分类号： C12Q1/002
摘要： Polymerizable silicon-containing compounds are polymerized or further polymerized in dispersed form to form cured layers or membranes when cured or polymerized in a dispersed layer upon removal of the continuous phase during curing to provide a layer or membrane having unexpectedly good oxygen and glucose-permeability without allowing the passage of electrode-sensitive interferants therethrough. The membranes also are permeable to cholesterol, uric acid, and lower alcohols, such as ethanol. The polymerizable silicon-containing compounds, after dispersion in a continuous phase, such as by including an emulsifier, can be cured in any known manner during removal of the continuous phase, such as by evaporation of water from a water-continuous phase silicon emulsion or dispersion. A glucose catalyst layer, such as glycose oxidase, can be bonded directly to an electrical, signal-receiving surface, such as an electrode, and the membrane applied over the catalyst to form an electrochemical sensor having new and unexpected accuracy. Whole blood is applied directly onto the membrane, allowing passage of glucose and oxygen to the glucose oxidase layer while preventing passage of substantially all other electrode interferants present in whole blood. The glucose and oxygen interact with the glucose oxidase catalyst to produce hydrogen peroxide which is received immediately by the electrode surface. Since the membrane is whole blood compatible, at the conclusion of the measurement, the whole blood on the surface of the membrane may be rinsed or wiped off and the sensor is ready for measurement of another specimen.

10. 发明公开

EP0212660A3 Method for quantitative analysis of analyte in liquid sample using analytical element 失效
标题翻译：使用分析元素的液体样品中分析物的定量分析方法
公开(公告)号：EP0212660A3
公开(公告)日：1988-01-13
申请号：EP86111800
申请日：1986-08-26
申请人： FUJI PHOTO FILM CO., LTD.
发明人： Iwata, Yuzo c/o Fuji Photo Film Co., Ltd. , Makiuchi, Hajima c/o Fuji Photo Film Co., Ltd. , Kitajima, Masao c/o Fuji Photo Film Co., Ltd.
IPC分类号： G01N33/52 , G01N21/27 , C12Q01/54 , C12Q01/58 , G01N33/68
CPC分类号： C12Q1/58 , C12Q1/54 , G01N21/274 , G01N21/4738 , G01N21/8483 , G01N33/525
摘要： In a method for quantitatively analyzing an analyte in a liquid sample by applying the liquid sample on one of a set of analytical elements and measuring a color developed in the analytical element through reflection photometory in which said set of analytical elements are the same elements as a standard element except for deviation of sensitivity to the analyte, but said deviation of sensitivity is essentially equivalent to each other among the set of analytical elements, the calibration curve of the standard element with respect to said analyte being predetermined, an improvement involving preparation of a linear equation for defining a relationship between an optical reflection density value OD x to be measured on an analytical element belonging to said set of the analytical elements and an optical reflection density value OD s being predetermined on the standard analytical element, in which the optical reflection density values OD x and OD s are those to be determined on colors developed on the respective elements upon application of a liquid sample containing the analyte in the same content C x .
摘要翻译：在通过将液体样品应用于一组分析元件之一并通过反射光度测量在分析元件中显影的颜色来定量分析液体样品中的分析物的方法中，其中所述一组分析元件是与除了对分析物的敏感性偏差之外，所述灵敏度的偏差在所述一组分析元件中基本相同，所述标准元件相对于所述分析物的校准曲线是预定的，改进涉及制备用于定义属于所述分析单元组的分析单元的光反射浓度值ODx与标准分析单元上规定的光反射浓度值OD之间的关系的线性方程式，其中光学反射浓度值ODx和OD是在颜色设计上确定的值在将含有相同含量C x的分析物的液体样品应用于相应的元件上。

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