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1. 发明公开

EP4365298A1 METHOD OF PRODUCING NEGATIVE-STRAND RNA VIRUS VECTOR AND PRODUCED NEGATIVE-STRAND RNA VIRUS VECTOR 审中-实审
公开(公告)号：EP4365298A1
公开(公告)日：2024-05-08
申请号：EP22833215.1
申请日：2022-06-29
申请人： Repli-Tech Co., Ltd.
发明人： SAEKI, Koichi
IPC分类号： C12N15/86 , C12N5/071 , C12N7/01 , C12N15/38 , C12N15/39 , C12N15/44 , C12N15/49
CPC分类号： Y02A50/30 , C07K14/11 , C07K14/065 , C07K14/155 , C12N5/06 , C07K14/03 , C12N15/86 , C12N7/00
摘要： The present disclosure provides a method of producing a negative-strand RNA virus vector. The present disclosure specifically provides a method of producing a negative-strand RNA virus vector in the presence of a PKR inhibitory factor.

2. 发明公开

EP4324918A3 IMMUNO-ONCOLYTIC THERAPIES 审中-实审
公开(公告)号：EP4324918A3
公开(公告)日：2024-04-24
申请号：EP23215391.6
申请日：2014-08-22
申请人： University of Pittsburgh - of The Commonwealth System of Higher Education
发明人： THORNE, Stephen Howard
IPC分类号： C12N15/39 , A61K39/285 , A61K35/768 , C12N7/00
CPC分类号： C12N2710/2413220130101 , A61K39/12 , A61K2039/525620130101 , A61K2039/57220130101 , A61K2039/58520130101 , C12N2710/2412120130101 , C12N2710/2413420130101 , A61K2039/57520130101 , A61P35/00 , A61P35/02
摘要： The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.

3. 发明公开

EP3970740A1 CELL FUSION-INDUCING VACCINIA VIRUS AND USE THEREOF 审中-实审转让
公开(公告)号：EP3970740A1
公开(公告)日：2022-03-23
申请号：EP20806805.6
申请日：2020-05-12
申请人： National University Corporation Tottori University , Evolve Biotherapeutics Co., Ltd.
发明人： NAKAMURA Takafumi , KUWANO Nozomi , NAKATAKE Motomu , KUROSAKI Hajime
IPC分类号： A61K39/002 , A61K39/02 , A61K39/12 , A61P31/04 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/04 , C12N7/01 , C12N15/39 , C12N15/863 , A61K35/76
摘要： This invention provides a vaccinia virus that induces cell fusion between infected cells and a method for producing the same. Such vaccinia virus is deprived of the K2L gene or the HA gene or functions of the K2L gene and the HA gene and is mutated to induce cell fusion between infected cells and induce cell death.

4. 发明公开

EP3735466A1 MODIFIED ORTHOPOXVIRUS VECTORS 审中-实审
公开(公告)号：EP3735466A1
公开(公告)日：2020-11-11
申请号：EP19736067.0
申请日：2019-01-04
申请人： Ottawa Hospital Research Institute , TURNSTONE BIOLOGICS CORP.
发明人： BELL, John C. , LE BOEUF, Fabrice , HUH, Michael S. , TANG, Matthew Y. , PELIN, Adrian , KELLER, Brian Andrew , BREITBACH, Caroline J. , BURGESS, Michael F. , BERNSTEIN, Steven H.
IPC分类号： C12N15/863 , C12N15/12 , C12N15/13 , C12N15/37 , C12N15/39 , C12N15/52 , C12N7/01

5. 发明授权

EP1335987B2 MODIFIED VACCINIA ANKARA VIRUS VARIANT 有权转让
标题翻译：变化修饰的安卡拉牛痘病毒的
公开(公告)号：EP1335987B2
公开(公告)日：2016-06-15
申请号：EP01991753.3
申请日：2001-11-22
申请人： Bavarian Nordic A/S
发明人： CHAPLIN, Paul , HOWLEY, Paul , MEISINGER, Christine
IPC分类号： C12N15/863 , C12N15/39 , C12N7/04 , A61K39/285 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/285 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/24121 , C12N2710/24143 , C12N2740/16322

6. 发明公开

EP2496699A2 DIAGNOSTIC ASSAYS FOR CHORDOPOXVIRUSES 有权转让
标题翻译：对于Chordopox病毒的诊断性分析
公开(公告)号：EP2496699A2
公开(公告)日：2012-09-12
申请号：EP10828963.8
申请日：2010-11-02
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
发明人： LI, Yu , DAMON, Inger, K. , ZHAO, Hui
IPC分类号： C12N15/39 , C12Q1/68
CPC分类号： C12Q1/701
摘要： This disclosure relates to compositions and methods of their use in detection and identification of a chordopoxvirus in a sample, such as diagnosis of an infection in a subject. The compositions and methods allow for detection and identification of all non- avian low-GC content chordopoxviruses, identification of most known high-GC content chordopoxvirus, and species-specific detection of Canarypox virus, Fowlpox virus, and Sealpox virus.
摘要翻译：本公开涉及其用于检测和鉴定样品中脊索痘病毒的组合物和方法，例如诊断受试者中的感染。该组合物和方法允许检测和鉴定所有非禽类低GC含量的脊索痘病毒，鉴定最知名的高GC含量脊索痘病毒，以及对金丝雀痘病毒，鸡痘病毒和海痘病毒的种类特异性检测。

7. 发明公开

EP2235166A1 VECTEURS VACCINAUX DERIVES DE LEPORIPOXVIRUS 审中-公开
公开(公告)号：EP2235166A1
公开(公告)日：2010-10-06
申请号：EP08872097.4
申请日：2008-12-03
申请人： Institut National De La Recherche Agronomique , Ecole Nationale Veterinaire Toulouse
发明人： BERTAGNOLI, Stéphane , PIGNOLET, Béatrice , GELFI, Jacqueline , CAMUS-BOUCLAINVILLE, Christelle
IPC分类号： C12N7/04 , C12N15/39 , C12N15/62 , A61K39/275 , A61K39/295
CPC分类号： C07K16/081 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/40 , C07K2319/60 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2710/24022 , C12N2710/24043 , C12N2710/24062
摘要： The invention relates to modified leporipoxviruses expressing a chimeric envelope protein resulting from the fusion of an envelope protein of mature intracellular virions or of an envelope protein of enveloped extracellular virions, with an exogenous protein. These modified leporipoxviruses can be used in particular for obtaining vaccines.
摘要翻译：本发明涉及表达由成熟细胞内病毒粒子的包膜蛋白或包膜胞外病毒粒子的包膜蛋白与外源蛋白质融合产生的嵌合包膜蛋白的经修饰的Leporipoxviruses。这些修饰的猪痘病毒特别可用于获得疫苗。

8. 发明公开

EP1398380A1 Orthopoxvirus antigens and use thereof 审中-公开
标题翻译： Antigene des Orthopoxvirus und ihre Verwendung
公开(公告)号：EP1398380A1
公开(公告)日：2004-03-17
申请号：EP02022252.7
申请日：2002-10-02
申请人： GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
发明人： Drexler, Ingo , Erfle, Volker , Staib, Caroline , Sutter, Gerd
IPC分类号： C12N15/39 , C12N15/09 , C12N15/63 , C07K7/06 , C12N5/14 , C12N5/16 , C12N5/22 , G01N33/53 , A61K39/295
CPC分类号： G01N33/505 , A61K38/00 , A61K39/00 , C07K14/005 , C12N2710/24022 , C12N2710/24122 , C12N2710/24143 , C12N2760/16122 , G01N2333/065
摘要： The present invention is directed to a method of detecting a T cell response induced by smallpox vaccines or Orthopoxvirus vector vaccines in a mammal and to immunogenic Orthopoxvirus antigens and the nucleic acids encoding same. The present invention further relates to pharmaceutical compositions and their use in the protective immunization against a smallpox infection.
摘要翻译：包含其中一个肽（P1）的免疫原性正痘病毒抗原（I），其具有选自50个氨基酸序列或其变体的序列，其包含与各自（P1）相比的一个或多个添加，插入，取代和/或缺失，该变体的免疫原性活性基本上等于相应未修饰（P1）的活性，是新的。包含至少一种肽（P1）的免疫原性正痘病毒抗原（I），其具有选自50个氨基酸序列的序列，例如（Ⅰa）或其变体包含与各自（P1）相比的一个或多个添加，插入，取代和/或缺失，并且其中变体的免疫原性活性基本上等于相应未修饰（P1）的活性，。 Ile-Ile-Ala-Ile-Val-Phe-Val-Phe-Ile-Leu（Ia）Tyr-Leu-Asp-Asn-Leu-Leu-Pro-Ser-Thr-Leu（Ib）Phe-Ile-Leu- Thr-Ala-Ile-Leu-Phe-Leu（Ic）Tyr-Leu-Asp-Asn-Leu-Leu-Pro-Ser-Thr（Id）Gly-Leu-Ile-Ile-Ile-Ser-Ile-Phe- Leu（Ie）Ile-Ile-Ile-Ser-Ile-Phe-Leu-Gln-Val（If）Phe-Ala-Ile-Ile-Ala-Ile-Val-Phe-Val（Ig）Tyr-Leu-Phe- Arg-Ile-Val-Ser-Thr-Val（Ih）Leu-Leu-Asn-Asn-Ser-Leu-Gly-Ser-Val（Ii）Asn-Leu-Ala-Thr-Ser-Ile-Tyr-Thr- Ile（Ij）独立权利要求也包括：（1）分离的核酸（II），其编码（P1）中的一个或多个; （2）分离的核酸（III），其是（II）的转录产物; （3）分离的核酸（IV），其在中等严格条件下与（II）或（III）选择性杂交; （4）由（II），（III）或（IV）编码的免疫原性抗原（V）; （5）载体（VI），其包含一种或多种（II），（III）或（IV）的核酸序列; （6）包含一种或多种（II），（III）或（IV）的核酸序列和一种或多种调节序列的表达载体（VII）（7）用（VI）或（VII）转化的宿主细胞（VIII）; （8）已经用（P1）中的一种或多种脉冲的抗原呈递细胞（APC）; （9）包含（P1）和/或APC中的一种或多种的诊断组合物（C1）（10）用于检测由包含至少一种或多种（P1）或APC的天花疫苗或正痘病毒载体疫苗诱导的免疫应答的诊断试剂盒（K1）和（11）包含（P1），（II），（III）或（IV）或（VI）或（VII）中的一种或多种的载体的组合物（C2）。活动：病毒。没有给出生物数据。动作机制：疫苗。没有给出生物数据。

9. 发明公开

EP1200595A2 MYXOMA VIRUS GENES FOR IMMUNE MODULATION 审中-公开
标题翻译：基因克隆myxomavirus对免疫调制可以使用
公开(公告)号：EP1200595A2
公开(公告)日：2002-05-02
申请号：EP00948188.8
申请日：2000-07-12
申请人： Viron Therapeutics, Inc.
发明人： MCFADDEN, Grant
IPC分类号： C12N15/39 , C07K14/065 , C12N15/11 , C07K16/08 , C12Q1/68 , G01N33/50 , G01N33/569 , A61K39/275 , A61K48/00 , A01K67/027
CPC分类号： C07K14/005 , A01K2217/05 , A61K39/00 , A61K48/00 , C12N2710/14143 , C12N2710/24022 , C12N2740/13043
摘要： The present invention provides genes of the viral genus leporipox that encode immunomodulatory proteins. The present invention also provides therapeutic compositions containing these polypeptides and methods for use for treating a variety of inflammatory and autoimmune disorders. In one preferred embodiment, the present invention provides methods for producing the immunomodulatory polypeptides in a substantially pure form. In another preferred embodiment, the invention provides methods for treating individuals diagnosed with autoimmune or inflammatory disorders by gene therapy. In yet another preferred embodiment, the methods and compositions of the present invention may be used to treat cancer. Finally, the invention provides methods to identify and isolate additional leporipox virus immunomodulatory polypeptides.

10. 发明公开

EP1180155A1 VECTOR FOR INTEGRATION OF HETEROLOGOUS SEQUENCES INTO POXVIRAL GENOMES 有权
标题翻译：载体把在POXVIRUSGENOMEN异源序列整合
公开(公告)号：EP1180155A1
公开(公告)日：2002-02-20
申请号：EP00938684.8
申请日：2000-05-25
申请人： GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
发明人： WINTERSPERGER, Stefan , BAIER, Robert , SUTTER, Gerd , OHLMANN, Marion , ERFLE, Volker
IPC分类号： C12N15/86 , C12N15/39 , C07K14/07 , A61K39/285
CPC分类号： C12N15/86 , A61K2039/5256 , C07K14/005 , C12N2710/24122 , C12N2710/24143
摘要： The present invention provides a DNA vector comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. The present invention relates also, inter alia, to recombinant poxviruses carrying heterologous coding sequences transferred by the vector according to the present invention.

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