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    • 2. 发明公开
    • New method of preparation of oxalic acid esters and amides
    • Verfahren zur Herstellung vonOxalsäureesternund -amiden。
    • EP0338386A1
    • 1989-10-25
    • EP89106405.7
    • 1989-04-11
    • Enichem Anic S.r.l.
    • Messina, GiuseppeSechi, Giovanni MatteoLorenzoni, LorenoChessa, Giovanna
    • C07C69/36C07C235/70C07C67/20C07C231/00C08F18/14C08G63/02
    • C07D295/185C07C67/20C07C231/10C07C233/56C07C69/36
    • A new process is described for the preparation of oxalic acid esters and amides of general formula (I)
      Z- - -Z¹      (I)
      wherein
      Z designates an -OR or -NR¹R² group, wherein R represents substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or aryl-alkyl, R¹ is hydrogen or substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or aryl-alkyl, R² represents substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or aryl-alkyl, or R¹ and R² taken together with the adjacent nitrogen atom represent a saturated 5-, 6-, 7-, or 8-membered heterocyclic ring, which may contain an additional heteroatom selected from -O-, -S-, and -N(H, Alkyl)-, and optionally bear one or more alkyl or alkenyl substituents, and
      Z¹ designates an -OR or -NR¹R² group, wherein R, R¹, and R² are as defined before, or a group -NHCOCH₃, which comprises the base-catalysed reaction of diacetyloxamide with an alcohol ROH or/and an amine HNR¹R².
      The compounds of formula (I) have many industrial utilities, mainly as intermediates and stabilizers in the polymer field.
    • 描述了用于制备通式(I)Z-R 1 -Z 1(I)的草酸酯和酰胺的新方法,其中Z表示-OR或-NR 1 R 2基团 其中R表示取代或未取代的烷基,烯基,环烷基,芳基或芳基 - 烷基,R 1是氢或取代或未取代的烷基,烯基,环烷基,芳基或芳基 - 烷基,R 2表示取代或 未取代的烷基,烯基,环烷基,芳基或芳基 - 烷基,或R 1和R 2与相邻的氮原子一起表示饱和的5-,6-,7-或8-元杂环, 其可以含有选自-O - , - S-和-N(H,烷基) - 的另外的杂原子,并且任选地具有一个或多个烷基或烯基取代基,Z 1表示-OR或-NR 其中R 1,R 2和R 2如上所定义,或基团-NHCOCH 3,其包含二酰基脯氨酰胺与醇ROH或/或胺的碱催化反应 HNR <1> [R <2>。 式(I)化合物具有许多工业实用性,主要作为聚合物领域的中间体和稳定剂。
    • 5. 发明公开
    • Dental composition
    • 牙科组成
    • EP2460507A1
    • 2012-06-06
    • EP12000236.5
    • 2009-12-15
    • Dentsply DeTrey GmbH
    • Klee, Joachim E.Ritter, HelmutPohle, SvenElsner, OliverBardts, Mareike
    • A61K6/00C08F18/14C08F218/06
    • A61K6/0835A61K6/0038A61K6/083C08F218/06C08F265/02C08F267/04C08L33/00
    • Dental cement composition comprising a polymerizable polyacidic polymer having repeating units in the polymer backbone, which are represented by the following formula (I) and/or (II):

      wherein
      X
      represents O, S, or NR', whereby R' represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group,
      Y
      a group of the following formula (IV)

      wherein
      each of L 1 , L 2 , L 3 and L 4 ,
      which are independent from each other represents a single bond, a straight or branched C 1 -C 6 alkylene group, a straight or branched C 1 -C 6 alkenylene, or a straight or branched C 1 -C 20 alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms,
      X'
      represents O, S, or NR", whereby R" represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group,

      m is 0 to 3, and
      n is 0 to 3,
      provided that X' is O when n is 0; and
      provided that when n is 0, then L 3 in formula (IV) represents a straight or branched C1-C6 alkenylene, or other repeating units of formula (I), (II), (III), or (IV) are present wherein n is not 0.
    • 包含在聚合物骨架中具有由下式(I)和/或(II)表示的重复单元的可聚合多酸聚合物的牙科粘固剂组合物:其中X代表O,S或NR',其中R'代表氢 原子或直链或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,Y是下式(IV)的基团:其中L 1,L 2,L 3和L 4各自独立于 彼此表示单键,直链或支链C 1 -C 6亚烷基,直链或支链C 1 -C 6亚烯基或包含1至8个选自氧和硫原子的原子的直链或支链C 1 -C 20亚烷基,X '表示O,S或NR“,其中R”表示氢原子或直链或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,m为0-3,且n为 0至3,条件是当n是0时X'是O; 并且条件是当n为0时,则式(IV)中的L 3表示直链或支链的C 1 -C 6亚烯基,或存在其中式(I),(II),(III)或(IV)的其他重复单元,其中 n不是0。
    • 9. 发明公开
    • Dental composition
    • 牙科组成
    • EP2633847A2
    • 2013-09-04
    • EP13002770.9
    • 2009-12-15
    • Dentsply DeTrey GmbH
    • Klee, Joachim E.Ritter, HelmutPohle, SvenElsner, OliverBardts, Mareike
    • A61K6/00C08F18/14C08F218/06
    • A61K6/0835A61K6/0038A61K6/083C08F218/06C08F265/02C08F267/04C08L33/00
    • Dental cement composition comprising a polymerizable polyacidic polymer having repeating units in the polymer backbone, which are represented by the following formula (III):

      wherein
      X represents O, S, or NR', whereby R' represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group,
      Y a group of the following formula (IV)

      wherein each of L 3 and L 4 ,
      which are independent from each other represents a single bond, a straight or branched C 1 -C 6 alkylene group, a straight or branched C 1 -C 6 alkenylene, or a straight or branched C 1 -C 20 alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms,
      X' represents O, S, or NR", whereby R" represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group,
      m is 0 to 3, and
      n is 0, wherein
      L 3 in formula (IV) represent a straight or branched C1-C6 alkenylene, or other repeating units of the following formula (I), (II), or the above formula (III) or (IV) are present wherein n is 1, 2 or 3:

      wherein each of L 1 and L 2 ,
      which are independent from each other represents a single bond, a straight or branched C 1 -C 6 alkylene group, a straight or branched C 1 -C 6 alkenylene, or a straight or branched C 1 -C 20 alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms, and
      X and Y are as defined above.
    • 包含在聚合物骨架中具有重复单元的可聚合多酸聚合物的牙科粘固剂组合物,其由下式(III)表示:其中X代表O,S或NR',其中R'代表氢原子或直链或支链 C1-C6烷基,C3-C6环烷基或C4-C8环烷基烷基,Y是下式(IV)的基团,其中彼此独立的L3和L4中的每一个代表单键,直链或 支链C 1 -C 6亚烷基,直链或支链C 1 -C 6亚烯基或包含1至8个选自氧和硫原子的原子的直链或支链C 1 -C 20亚烷基,X'表示O,S或NR“, 其中R“代表氢原子或直链或支链的C1-C6烷基,C3-C6环烷基或C4-C8环烷基烷基,m为0-3,且n为0,其中式(IV)中的L3代表 直链或支链C 1 -C 6亚烯基或下式的其它重复单元 (I),(II)或上述式(III)或(IV)存在,其中n是1,2或3:其中彼此独立的L1和L2中的每一个代表单键, 或支链C 1 -C 6亚烷基,直链或支链C 1 -C 6亚烯基或包含1至8个选自氧和硫原子的原子的直链或支链C 1 -C 20亚烷基,并且X和Y如上所定义。
    • 10. 发明公开
    • DENTAL COMPOSITION
    • 牙科组合物
    • EP2470153A1
    • 2012-07-04
    • EP10790359.3
    • 2010-12-07
    • Dentsply DeTrey GmbH
    • KLEE, Joachim, E.RITTER, HelmutPOHLE, SvenELSNER, OliverBARDTS, Mareike
    • A61K6/00C08F18/14C08F218/06
    • A61K6/0835A61K6/0038A61K6/083C08F218/06C08F265/02C08F267/04C08L33/00
    • Dental cement composition comprising a polymerizable polyacidic polymer having repeating units in the polymer backbone, which are represented by the following formula (I)1 (II), and/or (III): wherein X represents O, S, or NR', whereby R' represents a hydrogen atom or a straight or branched C
      1 -C
      6 alkyl group, C
      3 -C
      6 cycloalkyl group, or C
      4 -C
      8 cycloalkylalkyl group, Y a group of the following formula (IV), wherein each of L
      1 , L
      2 , L
      3 and L
      4 , which are independent from each other represents a single bond, a straight or branched C
      1 -C
      6 alkylene group, a straight or branched C
      1 -C
      6 alkenylene, or a straight or branched C
      1 -C
      20 alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms, X' represents O, S, or NR", whereby R" represents a hydrogen atom or a straight or branched C
      1 -C
      6 alkyl group, C
      3 -C
      6 cycloalkyl group, or C
      4 -C
      8 cycloalkylalkyl group, m is 0 to 3, and n is 1 to 3.
    • 包含在由下式(I)1(II)和/或(III)表示的聚合物骨架中具有重复单元的可聚合多酸聚合物的牙科粘固剂组合物:其中X代表O,S或NR' R'表示氢原子或直链或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,Y是下式(IV)的基团,其中每个 L 1,L 2,L 3和L 4彼此独立地表示单键,直链或支链C 1 -C 6亚烷基,直链或支链C 1 -C 6亚烯基或直链或支链C 1 -C 6亚烷基 包含1-8个选自氧和硫原子的原子的支链C 1 -C 20亚烷基,X'表示O,S或NR“,其中R”表示氢原子或直链或支链C 1 -C 6烷基 基团,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,m为0至3,并且n为1至3。