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1. 发明公开

EP4204419A1 SOLID STATE FORMS OF RESMETIROM 审中-实审
公开(公告)号：EP4204419A1
公开(公告)日：2023-07-05
申请号：EP21805804.8
申请日：2021-10-19
申请人： Teva Pharmaceuticals International GmbH
发明人： LAPIDO, Polina , GOLDSHTEIN, Jenny , KRIMER, Vitaly , RUDIK, Doron
IPC分类号： C07D473/12 , C07D207/16 , C07D213/55 , C07D213/56 , C07D295/02 , C07D307/06 , C07D403/12 , C07C49/10 , A61P1/16 , A61K31/53

2. 发明公开

EP3456701A1 METHOD FOR ALKYLATING A MOLECULE OR AN ION 审中-公开
公开(公告)号：EP3456701A1
公开(公告)日：2019-03-20
申请号：EP17191887.3
申请日：2017-09-19
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： ANTONIETTI, Markus , GUTERMAN, Ryan , MIAO, Han
IPC分类号： C07B61/00 , C07D233/84 , C07D235/28 , C07D473/12
摘要： The present invention relates to a method for alkylating a molecule or an ion, wherein the molecule or the ion is alkylated by reacting it with an alkylating agent, wherein the alkylating agent is a compound according to formula (1). In the formula (1), R 1 is a substituted or unsubstituted C 1-20 hydrocarbon residue or a polymer, R 2 is a substituted or unsubstituted C 1-20 hydrocarbon residue or a hydrogen atom, R 3 is absent, a substituted or unsubstituted C 1-20 hydrocarbon residue or a hydrogen atom, R 4 and R 5 are linked with each other to form an aromatic group or are independently from each other selected from the group consisting of a hydrogen atom, substituted and unsubstituted C 1-20 hydrocarbon residues and electron withdrawing groups, X 1 is an oxygen atom, a nitrogen atom or a sulfur atom, wherin R 3 is not present in formula (1) if X 1 is an oxygen atom or a sulfur atom, Z is a covalent bond or an aromatic group and A - is an anion.

3. 发明公开

EP3217985A1 COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY 有权转让
标题翻译：用于治疗编程性肌营养不良症的化合物
公开(公告)号：EP3217985A1
公开(公告)日：2017-09-20
申请号：EP15797925.3
申请日：2015-11-13
申请人： Universitat de València , Institut Químic de Sarrià CETS Fundació Privada , Institut Univ. de Ciència i Tecnologia, S.A.
发明人： ARTERO ALLEPUZ, Ruben , CASTELLS BOLIART, Josep , BORRELL BILBAO, José Ignacio , LLAMUSI TROÍSI, Beatriz , BARGIELA SCHÖNBRUNN, Ariadna , KONIECZNY, Piotr , PASCUAL GILABERT, Marta , TEIXIDÓ CLOSA, Jordi , ESTRADA TEJEDOR, Roger , LÓPEZ GONZÁLEZ, Alejandro
IPC分类号： A61K31/522 , C07D473/12 , A61P21/00 , A61P43/00
CPC分类号： A61K31/522 , A23C9/13 , A23C9/152 , A23C23/00 , A23G1/32 , A23L2/52 , A23L7/122 , A23V2002/00 , C07D473/08 , A61K2300/00
摘要： The present invention relates to a compound of formula (I), provided that this compound is not caffeine, for use in the treatment of myotonic dystrophy type 1 and type 2. The present invention also relates to compositions comprising the compound of formula (I) as defined herein. The present invention further relates to new compounds which are dimers of compounds of formula (I).
摘要翻译：本发明涉及式（I）化合物，条件是该化合物不是咖啡因，用于治疗1型和2型肌强直性营养不良症。本发明还涉及包含式（I）化合物的组合物，如本文所定义的。本发明还涉及式（I）化合物的二聚体的新化合物。

4. 发明授权

EP2415767B1 Poly (ADP-ribose) Polymerase (PARP) Inhibitors 有权
标题翻译：聚（ADP-核糖）聚合酶 - （PARP-）抑制剂
公开(公告)号：EP2415767B1
公开(公告)日：2014-09-03
申请号：EP11187698.3
申请日：2010-03-26
申请人： Takeda Pharmaceutical Company Limited
发明人： Brown, Jason, W. , Gangloff, Anthony, R. , Jennings, Andrew, John , Vu, Phong, H.
IPC分类号： C07D265/36 , C07D413/06 , C07D413/14 , C07D417/12 , C07D413/12 , C07D473/12 , A61K31/538 , A61P35/00 , A61P9/00 , A61P3/00 , A61P29/00 , A61P25/28
CPC分类号： C07D265/36 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D473/12

5. 发明公开

EP1556129A4 COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS 审中-公开
标题翻译：组合物和方法诱导成骨
公开(公告)号：EP1556129A4
公开(公告)日：2011-02-09
申请号：EP03809017
申请日：2003-10-15
申请人： IRM LLC , SCRIPPS RESEARCH INST
发明人： WU XU , DING SHENG , GRAY NATHANAEL S
IPC分类号： A61K31/52 , A61K31/522 , A61N20060101 , A61N1/00 , A61P7/00 , C07D473/12 , C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40
CPC分类号： C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40

6. 发明公开

EP1640007A1 ANTIEPILEPTIC AGENT 审中-公开
标题翻译： ANTIEPILEPSIE-MITTEL
公开(公告)号：EP1640007A1
公开(公告)日：2006-03-29
申请号：EP04746827.7
申请日：2004-06-25
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： ICHIKAWA, Shunji Pharmaceutical Research Centre, , TAKASHIMA, Chiemi Pharmaceutical Research Center, , IMMA, Hironori c/o Head Office, Kyoka Hakko , SHIMADA, Junichi Pharmaceutical Reasearch Center,
IPC分类号： A61K31/522 , A61P25/08 , C07D473/06 , C07D473/12
CPC分类号： A61K31/522 , C07D473/12
摘要： (wherein R 1 , R 2 and R 3 are the same or different and each represents a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R 4 represents cycloalkyl,-(CH 2 ) n -R 5 or the above formula (II); and X 1 and X 2 are the same or different and each represents an oxygen atom or a sulfur atom)
An antiepil eptic agent comprising the xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient is provided.
摘要翻译：（其中R 1，R 2和R 3相同或不同，各自表示氢原子，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n -R 5或上述式 II）; X 1和X 2相同或不同，各自表示氧原子或硫原子）包含上述式（I）表示的黄嘌呤衍生物或其药学上可接受的盐作为活性物质的抗菌素提供配料。

7. 发明授权

EP0485156B1 Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes 失效转让
标题翻译：的方法和化合物用于标记DNA与黄嘌呤和低级烷基取代的Xathinderivaten和Reagentrien为染色体的“原位”检测
公开(公告)号：EP0485156B1
公开(公告)日：1997-03-05
申请号：EP91310203.4
申请日：1991-11-05
申请人： AMOCO CORPORATION
发明人： Cruickshank, Kenneth Alexander , Taron, Douglas James
IPC分类号： C07H21/00 , C12Q1/68 , C07D473/06 , C07D473/08 , C07D473/12
CPC分类号： C07H21/00 , C12Q1/6816 , C12Q1/6841

8. 发明公开

EP0580892A1 Process for recovery of caffeine from activated carbon 失效
标题翻译： Verfahren zurRückgewinnungvon Caffein aus Aktivkohle。
公开(公告)号：EP0580892A1
公开(公告)日：1994-02-02
申请号：EP92113069.6
申请日：1992-07-31
申请人： Jacobs Suchard AG
发明人： Sipos, Stefan , Jones, Gary
IPC分类号： C07D473/12 , A23F5/22
CPC分类号： A23F5/223 , C07D473/12
摘要： The invention relates to a process for recovering caffeine from caffeine-loaded activated carbon using a circulated inert gas sweeping stream held at a temperature of 250° to 460°C, in which process the activated carbon is preheated prior to the desorption of the caffeine with heat sources other than the sweeping gas and held during the desorption step at a uniform temperature or at a temperature increasing from the inlet to the outlet of the inert gas sweeping stream within the range of 250° to 460°C and the caffeine is subsequently separated from the inert gas sweeping stream by conventional means.
摘要翻译：本发明涉及一种使用保持在250-460℃的循环的惰性气体清扫流从含咖啡因的活性炭中回收咖啡因的方法，在该方法中，在咖啡因解吸之前将活性炭预热，除了清扫气体之外的热源，并且在脱附步骤期间保持在均匀的温度或在惰性气体清扫流的入口到出口的温度在250-460℃的范围内增加的温度，并且咖啡因随后被分离通过常规方法从惰性气体清扫流中。

9. 发明公开

EP0485156A1 Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes 失效转让
标题翻译：的方法和化合物用于标记DNA与黄嘌呤和低级烷基取代的Xathinderivaten和Reagentrien为染色体的“原位”检测。
公开(公告)号：EP0485156A1
公开(公告)日：1992-05-13
申请号：EP91310203.4
申请日：1991-11-05
申请人： AMOCO CORPORATION
发明人： Cruickshank, Kenneth Alexander , Taron, Douglas James
IPC分类号： C07H21/00 , C12Q1/68 , C07D473/06 , C07D473/08 , C07D473/12
CPC分类号： C07H21/00 , C12Q1/6816 , C12Q1/6841
摘要： This invention discloses methods and compounds for covalently linking xanthine or lower alkyl substituted derivatives of xanthine to DNA and the resulting xanthine or lower alkyl substituted xanthine derivative labeled DNA reagents. Reagents for the in situ detection of a chromosome or a region of a chromosome are disclosed. These reagents include a multiplicity of DNA sequences that are complementary to different portions of the chromosome or chromosome region to be detected. Multiple xanthine or lower alkyl substituted xanthine derivative labels are covalently linked to the DNA sequences. These xanthine or lower alkyl substituted xanthine derivative labeled reagents are contacted under hybridizing conditions with the chromosome or chromosome region of interest. Any binding of the reagent with the chromosome or chromosome region of interest may then be detected by immunological techniques.
摘要翻译：本发明的盘以下的方法和化合物用于共价连接或黄嘌呤黄嘌呤到DNA的低级烷基substituiertem衍生物和所得黄嘌呤或低级烷基substituiertem黄嘌呤衍生物标记的DNA的试剂。用于原位检测染色体或染色体区域试剂盘游离缺失。这些试剂包括DNA序列的多个做是对染色体或染色体区域的不同部分互补的被检测到。多个黄嘌呤或低级烷基substituiertem黄嘌呤衍生物标签共价连接到DNA序列。这些黄嘌呤或低级烷基substituiertem黄嘌呤衍生物标记的试剂下杂交与感兴趣的染色体或染色体区域条件接触。任何与感兴趣的染色体或染色体区中的试剂的结合可然后通过免疫学技术来检测。

10. 发明公开

EP0424579A1 Decaffeination of coffee 失效转让
标题翻译： KAFFEE-Entkoffeinierung。
公开(公告)号：EP0424579A1
公开(公告)日：1991-05-02
申请号：EP89310933.0
申请日：1989-10-24
申请人： KRAFT GENERAL FOODS, INC.
发明人： Katz, Saul Norman , Spence, Jean Ellen , O'Brien, Michael J. , Skiff, Ronald H. , Vogel, Gerald J. , Prasad, Ravi
IPC分类号： A23F5/20 , C07D473/12
CPC分类号： A23F5/206
摘要： A method of extracting caffeine from green coffee beans whereby an essentially caffeine-free supercritical fluid is continuously fed to one end of an extraction vessel containing green coffee beans and caffeine-laden supercritical fluid is continuously withdrawn from the opposite end. A portion of decaffeinated beans is periodically discharged while a fresh portion of undecaffeinated beans is essentially simultaneously charged to the extraction vessel. The caffeine-laden supercritical fluid is fed to a countercurrent water absorber.
Supercritical carbon dioxide is the preferred supercritical fluid. The rich caffeine laden water from the absorber is concentrated by reverse osmosis to obtain caffeine of 97% or greater purity and a permeate containing acidic non-caffeine solids which are added to the process to improve yield and increase the rate of extraction. The method of the present invention is more efficient than batch processes and produces an improved decaffeinated coffee.
摘要翻译：从生咖啡豆中提取咖啡因的方法，其中连续将基本上不含咖啡因的超临界流体输送到含有生咖啡豆和含咖啡因的超临界流体的提取容器的一端，从另一端连续取出。一部分脱咖啡因的豆被定期排出，而新鲜部分的未脱咖啡因的豆基本上同时装入提取容器。将含咖啡因的超临界流体供给到逆流吸水剂中。超临界二氧化碳是优选的超临界流体。通过反渗透浓缩来自吸收器的富含咖啡因的水，以获得97％或更高纯度的咖啡因和含有酸性非咖啡因固体的渗透物，其加入该方法中以提高产量并提高提取速率。本发明的方法比分批方法更有效，并产生改进的脱咖啡因咖啡。

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