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1. 发明授权

EP0629617B2 Heteroatom-bearing ligands and metal complexes thereof 失效
标题翻译：杂原子取代的配体及其金属络合物
公开(公告)号：EP0629617B2
公开(公告)日：2007-09-26
申请号：EP94108968.2
申请日：1994-06-10
申请人： BRACCO International B.V.
发明人： Ramalingam, Kondareddiar , Raju, Natarajan
IPC分类号： C07D233/91 , C07D307/71 , C07C251/38 , A61K51/04
CPC分类号： C07D307/71 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C251/38 , C07D233/91

2. 发明公开

EP1699752A1 (HETERO)CYCLYLCARBOXANILIDE ZUR BEK MPFUNG VON SCHADPILZEN 有权
标题翻译：（杂）cyclylcarboxanilide对有害真菌
公开(公告)号：EP1699752A1
公开(公告)日：2006-09-13
申请号：EP04804217.0
申请日：2004-12-22
申请人： BASF Aktiengesellschaft
发明人： GEWEHR, Markus , MÜLLER, Bernd , GROTE, Thomas , GRAMMENOS, Wassilios , TORMO I BLASCO, Jordi , SCHWÖGLER, Anja , RHEINHEIMER, Joachim , BLETTNER, Carsten , SCHÄFER, Peter , SCHIEWECK, Frank , WAGNER, Oliver , SPEAKMAN, John-Bryan , RETHER, Jan , STRATHMANN, Siegfried , STIERL, Reinhard
IPC分类号： C07C251/38 , C07D213/82 , C07D207/34 , C07D263/34 , C07D277/56 , C07D279/12 , C07D307/30 , C07D307/54 , C07D307/71 , C07D333/38 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/74
CPC分类号： C07D213/82 , A01N43/40 , A01N43/56 , A01N43/78 , A01N47/48 , C07C251/38 , C07D207/34 , C07D231/14 , C07D263/34 , C07D277/56 , C07D279/12 , C07D307/30 , C07D307/54 , C07D307/71 , C07D333/38
摘要： The invention relates to (hetero)cyclyl carboxanilides of general formula (I), wherein n represents 0, 1, 2, 3, or 4, m represents 1, 2, or 3, Y represents oxygen or sulfur, A represents optionally substituted phenyl or an at least monounsaturated, optionally substituted five-membered or six-membered heterocycle, and R1, R2, R3m, R4, R5, and R6 have the meanings indicated in claim 1, and the agriculturally useful salts thereof. The invention further relates to the use of said (hetero)cyclyl carboxanilides of general formula (I) and the agriculturally useful salts thereof as fungicides as well as plant protection agents containing the same.

3. 发明公开

EP0833629A4 ARYL ACRYLIC ACID DERIVATIVES USEFUL AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS 失效
标题翻译： ARYLACRYLSÄUREDERIVATEZUR VERWENDUNG ALS蛋白酪氨酸磷酸酶抑制剂
公开(公告)号：EP0833629A4
公开(公告)日：1998-09-16
申请号：EP96940489
申请日：1996-06-19
申请人： ONTOGEN CORP
发明人： MJALLI ADNAN M M , CAO XIAODONG , MORAN EDMUND J
IPC分类号： C07D317/60 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/33 , A61K31/34 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/39 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K38/00 , A61P3/02 , A61P7/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07C59/52 , C07C59/84 , C07C59/88 , C07C69/732 , C07C69/738 , C07C69/92 , C07C235/12 , C07C235/34 , C07C235/78 , C07C235/80 , C07C237/22 , C07C323/60 , C07D207/337 , C07D209/14 , C07D209/20 , C07D209/26 , C07D213/81 , C07D215/14 , C07D233/54 , C07D233/90 , C07D241/42 , C07D263/34 , C07D277/30 , C07D307/52 , C07D307/54 , C07D307/68 , C07D307/71 , C07D333/32 , C07D333/38 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/083
CPC分类号： C07K5/0806 , A61K38/00 , C07C237/22 , C07C323/60 , C07C2601/14 , C07D209/26 , C07D233/64 , C07D233/90 , C07D241/42 , C07D263/34 , C07D277/30 , C07D307/54 , C07D307/71 , C07D317/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07K5/06017 , C07K5/06034 , C07K5/06078 , C07K5/06191
摘要： The present invention provides novel protein tyrosine phosphatase modulating compounds having an aryl acrylic acid structure, compositions comprising the compounds, and methods of making and using the same.
摘要翻译：本发明提供了具有芳基丙烯酸结构的新型蛋白酪氨酸磷酸酶调节化合物，包含该化合物的组合物，以及制备和使用该化合物的方法。

4. 发明公开

EP0673925A1 ACETAMIDE DERIVATIVE 失效
标题翻译：乙酰胺衍。
公开(公告)号：EP0673925A1
公开(公告)日：1995-09-27
申请号：EP94900285.1
申请日：1993-11-18
申请人： KAKEN PHARMACEUTICAL CO., LTD.
发明人： ISHIYAMA, Nobuo, Chuo Kenkyusho,Kaken Pharm.Co.Ltd , KOYAMA, Toshihiro, Chuo Kenkyusho,Kaken Pharm. Co. , HAYASHIDA, Mitsuo, Chuo Kenkyusho, Kaken Pharm.Co. , OTSUKA, Katsuyuki, Chuo Kenkyusho, Kaken Pharm.Co. , FUJII, Masahiro, Chuo Kenkyusho, Kaken Pharm. Co. , KIMURA, Kunio, Chuo Kenkyusho, Kaken Pharm.Co.,Ltd , HATA, Yoshiyuki, Chuo Kenkyusho, Kaken Pharm. Co. , MIYAO, Nobuko, Chuo Kenkyusho, Kaken Pharm.Co.,Ltd
IPC分类号： C07C317/28 , C07C323/41 , C07C323/42 , C07C323/60 , C07D213/64 , C07D213/81 , C07D295/08 , C07D307/68 , C07D333/38 , C07D307/71 , C07D207/34 , C07D333/24 , C07D405/12 , C07C323/52 , C07C317/44
CPC分类号： C07D213/64 , C07C317/44 , C07C323/43 , C07D207/34 , C07D213/78 , C07D213/81 , C07D213/82 , C07D295/096 , C07D307/68 , C07D307/71 , C07D333/24 , C07D333/38 , C07D333/58 , C07D403/12 , Y10S514/927
摘要： An acetamide derivative represented by general formula (I) or a pharmacologically acceptable salt thereof; an intermediate for theproduction thereof; a remedy for peptic ulcer and gastritis containing the compound (I) as the active ingredient; and a method of treating peptic ulcer and gastritis with the compound (I).
摘要翻译：由通式（I）表示的乙酰胺衍生物或其药理学上可接受的盐; 生产中间体; 含有化合物（I）作为活性成分的消化性溃疡和胃炎的补救措施; 和化合物（I）治疗消化性溃疡和胃炎的方法。

5. 发明公开

EP1646616A2 COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION 审中-公开
标题翻译： COMBRETASTATINDERIVATE细胞毒性活动
公开(公告)号：EP1646616A2
公开(公告)日：2006-04-19
申请号：EP04745198.4
申请日：2004-07-06
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
发明人： SIMONI, Daniele Simgma-Tau Ind. Farm. Riunite Spa , ROMAGNOLI, Romeo Simgma-Tau Ind. Farm. Riunite Spa , GIANNINI, G. Simgma-Tau Ind. Farm. Riunite Spa , ALLOATI, D. Simgma-Tau Ind. Farm. Riunite Spa , PISANO, Claudio Sigma-Tau Ind. Farm. Riunite Spa
IPC分类号： C07D261/12 , C07D261/08 , C07D307/79 , C07D333/54 , C07C43/215 , C07C43/23 , C07D231/56 , C07D307/71 , C07D333/44 , C07F9/655 , C07F9/553 , C07F7/18 , A61K31/09 , A61K31/41 , A61K31/343
CPC分类号： C07F7/1856 , C07C43/215 , C07C43/23 , C07D231/56 , C07D261/04 , C07D261/08 , C07D307/58 , C07D307/70 , C07D307/79 , C07D333/32 , C07D333/44 , C07D333/54 , C07D407/06 , C07D409/06
摘要： The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula (I) in which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.

6. 发明公开

EP0673925A4 ACETAMIDE DERIVATIVE. 失效
标题翻译：乙酰胺衍生物。
公开(公告)号：EP0673925A4
公开(公告)日：1996-04-03
申请号：EP94900285
申请日：1993-11-18
申请人： KAKEN PHARMA CO LTD
发明人： ISHIYAMA NOBUO , KOYAMA TOSHIHIRO , HAYASHIDA MITSUO , OTSUKA KATSUYUKI , FUJII MASAHIRO , KIMURA KUNIO , HATA YOSHIYUKI , MIYAO NOBUKO
IPC分类号： C07C317/44 , C07C323/43 , C07D207/34 , C07D213/64 , C07D213/78 , C07D213/81 , C07D213/82 , C07D295/096 , C07D307/68 , C07D307/71 , C07D333/24 , C07D333/38 , C07D333/58 , C07D403/12 , C07C317/28 , C07C323/41 , C07C323/42 , C07C323/60
CPC分类号： C07D213/64 , C07C317/44 , C07C323/43 , C07D207/34 , C07D213/78 , C07D213/81 , C07D213/82 , C07D295/096 , C07D307/68 , C07D307/71 , C07D333/24 , C07D333/38 , C07D333/58 , C07D403/12 , Y10S514/927
摘要： An acetamide derivative represented by general formula (I) or a pharmacologically acceptable salt thereof; an intermediate for theproduction thereof; a remedy for peptic ulcer and gastritis containing the compound (I) as the active ingredient; and a method of treating peptic ulcer and gastritis with the compound (I).

7. 发明公开

EP0355279A3 Use of nitrogen-containing compounds as antiparasitics, and compositions containing them 失效
标题翻译：使用含氮化合物作为抗菌剂，以及含有它们的组合物
公开(公告)号：EP0355279A3
公开(公告)日：1992-07-08
申请号：EP89109658.8
申请日：1989-05-29
申请人： DRUG & VACCINE DEVELOPMENT CORPORATION
发明人： Henderson, Graeme B. , Ulrich, Peter C. , Cerami, Anthony
IPC分类号： A61K31/175 , A61K31/345 , A61K31/00 , A61K31/495 , C07D307/71 , C07C281/10 , C07C281/18 , C07C337/08
CPC分类号： A61K31/175 , A61K31/00 , A61K31/345 , A61K31/495 , Y02A50/409 , Y02A50/414 , Y02A50/415
摘要： The present invention relates to the treatment of diseases caused by invading organisms in a host by first identifying an enzymatic difference between the host and the invading organism and then administering to the host a pharmaceutically effective amount of a subversive substrate for the differing enzyme of the invading organism, whereby the action of the differing enzyme causes a result counter to the intended result and function of the enzyme that results in its debilitation or death. In particular, treatment of parasitic diseases caused by kinetoplastids including trypanosomes and leishmanias, e.g., African sleeping sickness, Chagas' disease, oriental sore and kala-azar is accomplished by administration of a pharmaceutically effective antiparasitic amount of a competitive toxigenic substrate for trypanothione reductase. Methods of treatment and compositions therefor lcontain a competitive toxigenic substrate for trypanothione reductase. Numerous compounds and corresponding compositions are disclosed.
摘要翻译：本发明涉及通过首先鉴定宿主与入侵生物体之间的酶差异，然后向宿主施用药学有效量的侵入性不同酶的颠覆性底物来治疗宿主入侵生物引起的疾病由此不同酶的作用导致与预期的导致其衰弱或死亡的酶的预期结果和功能相反的结果。特别是，通过给予药学上有效的抗寄生虫剂量的针对锥虫硫代还原酶的竞争性产毒底物来实现由包括锥虫和利什曼原虫在内的动物造成的寄生虫病，例如非洲睡眠病，恰加斯病，东方疮和卡拉 - 沙ar的治疗。化合物选自结构式为R 1 C（X）= NNHC（= Z）NHR 2（I）的化合物，其中R 1 = H或低级烷基X =可还原的芳族体系或可还原芳烷基Z = O，S或NHR 2 = H或下式的烷基氨基烷基：其中n为1至6的整数，R 3和R 3为 4独立地是低级烷基或一起形成含有1至2个杂原子的环烷基或杂环基的一部分，其中至少一个是氮; 并且所述杂原子中的第二个选自氮，氧和硫; 条件是当杂环的第二个杂原子是氮并形成哌嗪环时，它可以任选被与哌嗪环的第一氮上的化合物部分相同的取代基取代。或者，当R 3为低级烷基时，R 4可以是R 1 C（X）= NNHC（= Z）NH（CH 2）n - 的第二组，其中R 1，X ，Z和n具有如上所定义的值，而所述第二组R 4与已经连接至带有第一组R 4的氮的基团相同。 X的环系可以选自许多醌类和杂环或杂环变体。

9. 发明公开

EP0147980A2 A 5-nitro-2-furanyl derivative and its use as an anti-parasitic agent 失效
标题翻译： 5-Nitro-2-Furanylderivat und seine Verwendung als Mittel gegen Parasiten。
公开(公告)号：EP0147980A2
公开(公告)日：1985-07-10
申请号：EP84308652.1
申请日：1984-12-12
申请人： Rossignol, Jean François
发明人： Rossignol, Jean François
IPC分类号： C07D307/71 , A61K31/34
CPC分类号： C07D307/71
摘要： N-(4-methoxy-2-methylphenyl)-3-(5-nitro-2-furanyl) propenamide of structure (I).
a process for its preparation, pharmaceutical compositions containing it and its use as an anti-parasitic agent are described.
摘要翻译：结构（I）的N-（4-甲氧基-2-甲基苯基）-3-（5-硝基-2-呋喃基）丙烯酰胺。其准备过程。描述含有它的药物组合物及其作为抗寄生虫剂的用途。

10. 发明授权

EP0043598B1 Procédé de transformation de furfural ou de nitro-5 furfural en furonitrile ou en nitro-5 furonitrile 失效
标题翻译：将苜蓿或5-NITRO-FURFURAL转化为呋喃酮或5-硝基呋喃的方法
公开(公告)号：EP0043598B1
公开(公告)日：1984-07-11
申请号：EP81200543.7
申请日：1981-05-21
申请人： AGRIFURANE S.A.
发明人： Gaset, Antoine , Gorrichon, Jean-Pierre , Audoye, Paul
IPC分类号： C07D307/68 , C07D307/71
CPC分类号： C07D333/38 , C07D307/68 , C07D307/71

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