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1. 发明授权

EP1087981B1 PRENYL TRANSFERASE INHIBITORS 有权
标题翻译：异戊烯抑制剂
公开(公告)号：EP1087981B1
公开(公告)日：2006-04-12
申请号：EP99926104.3
申请日：1999-06-01
申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.
发明人： KIM, Sun, H.
IPC分类号： C07D513/04 , A61K31/55 , A61K31/495 , C07D513/14 , C07D241/04 , C07D285/36 , C07D285/38 , C07K5/06 , A61K38/05
CPC分类号： C07D513/04 , A61K38/00 , C07C323/60 , C07D217/26 , C07D241/04 , C07D285/36 , C07D285/38 , C07D339/00 , C07D417/06 , C07D417/14 , C07D513/14 , C07K5/0606 , C07K5/081
摘要： A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by five formulas (I), (II), (III), (IV), (V). Each of the R groups is defined in the disclosure.

2. 发明公开

EP1015439A4 PRENYL TRANSFERASE INHIBITORS 失效
标题翻译：异戊二烯基转移酶抑制剂
公开(公告)号：EP1015439A4
公开(公告)日：2001-10-17
申请号：EP97926849
申请日：1997-05-29
申请人： BIOMEASURE INC
发明人： KIM SUN H
IPC分类号： C12N9/99 , A61K31/17 , A61K31/33 , A61K31/395 , A61K38/00 , A61P9/10 , A61P13/08 , A61P35/00 , A61P43/00 , C07C323/60 , C07D241/04 , C07D285/00 , C07D285/36 , C07D285/38 , C07D339/00 , C07D513/04 , C07D513/14 , C07K5/06 , C07K5/08 , C07K5/083
CPC分类号： C07D513/04 , A61K38/00 , C07C323/60 , C07D217/26 , C07D241/04 , C07D285/36 , C07D285/38 , C07D339/00 , C07D417/06 , C07D417/14 , C07D513/14 , C07K5/0606 , C07K5/081

3. 发明公开

EP1015439A1 PRENYL TRANSFERASE INHIBITORS 失效
标题翻译：异戊二烯基转移酶抑制剂
公开(公告)号：EP1015439A1
公开(公告)日：2000-07-05
申请号：EP97926849.7
申请日：1997-05-29
申请人： BIOMEASURE, INC.
发明人： KIM, Sun, H.
IPC分类号： C07D285/38 , A61K31/33
CPC分类号： C07D513/04 , A61K38/00 , C07C323/60 , C07D217/26 , C07D241/04 , C07D285/36 , C07D285/38 , C07D339/00 , C07D417/06 , C07D417/14 , C07D513/14 , C07K5/0606 , C07K5/081
摘要： A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by either of two formulas (I, II). Each of the R groups is defined in the disclosure.

5. 发明公开

EP0659179A4 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. 失效
标题翻译： DIE FREISETZUNG VON WACHSTUMSHORMON STIMULIERENDEBENZOVERKNÜPFTELACTAME。
公开(公告)号：EP0659179A4
公开(公告)日：1995-08-09
申请号：EP93920190
申请日：1993-08-18
申请人： MERCK & CO INC
发明人： BOCHIS RICHARD J , WYVRATT MATTHEW J , SCHOEN WILLIAM R , DEVITA ROBERT J
IPC分类号： A23K1/16 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/535 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/66 , A61K38/00 , A61K38/04 , A61K38/25 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61P3/00 , A61P3/04 , A61P5/00 , A61P43/00 , C07D209/40 , C07D223/16 , C07D225/06 , C07D265/36 , C07D267/14 , C07D267/22 , C07D279/16 , C07D281/10 , C07D285/38 , C07D401/12 , C07D403/12 , C07D453/02 , C07K5/06 , C07K5/065 , C07K5/078 , A61K31/395 , A61K31/47 , C07D215/38
CPC分类号： C07D223/16 , A23K20/132 , A23K20/137 , A61K38/25 , A61K38/28 , A61K38/29 , A61K38/30 , C07D281/10 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06147 , C07K5/06156 , A61K2300/00 , A61K31/66 , A61K31/00
摘要： There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.
摘要翻译：已经公开了一些新型化合物，其被鉴定为促进人和动物中生长激素释放的苯并稠合内酰胺。这种特性可以用来促进食用动物的生长，使食用肉制品的生产效率更高，而且在人体中，可以增加那些缺乏天然生长激素正常分泌物的人的身材。还公开了含有这种苯并稠合内酰胺作为其活性成分的生长促进组合物。

6. 发明公开

EP3728245A1 DITHIAZOCANE COMPOUNDS FOR THE COSMETIC USE THEREOF 审中-公开
公开(公告)号：EP3728245A1
公开(公告)日：2020-10-28
申请号：EP18816148.3
申请日：2018-12-18
申请人： L'OREAL
发明人： MARAT, Xavier , PREVOT-GUEGUINIAT, Amélie
IPC分类号： C07D417/12 , A61K8/49 , A61Q19/02 , C07D285/38

7. 发明授权

EP1973887B1 AZA HETEROCYCLICS FOR THE TREATMENT OF MALARIA OR AIDS 有权
标题翻译： AZA-杂环用于治疗疟疾和艾滋病
公开(公告)号：EP1973887B1
公开(公告)日：2012-09-19
申请号：EP06841645.2
申请日：2006-12-28
申请人： Immupharma France SA
发明人： GILLES, Guichard , LENA, Gersande , LALLEMAND, Eliette , RENIA, Laurent
IPC分类号： C07D255/02 , C07D273/02 , C07D273/06 , C07D285/38 , A61K31/395 , A61P31/18 , A61P33/06
CPC分类号： C07D255/02 , C07D273/02 , C07D273/06 , C07D285/38

8. 发明公开

EP1461324A4 HETEROCYCLIC COMPOUNDS, COMBINATORIAL LIBRARIES THEREOF AND METHODS OF SELECTING DRUG LEADS 审中-公开
标题翻译：杂环化合物，它组合库和ARZNEIMITTELLEITSTRUKTUREN的选择
公开(公告)号：EP1461324A4
公开(公告)日：2006-02-01
申请号：EP03704946
申请日：2003-01-02
申请人： YISSUM RES DEV CO
发明人： GILON CHAIM
IPC分类号： C07B61/00 , C07D285/00 , C07D285/38 , C07K1/04 , C07D265/00 , A61K38/12 , A61P35/00 , C07K5/06
CPC分类号： C07D285/00 , C07D285/38 , C07K1/047 , C40B40/00

9. 发明授权

EP0648205B1 PEPTIDYL DERIVATIVES AS METALLOPROTEINASE INHIBITORS 失效
标题翻译： PEPTIDYADERDATE ALS INHIBITOREN VON METROOPROTEINASE
公开(公告)号：EP0648205B1
公开(公告)日：1999-07-14
申请号：EP94913709.5
申请日：1994-04-27
申请人： CELLTECH THERAPEUTICS LIMITED
发明人： MORPHY, Richard, John , MILLICAN, Andrew, Thomas
IPC分类号： C07C323/60 , C07D295/08 , C07C259/06 , C07D285/38 , C07C317/50 , A61K31/16
CPC分类号： C07D285/38 , A61K41/00 , C07C317/50 , C07C323/60 , C07C323/61 , C07C2601/02
摘要： Compounds of formula (1) are described where R represents a -CONHOR6 [where R6 is a hydrogen atom or an acyl group], carboxyl (-CO¿2?H), esterified carboxyl, -SR?6¿ or -P(O)(X?1R7)- -X2R8¿ group, where X?1 and X2¿, which may be the same or different, is each an oxygen or sulphur atom and R?7 and R8¿, which may be the same or different each represents a hydrogen atom or an optionally substituted alkyl, aryl, or aralkyl group; R1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group, R2 represents a group -Z2(CH2)mZ1-Ar wherein Ar is an aryl or heteroaryl group, Z?1 and Z2¿, which may be the same or different, is each a bond or a heteroatom, and m is zero or an integer 1 to 6 with the proviso that when m is zero, Z2 is a bond, and Z1 is a heteroatom; R3 represents a hydrogen atom or an alkyl group; R4 represents a hydrogen atom or an alkyl group; R5 represents a group -C(R?9)(R10)Het-R11¿, wherein R?9 and R10¿ which may be the same or different is each an optionally substituted alkyl or alkenyl group optionally interrupted by one or more -O- or -S- atoms or -N(R12)- groups (where R12 is a hydrogen atom or an optionally substituted alkyl group), or an optionally substituted cycloalkyl, cycloalkenyl, aryl or heteroaryl group, or R?9 and R10¿ together with the carbon atom to which they are attached are linked together to form an optionally substituted cycloalkyl or cycloalkenyl group, Het is -O-, -S(O)¿p?- [where p is zero, or an integer 1 or 2] or -N(R?12¿)-, and R11 is a hydrogen atom or an aliphatic, cycloaliphatic, heterocycloaliphatic, aromatic, or heteroaromatic group; X is an amino (-NH¿2?), substituted amino, hydroxyl or substituted hydroxyl group, or is linked to the atom of group Het in R?5¿ to form a chain -X-Alk-R5- where X is -N(R12)-, Alk is an optionally substituted alkylene chain and R5 is -Het-C(R9)(R10)-; and the salts, solvates, hydrates and prodrugs thereof. The compounds are orally active metalloproteinase inhibitors and in particular have a selective gelatinase action, have a long duration of action, and may be of use in the prophylaxis or treatment of diseases or disorders in which stromelysis, collagenase or gelatinase have a role, for example in the treatment of cancer to control the development of tumor metastases.
摘要翻译： PCT No.PCT / GB94 / 00895 Sec。 371日期：1995年2月6日 102（e）日期1995年2月6日PCT 1994年4月27日PCT PCT。公开号WO94 / 25434 日期：1994年11月10日公开了作为口服活性金属蛋白酶抑制剂的肽基衍生物。肽基衍生物具有选择性明胶酶作用，具有长的作用持续时间，并且可用于预防或治疗其中溶质，胶原酶或明胶酶具有作用的疾病或病症，例如用于治疗癌症以控制肿瘤转移的发展。

10. 发明公开

EP1973887A1 AZA HETEROCYCLICS FOR THE TREATMENT OF MALARIA OR AIDS 有权
标题翻译： AZA-杂环用于治疗疟疾和艾滋病
公开(公告)号：EP1973887A1
公开(公告)日：2008-10-01
申请号：EP06841645.2
申请日：2006-12-28
申请人： Immupharma France SA
发明人： GILLES, Guichard , LENA, Gersande , LALLEMAND, Eliette , RENIA, Laurent
IPC分类号： C07D255/02 , C07D273/02 , C07D273/06 , C07D285/38 , A61K31/395 , A61P31/18 , A61P33/06
CPC分类号： C07D255/02 , C07D273/02 , C07D273/06 , C07D285/38
摘要： Methods for the synthesis of various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds (I) and their pharmaceutically acceptable salt derivatives are provided. The compounds of the invention are claimed and are useful as medicaments for the treatment or prevention of disease in a mammal, for example a human. In particular the compounds are useful as immuno therapeutics and anti -microbial drugs or vaccines. These heterocyclic derivatives can be used as an active agent in a pharmaceutical, as well as a diagnostic utility.

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