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1. 发明公开

EP1996565A2 SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY 审中-公开
标题翻译：具有抗HCV活性SUBSITUIERTE氨基噻唑衍生物
公开(公告)号：EP1996565A2
公开(公告)日：2008-12-03
申请号：EP07752705.9
申请日：2007-03-08
申请人： Achillion Pharmaceuticals, Inc.
发明人： ZHANG, Suoming , PHADKE, Avinash , WANG, Xiangzhu , LIU, Cuixian
IPC分类号： C07D277/42 , C07D277/46 , C07D277/48 , C07D277/50 , C07D277/56 , C07D417/04 , C07D417/14 , C07F9/09 , A61K31/426 , A61K31/4436 , A61P31/14
CPC分类号： C07D277/46 , C07D277/42 , C07D277/48 , C07D277/50 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/6539 , C07F9/65583
摘要： The invention provides amino-substituted aminothiazole compounds of formula (I) in which A is a group of the formula and the variables R and R1 to R7 are described herein. These compounds are useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well as to processes and intermediates useful for preparing such compounds are also provided by the invention.

2. 发明公开

EP1295872A4 DRUG COMPOSITION ANTAGONISTIC TO BOTH PGD 2/TX A 22 RECEPTORS 审中-公开
标题翻译： Bicycloheptanes ALS凝血恶烷A 2和前列腺素D2受体拮抗剂和它们的药物组合物
公开(公告)号：EP1295872A4
公开(公告)日：2007-05-16
申请号：EP01934363
申请日：2001-05-28
申请人： SHIONOGI & CO
发明人： TANIMOTO NORIHIKO , ARIMURA AKINORI
IPC分类号： C07D277/46 , C07D277/50 , C07D333/38 , A61K31/381 , A61P11/00 , C07D207/32
CPC分类号： C07D333/38
摘要： A compound which has an antagonistic effect on both thromboxane A2 and prostaglandin D2 receptors. The compound is represented by the formula (I), wherein A is alkylene optionally having an unsaturated bond; R is -C(=O)-R1, etc. (R1 is hydroxy, etc.); m is 0 or 1; p is 0 or 1; X?1 and X3¿ each independently is optionally substituted aryl, optionally substituted heteroaryl, etc.; X2 is a single bond, -CH¿2?-, -S-, -SO2-, -CH2-O-, -O-CH2-, -CH2-S-, -S-CH2-, etc.; and X?4¿ is -CH¿2?-, -CH2-CH2-, -C(=O)-, etc.

3. 发明公开

EP1498411A4 DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT 失效
标题翻译： DIZETHYDRAZINDERIVATVERBINDUNGEN UND ARZNEIMITTEL，DIE DIE VERBINDUNGEN ALS WIRKSTOFF ENTHALTEN
公开(公告)号：EP1498411A4
公开(公告)日：2005-11-30
申请号：EP03723188
申请日：2003-04-24
申请人： ONO PHARMACEUTICAL CO
发明人： HATAYAMA AKIRA , TSURUTA HIROSHI , OCHI YASUO , IMAWAKA HARUO , OHMOTO KAZUYUKI
IPC分类号： C07C243/24 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4152 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07C243/34 , C07C251/76 , C07C251/84 , C07C251/86 , C07D207/22 , C07D207/50 , C07D209/46 , C07D209/48 , C07D211/28 , C07D211/72 , C07D211/86 , C07D211/98 , C07D213/70 , C07D213/76 , C07D213/77 , C07D213/78 , C07D233/38 , C07D233/52 , C07D233/80 , C07D239/10 , C07D239/18 , C07D239/36 , C07D241/08 , C07D241/18 , C07D263/26 , C07D263/28 , C07D265/08 , C07D265/10 , C07D265/32 , C07D265/33 , C07D275/02 , C07D275/03 , C07D275/06 , C07D277/18 , C07D277/36 , C07D277/50 , C07D277/54 , C07D277/60 , C07D277/82 , C07D279/02 , C07D279/06 , C07D279/12 , C07D285/10 , C07D285/16 , C07D309/04 , C07D309/28 , C07D335/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/10 , C07F9/59 , C07F9/6558 , C07D207/408 , C07D211/26 , C07D213/53 , C07D231/08 , C07D233/32 , C07D307/52 , C07D309/06 , C07D413/12 , C07D487/04
CPC分类号： C07D209/48 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4152 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07C243/34 , C07C251/76 , C07C251/84 , C07C251/86 , C07C2601/08 , C07C2601/14 , C07D207/22 , C07D207/50 , C07D209/46 , C07D211/28 , C07D211/72 , C07D211/86 , C07D211/98 , C07D213/70 , C07D213/76 , C07D213/77 , C07D213/78 , C07D233/38 , C07D233/52 , C07D233/80 , C07D239/10 , C07D239/18 , C07D239/36 , C07D241/08 , C07D241/18 , C07D263/26 , C07D263/28 , C07D265/08 , C07D265/10 , C07D265/33 , C07D275/02 , C07D275/03 , C07D275/06 , C07D277/18 , C07D277/36 , C07D277/50 , C07D277/54 , C07D277/60 , C07D277/82 , C07D279/02 , C07D279/06 , C07D279/12 , C07D285/10 , C07D285/16 , C07D309/04 , C07D309/28 , C07D335/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/10 , C07F9/591 , C07F9/65583
摘要： The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
摘要翻译：本发明涉及式（I）的二酮肼衍生物及其药学上可接受的盐（式中的符号具有与说明书中所述相同的含义）。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，可用于治疗炎性疾病，免疫疾病，缺血性疾病，呼吸系统疾病，循环系统疾病，血液病，神经元疾病，肝或胆道疾病，骨关节疾病，代谢疾病等。该化合物对弹性蛋白酶具有抑制活性，也可用于治疗慢性阻塞性肺疾病（慢性阻塞性肺疾病）。

4. 发明公开

EP0230985A3 Alpha-glutamyl-4-azoanilides, process for their preparation and their use for the determination of alpha-glutamyltransferase 失效
标题翻译： ALPHA-GLUTAMYL-4-AZOANILIDES，其制备方法及其用于测定阿尔法 - 谷氨酰胺转移酶
公开(公告)号：EP0230985A3
公开(公告)日：1988-03-30
申请号：EP87100836
申请日：1987-01-22
申请人： BOEHRINGER MANNHEIM GMBH
发明人： Rauscher, Elli, Dr.rer.nat. , Griffiths, John Dr. , Dixon, Leonard Fox
IPC分类号： C07C107/06 , C07C121/50 , C07D333/36 , C07D277/50 , C07D275/04 , C07K05/06 , G01N33/68
CPC分类号： C12Q1/48 , Y10S435/81 , Y10T436/11

5. 发明公开

EP0159707A3 Triazolopyrimidine derivatives 有权转让
标题翻译：三唑并嘧啶衍生物
公开(公告)号：EP0159707A3
公开(公告)日：1986-10-22
申请号：EP85104988
申请日：1985-04-24
申请人： DAIICHI SEIYAKU CO. LTD.
发明人： Isoda, Sumiro , Suzuki, Norio , Miwa, Tamotsu , Aibara, Shunzo
IPC分类号： C07D513/14 , A61K31/505 , C07D513/04 , C07D285/08 , C07D417/04 , C07D277/40 , C07D277/50 , C07D285/00 , C07D249/00 , C07D239/00 , C07D277/00
CPC分类号： C07D285/08 , C07D277/40 , C07D277/50 , C07D417/04 , C07D513/04 , C07D513/14
摘要： Novel triazolopyrimidine compounds represented by the formula (I) and physiologically acceptable salts thereof are disclosed. These compounds have an excellent antial- lergic activity in oral administration and are useful for treatment and prophylaxis of allergic diseases such as bronchial asthma, allergic gastro-intestinal disorders, allergic rhinitis, hay fever, urticaria and the like.

6. 发明公开

EP4116296A1 ANTI-RNA VIRUS DRUG AND APPLICATION THEREOF 无效
公开(公告)号：EP4116296A1
公开(公告)日：2023-01-11
申请号：EP21765519.0
申请日：2021-03-02
申请人： East China University of Science and Technology , Wuhan University
发明人： LI, Honglin , XU, Ke , LI, Shiliang , ZHU, Lili , ZHAO, Zhenjiang
IPC分类号： C07D277/50 , A61K31/426 , A61P31/12
摘要： An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.

7. 发明公开

EP3459937A1 THIAZOLE DERIVATIVE AND APPLICATIONS 有权
公开(公告)号：EP3459937A1
公开(公告)日：2019-03-27
申请号：EP17798741.9
申请日：2017-05-17
申请人： East China University of Science and Technology
发明人： LI, Honglin , XU, Yufang , WANG, Rui , ZHAO, Zhenjiang , SONG, Wenlin , XU, Liuxin
IPC分类号： C07D277/50 , A61K31/426 , A61P37/00 , A61P31/04 , A61P33/00 , A61P35/00 , A61P29/00 , A61P19/02 , A61P37/06 , A61P17/06
摘要： A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

8. 发明公开

EP3077369A1 BENZAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF MUSCULAR DISORDERSAND PAIN AND FOR CONTROLLING SPASTICITY AND TREMORS 有权转让
标题翻译：苯甲酰胺衍生物FOR USE肌肉疾病以及疼痛的治疗和控制痉挛和震颤
公开(公告)号：EP3077369A1
公开(公告)日：2016-10-12
申请号：EP14819052.3
申请日：2014-12-05
申请人： Canbex Therapeutics Limited
发明人： SELWOOD, David
IPC分类号： C07C233/83 , C07C233/87 , C07C255/41 , C07C311/06 , C07C311/13 , C07D213/64 , C07D277/50 , C07D295/192 , A61K31/18 , A61P21/00
CPC分类号： C07C233/83 , C07C231/12 , C07C233/87 , C07C253/30 , C07C255/41 , C07C303/40 , C07C311/06 , C07C311/13 , C07C311/46 , C07D207/06 , C07D211/16 , C07D213/64 , C07D277/30 , C07D295/10
摘要： The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof : (I) wherein: n is 0 or 1; R1 is selected from H, alkyl and aralkyl, wherein said alkyl and aralkyl groups may be optionally substituted by one or more OH groups; X is a group selected from -C≡C-(CH2)p-; -C(R5)=C(R6)-(CH2)q-; and -C(R5)(R6)C(R7)(R8)-(CH2)r-; where each of R5, R6, R7 and R8 is independently H or alkyl, and each of p, q and r is independently 1, 2, 3, 4 or 5; Y is a group selected from: CN; COOR2; CONR3R4; SO2NR9R10; NR12COR13; NR14SO2R15; and a heterocyclic group selected from oxadiazolyl, thiazolyl, iso- thiazolyl, oxazolyl, iso-oxazolyl, pyrazolyl and imidazolyl; where each of R2, R3 and R4 is independently H or alkyl; or R3 and R4 are linked, together with the nitrogen to which they are attached, to form a 5 or 6-membered heterocycloalkyl or heterocycloalkenyl group, said heterocycloalkyl or heterocycloalkenyl group optionally containing one or more further groups selected from O, N, CO and S, and where each of R9, R10, R11, R12, R13, R14 and R15 is independently H or alkyl. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, pain, or for controlling spasticity or tremors, for example, spasticity in MS.

9. 发明公开

EP2913349A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICAL ANISTROPIC BODY 有权
标题翻译： POLYMERISIERBARE VERBINDUNG，POLYMERISIERBARE ZUSAMMENSETZUNG，POLYMER SOWIE OPTISCHER ANISOTROPERKÖRPER
公开(公告)号：EP2913349A1
公开(公告)日：2015-09-02
申请号：EP13848209.6
申请日：2013-10-16
申请人： Zeon Corporation
发明人： SAKAMOTO Kei , KIRIKI Satoshi , OKUYAMA Kumi
IPC分类号： C08F20/38 , C07D277/20 , C07D277/50 , G02B1/08 , G02B5/30 , G02F1/13363
CPC分类号： C08F222/24 , C07D277/20 , C07D277/50 , C08F222/1006 , G02B1/04 , G02B1/08 , G02B5/3016 , G02F2001/133633
摘要： The present invention pertains to: a polymerizable compound represented by a formula (I); a polymerizable composition comprising the polymerizable compound and an initiator; a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition; and an optically anisotropic article comprising the polymer. The present invention provides a polymerizable compound, a polymerizable composition, and a polymer that have a practical low melting point, exhibit excellent solubility in a general-purpose solvent, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and also provide an optically anisotropic article.

[In the formula: Y 1 to Y 8 are a chemical single bond, -O-, -O-C(=O)-, -O-C(=O)-O-, etc.; G 1 and G 2 are a divalent aliphatic group having 1 to 20 carbon atoms, etc.; Z 1 and Z 2 are an alkenyl group having 2 to 10 carbon atoms that is substituted with a halogen atom, or unsubstituted, etc.; A x is a group represented by a formula (II), wherein X is a nitrogen atom, etc.; R a and R b are a hydrogen atom, an aromatic hydrocarbon ring group having 1 to 20 carbon atoms, etc.; A y is a hydrogen atom, the group represented by the formula (II), etc.; A 1 is a trivalent aromatic group, etc; A 2 and A 3 are a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms, etc.; A 4 and A 5 are a divalent aromatic group having 4 to 30 carbon atoms, etc.; Q 1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, etc.]
摘要翻译：本发明涉及：由式（I）表示的可聚合化合物; 包含可聚合化合物和引发剂的可聚合组合物; 通过聚合可聚合化合物或可聚合组合物而获得的聚合物; 和包含聚合物的光学各向异性制品。本发明提供具有实用低熔点，在通用溶剂中表现出优异溶解性的聚合性化合物，聚合性组合物和聚合物，能够以低成本制造出可以得到均匀转化率的光学膜的偏振光，并且还提供光学各向异性制品。 [式中，Y 1〜Y 8为化学单键，-O - ， - O-C（= O） - ， - O-C（= O）-O-等。 G 1和G 2是碳原子数1〜20的二价脂肪族基团等。 Z 1和Z 2是被卤素原子取代的具有2-10个碳原子的烯基，或未被取代的; A x为由式（II）表示的基团，其中X为氮原子等; R a和R b为氢原子，碳原子数1〜20的芳香族烃环基等。 y是氢原子，式（II）表示的基团等; A 1为三价芳族基团等; A 2和A 3为碳原子数3〜30的二价脂环式烃基等。 A 4和A 5为碳原子数为4〜30的二价芳香族基团等。 Q 1为氢原子，碳原子数为1〜6的烷基等]

10. 发明公开

EP1193254A4 PHTHALAMIDE DERIVATIVES, INTERMEDIATES IN THE PRODUCTION THEREOF, AND AGRICULTURAL/HORTICULTURAL INSECTICIDES AND METHOD OF USING THE SAME 审中-公开
标题翻译：邻苯二甲酰胺衍生物，中间体产品的生产和INSKTIZIDE为农民柄/园艺和申请流程。
公开(公告)号：EP1193254A4
公开(公告)日：2007-09-19
申请号：EP00942473
申请日：2000-07-04
申请人： NIHON NOHYAKU CO LTD
发明人： MACHIYA KOUZOU , ENDOH KAZUYOSHI , FURUYA TAKASHI , NAKAO HAYAMI , GOTOH MAKOTO , KOHNO EIJI , TOHNISHI MASANORI , SAKATA KAZUYUKI , MORIMOTO MASAYUKI , SEO AKIRA
IPC分类号： A01N43/08 , A01N43/10 , A01N43/34 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , C07D207/34 , C07D213/73 , C07D213/75 , C07D231/40 , C07D233/88 , C07D239/42 , C07D241/20 , C07D249/02 , C07D249/14 , C07D261/14 , C07D263/48 , C07D271/04 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/44 , C07D277/50 , C07D277/82 , C07D285/06 , C07D285/08 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36
CPC分类号： C07D213/73 , A01N43/08 , A01N43/10 , A01N43/34 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , C07D207/34 , C07D213/75 , C07D231/40 , C07D233/88 , C07D239/42 , C07D241/20 , C07D249/02 , C07D249/14 , C07D261/14 , C07D263/48 , C07D271/04 , C07D271/113 , C07D275/03 , C07D277/50 , C07D277/82 , C07D285/06 , C07D285/08 , C07D285/135 , C07D307/66 , C07D333/36
摘要： Heterocyclic amine derivatives represented by general formula (I) wherein R?1, R2 and R3¿ represent each H, optionally halogenated C¿3-6? cycloalkyl, etc.; Q represents an optionally substituted heterocycle containing O, S or N; X represents halogeno, cyano, halo(C1-6)alkyl, etc.; n is from 1 to 4; and Z?1 and Z2¿ represent each O or S; and intermediates thereof represented by the following general formula (IV'): Q'-NH¿2? wherein Q' represents a definite heterocycle selected from among those represented by Q. Agricultural/horticultural insecticides having a remarkable effect of controlling pest insects of crops such as rice, fruit trees and vegetables, as well as various agricultural, forestry, horticultural and stored grain pest insects.

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