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1. 发明授权

EP2513030B2 BETA-GAMMA UNSATURATED ESTERS AND PROCESS OF PRODUCTION OF BETA-GAMMA UNSATURATED ESTERS. 有权
公开(公告)号：EP2513030B2
公开(公告)日：2018-08-29
申请号：EP10798071.6
申请日：2010-12-17
申请人： Givaudan SA
发明人： SCHRÖDER, Fridtjof , MUELLER, Urs , GYGAX, Peter
IPC分类号： C07C67/32 , C07C69/608 , C07D307/92
CPC分类号： C07C67/32 , C07C2601/16 , C07D307/92 , C07C69/608
摘要： A process for the preparation of &bgr;,γ-unsaturated-γ, γ-disubstituted esters 1 with high E/Z- and &bgr;,γ/α,&bgr;-ratios, Formula (1) by reacting at a temperature of between about 130 and 170 degrees centigrade the conjugated malonate Formula (3) with, a group I, II or III metal halide or an organic cation/halide anion pair, an inorganic proton source and a polar solvent.

2. 发明公开

EP3157900A1 VERFAHREN ZUR HERSTELLUNG VON 2-HALOGENACRYLSÄUREESTERN 有权
公开(公告)号：EP3157900A1
公开(公告)日：2017-04-26
申请号：EP15728903.4
申请日：2015-06-17
申请人： Saltigo GmbH
发明人： VON DEM BRUCH, Karsten , SCHERWITZKI, Andreas
IPC分类号： C07C67/307 , C07C67/32 , C07C69/63
CPC分类号： C07C69/63 , C07C67/287 , C07C67/307 , C07C67/32 , C07C67/327 , C07C301/00 , C07C69/653
摘要： The invention relates to a method for producing 2-halogen-acrylic acid esters from 2-hydroxymethyl- or 2-halogen-methyl- or 2-chlorosulfinyloxymethyl-2-halogen-malonic acid diesters. The invention further relates to 2-halogen-methyl-2-halogen-malonic acid diesters or 2-chlorosulfinyloxymethyl-2-halogen-malonic acid diesters of a new type, which can be used to produce the 2-halogen-acrylic acid esters.
摘要翻译：本发明涉及由2-羟甲基 - 或2-卤代 - 甲基 - 或2-氯亚磺酰氧基甲基-2-卤素 - 丙二酸二酯制备2-卤素 - 丙烯酸酯的方法。本发明还涉及可用于生产2-卤素 - 丙烯酸酯的新型2-卤代 - 甲基-2-卤代 - 丙二酸二酯或2-氯亚磺酰氧基甲基-2-卤代 - 丙二酸二酯。

3. 发明公开

EP2949641A1 METHOD FOR PRODUCING 3,5-DIMETHYLDODECANOIC ACID 有权
标题翻译：生产3,5-二甲基二氢肉酸的方法
公开(公告)号：EP2949641A1
公开(公告)日：2015-12-02
申请号：EP15168198.8
申请日：2015-05-19
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Ishibashi, Naoki , Baba, Akihiro , Kinsho, Takeshi
IPC分类号： C07C67/32 , C07C67/347 , C07F3/02 , C07C51/09 , C07C51/38
CPC分类号： C07C51/38 , C07C51/09 , C07C55/02 , C07C67/32 , C07C67/343 , C07C67/347 , C07F3/02 , C07C69/34 , C07C69/24 , C07C53/126 , C07C55/21
摘要： Provided is a short process for simply and efficiently producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus. More specifically provided is a method for producing 3,5-dimethyldodecanoic acid (5) comprising the steps of: converting 2-methylnonyl halide (1) to a 2-methylnonyl metal reagent (2), and reacting the 2-methylnonyl metal reagent (2) with 2-ethylidene malonic acid ester (3) to form 2-(1,3-dimethyldecyl)malonic acid ester (4) as a result of 1,4-addition of the 2-methylnonyl metal reagent (2) to the 2-ethylidene malonic acid ester (3), as shown in the following scheme:
摘要翻译：提供简单有效地生产加利福尼亚prionus的信息素的活性成分3,5-二甲基十二烷酸的简短方法。更具体地说，提供了一种制备3,5-二甲基十二烷酸（5）的方法，该方法包括以下步骤：将2-甲基壬基卤（1）转化为2-甲基壬基金属试剂（2），并使2-甲基壬基金属试剂 2）与2-亚乙基丙二酸酯（3）反应形成2-（1,3-二甲基癸基）丙二酸酯（4），其结果是2-甲基壬基金属试剂（2）1,4-加成到 2-亚乙基丙二酸酯（3），如以下方案所示：

4. 发明授权

EP1992607B1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND 有权转让
标题翻译：制造方法-4-氧代喹CONNECTION
公开(公告)号：EP1992607B1
公开(公告)日：2014-12-31
申请号：EP07737895.8
申请日：2007-03-06
申请人： Japan Tobacco, Inc.
发明人： MATSUDA, Koji , ANDO, Koji , OHKI, Shigeji , HOSHI, Jun-ichi , YAMASAKI, Takahiro
IPC分类号： C07C65/24 , C07C51/353 , C07C67/32 , C07C67/343 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56

5. 发明公开

EP2513030A1 ORGANIC COMPOUNDS 有权
标题翻译：维多利亚州朱庇特·赫伯特（BETA-GAMMAUNGESÄTTIGTEESTER UND VERFAHREN ZU IHRER HERSTELLUNG）
公开(公告)号：EP2513030A1
公开(公告)日：2012-10-24
申请号：EP10798071.6
申请日：2010-12-17
申请人： Givaudan SA
发明人： SCHRÖDER, Fridtjof , MUELLER, Urs , GYGAX, Peter
IPC分类号： C07C67/32 , C07C69/608 , C07D307/92
CPC分类号： C07C67/32 , C07C2601/16 , C07D307/92 , C07C69/608
摘要： A process for the preparation of β,γ-unsaturated-γ,γ-disubstituted esters 1 with high
E/Z - and β,γ/α,β-ratios, Formula (1) by reacting at a temperature of between about 130 and 170 degrees centigrade the conjugated malonate Formula (3) with, a group I, II or III metal halide or an organic cation/halide anion pair, an inorganic proton source and a polar solvent.
摘要翻译：一种制备具有高E / Z-和γb的γ不饱和-γ，γ-二取代酯1的方法，式（1）通过在温度为共轭丙二酸酯式（3）与I，II或III族金属卤化物或有机阳离子/卤化物阴离子对，无机质子源和极性溶剂约为130和170摄氏度。

6. 发明授权

EP1498407B1 Method of producing acetate derivative 有权
标题翻译：一种用于生产乙酸衍生物的过程
公开(公告)号：EP1498407B1
公开(公告)日：2012-09-05
申请号：EP04016607.6
申请日：2004-07-14
申请人： KAO CORPORATION
发明人： Mine, Koji , Hagi, Hisanori
IPC分类号： C07C67/32 , C07C69/716
CPC分类号： C07C67/32 , C07C2601/08 , C07C69/716

7. 发明公开

EP2060557A1 Intermediate compounds useful to prepare dolasetron 有权
标题翻译： Fürdie Zubereitung von DolasetronnützlicheZwischenprodukte
公开(公告)号：EP2060557A1
公开(公告)日：2009-05-20
申请号：EP07380317.3
申请日：2007-11-13
申请人： INKE, S.A.
发明人： Pérez Andrés, Juan, Antonio , Dalmases Barjoan, Pere , Huguet Clotet, Juan
IPC分类号： C07C67/32 , C07C69/67 , C07D451/14 , C07D471/18
CPC分类号： C07C67/313 , C07C67/32 , C07C67/343 , C07C69/708 , C07D451/14 , C07D471/18 , C07D471/22 , C07C69/716
摘要： The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.
摘要翻译：本发明涉及可用于合成杜拉司琼及其合成前体的中间体以及获得它们的方法。此外，它是指多沙司琼的盐酸盐和多沙司琼的多晶型物及其前体。

8. 发明公开

EP1992607A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER 4-OXOCHINOLIN-VERBINDUNG
公开(公告)号：EP1992607A1
公开(公告)日：2008-11-19
申请号：EP07737895.8
申请日：2007-03-06
申请人： Japan Tobacco, Inc.
发明人： MATSUDA, Koji , ANDO, Koji , OHKI, Shigeji , HOSHI, Jun-ichi , YAMASAKI, Takahiro
IPC分类号： C07C65/24 , C07C51/353 , C07C67/32 , C07C67/343 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2'):

wherein R is a fluorine atom or a methoxy group, and R 400 is a hydrogen atom or a C 1 - C 4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物及其制备方法，以及使用该合成中间体的抗HIV剂的制备方法。具体地说，例如，由式（2'）表示的化合物或其盐，其中R是氟原子或甲氧基，R 400是氢原子或C 1 -C 4烷基，和其制备方法和使用该合成中间体的抗HIV剂的制备方法。

9. 发明公开

EP1801094A1 METHOD FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOATE AND OPTICALLY ACTIVE SUBSTANCE THEREOF 审中-公开
标题翻译：用于生产（4E）-5-氯-2-异丙基-4-戊烯酸酯及其旋光物
公开(公告)号：EP1801094A1
公开(公告)日：2007-06-27
申请号：EP05793121.4
申请日：2005-10-11
申请人： Asahi Glass Company, Limited
发明人： SAKAEDA, Toshitsugu, Asahi Glass Company, Limited , MORI, Nobuaki, Asahi Glass Company, Limited , KANOH, Hideto, Seimi Chemical Co., Ltd.
IPC分类号： C07C67/32 , C07C69/65 , C12P41/00 , C07C67/343
CPC分类号： C12P41/005 , C07C67/32 , C07C67/343 , C12P7/62 , C07C69/65
摘要： To provide a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate in high yield and efficiently.
A compound (2) is reacted with a base in the presence of an aprotic solvent and then with (1E)-1,3-dichloro-1-propene in the same reaction vessel to obtain a compound (3), and then either of -COOR moieties in the compound (3) is replaced with a hydrogen atom in the same reaction vessel to obtain a compound (4):

wherein R is a lower alkyl group or an aralkyl group.

10. 发明公开

EP1571138A4 PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ESTER AND OPTICALLY ACTIVE ISOMER THEREOF 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON（4E）-5-氯-2-异丙基-4-戊烯酸酯和OPTISCHAKTIVEM ISOMER DAVON
公开(公告)号：EP1571138A4
公开(公告)日：2005-12-07
申请号：EP03777366
申请日：2003-12-09
申请人： ASAHI GLASS CO LTD
发明人： MORI NOBUAKI , MATSUMURA YASUSHI , MORIZAWA YOSHITOMI , KAMINUMA TOSHIHIKO , AOKI YUUICHI
IPC分类号： C07C67/32 , C07C67/343 , C07C67/48 , C07B53/00 , C07B57/00 , C07C69/65
CPC分类号： C07C67/343 , C07B2200/07 , C07B2200/09 , C07C67/32 , C07C67/48 , C07C69/65
摘要： Processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoic ester and an optically active isomer thereof which are useful as intermediates for medicines and agricultural chemicals. One of the processes, which is for producing a (4E)-5-chloro-2-isopropyl-4-pentenoic ester represented by the following formula (4), is characterized by reacting a compound represented by the following formula (2) with a base (II) in the presence of an aprotic solvent (II) and subsequently with (1E)-1,3-dichloro-1-propene to obtain a compound represented by the following formula (3) and then eliminating the alkoxycarbonyl group from one of the ester groups of the compound represented by the following formula (3). The other process, which is for producing an (S)-(4E)-5-chloro-2-isopropyl-4-pentenoic ester represented by the following formula (5), is characterized by optically resolving the (4E)-5-chloro-2-isopropyl-4-pentenoic ester represented by the formula (4), which is obtained by that production process. (In the formulae, R represents lower alkyl or aralkyl.)
摘要翻译：生产用作药物和农业化学品中间体的（4E）-5-氯-2-异丙基-4-戊烯酸酯及其旋光异构体的方法。用于制备由下式（4）表示的（4E）-5-氯-2-异丙基-4-戊烯酸酯的方法之一的特征在于使由下式（2）表示的化合物与在非质子传递溶剂（II）存在下，然后用（1E）-1,3-二氯-1-丙烯处理碱（II），得到下式（3）代表的化合物，然后从其中除去烷氧基羰基由下式（3）表示的化合物的酯基之一。另一种用于制备由下式（5）表示的（S） - （4E）-5-氯-2-异丙基-4-戊烯酸酯的方法的特征在于通过光学拆分（4E）-5- （4）所示的3-氯-2-异丙基-4-戊烯酸酯，由该制造方法得到。（式中，R表示低级烷基或芳烷基。）

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